In JoVE (1)
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Articles by Bridie J. Goggin in JoVE
Ex Vivo Intestinal Sacs to Assess Mucosal Permeability in Models of Gastrointestinal Disease Sean W. Mateer1, Jocelle Cardona1, Ellen Marks1, Bridie J. Goggin1, Susan Hua1, Simon Keely1 1School of Biomedical Science and Pharmacy, University of Newcastle This protocol describes the use of excised intestinal tissue preparations or "intestinal sacs" as an ex vivo model of intestinal barrier function. This model may be used to assess integrity of both the epithelial barrier and the mucous gel layer at specific intestinal sites in animal models of digestive disease.