Carl Cotman Biography Publications JoVE Articles Carl Cotman has not added a biography. If you are Carl Cotman and would like to personalize this page please email our Author Liaison for assistance. Publications Caspase-3 Activation As a Bifurcation Point Between Plasticity and Cell Death Neuroscience Bulletin. Feb, 2012 | Pubmed ID: 22233886 Cardiovascular Fitness is Associated with Altered Cortical Glucose Metabolism During Working Memory in ɛ4 Carriers Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jan, 2012 | Pubmed ID: 22226798 Age and Distraction Are Determinants of Performance on a Novel Visual Search Task in Aged Beagle Dogs Age (Dordrecht, Netherlands). Feb, 2012 | Pubmed ID: 21336566 BDNF Increases with Behavioral Enrichment and an Antioxidant Diet in the Aged Dog Neurobiology of Aging. Mar, 2012 | Pubmed ID: 20447733 Aβ Aggregation Profiles and Shifts in APP Processing Favor Amyloidogenesis in Canines Neurobiology of Aging. Jan, 2012 | Pubmed ID: 20434811 Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease PloS One. 2011 | Pubmed ID: 22046234 Dietary and Behavioral Interventions Protect Against Age Related Activation of Caspase Cascades in the Canine Brain PloS One. 2011 | Pubmed ID: 21931796 An Amyloid β(42)-dependent Deficit in Anandamide Mobilization is Associated with Cognitive Dysfunction in Alzheimer's Disease Neurobiology of Aging. May, 2011 | Pubmed ID: 21546126 Common Variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 Are Associated with Late-onset Alzheimer's Disease Nature Genetics. May, 2011 | Pubmed ID: 21460841 Mild Stress Facilitates Learning and Exercise Improves Retention in Aged Mice Experimental Gerontology. Jan, 2011 | Pubmed ID: 20951791 β-Amyloid Impairs Axonal BDNF Retrograde Trafficking Neurobiology of Aging. May, 2011 | Pubmed ID: 19540623 Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease PloS One. 2010 | Pubmed ID: 20838618 Synergistic Effects of Long-term Antioxidant Diet and Behavioral Enrichment on Beta-amyloid Load and Non-amyloidogenic Processing in Aged Canines The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2010 | Pubmed ID: 20660265 Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20463402 Linear and Conformation Specific Antibodies in Aged Beagles After Prolonged Vaccination with Aggregated Abeta Neurobiology of Disease. Sep, 2010 | Pubmed ID: 20451612 Common Variants at 7p21 Are Associated with Frontotemporal Lobar Degeneration with TDP-43 Inclusions Nature Genetics. Mar, 2010 | Pubmed ID: 20154673 Rescue of Radiation-induced Cognitive Impairment Through Cranial Transplantation of Human Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19901336 Short-term Supplementation with Acetyl-L-carnitine and Lipoic Acid Alters Plasma Protein Carbonyl Levels but Does Not Improve Cognition in Aged Beagles Experimental Gerontology. Dec, 2009 | Pubmed ID: 19735717 Exercise Improves Cognition and Hippocampal Plasticity in APOE Epsilon4 Mice Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jul, 2009 | Pubmed ID: 19560099 Axonal MRNA in Uninjured and Regenerating Cortical Mammalian Axons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19369540 Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-lipoic Acid and Acetyl-L-carnitine Neurochemical Research. Apr, 2009 | Pubmed ID: 18846423 The Canine (dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches Journal of Alzheimer's Disease : JAD. Dec, 2008 | Pubmed ID: 19096165 Healthy Brain Aging: a Meeting Report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Nov, 2008 | Pubmed ID: 18945646 Gene Expression Changes in the Course of Normal Brain Aging Are Sexually Dimorphic Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008 | Pubmed ID: 18832152 Rhinal and Dorsolateral Prefrontal Cortex Lesions Produce Selective Impairments in Object and Spatial Learning and Memory in Canines The Journal of Comparative Neurology. Nov, 2008 | Pubmed ID: 18792072 Exercise Alters the Immune Profile in Tg2576 Alzheimer Mice Toward a Response Coincident with Improved Cognitive Performance and Decreased Amyloid Journal of Neuroinflammation. 2008 | Pubmed ID: 18400101 Lipoamide Protects Retinal Pigment Epithelial Cells from Oxidative Stress and Mitochondrial Dysfunction Free Radical Biology & Medicine. Apr, 2008 | Pubmed ID: 18258206 Voluntary Running Attenuates Age-related Deficits Following SCI Experimental Neurology. Mar, 2008 | Pubmed ID: 18164294 Interleukin-1beta Interferes with Signal Transduction Induced by Neurotrophin-3 in Cortical Neurons Brain Research. Jan, 2008 | Pubmed ID: 18036576 Interleukin-1 Beta Impairs Brain Derived Neurotrophic Factor-induced Signal Transduction Neurobiology of Aging. Sep, 2008 | Pubmed ID: 17467122 Region Specific Neuron Loss in the Aged Canine Hippocampus is Reduced by Enrichment Neurobiology of Aging. Jan, 2008 | Pubmed ID: 17092609 Proteomic Identification of Brain Proteins in the Canine Model of Human Aging Following a Long-term Treatment with Antioxidants and a Program of Behavioral Enrichment: Relevance to Alzheimer's Disease Neurobiology of Aging. Jan, 2008 | Pubmed ID: 17055614 Physical Activity and the Maintenance of Cognition: Learning from Animal Models Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Apr, 2007 | Pubmed ID: 19595972 Fibril Specific, Conformation Dependent Antibodies Recognize a Generic Epitope Common to Amyloid Fibrils and Fibrillar Oligomers That is Absent in Prefibrillar Oligomers Molecular Neurodegeneration. 2007 | Pubmed ID: 17897471 Exercise Builds Brain Health: Key Roles of Growth Factor Cascades and Inflammation Trends in Neurosciences. Sep, 2007 | Pubmed ID: 17765329 Three Weeks of Running Wheel Exposure Improves Cognitive Performance in the Aged Tg2576 Mouse Behavioural Brain Research. Dec, 2007 | Pubmed ID: 17698211 Neurogenesis Decreases with Age in the Canine Hippocampus and Correlates with Cognitive Function Neurobiology of Learning and Memory. Sep, 2007 | Pubmed ID: 17587610 Wheel Running Following Spinal Cord Injury Improves Locomotor Recovery and Stimulates Serotonergic Fiber Growth The European Journal of Neuroscience. Apr, 2007 | Pubmed ID: 17439482 Differential Regulation of Inhibitors of Apoptosis Proteins in Alzheimer's Disease Brains Neurobiology of Disease. Apr, 2007 | Pubmed ID: 17292615 Acrolein, a Toxicant in Cigarette Smoke, Causes Oxidative Damage and Mitochondrial Dysfunction in RPE Cells: Protection by (R)-alpha-lipoic Acid Investigative Ophthalmology & Visual Science. Jan, 2007 | Pubmed ID: 17197552 Effects of Melatonin and Age on Gene Expression in Mouse CNS Using Microarray Analysis Neurochemistry International. Jan, 2007 | Pubmed ID: 17118492 External Force-assisted Cell Positioning Inside Microfluidic Devices Biomedical Microdevices. Feb, 2007 | Pubmed ID: 17091393 Musashi1 Antigen Expression in Human Fetal Germinal Matrix Development Experimental Neurology. Oct, 2006 | Pubmed ID: 16777095 Neurobiology of Exercise Obesity (Silver Spring, Md.). Mar, 2006 | Pubmed ID: 16648603 Visuospatial Function in the Beagle Dog: an Early Marker of Cognitive Decline in a Model of Human Aging and Dementia Neurobiology of Learning and Memory. Sep, 2006 | Pubmed ID: 16616528 Immunization with Fibrillar Abeta(1-42) in Young and Aged Canines: Antibody Generation and Characteristics, and Effects on CSF and Brain Abeta Vaccine. Apr, 2006 | Pubmed ID: 16460841 Effects of Testosterone on Cognition and Mood in Male Patients with Mild Alzheimer Disease and Healthy Elderly Men Archives of Neurology. Feb, 2006 | Pubmed ID: 16344336 BioVision: an Application for the Automated Image Analysis of Histological Sections Neurobiology of Aging. Oct, 2006 | Pubmed ID: 16271803 The Role of Neurotrophins in Brain Aging: a Perspective in Honor of Regino Perez-Polo Neurochemical Research. Jun-Jul, 2005 | Pubmed ID: 16187222 Nutritional Management of Brain Aging in Dogs Journal of the American Veterinary Medical Association. Sep, 2005 | Pubmed ID: 16178393 A Microfluidic Culture Platform for CNS Axonal Injury, Regeneration and Transport Nature Methods. Aug, 2005 | Pubmed ID: 16094385 Caspase-cleaved Tau Accumulation in Neurodegenerative Diseases Associated with Tau and Alpha-synuclein Pathology Acta Neuropathologica. Aug, 2005 | Pubmed ID: 15986225 Exercise-induced Gene Expression Changes in the Rat Spinal Cord Gene Expression. 2005 | Pubmed ID: 15892452 Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2005 | Pubmed ID: 15858047 Chronic Antioxidant and Mitochondrial Cofactor Administration Improves Discrimination Learning in Aged but Not Young Dogs Progress in Neuro-psychopharmacology & Biological Psychiatry. Mar, 2005 | Pubmed ID: 15795055 A Comparison of Egocentric and Allocentric Age-dependent Spatial Learning in the Beagle Dog Progress in Neuro-psychopharmacology & Biological Psychiatry. Mar, 2005 | Pubmed ID: 15795044 The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology Journal of Neuropathology and Experimental Neurology. Feb, 2005 | Pubmed ID: 15751224 Beta-amyloid Deposition and Tau Phosphorylation in Clinically Characterized Aged Cats Neurobiology of Aging. May, 2005 | Pubmed ID: 15708450 Voluntary Wheel Running Improves Recovery from a Moderate Spinal Cord Injury Journal of Neurotrauma. Jan, 2005 | Pubmed ID: 15665610 The Exercise-induced Expression of BDNF Within the Hippocampus Varies Across Life-span Neurobiology of Aging. Apr, 2005 | Pubmed ID: 15653179 Patterned Cell Culture Inside Microfluidic Devices Lab on a Chip. Jan, 2005 | Pubmed ID: 15616747 Activation of Complement Pathways After Contusion-induced Spinal Cord Injury Journal of Neurotrauma. Dec, 2004 | Pubmed ID: 15684772 Comparison of the Effects of L-carnitine and Acetyl-L-carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats Annals of the New York Academy of Sciences. Nov, 2004 | Pubmed ID: 15591009 Frontal Lobe Volume, Function, and Beta-amyloid Pathology in a Canine Model of Aging The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2004 | Pubmed ID: 15385603 Neutralization of the Chemokine CXCL10 Enhances Tissue Sparing and Angiogenesis Following Spinal Cord Injury Journal of Neuroscience Research. Sep, 2004 | Pubmed ID: 15352216 Beta-amyloid Peptide at Sublethal Concentrations Downregulates Brain-derived Neurotrophic Factor Functions in Cultured Cortical Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2004 | Pubmed ID: 15282285 Caspase-cleavage of Tau is an Early Event in Alzheimer Disease Tangle Pathology The Journal of Clinical Investigation. Jul, 2004 | Pubmed ID: 15232619 Concept Abstraction in the Aging Dog: Development of a Protocol Using Successive Discrimination and Size Concept Tasks Behavioural Brain Research. Aug, 2004 | Pubmed ID: 15219721 Isolated Executive Impairment and Associated Frontal Neuropathology Dementia and Geriatric Cognitive Disorders. 2004 | Pubmed ID: 15178954 The Timecourse of Induction of Brain-derived Neurotrophic Factor MRNA and Protein in the Rat Hippocampus Following Voluntary Exercise Neuroscience Letters. Jun, 2004 | Pubmed ID: 15157993 Long-term Treatment with Antioxidants and a Program of Behavioral Enrichment Reduces Age-dependent Impairment in Discrimination and Reversal Learning in Beagle Dogs Experimental Gerontology. May, 2004 | Pubmed ID: 15130670 Microfluidic Multicompartment Device for Neuroscience Research Langmuir : the ACS Journal of Surfaces and Colloids. Mar, 2003 | Pubmed ID: 20725530 Accumulation of Caspase Cleaved Amyloid Precursor Protein Represents an Early Neurodegenerative Event in Aging and in Alzheimer's Disease Neurobiology of Disease. Dec, 2003 | Pubmed ID: 14678756 Response Latency in Canis Familiaris: Mental Ability or Mental Strategy? Behavioral Neuroscience. Oct, 2003 | Pubmed ID: 14570555 Locomotor Activity Rhythms in Dogs Vary with Age and Cognitive Status Behavioral Neuroscience. Aug, 2003 | Pubmed ID: 12931965 Spatial Patterns of Mammalian Brain Aging: Distribution of Cathepsin D-immunoreactive Cell Bodies and Dystrophic Dendrites in Aging Dogs Resembles That in Alzheimer's Disease The Journal of Comparative Neurology. Sep, 2003 | Pubmed ID: 12900930 Fas and Fas Ligand Are Associated with Neuritic Degeneration in the AD Brain and Participate in Beta-amyloid-induced Neuronal Death Neurobiology of Disease. Apr, 2003 | Pubmed ID: 12742739 Exercise Increases the Vulnerability of Rat Hippocampal Neurons to Kainate Lesion Brain Research. May, 2003 | Pubmed ID: 12706240 Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis Science (New York, N.Y.). Apr, 2003 | Pubmed ID: 12702875 Adjuvant-dependent Modulation of Th1 and Th2 Responses to Immunization with Beta-amyloid International Immunology. Apr, 2003 | Pubmed ID: 12663680 The Induction of the TNFalpha Death Domain Signaling Pathway in Alzheimer's Disease Brain Neurochemical Research. Feb, 2003 | Pubmed ID: 12608703 Size and Reversal Learning in the Beagle Dog As a Measure of Executive Function and Inhibitory Control in Aging Learning & Memory (Cold Spring Harbor, N.Y.). Jan-Feb, 2003 | Pubmed ID: 12551965 Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous Drug News & Perspectives. Nov, 2002 | Pubmed ID: 12677194 Caspase-9 Activation and Caspase Cleavage of Tau in the Alzheimer's Disease Brain Neurobiology of Disease. Nov, 2002 | Pubmed ID: 12505426 Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels As a Central Target for the Development of Human AD and AD-like Pathology in Aged Transgenic Mice Annals of the New York Academy of Sciences. Nov, 2002 | Pubmed ID: 12480733 Brain Aging in the Canine: a Diet Enriched in Antioxidants Reduces Cognitive Dysfunction Neurobiology of Aging. Sep-Oct, 2002 | Pubmed ID: 12392784 Beta-amyloid Deposition and Neurofibrillary Tangle Association with Caspase Activation in Down Syndrome Neuroscience Letters. Sep, 2002 | Pubmed ID: 12213643 Evidence for Decreased DARPP-32 in the Prefrontal Cortex of Patients with Schizophrenia Archives of General Psychiatry. Aug, 2002 | Pubmed ID: 12150646 Hippocampal Brain-derived Neurotrophic Factor Gene Regulation by Exercise and the Medial Septum Journal of Neuroscience Research. Jun, 2002 | Pubmed ID: 12111841 Achieving and Maintaining Cognitive Vitality with Aging Mayo Clinic Proceedings. Mayo Clinic. Jul, 2002 | Pubmed ID: 12108606 Exercise: a Behavioral Intervention to Enhance Brain Health and Plasticity Trends in Neurosciences. Jun, 2002 | Pubmed ID: 12086747 Caspase-cleaved Amyloid Precursor Protein and Activated Caspase-3 Are Co-localized in the Granules of Granulovacuolar Degeneration in Alzheimer's Disease and Down's Syndrome Brain Acta Neuropathologica. Jul, 2002 | Pubmed ID: 12070657 Visuospatial Impairments in Aged Canines (Canis Familiaris): the Role of Cognitive-behavioral Flexibility Behavioral Neuroscience. Jun, 2002 | Pubmed ID: 12049325 The Influence of the Carboxyl Terminus of the Alzheimer Abeta Peptide on Its Conformation, Aggregation, and Neurotoxic Properties Neuromolecular Medicine. 2002 | Pubmed ID: 12025818 Exercise Enhances and Protects Brain Function Exercise and Sport Sciences Reviews. Apr, 2002 | Pubmed ID: 11991541 Memory Loss in Old Rats is Associated with Brain Mitochondrial Decay and RNA/DNA Oxidation: Partial Reversal by Feeding Acetyl-L-carnitine And/or R-alpha -lipoic Acid Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11854529 Non-plasma Bonding of PDMS for Inexpensive Fabrication of Microfluidic Devices JoVE 410 Biology Preparing E18 Cortical Rat Neurons for Compartmentalization in a Microfluidic Device JoVE 305 Biology Fabrication of a Microfluidic Device for the Compartmentalization of Neuron Soma and Axons JoVE 261 Biology
Preparing E18 Cortical Rat Neurons for Compartmentalization in a Microfluidic Device JoVE 305 Biology
Fabrication of a Microfluidic Device for the Compartmentalization of Neuron Soma and Axons JoVE 261 Biology