Bruce D. Trapp Department of Neurosciences, Lerner Research Institute Cleveland Clinic Biography Publications Institution JoVE Articles Bruce D. Trapp has not added a biography. If you are Bruce D. Trapp and would like to personalize this page please email our Author Liaison for assistance. Publications Brain Fibrinogen Deposition Plays a Key Role in MS Pathophysiology - Yes Multiple Sclerosis (Houndmills, Basingstoke, England). Jul, 2019 | Pubmed ID: 31315512 PHERV-W Envelope Protein Fuels Microglial Cell-dependent Damage of Myelinated Axons in Multiple Sclerosis Proceedings of the National Academy of Sciences of the United States of America. Jun, 2019 | Pubmed ID: 31213545 The Role of the Thalamus and Hippocampus in Episodic Memory Performance in Patients with Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). 04, 2019 | Pubmed ID: 29512427 Identifying a New Subtype of Multiple Sclerosis Neurodegenerative Disease Management. 12, 2018 | Pubmed ID: 30215581 Cortical Neuronal Densities and Cerebral White Matter Demyelination in Multiple Sclerosis: a Retrospective Study The Lancet. Neurology. 10, 2018 | Pubmed ID: 30143361 Lateral Cerebellar Nucleus Stimulation Promotes Motor Recovery and Suppresses Neuroinflammation in a Fluid Percussion Injury Rodent Model Brain Stimulation. Nov - Dec, 2018 | Pubmed ID: 30061053 Much, if Not All, of the Cortical Damage in MS Can Be Attributed to the Microglial Cell - No Multiple Sclerosis (Houndmills, Basingstoke, England). 06, 2018 | Pubmed ID: 29754529 A Histone Deacetylase 3-dependent Pathway Delimits Peripheral Myelin Growth and Functional Regeneration Nature Medicine. 03, 2018 | Pubmed ID: 29431744 MR Imaging-based Estimation of Upper Motor Neuron Density in Patients with Amyotrophic Lateral Sclerosis: A Feasibility Study Radiology. 06, 2018 | Pubmed ID: 29361242 Alterations in CA1 Hippocampal Synapses in a Mouse Model of Fragile X Syndrome Glia. 04, 2018 | Pubmed ID: 29274095 T1-/T2-weighted Ratio Differs in Demyelinated Cortex in Multiple Sclerosis Annals of Neurology. Oct, 2017 | Pubmed ID: 28833377 DNA Methylation in Demyelinated Multiple Sclerosis Hippocampus Scientific Reports. 08, 2017 | Pubmed ID: 28821749 Integrin-Kindlin3 Requirements for Microglial Motility in Vivo Are Distinct from Those for Macrophages JCI Insight. Jun, 2017 | Pubmed ID: 28570266 BACE1 Regulates the Proliferation and Cellular Functions of Schwann Cells Glia. 05, 2017 | Pubmed ID: 28191691 GlcNAc6ST-1 Regulates Sulfation of N-glycans and Myelination in the Peripheral Nervous System Scientific Reports. 02, 2017 | Pubmed ID: 28186137 Discovery of 1,2,3-Triazole Derivatives for Multimodality PET/CT/Cryoimaging of Myelination in the Central Nervous System Journal of Medicinal Chemistry. 02, 2017 | Pubmed ID: 28107629 Proteolipid Protein-deficient Myelin Promotes Axonal Mitochondrial Dysfunction Via Altered Metabolic Coupling The Journal of Cell Biology. Nov, 2016 | Pubmed ID: 27872255 Is Axonal Degeneration a Key Early Event in Parkinson's Disease? Journal of Parkinson's Disease. 10, 2016 | Pubmed ID: 27497486 Relapses in Multiple Sclerosis: Relationship to Disability Multiple Sclerosis and Related Disorders. Mar, 2016 | Pubmed ID: 27063617 Microglia and Neuroprotection Journal of Neurochemistry. Jan, 2016 | Pubmed ID: 25693054 Interleukin-10 is a Critical Regulator of White Matter Lesion Containment Following Viral Induced Demyelination Glia. Nov, 2015 | Pubmed ID: 26132901 The Relationship Between Cognitive Function and High-resolution Diffusion Tensor MRI of the Cingulum Bundle in Multiple Sclerosis Multiple Sclerosis (Houndmills, Basingstoke, England). Dec, 2015 | Pubmed ID: 26106010 Astrocyte Response to IFN-γ Limits IL-6-mediated Microglia Activation and Progressive Autoimmune Encephalomyelitis Journal of Neuroinflammation. Apr, 2015 | Pubmed ID: 25896970 Pathological Mechanisms in Progressive Multiple Sclerosis The Lancet. Neurology. Feb, 2015 | Pubmed ID: 25772897 Cuprizone Does Not Induce CNS Demyelination in Nonhuman Primates Annals of Clinical and Translational Neurology. Feb, 2015 | Pubmed ID: 25750925 Mitochondrial Fission Augments Capsaicin-induced Axonal Degeneration Acta Neuropathologica. Jan, 2015 | Pubmed ID: 25322817 Proteolipid Protein Cannot Replace P0 Protein As the Major Structural Protein of Peripheral Nervous System Myelin Glia. Jan, 2015 | Pubmed ID: 25066805 Discrepancy in CCL2 and CCR2 Expression in White Versus Grey Matter Hippocampal Lesions of Multiple Sclerosis Patients Acta Neuropathologica Communications. Aug, 2014 | Pubmed ID: 25149422 Microglial Displacement of Inhibitory Synapses Provides Neuroprotection in the Adult Brain Nature Communications. Month, 2014 | Pubmed ID: 25047355 Mitochondrial Immobilization Mediated by Syntaphilin Facilitates Survival of Demyelinated Axons Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014 | Pubmed ID: 24958879 Relapsing and Progressive Forms of Multiple Sclerosis: Insights from Pathology Current Opinion in Neurology. Jun, 2014 | Pubmed ID: 24722325 Hippocampal Volume is Related to Cognitive Decline and Fornicial Diffusion Measures in Multiple Sclerosis Magnetic Resonance Imaging. May, 2014 | Pubmed ID: 24512796 Axonal Loss in Multiple Sclerosis: Causes and Mechanisms Handbook of Clinical Neurology. Month, 2014 | Pubmed ID: 24507515 Epigenome-wide Differences in Pathology-free Regions of Multiple Sclerosis-affected Brains Nature Neuroscience. Jan, 2014 | Pubmed ID: 24270187 Act1 Mediates IL-17-induced EAE Pathogenesis Selectively in NG2+ Glial Cells Nature Neuroscience. Oct, 2013 | Pubmed ID: 23995070 Biology of Schwann Cells Handbook of Clinical Neurology. Month, 2013 | Pubmed ID: 23931775 Activated Microglia Enhance Neurogenesis Via Trypsinogen Secretion Proceedings of the National Academy of Sciences of the United States of America. May, 2013 | Pubmed ID: 23650361 Hippocampal Demyelination and Memory Dysfunction Are Associated with Increased Levels of the Neuronal MicroRNA MiR-124 and Reduced AMPA Receptors Annals of Neurology. May, 2013 | Pubmed ID: 23595422 High Spatial and Angular Resolution Diffusion-weighted Imaging Reveals Forniceal Damage Related to Memory Impairment Magnetic Resonance Imaging. Jun, 2013 | Pubmed ID: 23295147 Clinically Feasible MTR is Sensitive to Cortical Demyelination in MS Neurology. Jan, 2013 | Pubmed ID: 23269598 Lessons from Jack Griffin and the "pathogenesis of Peripheral Nerve Disease" Journal of the Peripheral Nervous System : JPNS. Dec, 2012 | Pubmed ID: 23279427 Cortical Remyelination: a New Target for Repair Therapies in Multiple Sclerosis Annals of Neurology. Dec, 2012 | Pubmed ID: 23076662 Lipopolysaccharide-induced Microglial Activation and Neuroprotection Against Experimental Brain Injury is Independent of Hematogenous TLR4 The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Aug, 2012 | Pubmed ID: 22915113 Gene Expression Profiling in Multiple Sclerosis Brain Neurobiology of Disease. Jan, 2012 | Pubmed ID: 21147224 Increased Mitochondrial Content in Remyelinated Axons: Implications for Multiple Sclerosis Brain : a Journal of Neurology. Jul, 2011 | Pubmed ID: 21705418 Myelination and Axonal Electrical Activity Modulate the Distribution and Motility of Mitochondria at CNS Nodes of Ranvier The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2011 | Pubmed ID: 21593309 Cleavage of Neuregulin-1 by BACE1 or ADAM10 Protein Produces Differential Effects on Myelination The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21576249 Demyelination Causes Synaptic Alterations in Hippocampi from Multiple Sclerosis Patients Annals of Neurology. Mar, 2011 | Pubmed ID: 21446020 Mechanisms of Neuronal Dysfunction and Degeneration in Multiple Sclerosis Progress in Neurobiology. Jan, 2011 | Pubmed ID: 20946934 Demyelination Increases Axonal Stationary Mitochondrial Size and the Speed of Axonal Mitochondrial Transport The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2010 | Pubmed ID: 20463228 The Oligodendrocyte-specific G Protein-coupled Receptor GPR17 is a Cell-intrinsic Timer of Myelination Nature Neuroscience. Nov, 2009 | Pubmed ID: 19838178 Gray-matter Injury in Multiple Sclerosis The New England Journal of Medicine. Oct, 2009 | Pubmed ID: 19812410 NG2-positive Glia in the Human Central Nervous System Neuron Glia Biology. Nov, 2009 | Pubmed ID: 19785924 Human Myelin Proteome and Comparative Analysis with Mouse Myelin Proceedings of the National Academy of Sciences of the United States of America. Aug, 2009 | Pubmed ID: 19706548 Beta4 Tubulin Identifies a Primitive Cell Source for Oligodendrocytes in the Mammalian Brain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2009 | Pubmed ID: 19535576 Virtual Hypoxia and Chronic Necrosis of Demyelinated Axons in Multiple Sclerosis The Lancet. Neurology. Mar, 2009 | Pubmed ID: 19233038 Imaging Correlates of Leukocyte Accumulation and CXCR4/CXCL12 in Multiple Sclerosis Archives of Neurology. Jan, 2009 | Pubmed ID: 19139298 Neurogenesis in the Chronic Lesions of Multiple Sclerosis Brain : a Journal of Neurology. Sep, 2008 | Pubmed ID: 18669500 P0 Protein is Required for and Can Induce Formation of Schmidt-lantermann Incisures in Myelin Internodes The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2008 | Pubmed ID: 18614675 Multiple Sclerosis: an Immune or Neurodegenerative Disorder? Annual Review of Neuroscience. Month, 2008 | Pubmed ID: 18558855 Preconditioning Paradigms and Pathways in the Brain Cleveland Clinic Journal of Medicine. Mar, 2008 | Pubmed ID: 18540152 Rescue of Congenital Hypomyelination by Progenitor Cell Transplantation Cell Stem Cell. Jun, 2008 | Pubmed ID: 18522843 Genetic Deletion of BACE1 in Mice Affects Remyelination of Sciatic Nerves FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Aug, 2008 | Pubmed ID: 18413858 Activation of the Ciliary Neurotrophic Factor (CNTF) Signalling Pathway in Cortical Neurons of Multiple Sclerosis Patients Brain : a Journal of Neurology. Oct, 2007 | Pubmed ID: 17898009 Pathogenesis of Axonal and Neuronal Damage in Multiple Sclerosis Neurology. May, 2007 | Pubmed ID: 17548565 Evidence for Synaptic Stripping by Cortical Microglia Glia. Mar, 2007 | Pubmed ID: 17136771 Bace1 Modulates Myelination in the Central and Peripheral Nervous System Nature Neuroscience. Dec, 2006 | Pubmed ID: 17099708 Neurodegeneration and Neuroprotection in Multiple Sclerosis and Other Neurodegenerative Diseases Journal of Neuroimmunology. Jul, 2006 | Pubmed ID: 16983747 [Pathology and Definition of Multiple Sclerosis] La Revue Du Praticien. Jun, 2006 | Pubmed ID: 16948216 N-acetyl-L-aspartate in Multiple Sclerosis Advances in Experimental Medicine and Biology. Month, 2006 | Pubmed ID: 16802714 A Dual Tyrosine-leucine Motif Mediates Myelin Protein P0 Targeting in MDCK Cells Glia. Aug, 2006 | Pubmed ID: 16788992 Evolution of a Neuroprotective Function of Central Nervous System Myelin The Journal of Cell Biology. Jan, 2006 | Pubmed ID: 16449196 Mitochondrial Dysfunction As a Cause of Axonal Degeneration in Multiple Sclerosis Patients Annals of Neurology. Mar, 2006 | Pubmed ID: 16392116 Taking Two TRAILS Neuron. May, 2005 | Pubmed ID: 15882629 Beta IV Tubulin is Selectively Expressed by Oligodendrocytes in the Central Nervous System Glia. May, 2005 | Pubmed ID: 15712210 Neuropathobiology of Multiple Sclerosis Neurologic Clinics. Feb, 2005 | Pubmed ID: 15661090 Dysmyelinated Lower Motor Neurons Retract and Regenerate Dysfunctional Synaptic Terminals The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2004 | Pubmed ID: 15084670 The 36K Protein of Zebrafish CNS Myelin is a Short-chain Dehydrogenase Glia. Mar, 2004 | Pubmed ID: 14966869 Axonal Degeneration and Progressive Neurologic Disability in Multiple Sclerosis Neurotoxicity Research. Month, 2003 | Pubmed ID: 12832230 The Tetraspanin Protein, CD9, is Expressed by Progenitor Cells Committed to Oligodendrogenesis and is Linked to Beta1 Integrin, CD81, and Tspan-2 Glia. Dec, 2002 | Pubmed ID: 12420314 Treatment of Experimental Autoimmune Encephalomyelitis with the Chemokine Receptor Antagonist Met-RANTES Journal of Neuroimmunology. Jul, 2002 | Pubmed ID: 12098506 VCAM-1-positive Microglia Target Oligodendrocytes at the Border of Multiple Sclerosis Lesions Journal of Neuropathology and Experimental Neurology. Jun, 2002 | Pubmed ID: 12071637 Axon Loss in the Spinal Cord Determines Permanent Neurological Disability in an Animal Model of Multiple Sclerosis Journal of Neuropathology and Experimental Neurology. Jan, 2002 | Pubmed ID: 11829341 Premyelinating Oligodendrocytes in Chronic Lesions of Multiple Sclerosis The New England Journal of Medicine. Jan, 2002 | Pubmed ID: 11796850 N-acetylaspartate is an Axon-specific Marker of Mature White Matter in Vivo: a Biochemical and Immunohistochemical Study on the Rat Optic Nerve Annals of Neurology. Jan, 2002 | Pubmed ID: 11782984 Axonal and Neuronal Degeneration in Multiple Sclerosis: Mechanisms and Functional Consequences Current Opinion in Neurology. Jun, 2001 | Pubmed ID: 11371748 Axo-glial Septate Junctions. The Maestro of Nodal Formation and Myelination? The Journal of Cell Biology. Aug, 2000 | Pubmed ID: 10931879 P(0) Glycoprotein Overexpression Causes Congenital Hypomyelination of Peripheral Nerves The Journal of Cell Biology. Mar, 2000 | Pubmed ID: 10704451 Axonal Pathology in Multiple Sclerosis: Relationship to Neurologic Disability Current Opinion in Neurology. Jun, 1999 | Pubmed ID: 10499174 Expression of Oligodendrocyte Progenitor Cell Antigens by Gliomas: Implications for the Histogenesis of Brain Tumors Proceedings of the National Academy of Sciences of the United States of America. Aug, 1999 | Pubmed ID: 10468613 Differentiation and Death of Premyelinating Oligodendrocytes in Developing Rodent Brain The Journal of Cell Biology. Apr, 1997 | Pubmed ID: 9128255 多発性硬化症の個人のための包括的な解剖プログラム Ranjan Dutta*1, Kedar R. Mahajan*1,3, Kunio Nakamura*3, Daniel Ontaneda*2, Jacqueline Chen1, Christina Volsko1, Jessica Dudman1, Emilie Christie1, Jordon Dunham1, Robert J. Fox3, Bruce D. Trapp1 1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 2Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 3Mellen Center for Treatment and Research in Multiple Sclerosis, Neurological Institute, Cleveland Clinic JoVE 59511 Neuroscience
多発性硬化症の個人のための包括的な解剖プログラム Ranjan Dutta*1, Kedar R. Mahajan*1,3, Kunio Nakamura*3, Daniel Ontaneda*2, Jacqueline Chen1, Christina Volsko1, Jessica Dudman1, Emilie Christie1, Jordon Dunham1, Robert J. Fox3, Bruce D. Trapp1 1Department of Neurosciences, Lerner Research Institute, Cleveland Clinic, 2Department of Biomedical Engineering, Lerner Research Institute, Cleveland Clinic, 3Mellen Center for Treatment and Research in Multiple Sclerosis, Neurological Institute, Cleveland Clinic JoVE 59511 Neuroscience
