Birgit Schilling Biography Publications JoVE Articles Birgit Schilling has not added a biography. If you are Birgit Schilling and would like to personalize this page please email our Author Liaison for assistance. Publications Cytotrophoblast Extracellular Vesicles Enhance Decidual Cell Secretion of Immune Modulators Via TNF-alpha Development (Cambridge, England). Aug, 2020 | Pubmed ID: 32747437 Translational Control of One-carbon Metabolism Underpins Ribosomal Protein Phenotypes in Cell Division and Longevity ELife. May, 2020 | Pubmed ID: 32432546 The Power of Proteomics to Monitor Senescence-associated Secretory Phenotypes and Beyond: Toward Clinical Applications Expert Review of Proteomics. Apr, 2020 | Pubmed ID: 32425074 Abundances of Transcripts, Proteins, and Metabolites in the Cell Cycle of Budding Yeast Reveal Coordinate Control of Lipid Metabolism Molecular Biology of the Cell. 05, 2020 | Pubmed ID: 32129706 Skyline for Small Molecules: A Unifying Software Package for Quantitative Metabolomics Journal of Proteome Research. Apr, 2020 | Pubmed ID: 31984744 Activating Transcription Factor 4 (ATF4) Promotes Skeletal Muscle Atrophy by Forming a Heterodimer with the Transcriptional Regulator C/EBPβ The Journal of Biological Chemistry. Feb, 2020 | Pubmed ID: 31953319 A Proteomic Atlas of Senescence-associated Secretomes for Aging Biomarker Development PLoS Biology. Jan, 2020 | Pubmed ID: 31945054 Proteome and Secretome Dynamics of Human Retinal Pigment Epithelium in Response to Reactive Oxygen Species Scientific Reports. Oct, 2019 | Pubmed ID: 31659173 Dietary Sugars Alter Hepatic Fatty Acid Oxidation Via Transcriptional and Post-translational Modifications of Mitochondrial Proteins Cell Metabolism. Oct, 2019 | Pubmed ID: 31577934 Sirtuin 5 Regulates Proximal Tubule Fatty Acid Oxidation to Protect Against AKI Journal of the American Society of Nephrology : JASN. Dec, 2019 | Pubmed ID: 31575700 SILAC Analysis Reveals Increased Secretion of Hemostasis-Related Factors by Senescent Cells Cell Reports. Sep, 2019 | Pubmed ID: 31553904 Accumulation of "Old Proteins" and the Critical Need for MS-based Protein Turnover Measurements in Aging and Longevity Proteomics. Aug, 2019 | Pubmed ID: 31408259 Post-translational Protein Acetylation: An Elegant Mechanism for Bacteria to Dynamically Regulate Metabolic Functions Frontiers in Microbiology. 2019 | Pubmed ID: 31354686 High-Resolution Mass Spectrometry to Identify and Quantify Acetylation Protein Targets Methods in Molecular Biology (Clifton, N.J.). 2019 | Pubmed ID: 31087289 Regulation of UCP1 and Mitochondrial Metabolism in Brown Adipose Tissue by Reversible Succinylation Molecular Cell. 05, 2019 | Pubmed ID: 31000437 Correction for Christensen Et Al., "Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli" MBio. 04, 2019 | Pubmed ID: 30967468 JNK Modifies Neuronal Metabolism to Promote Proteostasis and Longevity Aging Cell. 06, 2019 | Pubmed ID: 30810280 Global Lysine Acetylation in Results from Growth Conditions That Favor Acetate Fermentation Journal of Bacteriology. 05, 2019 | Pubmed ID: 30782634 Temporal Dynamics of Liver Mitochondrial Protein Acetylation and Succinylation and Metabolites Due to High Fat Diet And/or Excess Glucose or Fructose PloS One. 2018 | Pubmed ID: 30586434 Identification of Novel Protein Lysine Acetyltransferases in Escherichia Coli MBio. 10, 2018 | Pubmed ID: 30352934 Identifying Ubiquitinated Proteins and Aggregates Aging. 10, 2018 | Pubmed ID: 30335616 Impairment of Angiogenesis by Fatty Acid Synthase Inhibition Involves MTOR Malonylation Cell Metabolism. 12, 2018 | Pubmed ID: 30146486 Simultaneous Quantification of the Acetylome and Succinylome by 'One-Pot' Affinity Enrichment Proteomics. 09, 2018 | Pubmed ID: 30035354 Removing 4E-BP Enables Synapses to Refine Without Postsynaptic Activity Cell Reports. 04, 2018 | Pubmed ID: 29617653 Protein Turnover in Aging and Longevity Proteomics. Mar, 2018 | Pubmed ID: 29453826 An Acetylatable Lysine Controls CRP Function in E. Coli Molecular Microbiology. Jan, 2018 | Pubmed ID: 29105190 Ancient Regulatory Role of Lysine Acetylation in Central Metabolism MBio. Nov, 2017 | Pubmed ID: 29184018 Characterization of Inner and Outer Membrane Proteins FromStrains LVS and Schu S4 and Identification of Potential Subunit Vaccine Candidates MBio. Oct, 2017 | Pubmed ID: 29018123 Multi-laboratory Assessment of Reproducibility, Qualitative and Quantitative Performance of SWATH-mass Spectrometry Nature Communications. 08, 2017 | Pubmed ID: 28827567 PIQED: Automated Identification and Quantification of Protein Modifications from DIA-MS Data Nature Methods. Jun, 2017 | Pubmed ID: 28661500 Identification and Characterization of AckA-dependent Protein Acetylation in Neisseria Gonorrhoeae PloS One. 2017 | Pubmed ID: 28654654 MSstatsQC: Longitudinal System Suitability Monitoring and Quality Control for Targeted Proteomic Experiments Molecular & Cellular Proteomics : MCP. Jul, 2017 | Pubmed ID: 28483925 Clinical Applications of Quantitative Proteomics Using Targeted and Untargeted Data-independent Acquisition Techniques Expert Review of Proteomics. 05, 2017 | Pubmed ID: 28436239 Generation of High-Quality SWATHAcquisition Data for Label-free Quantitative Proteomics Studies Using TripleTOFMass Spectrometers Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 28188533 Vitamin D Promotes Protein Homeostasis and Longevity Via the Stress Response Pathway Genes Skn-1, Ire-1, and Xbp-1 Cell Reports. 10, 2016 | Pubmed ID: 27783938 Stable Nuclear Expression of ATP8 and ATP6 Genes Rescues a MtDNA Complex V Null Mutant Nucleic Acids Research. Nov, 2016 | Pubmed ID: 27596602 Quantification of Lysine Acetylation and Succinylation Stoichiometry in Proteins Using Mass Spectrometric Data-Independent Acquisitions (SWATH) Journal of the American Society for Mass Spectrometry. Nov, 2016 | Pubmed ID: 27590315 Gadd45a Protein Promotes Skeletal Muscle Atrophy by Forming a Complex with the Protein Kinase MEKK4 The Journal of Biological Chemistry. 08, 2016 | Pubmed ID: 27358404 Acetylated Tau Obstructs KIBRA-Mediated Signaling in Synaptic Plasticity and Promotes Tauopathy-Related Memory Loss Neuron. 04, 2016 | Pubmed ID: 27041503 Multiplexed, Scheduled, High-Resolution Parallel Reaction Monitoring on a Full Scan QqTOF Instrument with Integrated Data-Dependent and Targeted Mass Spectrometric Workflows Analytical Chemistry. Oct, 2015 | Pubmed ID: 26398777 Critical Role of Acetylation in Tau-mediated Neurodegeneration and Cognitive Deficits Nature Medicine. Oct, 2015 | Pubmed ID: 26390242 Protein Acetylation Dynamics in Response to Carbon Overflow in Escherichia Coli Molecular Microbiology. Dec, 2015 | Pubmed ID: 26264774 SIRT1 Deacetylates RORγt and Enhances Th17 Cell Generation The Journal of Experimental Medicine. May, 2015 | Pubmed ID: 25918343 Large-Scale Interlaboratory Study to Develop, Analytically Validate and Apply Highly Multiplexed, Quantitative Peptide Assays to Measure Cancer-Relevant Proteins in Plasma Molecular & Cellular Proteomics : MCP. Sep, 2015 | Pubmed ID: 25693799 Iron Promotes Protein Insolubility and Aging in C. Elegans Aging. Nov, 2014 | Pubmed ID: 25554795 Panorama: a Targeted Proteomics Knowledge Base Journal of Proteome Research. Sep, 2014 | Pubmed ID: 25102069 RPL24: a Potential Therapeutic Target Whose Depletion or Acetylation Inhibits Polysome Assembly and Cancer Cell Growth Oncotarget. Jul, 2014 | Pubmed ID: 24970821 Variation and Quantification Among a Target Set of Phosphopeptides in Human Plasma by Multiple Reaction Monitoring and SWATH-MS2 Data-independent Acquisition Electrophoresis. Dec, 2014 | Pubmed ID: 24853916 Structural, Kinetic and Proteomic Characterization of Acetyl Phosphate-dependent Bacterial Protein Acetylation PloS One. 2014 | Pubmed ID: 24756028 Phosphoprotein Secretome of Tumor Cells As a Source of Candidates for Breast Cancer Biomarkers in Plasma Molecular & Cellular Proteomics : MCP. Apr, 2014 | Pubmed ID: 24505115 Site-specific Acylation Changes in the Lipid A of Escherichia Coli LpxL Mutants Grown at High Temperatures Innate Immunity. Apr, 2014 | Pubmed ID: 23812252 Label-Free Quantitation and Mapping of the ErbB2 Tumor Receptor by Multiple Protease Digestion with Data-Dependent (MS1) and Data-Independent (MS2) Acquisitions International Journal of Proteomics. 2013 | Pubmed ID: 23710360 Label-free Quantitative Proteomics of the Lysine Acetylome in Mitochondria Identifies Substrates of SIRT3 in Metabolic Pathways Proceedings of the National Academy of Sciences of the United States of America. Apr, 2013 | Pubmed ID: 23576753 Ligand Binding Promotes CDK-dependent Phosphorylation of ER-alpha on Hinge Serine 294 but Inhibits Ligand-independent Phosphorylation of Serine 305 Molecular Cancer Research : MCR. Aug, 2012 | Pubmed ID: 22669764 Ubiquitin-specific Peptidase 9, X-linked (USP9X) Modulates Activity of Mammalian Target of Rapamycin (mTOR) The Journal of Biological Chemistry. Jun, 2012 | Pubmed ID: 22544753 Platform-independent and Label-free Quantitation of Proteomic Data Using MS1 Extracted Ion Chromatograms in Skyline: Application to Protein Acetylation and Phosphorylation Molecular & Cellular Proteomics : MCP. May, 2012 | Pubmed ID: 22454539 レクチン クロマトグラフィー/質量分析法検出ワークフロー攻撃的な乳癌の推定のバイオ マーカーを識別します。 Journal of Proteome Research. Feb, 2012 | Pubmed ID: 22309216 2S03 Huntingtin 小説リジン アセチル化サイト。 Molecular & Cellular Proteomics : MCP. Oct, 2011 | Pubmed ID: 21685499 シーケンスのタグ付けを介してタンデム質量スペクトルの ScanRanker: 品質評価。 Journal of Proteome Research. Jul, 2011 | Pubmed ID: 21520941 3-ニトロチロシン修正マススペクトル データを複数の質量分析プラットフォーム間での自信を持って識別。 Journal of Proteomics. Oct, 2011 | Pubmed ID: 21514405 トリプシン消化したヒト血漿中Glycosite特有のがん関連糖鎖構造を標的とレクチン親和性のワークフロー Analytical Biochemistry. Jan, 2011 | Pubmed ID: 20705048 新しい変調器と非アポトーシスにおける蛋白質の変化の同定プログラムされた細胞死。 Journal of Cellular Biochemistry. Dec, 2010 | Pubmed ID: 20830744 ターゲットを絞った Quantitation のサイト固有のシステインの酸化差動アルキル化および質量分析アプローチを監視複数の反応を用いた内因性タンパク質で。 Molecular & Cellular Proteomics : MCP. Jul, 2010 | Pubmed ID: 20233844 液体クロマトグラフィー - タンデム質量分析法によるプロテオーム識別]の再現性と再現性 Journal of Proteome Research. Feb, 2010 | Pubmed ID: 19921851 ベンチマークLC-MSプラットフォームのパフォーマンスのための酵母の性能標準の特性室間共同試験 Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19858499 プロテオミクス解析における液体クロマトグラフィー - タンデム質量分析システムのパフォーマンス·メトリック Molecular & Cellular Proteomics : MCP. Feb, 2010 | Pubmed ID: 19837981 結核菌 Bovis Bcg Bacille ファゴソーム プロテオーム。 Molecular & Cellular Proteomics : MCP. Jan, 2010 | Pubmed ID: 19815536 Α-シヌクレインのチロシン-39 パーキンソン病の細胞酸化モデルでの優先的増加ニトロ化。 Analytical Chemistry. Sep, 2009 | Pubmed ID: 19697948 血漿中のタンパク質の複数の反応モニタリングベースの測定の精度と再現性のマルチサイトの評価 Nature Biotechnology. Jul, 2009 | Pubmed ID: 19561596 IDPicker 2.0:フィルターハイ差別ペプチドの同定と改善されたタンパク質のアセンブリ Journal of Proteome Research. Aug, 2009 | Pubmed ID: 19522537 修飾ヒトエストロゲン受容体 α 重点新規リン酸化のサイトでの体系的なマッピングです。 Molecular & Cellular Proteomics : MCP. Mar, 2009 | Pubmed ID: 18984578 エストロゲン受容体の N 末端ドメインで検出された新規のセリンプロテアーゼのリン酸化部位はひと乳癌細胞から分離。 Journal of the American Society for Mass Spectrometry. May, 2008 | Pubmed ID: 18367407 Intraprotein 架橋部分のアセチル化リジン残基を向上させます。 Analytical Chemistry. Feb, 2008 | Pubmed ID: 18201069 後半レシチンコレステロールアシルトランスフェラーゼ野兎の LpxL の同定 Infection and Immunity. Nov, 2007 | Pubmed ID: 17724076 ミトコンドリアの酸化ストレスは、tauの過リン酸化を引き起こす PloS One. 2007 | Pubmed ID: 17579710 小規模 Immunopurification シトクロム C 酸化酵素の酵素活性及び量の高スループット多重分析。 Biotechnology and Applied Biochemistry. Dec, 2007 | Pubmed ID: 17508937 リピド A アシル化パターンの野兎、野兎病菌 Novicida 多段質量分析およびマトリックス支援レーザー脱離イオン中間真空ソース線形イオン トラップでを使用して野兎病菌 Philomiragia のキャラクタリゼーション Analytical Chemistry. Feb, 2007 | Pubmed ID: 17263332 新規経路乳癌細胞におけるキノン誘起応力に関連付けられています。 Drug Metabolism Reviews. 2006 | Pubmed ID: 17145690 質量分析法によるマップされて Huntingtin のリン酸化のサイト。胸の谷間と毒性の変調。 The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16782707 プロテオーム解析によるウシおよびマウス心臓ミトコンドリアから免疫沈降分離コハク酸脱水素酵素およびユビキノール-シトクロム C レダクターゼ (複合体 II と III) の。 Biochimica Et Biophysica Acta. Feb, 2006 | Pubmed ID: 16120479 アルツハイマー病におけるアミロイド前駆体インターアクターのパイロットプロテオミクス研究 Annals of Neurology. Aug, 2005 | Pubmed ID: 16049941 新規リン酸化の質量分析法による同定ウシ ミトコンドリア複合体サブユニット NDUFA10 サイトします。 FEBS Letters. Apr, 2005 | Pubmed ID: 15848193 迅速な精製とミトコンドリア NADH 脱水素酵素の質量分析法によるキャラクタリゼーション (複雑な私は) 齧歯類脳とドーパミン神経細胞ラインから。 Molecular & Cellular Proteomics : MCP. Jan, 2005 | Pubmed ID: 15591592 新規修飾脂質野兎 A の。 Infection and Immunity. Sep, 2004 | Pubmed ID: 15322031 新規レクチン Dlta が、ヘモフィルス デュクレイ中における血清抵抗性表現型の式が必要です。 Infection and Immunity. Jun, 2004 | Pubmed ID: 15155648 プロテオミクスおよびスタスミン成体での役割の免疫化学的キャラクタリゼーション FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Feb, 2004 | Pubmed ID: 14769823 小胞体ストレスによって活性化細胞死経路の分子のコンポーネント。 The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14561754 同位体標識架橋試薬: 架橋ペプチドの同定における質量縮退の解像度。 Bioorganic & Medicinal Chemistry Letters. Nov, 2003 | Pubmed ID: 14592499 Phosphospecific タンパク質を分解タンパク質リン酸化のサイトのマッピング。 Nature Biotechnology. Sep, 2003 | Pubmed ID: 12923550 MS2Assign、自動割り当てとタンデム質量スペクトルの化学的架橋ペプチドの命名。 Journal of the American Society for Mass Spectrometry. Aug, 2003 | Pubmed ID: 12892908 カテプシン L の分泌小胞エンケファリン ペプチド神経伝達物質の生産のためのプロホルモン処理酵素として機能します。 Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12869695 ヘモフィルス デュクレイ Lipooligosaccharides に不自然なシアル酸の代謝の混入。 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2003 | Pubmed ID: 12615992 Lipooligosaccharides Polylactosamine を含むインフルエンザ菌は性からの特性が繰り返されます。 Journal of the American Society for Mass Spectrometry. Jun, 2002 | Pubmed ID: 12056572 Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology 定量化とサイトローカリゼーションのための2つの翻訳後修飾の同時アフィニティエンリッチメント Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology 部位特異的タンパク質のリジンのアセチル化のサクシニル化化学量論組成データに依存しない取得質量分析法による定量 Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology 複雑な生体試料から選択的グリコシル化ペプチドを豊かにするためにレクチンHPLC法 Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology
Quantification of Insoluble Protein Aggregation in Caenorhabditis elegans during Aging with a Novel Data-Independent Acquisition Workflow JoVE 61366 Biology
定量化とサイトローカリゼーションのための2つの翻訳後修飾の同時アフィニティエンリッチメント Xueshu Xie1, Samah Shah1, Anja Holtz1, Jacob Rose1, Nathan Basisty1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 60780 Biology
部位特異的タンパク質のリジンのアセチル化のサクシニル化化学量論組成データに依存しない取得質量分析法による定量 Lei Wei1, Jesse G. Meyer1, Birgit Schilling1 1Buck Institute for Research on Aging JoVE 57209 Biology
複雑な生体試料から選択的グリコシル化ペプチドを豊かにするためにレクチンHPLC法 Eric Johansen1, Birgit Schilling2, Michael Lerch1, Richard K. Niles1, Haichuan Liu1, Bensheng Li2, Simon Allen1, Steven C. Hall1, H. Ewa Witkowska1, Fred E. Regnier3, Bradford W. Gibson2, Susan J. Fisher1, Penelope M. Drake1 1Obstetrics, Gynecology and Reproductive Sciences, University of California, San Francisco - UCSF, 2Buck Institute for Age Research, 3Department of Chemistry, Purdue University JoVE 1398 Biology