Britta Engelhardt Theodor Kocher Institute University of Bern Biography Publications Institution JoVE Articles Britta Engelhardt has not added a biography. If you are Britta Engelhardt and would like to personalize this page please email our Author Liaison for assistance. Publications Compromised Blood-Brain Barrier Junctions Enhance Melanoma Cell Intercalation and Extravasation Cancers. Oct, 2023 | Pubmed ID: 37894438 SARS-CoV-2 Infects Epithelial Cells of the Blood-cerebrospinal Fluid Barrier Rather Than Endothelial Cells or Pericytes of the Blood-brain Barrier Fluids and Barriers of the CNS. Oct, 2023 | Pubmed ID: 37875964 A20 Regulates Lymphocyte Adhesion in Murine Neuroinflammation by Restricting Endothelial ICOSL Expression in the CNS The Journal of Clinical Investigation. Dec, 2023 | Pubmed ID: 37856217 Molecular Anatomy of Adult Mouse Leptomeninges Neuron. Dec, 2023 | Pubmed ID: 37776854 VE-cadherin in Arachnoid and Pia Mater Cells Serves As a Suitable Landmark for in Vivo Imaging of CNS Immune Surveillance and Inflammation Nature Communications. Sep, 2023 | Pubmed ID: 37730744 Correction To: The Choroid Plexus Acts As an Immune Cell Reservoir and Brain Entry Site in Experimental Autoimmune Encephalomyelitis Fluids and Barriers of the CNS. Jul, 2023 | Pubmed ID: 37452369 Integration of Immune Cells in Organs-on-chips: a Tutorial Frontiers in Bioengineering and Biotechnology. 2023 | Pubmed ID: 37324438 The Choroid Plexus Acts As an Immune Cell Reservoir and Brain Entry Site in Experimental Autoimmune Encephalomyelitis Fluids and Barriers of the CNS. Jun, 2023 | Pubmed ID: 37264368 Antigen Recognition Detains CD8 T Cells at the Blood-brain Barrier and Contributes to Its Breakdown Nature Communications. May, 2023 | Pubmed ID: 37253744 High Levels of Endothelial ICAM-1 Prohibit Natalizumab Mediated Abrogation of CD4 T Cell Arrest on the Inflamed BBB Under Flow in Vitro Journal of Neuroinflammation. May, 2023 | Pubmed ID: 37221552 Effects of a Small-Molecule Perforin Inhibitor in a Mouse Model of CD8 T Cell-Mediated Neuroinflammation Neurology(R) Neuroimmunology & Neuroinflammation. Jul, 2023 | Pubmed ID: 37080596 Blockade of VEGFR3 Signaling Leads to Functional Impairment of Dural Lymphatic Vessels Without Affecting Autoimmune Neuroinflammation Science Immunology. Apr, 2023 | Pubmed ID: 37058549 Open Pathways for Cerebrospinal Fluid Outflow at the Cribriform Plate Along the Olfactory Nerves EBioMedicine. May, 2023 | Pubmed ID: 37043871 Insulin-like Growth Factor-1 Receptor Controls the Function of CNS-resident Macrophages and Their Contribution to Neuroinflammation Acta Neuropathologica Communications. Mar, 2023 | Pubmed ID: 36890580 Macrophages Clear the Way for CNS Fluid Flow The Lancet. Neurology. Mar, 2023 | Pubmed ID: 36804079 Modeling Brain Vasculature Immune Interactions In Vitro Cold Spring Harbor Perspectives in Medicine. Dec, 2022 | Pubmed ID: 36617644 Bovine Neutrophil Chemotaxis to Listeria Monocytogenes in Neurolisteriosis Depends on Microglia-released Rather Than Bacterial Factors Journal of Neuroinflammation. Dec, 2022 | Pubmed ID: 36527076 Perivascular Spaces and Their Role in Neuroinflammation Neuron. Nov, 2022 | Pubmed ID: 36327898 A Potent and Selective Inhibitor for the Modulation of MAGL Activity in the Neurovasculature PloS One. 2022 | Pubmed ID: 36084029 Connexins Orchestrate Progression of Breast Cancer Metastasis to the Brain by Promoting FAK Activation Science Translational Medicine. Sep, 2022 | Pubmed ID: 36070364 The Modular µSiM: A Mass Produced, Rapidly Assembled, and Reconfigurable Platform for the Study of Barrier Tissue Models In Vitro Advanced Healthcare Materials. Jul, 2022 | Pubmed ID: 35899801 Full Spectrum of Vitamin D Immunomodulation in Multiple Sclerosis: Mechanisms and Therapeutic Implications Brain Communications. 2022 | Pubmed ID: 35813882 Autoimmune Neuroinflammation Triggers Mitochondrial Oxidation in Oligodendrocytes Glia. Nov, 2022 | Pubmed ID: 35762739 Multiple Sclerosis: Immunopathological Heterogeneity and Its Implications European Journal of Immunology. Jun, 2022 | Pubmed ID: 35476319 How Does the Immune System Enter the Brain? Frontiers in Immunology. 2022 | Pubmed ID: 35273596 COVID-19 and the Vasculature: Current Aspects and Long-Term Consequences Frontiers in Cell and Developmental Biology. 2022 | Pubmed ID: 35242762 Brain Barriers Virtual: an Interim Solution or Future Opportunity? Fluids and Barriers of the CNS. Mar, 2022 | Pubmed ID: 35232464 Central Nervous System Zoning: How Brain Barriers Establish Subdivisions for CNS Immune Privilege and Immune Surveillance Journal of Internal Medicine. Jul, 2022 | Pubmed ID: 35184353 Intrinsic Blood-brain Barrier Dysfunction Contributes to Multiple Sclerosis Pathogenesis Brain : a Journal of Neurology. Dec, 2022 | Pubmed ID: 35085379 ACKR1 Favors Transcellular over Paracellular T-cell Diapedesis Across the Blood-brain Barrier in Neuroinflammation in Vitro European Journal of Immunology. Jan, 2022 | Pubmed ID: 34524684 Brain Barriers and Multiple Sclerosis: Novel Treatment Approaches from a Brain Barriers Perspective Handbook of Experimental Pharmacology. 2022 | Pubmed ID: 33237504 Nano-scale Architecture of Blood-brain Barrier Tight-junctions ELife. Dec, 2021 | Pubmed ID: 34951586 Wnt Signaling Mediates Acquisition of Blood-brain Barrier Properties in Naïve Endothelium Derived from Human Pluripotent Stem Cells ELife. Nov, 2021 | Pubmed ID: 34755601 Covalent and Noncovalent Conjugation of Degradable Polymer Nanoparticles to T Lymphocytes Biomacromolecules. Aug, 2021 | Pubmed ID: 34170107 Differentiation of Human Pluripotent Stem Cells to Brain Microvascular Endothelial Cell-like Cells Suitable to Study Immune Cell Interactions STAR Protocols. Jun, 2021 | Pubmed ID: 34151293 Pro-resolving Lipid Mediator Lipoxin A Attenuates Neuro-inflammation by Modulating T cell Responses and Modifies the Spinal Cord Lipidome Cell Reports. Jun, 2021 | Pubmed ID: 34077725 Brain Endothelial Tricellular Junctions As Novel Sites for T Cell Diapedesis Across the Blood-brain Barrier Journal of Cell Science. Apr, 2021 | Pubmed ID: 33912914 Loss of Claudin-3 Impairs Hepatic Metabolism, Biliary Barrier Function, and Cell Proliferation in the Murine Liver Cellular and Molecular Gastroenterology and Hepatology. 2021 | Pubmed ID: 33866021 Selective Endocannabinoid Reuptake Inhibitor WOBE437 Reduces Disease Progression in a Mouse Model of Multiple Sclerosis ACS Pharmacology & Translational Science. Apr, 2021 | Pubmed ID: 33860200 Histone Deacetylase 1 Controls CD4 T Cell Trafficking in Autoinflammatory Diseases Journal of Autoimmunity. 05, 2021 | Pubmed ID: 33621930 Biotin-NeutrAvidin Mediated Immobilization of Polymer Micro- and Nanoparticles on T Lymphocytes Bioconjugate Chemistry. Mar, 2021 | Pubmed ID: 33621057 Novel Compounds with Dual S1P Receptor Agonist and Histamine H Receptor Antagonist Activities Act Protective in a Mouse Model of Multiple Sclerosis Neuropharmacology. Mar, 2021 | Pubmed ID: 33460688 T Cell-Mediated Transport of Polymer Nanoparticles Across the Blood-Brain Barrier Advanced Healthcare Materials. Jan, 2021 | Pubmed ID: 33241667 Maternal Infection Impairs Fetal Brain Development Via Choroid Plexus Inflammation Developmental Cell. Dec, 2020 | Pubmed ID: 33290691 Innovative High-resolution MicroCT Imaging of Animal Brain Vasculature Brain Structure & Function. Dec, 2020 | Pubmed ID: 33128675 Advancing Human Induced Pluripotent Stem Cell-derived Blood-brain Barrier Models for Studying Immune Cell Interactions FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Dec, 2020 | Pubmed ID: 33124083 Microglia Get a Little Help from "Th"-eir Friends Immunity. Sep, 2020 | Pubmed ID: 32937150 Immune Cell Trafficking Across the Blood-brain Barrier in the Absence and Presence of Neuroinflammation Vascular Biology (Bristol, England). 2020 | Pubmed ID: 32923970 Morpholino Analogues of Fingolimod As Novel and Selective S1P Ligands with In Vivo Efficacy in a Mouse Model of Experimental Antigen-Induced Encephalomyelitis International Journal of Molecular Sciences. Sep, 2020 | Pubmed ID: 32899717 Advancing Brain Barriers RNA Sequencing: Guidelines from Experimental Design to Publication Fluids and Barriers of the CNS. Aug, 2020 | Pubmed ID: 32811511 Contribution of Brain Pericytes in Blood-brain Barrier Formation and Maintenance: a Transcriptomic Study of Cocultured Human Endothelial Cells Derived from Hematopoietic Stem Cells Fluids and Barriers of the CNS. Jul, 2020 | Pubmed ID: 32723387 Oligomeric Forms of Human Amyloid-Beta(1-42) Inhibit Antigen Presentation Frontiers in Immunology. 2020 | Pubmed ID: 32582162 CD31 (PECAM-1) Serves As the Endothelial Cell-Specific Receptor of Clostridium Perfringens β-Toxin Cell Host & Microbe. Jul, 2020 | Pubmed ID: 32497498 Angiopoietin-2 Blockade Ameliorates Autoimmune Neuroinflammation by Inhibiting Leukocyte Recruitment into the CNS The Journal of Clinical Investigation. Apr, 2020 | Pubmed ID: 32149735 Human CD4 T Cell Subsets Differ in Their Abilities to Cross Endothelial and Epithelial Brain Barriers in Vitro Fluids and Barriers of the CNS. Feb, 2020 | Pubmed ID: 32008573 Functional Relevance of the Multi-drug Transporter Abcg2 on Teriflunomide Therapy in an Animal Model of Multiple Sclerosis Journal of Neuroinflammation. Jan, 2020 | Pubmed ID: 31915017 Sleep Enhances Numbers and Function of Monocytes and Improves Bacterial Infection Outcome in Mice Brain, Behavior, and Immunity. Jul, 2020 | Pubmed ID: 31904407 Intercellular Adhesion Molecule-1 (ICAM-1) and ICAM-2 Differentially Contribute to Peripheral Activation and CNS Entry of Autoaggressive Th1 and Th17 Cells in Experimental Autoimmune Encephalomyelitis Frontiers in Immunology. 2019 | Pubmed ID: 31993059 Distinct Migratory Pattern of Naive and Effector T Cells Through the Blood-CSF Barrier Following Echovirus 30 Infection Journal of Neuroinflammation. Nov, 2019 | Pubmed ID: 31752904 Structure and Junctional Complexes of Endothelial, Epithelial and Glial Brain Barriers International Journal of Molecular Sciences. Oct, 2019 | Pubmed ID: 31671721 Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies (second Edition) European Journal of Immunology. Oct, 2019 | Pubmed ID: 31633216 Claudin-12 is Not Required for Blood-brain Barrier Tight Junction Function Fluids and Barriers of the CNS. Sep, 2019 | Pubmed ID: 31511021 Publisher Correction: Claudin-3-deficient C57BL/6J Mice Display Intact Brain Barriers Scientific Reports. Jul, 2019 | Pubmed ID: 31320665 CD49d/CD29-integrin Controls the Accumulation of Plasmacytoid Dendritic Cells into the CNS During Neuroinflammation European Journal of Immunology. Nov, 2019 | Pubmed ID: 31318439 PECAM-1 Stabilizes Blood-Brain Barrier Integrity and Favors Paracellular T-Cell Diapedesis Across the Blood-Brain Barrier During Neuroinflammation Frontiers in Immunology. 2019 | Pubmed ID: 31024547 The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30901861 Claudin-3-deficient C57BL/6J Mice Display Intact Brain Barriers Scientific Reports. Jan, 2019 | Pubmed ID: 30659216 A Silicon Nanomembrane Platform for the Visualization of Immune Cell Trafficking Across the Human Blood-brain Barrier Under Flow Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2019 | Pubmed ID: 30565961 Ischemia-reperfusion Injury in Stroke: Impact of the Brain Barriers and Brain Immune Privilege on Neutrophil Function Therapeutic Advances in Neurological Disorders. 2018 | Pubmed ID: 30181779 Lack of Junctional Adhesion Molecule (JAM)-B Ameliorates Experimental Autoimmune Encephalomyelitis Brain, Behavior, and Immunity. Oct, 2018 | Pubmed ID: 29920328 Frequency and Clinical Characteristics of Multiple Sclerosis Rebounds After Withdrawal of Fingolimod CNS Neuroscience & Therapeutics. Oct, 2018 | Pubmed ID: 29898493 Brain-released Alarmins and Stress Response Synergize in Accelerating Atherosclerosis Progression After Stroke Science Translational Medicine. 03, 2018 | Pubmed ID: 29540615 ICAM-1 C57BL/6 Mice Are Not Protected from Experimental Ischemic Stroke Translational Stroke Research. Dec, 2018 | Pubmed ID: 29399739 Cluster: Barriers of the Central Nervous System Acta Neuropathologica. Mar, 2018 | Pubmed ID: 29397420 Molecular Anatomy and Functions of the Choroidal Blood-cerebrospinal Fluid Barrier in Health and Disease Acta Neuropathologica. Mar, 2018 | Pubmed ID: 29368213 TNFα Blockade Mediates Bone Protection in Antigen-induced Arthritis by Reducing Osteoclast Precursor Supply Bone. Feb, 2018 | Pubmed ID: 29081378 Immunosenescence in Persons with Spinal Cord Injury in Relation to Urinary Tract Infections -a Cross-sectional Study Immunity & Ageing : I & A. 2017 | Pubmed ID: 29176992 Impaired T-cell Migration to the CNS Under Fingolimod and Dimethyl Fumarate Neurology(R) Neuroimmunology & Neuroinflammation. Nov, 2017 | Pubmed ID: 29075657 Guidelines for the Use of Flow Cytometry and Cell Sorting in Immunological Studies European Journal of Immunology. Oct, 2017 | Pubmed ID: 29023707 ICAMs Support B Cell Interactions with T Follicular Helper Cells and Promote Clonal Selection The Journal of Experimental Medicine. Nov, 2017 | Pubmed ID: 28939548 The Choroid Plexus is a Key Cerebral Invasion Route for T Cells After Stroke Acta Neuropathologica. 12, 2017 | Pubmed ID: 28762187 A Novel Cervical Spinal Cord Window Preparation Allows for Two-Photon Imaging of T-Cell Interactions with the Cervical Spinal Cord Microvasculature During Experimental Autoimmune Encephalomyelitis Frontiers in Immunology. 2017 | Pubmed ID: 28443093 ALCAM (CD166) is Involved in Extravasation of Monocytes Rather Than T Cells Across the Blood-brain Barrier Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Aug, 2017 | Pubmed ID: 28273717 The Movers and Shapers in Immune Privilege of the CNS Nature Immunology. Feb, 2017 | Pubmed ID: 28092374 Dual Role of ALCAM in Neuroinflammation and Blood-brain Barrier Homeostasis Proceedings of the National Academy of Sciences of the United States of America. Jan, 2017 | Pubmed ID: 28069965 Non-invasive Near-infrared Fluorescence Imaging of the Neutrophil Response in a Mouse Model of Transient Cerebral Ischaemia Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Aug, 2017 | Pubmed ID: 27789786 Neutrophil Recruitment Limited by High-affinity Bent β2 Integrin Binding Ligand in Cis Nature Communications. Aug, 2016 | Pubmed ID: 27578049 Vascular, Glial, and Lymphatic Immune Gateways of the Central Nervous System Acta Neuropathologica. Sep, 2016 | Pubmed ID: 27522506 Refined Clinical Scoring in Comparative EAE Studies Does Not Enhance the Chance to Observe Statistically Significant Differences European Journal of Immunology. 10, 2016 | Pubmed ID: 27469626 Current Multiple Sclerosis Treatments Have Improved Our Understanding of MS Autoimmune Pathogenesis European Journal of Immunology. Sep, 2016 | Pubmed ID: 27467894 Postarrest Stalling Rather Than Crawling Favors CD8(+) over CD4(+) T-cell Migration Across the Blood-brain Barrier Under Flow in Vitro European Journal of Immunology. Sep, 2016 | Pubmed ID: 27338806 Modeling Immune Functions of the Mouse Blood-cerebrospinal Fluid Barrier in Vitro: Primary Rather Than Immortalized Mouse Choroid Plexus Epithelial Cells Are Suited to Study Immune Cell Migration Across This Brain Barrier Fluids and Barriers of the CNS. Jan, 2016 | Pubmed ID: 26833402 Lung ICAM-1 and ICAM-2 Support Spontaneous Intravascular Effector Lymphocyte Entrapment but Are Not Required for Neutrophil Entrapment or Emigration Inside Endotoxin-inflamed Lungs FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2016 | Pubmed ID: 26823454 Sphingosine Kinase 2 Deficient Mice Exhibit Reduced Experimental Autoimmune Encephalomyelitis: Resistance to FTY720 but Not ST-968 Treatments Neuropharmacology. Jun, 2016 | Pubmed ID: 26808312 Immune Cell Trafficking Across the Barriers of the Central Nervous System in Multiple Sclerosis and Stroke Biochimica Et Biophysica Acta. Mar, 2016 | Pubmed ID: 26527183 Inhibition and Deficiency of the Immunoproteasome Subunit LMP7 Attenuates LCMV-induced Meningitis European Journal of Immunology. Jan, 2016 | Pubmed ID: 26464284 Leptomeningeal Contrast Enhancement and Blood-CSF Barrier Dysfunction in Aseptic Meningitis Neurology(R) Neuroimmunology & Neuroinflammation. Dec, 2015 | Pubmed ID: 26516629 Migration of Encephalitogenic CD8 T Cells into the Central Nervous System is Dependent on the α4β1-integrin European Journal of Immunology. Dec, 2015 | Pubmed ID: 26358409 Wiring the Vascular Network with Neural Cues: A CNS Perspective Neuron. Jul, 2015 | Pubmed ID: 26182414 Brain Barriers: Crosstalk Between Complex Tight Junctions and Adherens Junctions The Journal of Cell Biology. May, 2015 | Pubmed ID: 26008742 Mode of Action of Claudin Peptidomimetics in the Transient Opening of Cellular Tight Junction Barriers Biomaterials. Jun, 2015 | Pubmed ID: 25907035 Investigation of Leptomeningeal Enhancement in MS: a Postcontrast FLAIR MRI Study Neurology. Feb, 2015 | Pubmed ID: 25616480 Cell Surface Levels of Endothelial ICAM-1 Influence the Transcellular or Paracellular T-cell Diapedesis Across the Blood-brain Barrier European Journal of Immunology. Apr, 2015 | Pubmed ID: 25545837 The Heparan Sulfate Proteoglycan Agrin Contributes to Barrier Properties of Mouse Brain Endothelial Cells by Stabilizing Adherens Junctions Cell and Tissue Research. Nov, 2014 | Pubmed ID: 25107608 Neutrophils Mediate Blood-spinal Cord Barrier Disruption in Demyelinating Neuroinflammatory Diseases Journal of Immunology (Baltimore, Md. : 1950). Sep, 2014 | Pubmed ID: 25049355 A Stable and Reproducible Human Blood-brain Barrier Model Derived from Hematopoietic Stem Cells PloS One. 2014 | Pubmed ID: 24936790 Novel Oxazolo-oxazole Derivatives of FTY720 Reduce Endothelial Cell Permeability, Immune Cell Chemotaxis and Symptoms of Experimental Autoimmune Encephalomyelitis in Mice Neuropharmacology. Oct, 2014 | Pubmed ID: 24863045 PSGL-1 and E/P-selectins Are Essential for T-cell Rolling in Inflamed CNS Microvessels but Dispensable for Initiation of EAE European Journal of Immunology. Aug, 2014 | Pubmed ID: 24740164 DARC Shuttles Inflammatory Chemokines Across the Blood-brain Barrier During Autoimmune Central Nervous System Inflammation Brain : a Journal of Neurology. May, 2014 | Pubmed ID: 24625696 Novel Insights into the Development and Maintenance of the Blood-brain Barrier Cell and Tissue Research. Mar, 2014 | Pubmed ID: 24590145 β2 Integrin-mediated Crawling on Endothelial ICAM-1 and ICAM-2 is a Prerequisite for Transcellular Neutrophil Diapedesis Across the Inflamed Blood-brain Barrier Journal of Immunology (Baltimore, Md. : 1950). Jan, 2014 | Pubmed ID: 24259506 Kindlin-3 Regulates Integrin Activation and Adhesion Reinforcement of Effector T Cells Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24089451 Wnt Activation of Immortalized Brain Endothelial Cells As a Tool for Generating a Standardized Model of the Blood Brain Barrier in Vitro PloS One. 2013 | Pubmed ID: 23940549 Live Cell Imaging Techniques to Study T Cell Trafficking Across the Blood-brain Barrier in Vitro and in Vivo Fluids and Barriers of the CNS. Jan, 2013 | Pubmed ID: 23336847 The Neurovascular Unit As a Selective Barrier to Polymorphonuclear Granulocyte (PMN) Infiltration into the Brain After Ischemic Injury Acta Neuropathologica. Mar, 2013 | Pubmed ID: 23269317 Immunologic Privilege in the Central Nervous System and the Blood-brain Barrier Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jan, 2013 | Pubmed ID: 23072749 Junctional Adhesion Molecule (JAM)-C Deficient C57BL/6 Mice Develop a Severe Hydrocephalus PloS One. 2012 | Pubmed ID: 23029139 Going Against the Tide--how Encephalitogenic T Cells Breach the Blood-brain Barrier Journal of Vascular Research. 2012 | Pubmed ID: 22948545 Capture, Crawl, Cross: the T Cell Code to Breach the Blood-brain Barriers Trends in Immunology. Dec, 2012 | Pubmed ID: 22926201 Loss of Astrocyte Polarization Upon Transient Focal Brain Ischemia As a Possible Mechanism to Counteract Early Edema Formation Glia. Nov, 2012 | Pubmed ID: 22782669 Neuroscience. Blood-brain Barrier Differentiation Science (New York, N.Y.). Dec, 2011 | Pubmed ID: 22194564 Claudin-1 Induced Sealing of Blood-brain Barrier Tight Junctions Ameliorates Chronic Experimental Autoimmune Encephalomyelitis Acta Neuropathologica. Nov, 2011 | Pubmed ID: 21983942 β1-integrin/matrix Interactions Support Blood-brain Barrier Integrity Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Oct, 2011 | Pubmed ID: 21772311 Brain Infiltration of Leukocytes Contributes to the Pathophysiology of Temporal Lobe Epilepsy The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Mar, 2011 | Pubmed ID: 21411646 Fluids and Barriers of the CNS Establish Immune Privilege by Confining Immune Surveillance to a Two-walled Castle Moat Surrounding the CNS Castle Fluids and Barriers of the CNS. Jan, 2011 | Pubmed ID: 21349152 TET Inducible Expression of the α4β7-integrin Ligand MAdCAM-1 on the Blood-brain Barrier Does Not Influence the Immunopathogenesis of Experimental Autoimmune Encephalomyelitis European Journal of Immunology. Mar, 2011 | Pubmed ID: 21341265 Tight Junctions in Brain Barriers During Central Nervous System Inflammation Antioxidants & Redox Signaling. Sep, 2011 | Pubmed ID: 21338320 PSGL-1 is Dispensible for the Development of Active Experimental Autoimmune Encephalomyelitis in SJL/J Mice Journal of Neuroimmunology. Mar, 2011 | Pubmed ID: 21051092 Comparison of Immortalized BEnd5 and Primary Mouse Brain Microvascular Endothelial Cells As in Vitro Blood-brain Barrier Models for the Study of T Cell Extravasation Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jan, 2011 | Pubmed ID: 20606687 Differential Roles for Endothelial ICAM-1, ICAM-2, and VCAM-1 in Shear-resistant T Cell Arrest, Polarization, and Directed Crawling on Blood-brain Barrier Endothelium Journal of Immunology (Baltimore, Md. : 1950). Oct, 2010 | Pubmed ID: 20861356 Alpha4beta1 Integrin Mediates the Recruitment of Immature Dendritic Cells Across the Blood-brain Barrier During Experimental Autoimmune Encephalomyelitis Journal of Immunology (Baltimore, Md. : 1950). Jun, 2010 | Pubmed ID: 20483748 Comprehensive Analysis of Lymph Node Stroma-expressed Ig Superfamily Members Reveals Redundant and Nonredundant Roles for ICAM-1, ICAM-2, and VCAM-1 in Lymphocyte Homing Blood. Aug, 2010 | Pubmed ID: 20395417 Preclinical Testing of Strategies for Therapeutic Targeting of Human T-cell Trafficking in Vivo Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20379881 The Blood-brain and the Blood-cerebrospinal Fluid Barriers: Function and Dysfunction Seminars in Immunopathology. Nov, 2009 | Pubmed ID: 19779720 Culture-induced Changes in Blood-brain Barrier Transcriptome: Implications for Amino-acid Transporters in Vivo Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Sep, 2009 | Pubmed ID: 19491922 Cutting Edge: Natalizumab Blocks Adhesion but Not Initial Contact of Human T Cells to the Blood-brain Barrier in Vivo in an Animal Model of Multiple Sclerosis Journal of Immunology (Baltimore, Md. : 1950). May, 2009 | Pubmed ID: 19414741 Flotillins Interact with PSGL-1 in Neutrophils And, Upon Stimulation, Rapidly Organize into Membrane Domains Subsequently Accumulating in the Uropod PloS One. 2009 | Pubmed ID: 19404397 Endothelial Cell Activation Leads to Neutrophil Transmigration As Supported by the Sequential Roles of ICAM-2, JAM-A, and PECAM-1 Blood. Jun, 2009 | Pubmed ID: 19211506 Beta1 Integrins Differentially Control Extravasation of Inflammatory Cell Subsets into the CNS During Autoimmunity Proceedings of the National Academy of Sciences of the United States of America. Feb, 2009 | Pubmed ID: 19179279 VE-PTP Maintains the Endothelial Barrier Via Plakoglobin and Becomes Dissociated from VE-cadherin by Leukocytes and by VEGF The Journal of Experimental Medicine. Nov, 2008 | Pubmed ID: 19015309 The Blood-central Nervous System Barriers Actively Control Immune Cell Entry into the Central Nervous System Current Pharmaceutical Design. 2008 | Pubmed ID: 18673197 L-Selectin-deficient SJL and C57BL/6 Mice Are Not Resistant to Experimental Autoimmune Encephalomyelitis European Journal of Immunology. Aug, 2008 | Pubmed ID: 18651702 Distinct Molecular Composition of Blood and Lymphatic Vascular Endothelial Cell Junctions Establishes Specific Functional Barriers Within the Peripheral Lymph Node European Journal of Immunology. Aug, 2008 | Pubmed ID: 18629939 Immune Cell Entry into the Central Nervous System: Involvement of Adhesion Molecules and Chemokines Journal of the Neurological Sciences. Nov, 2008 | Pubmed ID: 18573502 Effect of Interferon-beta and Atorvastatin on Th1/Th2 Cytokines in Multiple Sclerosis Neurochemistry International. Jul, 2008 | Pubmed ID: 18524417 Inducible Endothelial Cell-specific Gene Expression in Transgenic Mouse Embryos and Adult Mice Experimental Cell Research. Apr, 2008 | Pubmed ID: 18272150 Natalizumab: Targeting Alpha4-integrins in Multiple Sclerosis Neuro-degenerative Diseases. 2008 | Pubmed ID: 18075270 Therapeutic Targeting of Leukocyte Trafficking Across the Blood-brain Barrier Inflammation & Allergy Drug Targets. Dec, 2007 | Pubmed ID: 18220956 E- and P-selectin Are Not Required for the Development of Experimental Autoimmune Encephalomyelitis in C57BL/6 and SJL Mice Journal of Immunology (Baltimore, Md. : 1950). Dec, 2007 | Pubmed ID: 18056394 Regulation of Immune Cell Entry into the Central Nervous System Results and Problems in Cell Differentiation. 2006 | Pubmed ID: 17068976 The Circumventricular Organs Participate in the Immunopathogenesis of Experimental Autoimmune Encephalomyelitis Cerebrospinal Fluid Research. Sep, 2005 | Pubmed ID: 16197544 Therapeutic Targeting of Alpha 4-integrins in Chronic Inflammatory Diseases: Tipping the Scales of Risk Towards Benefit? European Journal of Immunology. Aug, 2005 | Pubmed ID: 16052610 The Ins and Outs of T-lymphocyte Trafficking to the CNS: Anatomical Sites and Molecular Mechanisms Trends in Immunology. Sep, 2005 | Pubmed ID: 16039904 P-selectin Glycoprotein Ligand 1 is Not Required for the Development of Experimental Autoimmune Encephalomyelitis in SJL and C57BL/6 Mice Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002731 Importance of Integrin LFA-1 Deactivation for the Generation of Immune Responses The Journal of Experimental Medicine. Jun, 2005 | Pubmed ID: 15955836 Gene and Protein Expression Profiling of the Microvascular Compartment in Experimental Autoimmune Encephalomyelitis in C57Bl/6 and SJL Mice Brain Pathology (Zurich, Switzerland). Jan, 2005 | Pubmed ID: 15779231 Mini-review: Transendothelial Migration of Leukocytes: Through the Front Door or Around the Side of the House? European Journal of Immunology. Nov, 2004 | Pubmed ID: 15376193 The Blood-CSF-brain Route of Neurological Disease: The Indirect Pathway into the Brain Neuropathology and Applied Neurobiology. | Pubmed ID: 34935179 Author Spotlight: Advancing the Use of Tissue Chip Technology for Studying Human Tissues Molly C. McCloskey1, Pelin Kasap2, Michelle Trempel1, Louis P. Widom3, Julia Kuebel1, Kaihua Chen1, Thomas R. Gaborski3, Britta Engelhardt2, James L. McGrath1 1Department of Biomedical Engineering, University of Rochester, 2Theodor Kocher Institute, University of Bern, 3Department of Biomedical Engineering, Rochester Institute of Technology JoVE 65258 Bioengineering 인간 유도 만능 줄기 세포를 성숙한 면역 표현형을 가진 뇌 미세혈관 내피 세포 유사 세포로 분화 Kinya Matsuo1, Britta Engelhardt2, Hideaki Nishihara3 1Graduate School of Medicine, Yamaguchi University, 2Theodor Kocher Institute, University of Bern, 3Department of Neurotherapeutics, Yamaguchi University of Medicine JoVE 65134 Bioengineering Vivo에서 실험적인 자기 면역 뇌 중 Neurovascular 단위의 내 피와 폐해 장벽의 장애 시각화 Silvia M. Tietz1, Britta Engelhardt1 1Theodor Kocher Institute, University of Bern JoVE 59249 Immunology and Infection
Author Spotlight: Advancing the Use of Tissue Chip Technology for Studying Human Tissues Molly C. McCloskey1, Pelin Kasap2, Michelle Trempel1, Louis P. Widom3, Julia Kuebel1, Kaihua Chen1, Thomas R. Gaborski3, Britta Engelhardt2, James L. McGrath1 1Department of Biomedical Engineering, University of Rochester, 2Theodor Kocher Institute, University of Bern, 3Department of Biomedical Engineering, Rochester Institute of Technology JoVE 65258 Bioengineering
인간 유도 만능 줄기 세포를 성숙한 면역 표현형을 가진 뇌 미세혈관 내피 세포 유사 세포로 분화 Kinya Matsuo1, Britta Engelhardt2, Hideaki Nishihara3 1Graduate School of Medicine, Yamaguchi University, 2Theodor Kocher Institute, University of Bern, 3Department of Neurotherapeutics, Yamaguchi University of Medicine JoVE 65134 Bioengineering
Vivo에서 실험적인 자기 면역 뇌 중 Neurovascular 단위의 내 피와 폐해 장벽의 장애 시각화 Silvia M. Tietz1, Britta Engelhardt1 1Theodor Kocher Institute, University of Bern JoVE 59249 Immunology and Infection
