Bruno Kyewski Division of Developmental Immunology German Cancer Research Center (DKFZ) Biography Publications Institution JoVE Articles Bruno Kyewski has not added a biography. If you are Bruno Kyewski and would like to personalize this page please email our Author Liaison for assistance. Publications Thymic B Cells Are Licensed to Present Self Antigens for Central T Cell Tolerance Induction Immunity. Jun, 2015 | Pubmed ID: 26070482 Materno-fetal Transfer of Preproinsulin Through the Neonatal Fc Receptor Prevents Autoimmune Diabetes Diabetes. Apr, 2015 | Pubmed ID: 25918233 Central T Cell Tolerance: Identification of Tissue-restricted Autoantigens in the Thymus HLA-DR Peptidome Journal of Autoimmunity. Jun, 2015 | Pubmed ID: 25911201 Homeodomain-interacting Protein Kinase 2, a Novel Autoimmune Regulator Interaction Partner, Modulates Promiscuous Gene Expression in Medullary Thymic Epithelial Cells Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25552543 Love is in the Aire: MTECs Share Their Assets Immunity. Sep, 2014 | Pubmed ID: 25238088 Adult Thymus Contains FoxN1(-) Epithelial Stem Cells That Are Bipotent for Medullary and Cortical Thymic Epithelial Lineages Immunity. Aug, 2014 | Pubmed ID: 25148026 Misinitiation of Intrathymic MART-1 Transcription and Biased TCR Usage Explain the High Frequency of MART-1-specific T Cells European Journal of Immunology. Sep, 2014 | Pubmed ID: 24846220 Positive and Negative Selection of the T Cell Repertoire: What Thymocytes See (and Don't See) Nature Reviews. Immunology. Jun, 2014 | Pubmed ID: 24830344 Overlapping Gene Coexpression Patterns in Human Medullary Thymic Epithelial Cells Generate Self-antigen Diversity Proceedings of the National Academy of Sciences of the United States of America. Sep, 2013 | Pubmed ID: 23980163 An Evolutionarily Conserved Mutual Interdependence Between Aire and MicroRNAs in Promiscuous Gene Expression European Journal of Immunology. Jul, 2013 | Pubmed ID: 23589212 An Organotypic Coculture Model Supporting Proliferation and Differentiation of Medullary Thymic Epithelial Cells and Promiscuous Gene Expression Journal of Immunology (Baltimore, Md. : 1950). Feb, 2013 | Pubmed ID: 23269248 The Classical Dichotomy Between Presentation of Endogenous Antigens Via the MHC Class I Pathway and Exogenous Antigens Via the MHC Class-II Pathway Current Opinion in Immunology. Feb, 2012 | Pubmed ID: 22305303 The Thymic Epithelial MicroRNA Network Elevates the Threshold for Infection-associated Thymic Involution Via MiR-29a Mediated Suppression of the IFN-α Receptor Nature Immunology. Feb, 2012 | Pubmed ID: 22179202 DNA Methylation Signatures of the AIRE Promoter in Thymic Epithelial Cells, Thymomas and Normal Tissues Molecular Immunology. Dec, 2011 | Pubmed ID: 22036612 Association of an SNP with Intrathymic Transcription of TSHR and Graves' Disease: a Role for Defective Thymic Tolerance Human Molecular Genetics. Sep, 2011 | Pubmed ID: 21642385 Impaired Thymic Tolerance to α-myosin Directs Autoimmunity to the Heart in Mice and Humans The Journal of Clinical Investigation. Apr, 2011 | Pubmed ID: 21436590 Jagged2 Acts As a Delta-like Notch Ligand During Early Hematopoietic Cell Fate Decisions Blood. Apr, 2011 | Pubmed ID: 21372153 Epigenetic Regulation of Promiscuous Gene Expression in Thymic Medullary Epithelial Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 20966351 How Thymic Antigen Presenting Cells Sample the Body's Self-antigens Current Opinion in Immunology. Oct, 2010 | Pubmed ID: 20832274 Chronic Inflammation is Regarded As a Strong Promoter of Tumorigenesis International Journal of Cancer. Journal International Du Cancer. Aug, 2010 | Pubmed ID: 20564540 Aire, Master of Many Trades Cell. Jan, 2010 | Pubmed ID: 20085700 Obligation for Cell Line Authentication: Appeal for Concerted Action International Journal of Cancer. Journal International Du Cancer. Jan, 2010 | Pubmed ID: 19882693 Antigen Presentation in the Thymus for Positive Selection and Central Tolerance Induction Nature Reviews. Immunology. Dec, 2009 | Pubmed ID: 19935803 The Thymic Medulla: a Unique Microenvironment for Intercellular Self-antigen Transfer The Journal of Experimental Medicine. Jul, 2009 | Pubmed ID: 19564355 The Thymus Medulla Slowly Yields Its Secrets Annals of the New York Academy of Sciences. Nov, 2008 | Pubmed ID: 19076347 Immunology. A Breath of Aire for the Periphery Science (New York, N.Y.). Aug, 2008 | Pubmed ID: 18687943 How Promiscuity Promotes Tolerance: the Case of Myasthenia Gravis Annals of the New York Academy of Sciences. 2008 | Pubmed ID: 18567865 Promiscuous Gene Expression Patterns in Single Medullary Thymic Epithelial Cells Argue for a Stochastic Mechanism Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18180458 Promiscuous Gene Expression and the Developmental Dynamics of Medullary Thymic Epithelial Cells European Journal of Immunology. Dec, 2007 | Pubmed ID: 18000951 An IRF8-binding Promoter Variant and AIRE Control CHRNA1 Promiscuous Expression in Thymus Nature. Aug, 2007 | Pubmed ID: 17687331 Expression of Tumor-associated Differentiation Antigens, MUC1 Glycoforms and CEA, in Human Thymic Epithelial Cells: Implications for Self-tolerance and Tumor Therapy Cancer Research. Apr, 2007 | Pubmed ID: 17440107 Highly Variable Expression of Tissue-restricted Self-antigens in Human Thymus: Implications for Self-tolerance and Autoimmunity European Journal of Immunology. Mar, 2007 | Pubmed ID: 17323415 Expression Profiling of Autoimmune Regulator AIRE MRNA in a Comprehensive Set of Human Normal and Neoplastic Tissues Immunology Letters. Aug, 2006 | Pubmed ID: 16876259 Foxp3+ CD25+ Regulatory T Cells Specific for a Neo-self-antigen Develop at the Double-positive Thymic Stage Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16709665 A Central Role for Central Tolerance Annual Review of Immunology. 2006 | Pubmed ID: 16551260 Conflicts of Interest: the Responsibility of the Authors and Editors of the International Journal of Cancer International Journal of Cancer. Journal International Du Cancer. Jun, 2006 | Pubmed ID: 16482565 Linking Signalling Pathways, Thymic Stroma Integrity and Autoimmunity Trends in Immunology. Oct, 2005 | Pubmed ID: 16039157 Expression of a Natural Tumor Antigen by Thymic Epithelial Cells Impairs the Tumor-protective CD4+ T-cell Repertoire Cancer Research. Jul, 2005 | Pubmed ID: 16024649 Promiscuous Gene Expression in Thymic Epithelial Cells is Regulated at Multiple Levels The Journal of Experimental Medicine. Jul, 2005 | Pubmed ID: 15983066 Regulating Self-tolerance by Deregulating Gene Expression Current Opinion in Immunology. Dec, 2004 | Pubmed ID: 15511667 Bone Marrow Microenvironment Facilitating Dendritic Cell: CD4 T Cell Interactions and Maintenance of CD4 Memory International Journal of Oncology. Oct, 2004 | Pubmed ID: 15375534 Self-representation in the Thymus: an Extended View Nature Reviews. Immunology. Sep, 2004 | Pubmed ID: 15343368 CREB Function is Required for Normal Thymic Cellularity and Post-irradiation Recovery European Journal of Immunology. Jul, 2004 | Pubmed ID: 15214044 Medullary Epithelial Cells of the Human Thymus Express a Highly Diverse Selection of Tissue-specific Genes Colocalized in Chromosomal Clusters The Journal of Experimental Medicine. Jan, 2004 | Pubmed ID: 14734521 Bone Marrow As a Priming Site for T-cell Responses to Blood-borne Antigen Nature Medicine. Sep, 2003 | Pubmed ID: 12910264 Dynamic Changes During the Immune Response in T Cell-antigen-presenting Cell Clusters Isolated from Lymph Nodes The Journal of Experimental Medicine. Feb, 2003 | Pubmed ID: 12566411 Promiscuous Gene Expression and Central T-cell Tolerance: More Than Meets the Eye Trends in Immunology. Jul, 2002 | Pubmed ID: 12103357 3D organotipica Co-cultura Modello Sostenere midollare timica epiteliale proliferazione, differenziazione e promiscua genica Sheena Pinto*1, Hans-Jürgen Stark*2, Iris Martin2, Petra Boukamp2, Bruno Kyewski1 1Division of Developmental Immunology, German Cancer Research Center (DKFZ), 2Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ) Developmental Biology
3D organotipica Co-cultura Modello Sostenere midollare timica epiteliale proliferazione, differenziazione e promiscua genica Sheena Pinto*1, Hans-Jürgen Stark*2, Iris Martin2, Petra Boukamp2, Bruno Kyewski1 1Division of Developmental Immunology, German Cancer Research Center (DKFZ), 2Genetics of Skin Carcinogenesis, German Cancer Research Center (DKFZ) Developmental Biology