Brian M. Zeglis

Publications

• Leveraging Bioorthogonal Click Chemistry to Improve Ac-Radioimmunotherapy of Pancreatic Ductal Adenocarcinoma
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2019   |   Pubmed ID: 30352909
• Pretargeted Imaging and Therapy
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. 10, 2017   |   Pubmed ID: 28687600
• ESPMIS: Helping Young Scientists Navigate the Molecular Imaging Landscape
  Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Feb, 2017   |   Pubmed ID: 28194633
• Establishment of the In Vivo Efficacy of Pretargeted Radioimmunotherapy Utilizing Inverse Electron Demand Diels-Alder Click Chemistry
  Molecular Cancer Therapeutics. Jan, 2017   |   Pubmed ID: 28062708
• A Pretargeted Approach for the Multimodal PET/NIRF Imaging of Colorectal Cancer
  Theranostics. Month, 2016   |   Pubmed ID: 27924162
• Click Chemistry and Radiochemistry: The First 10 Years
  Bioconjugate Chemistry. Dec, 2016   |   Pubmed ID: 27787983
• A Bone-Seeking Trans-Cyclooctene for Pretargeting and Bioorthogonal Chemistry: A Proof of Concept Study Using (99m)Tc- and (177)Lu-Labeled Tetrazines
  Journal of Medicinal Chemistry. Oct, 2016   |   Pubmed ID: 27676258
• Near-Infrared Intraoperative Chemiluminescence Imaging
  ChemMedChem. Sep, 2016   |   Pubmed ID: 27471800
• A Comparative Evaluation of the Chelators H4octapa and CHX-A″-DTPA with the Therapeutic Radiometal (90)Y
  Nuclear Medicine and Biology. Sep, 2016   |   Pubmed ID: 27419360
• Pretargeted PET Imaging Using a Site-Specifically Labeled Immunoconjugate
  Bioconjugate Chemistry. Aug, 2016   |   Pubmed ID: 27356886
• Molecular Imaging of Ovarian Cancer
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jun, 2016   |   Pubmed ID: 27127223
• Preclinical 89Zr Immuno-PET of High-Grade Serous Ovarian Cancer and Lymph Node Metastasis
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. May, 2016   |   Pubmed ID: 26837339
• Site-Specifically Labeled Immunoconjugates for Molecular Imaging--Part 2: Peptide Tags and Unnatural Amino Acids
  Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Apr, 2016   |   Pubmed ID: 26754791
• Site-Specifically Labeled Immunoconjugates for Molecular Imaging--Part 1: Cysteine Residues and Glycans
  Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging. Feb, 2016   |   Pubmed ID: 26754790
• (18)F-Based Pretargeted PET Imaging Based on Bioorthogonal Diels-Alder Click Chemistry
  Bioconjugate Chemistry. Feb, 2016   |   Pubmed ID: 26479967
• Pretargeted Immuno-PET of Pancreatic Cancer: Overcoming Circulating Antigen and Internalized Antibody to Reduce Radiation Doses
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Mar, 2016   |   Pubmed ID: 26471693
• Site-specifically Labeled CA19.9-targeted Immunoconjugates for the PET, NIRF, and Multimodal PET/NIRF Imaging of Pancreatic Cancer
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2015   |   Pubmed ID: 26668398
• Optimization of a Pretargeted Strategy for the PET Imaging of Colorectal Carcinoma Via the Modulation of Radioligand Pharmacokinetics
  Molecular Pharmaceutics. Oct, 2015   |   Pubmed ID: 26287993
• Chemoenzymatic Strategy for the Synthesis of Site-specifically Labeled Immunoconjugates for Multimodal PET and Optical Imaging
  Bioconjugate Chemistry. Dec, 2014   |   Pubmed ID: 25418333
• Synthesis and Evaluation of (18)F-labeled ATP Competitive Inhibitors of Topoisomerase II As Probes for Imaging Topoisomerase II Expression
  European Journal of Medicinal Chemistry. Oct, 2014   |   Pubmed ID: 25240701
• What a Difference a Carbon Makes: H₄octapa Vs H₄C3octapa, Ligands for In-111 and Lu-177 Radiochemistry
  Inorganic Chemistry. Oct, 2014   |   Pubmed ID: 25192223
• Synthesis of the First Radiolabeled 188Re N-heterocyclic Carbene Complex and Initial Studies on Its Potential Use in Radiopharmaceutical Applications
  Journal of Labelled Compounds & Radiopharmaceuticals. Jun, 2014   |   Pubmed ID: 24889257
• Alternative Chelator for ⁸⁹Zr Radiopharmaceuticals: Radiolabeling and Evaluation of 3,4,3-(LI-1,2-HOPO)
  Journal of Medicinal Chemistry. Jun, 2014   |   Pubmed ID: 24814511
• Building Blocks for the Construction of Bioorthogonally Reactive Peptides Via Solid-Phase Peptide Synthesis
  ChemistryOpen. Apr, 2014   |   Pubmed ID: 24808990
• The Inverse Electron Demand Diels-Alder Click Reaction in Radiochemistry
  Journal of Labelled Compounds & Radiopharmaceuticals. Apr, 2014   |   Pubmed ID: 24347429
• Underscoring the Influence of Inorganic Chemistry on Nuclear Imaging with Radiometals
  Inorganic Chemistry. Feb, 2014   |   Pubmed ID: 24313747
• H6phospa-trastuzumab: Bifunctional Methylenephosphonate-based Chelator with 89Zr, 111In and 177Lu
  Dalton Transactions (Cambridge, England : 2003). Jan, 2014   |   Pubmed ID: 24104523
• H(4)octapa-trastuzumab: Versatile Acyclic Chelate System for 111In and 177Lu Imaging and Therapy
  Journal of the American Chemical Society. Aug, 2013   |   Pubmed ID: 23901833
• A Pretargeted PET Imaging Strategy Based on Bioorthogonal Diels-Alder Click Chemistry
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Aug, 2013   |   Pubmed ID: 23708196
• Enzyme-mediated Methodology for the Site-specific Radiolabeling of Antibodies Based on Catalyst-free Click Chemistry
  Bioconjugate Chemistry. Jun, 2013   |   Pubmed ID: 23688208
• The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jun, 2013   |   Pubmed ID: 23616581
• PET Imaging with ⁸⁹Zr: from Radiochemistry to the Clinic
  Nuclear Medicine and Biology. Jan, 2013   |   Pubmed ID: 22998840
• H(2)azapa: a Versatile Acyclic Multifunctional Chelator for (67)Ga, (64)Cu, (111)In, and (177)Lu
  Inorganic Chemistry. Nov, 2012   |   Pubmed ID: 23106422
• Modular Strategy for the Construction of Radiometalated Antibodies for Positron Emission Tomography Based on Inverse Electron Demand Diels-Alder Click Chemistry
  Bioconjugate Chemistry. Oct, 2011   |   Pubmed ID: 21877749
• The Synthesis and Evaluation of N1-(4-(2-[18F]-fluoroethyl)phenyl)-N8-hydroxyoctanediamide ([18F]-FESAHA), a PET Radiotracer Designed for the Delineation of Histone Deacetylase Expression in Cancer
  Nuclear Medicine and Biology. Jul, 2011   |   Pubmed ID: 21718944
• A Practical Guide to the Construction of Radiometallated Bioconjugates for Positron Emission Tomography
  Dalton Transactions (Cambridge, England : 2003). Jun, 2011   |   Pubmed ID: 21442098
• Role of Metalation in the Topoisomerase IIα Inhibition and Antiproliferation Activity of a Series of α-heterocyclic-N4-substituted Thiosemicarbazones and Their Cu(II) Complexes
  Journal of Medicinal Chemistry. Apr, 2011   |   Pubmed ID: 21391686
• A Bulky Rhodium Complex Bound to an Adenosine-adenosine DNA Mismatch: General Architecture of the Metalloinsertion Binding Mode
  Biochemistry. May, 2009   |   Pubmed ID: 19374348
• Recognition of Abasic Sites and Single Base Bulges in DNA by a Metalloinsertor
  Biochemistry. Feb, 2009   |   Pubmed ID: 19146409
• Binding of Ru(bpy)2(eilatin)2+ to Matched and Mismatched DNA
  Inorganic Chemistry. Jul, 2008   |   Pubmed ID: 18576614
• Targeting Abasic Sites and Single Base Bulges in DNA with Metalloinsertors
  Journal of the American Chemical Society. Jun, 2008   |   Pubmed ID: 18491905
• Metallo-intercalators and Metallo-insertors
  Chemical Communications (Cambridge, England). Nov, 2007   |   Pubmed ID: 17989802
• DNA Base Mismatch Detection with Bulky Rhodium Intercalators: Synthesis and Applications
  Nature Protocols. Month, 2007   |   Pubmed ID: 17406597
• A Mismatch-selective Bifunctional Rhodium-Oregon Green Conjugate: a Fluorescent Probe for Mismatched DNA
  Journal of the American Chemical Society. May, 2006   |   Pubmed ID: 16637630
• Unexpected Oxidative C-C Cleavage in the Metallation of 2-substituted Imidazolium Salts to Give N-heterocyclic Carbene Complexes
  Chemical Communications (Cambridge, England). Oct, 2004   |   Pubmed ID: 15467859