Bruno Kyewski

Publications

• Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction
  Immunity. Jun, 2015  |   Pubmed ID: 26070482
• Materno-fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes
  Diabetes. Apr, 2015  |   Pubmed ID: 25918233
• Central T Cell Tolerance: Identification of Tissue-restricted Autoantigens in the Thymus HLA-DR Peptidome
  Journal of Autoimmunity. Jun, 2015  |   Pubmed ID: 25911201
• Homeodomain-interacting Protein Kinase 2, a Novel Autoimmune Regulator Interaction Partner, Modulates Promiscuous Gene Expression in Medullary Thymic Epithelial Cells
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015  |   Pubmed ID: 25552543
• Love is in the Aire: MTECs Share Their Assets
  Immunity. Sep, 2014  |   Pubmed ID: 25238088
• Adult Thymus Contains FoxN1(-) Epithelial Stem Cells That Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages
  Immunity. Aug, 2014  |   Pubmed ID: 25148026
• Misinitiation of Intrathymic MART-1 Transcription and Biased TCR Usage Explain the High Frequency of MART-1-specific T Cells
  European Journal of Immunology. Sep, 2014  |   Pubmed ID: 24846220
• Positive and Negative Selection of the T Cell Repertoire: What Thymocytes See (and Don't See)
  Nature Reviews. Immunology. Jun, 2014  |   Pubmed ID: 24830344
• Overlapping Gene Coexpression Patterns in Human Medullary Thymic Epithelial Cells Generate Self-antigen Diversity
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013  |   Pubmed ID: 23980163
• An Evolutionarily Conserved Mutual Interdependence Between Aire and MicroRNAs in Promiscuous Gene Expression
  European Journal of Immunology. Jul, 2013  |   Pubmed ID: 23589212
• An Organotypic Coculture Model Supporting Proliferation and Differentiation of Medullary Thymic Epithelial Cells and Promiscuous Gene Expression
  Journal of Immunology (Baltimore, Md. : 1950). Feb, 2013  |   Pubmed ID: 23269248
• The Classical Dichotomy Between Presentation of Endogenous Antigens Via the MHC Class I Pathway and Exogenous Antigens Via the MHC Class-II Pathway
  Current Opinion in Immunology. Feb, 2012  |   Pubmed ID: 22305303
• The Thymic Epithelial MicroRNA Network Elevates the Threshold for Infection-associated Thymic Involution Via MiR-29a Mediated Suppression of the IFN-α Receptor
  Nature Immunology. Feb, 2012  |   Pubmed ID: 22179202
• DNA Methylation Signatures of the AIRE Promoter in Thymic Epithelial Cells, Thymomas and Normal Tissues
  Molecular Immunology. Dec, 2011  |   Pubmed ID: 22036612
• Association of an SNP with Intrathymic Transcription of TSHR and Graves' Disease: a Role for Defective Thymic Tolerance
  Human Molecular Genetics. Sep, 2011  |   Pubmed ID: 21642385
• Impaired Thymic Tolerance to α-myosin Directs Autoimmunity to the Heart in Mice and Humans
  The Journal of Clinical Investigation. Apr, 2011  |   Pubmed ID: 21436590
• Jagged2 Acts As a Delta-like Notch Ligand During Early Hematopoietic Cell Fate Decisions
  Blood. Apr, 2011  |   Pubmed ID: 21372153
• Epigenetic Regulation of Promiscuous Gene Expression in Thymic Medullary Epithelial Cells
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010  |   Pubmed ID: 20966351
• How Thymic Antigen Presenting Cells Sample the Body's Self-antigens
  Current Opinion in Immunology. Oct, 2010  |   Pubmed ID: 20832274
• Chronic Inflammation is Regarded As a Strong Promoter of Tumorigenesis
  International Journal of Cancer. Journal International Du Cancer. Aug, 2010  |   Pubmed ID: 20564540
• Aire, Master of Many Trades
  Cell. Jan, 2010  |   Pubmed ID: 20085700
• Obligation for Cell Line Authentication: Appeal for Concerted Action
  International Journal of Cancer. Journal International Du Cancer. Jan, 2010  |   Pubmed ID: 19882693
• Antigen Presentation in the Thymus for Positive Selection and Central Tolerance Induction
  Nature Reviews. Immunology. Dec, 2009  |   Pubmed ID: 19935803
• The Thymic Medulla: a Unique Microenvironment for Intercellular Self-antigen Transfer
  The Journal of Experimental Medicine. Jul, 2009  |   Pubmed ID: 19564355
• The Thymus Medulla Slowly Yields Its Secrets
  Annals of the New York Academy of Sciences. Nov, 2008  |   Pubmed ID: 19076347
• Immunology. A Breath of Aire for the Periphery
  Science (New York, N.Y.). Aug, 2008  |   Pubmed ID: 18687943
• How Promiscuity Promotes Tolerance: the Case of Myasthenia Gravis
  Annals of the New York Academy of Sciences. 2008  |   Pubmed ID: 18567865
• Promiscuous Gene Expression Patterns in Single Medullary Thymic Epithelial Cells Argue for a Stochastic Mechanism
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008  |   Pubmed ID: 18180458
• Promiscuous Gene Expression and the Developmental Dynamics of Medullary Thymic Epithelial Cells
  European Journal of Immunology. Dec, 2007  |   Pubmed ID: 18000951
• An IRF8-binding Promoter Variant and AIRE Control CHRNA1 Promiscuous Expression in Thymus
  Nature. Aug, 2007  |   Pubmed ID: 17687331
• Expression of Tumor-associated Differentiation Antigens, MUC1 Glycoforms and CEA, in Human Thymic Epithelial Cells: Implications for Self-tolerance and Tumor Therapy
  Cancer Research. Apr, 2007  |   Pubmed ID: 17440107
• Highly Variable Expression of Tissue-restricted Self-antigens in Human Thymus: Implications for Self-tolerance and Autoimmunity
  European Journal of Immunology. Mar, 2007  |   Pubmed ID: 17323415
• Expression Profiling of Autoimmune Regulator AIRE MRNA in a Comprehensive Set of Human Normal and Neoplastic Tissues
  Immunology Letters. Aug, 2006  |   Pubmed ID: 16876259
• Foxp3+ CD25+ Regulatory T Cells Specific for a Neo-self-antigen Develop at the Double-positive Thymic Stage
  Proceedings of the National Academy of Sciences of the United States of America. May, 2006  |   Pubmed ID: 16709665
• A Central Role for Central Tolerance
  Annual Review of Immunology. 2006  |   Pubmed ID: 16551260
• Conflicts of Interest: the Responsibility of the Authors and Editors of the International Journal of Cancer
  International Journal of Cancer. Journal International Du Cancer. Jun, 2006  |   Pubmed ID: 16482565
• Linking Signalling Pathways, Thymic Stroma Integrity and Autoimmunity
  Trends in Immunology. Oct, 2005  |   Pubmed ID: 16039157
• Expression of a Natural Tumor Antigen by Thymic Epithelial Cells Impairs the Tumor-protective CD4+ T-cell Repertoire
  Cancer Research. Jul, 2005  |   Pubmed ID: 16024649
• Promiscuous Gene Expression in Thymic Epithelial Cells is Regulated at Multiple Levels
  The Journal of Experimental Medicine. Jul, 2005  |   Pubmed ID: 15983066
• Regulating Self-tolerance by Deregulating Gene Expression
  Current Opinion in Immunology. Dec, 2004  |   Pubmed ID: 15511667
• Bone Marrow Microenvironment Facilitating Dendritic Cell: CD4 T Cell Interactions and Maintenance of CD4 Memory
  International Journal of Oncology. Oct, 2004  |   Pubmed ID: 15375534
• Self-representation in the Thymus: an Extended View
  Nature Reviews. Immunology. Sep, 2004  |   Pubmed ID: 15343368
• CREB Function is Required for Normal Thymic Cellularity and Post-irradiation Recovery
  European Journal of Immunology. Jul, 2004  |   Pubmed ID: 15214044
• Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters
  The Journal of Experimental Medicine. Jan, 2004  |   Pubmed ID: 14734521
• Bone Marrow As a Priming Site for T-cell Responses to Blood-borne Antigen
  Nature Medicine. Sep, 2003  |   Pubmed ID: 12910264
• Dynamic Changes During the Immune Response in T Cell-antigen-presenting Cell Clusters Isolated from Lymph Nodes
  The Journal of Experimental Medicine. Feb, 2003  |   Pubmed ID: 12566411
• Promiscuous Gene Expression and Central T-cell Tolerance: More Than Meets the Eye
  Trends in Immunology. Jul, 2002  |   Pubmed ID: 12103357