Carl Cotman Institute for Brain Aging and Dementia University of California, Irvine (UCI) Biography Publications Institution JoVE Articles Carl Cotman has not added a biography. If you are Carl Cotman and would like to personalize this page please email our Author Liaison for assistance. Publications Caspase-3 Activation As a Bifurcation Point Between Plasticity and Cell Death Neuroscience Bulletin. Feb, 2012 | Pubmed ID: 22233886 Cardiovascular Fitness is Associated with Altered Cortical Glucose Metabolism During Working Memory in É›4 Carriers Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jan, 2012 | Pubmed ID: 22226798 Age and Distraction Are Determinants of Performance on a Novel Visual Search Task in Aged Beagle Dogs Age (Dordrecht, Netherlands). Feb, 2012 | Pubmed ID: 21336566 BDNF Increases with Behavioral Enrichment and an Antioxidant Diet in the Aged Dog Neurobiology of Aging. Mar, 2012 | Pubmed ID: 20447733 Aβ Aggregation Profiles and Shifts in APP Processing Favor Amyloidogenesis in Canines Neurobiology of Aging. Jan, 2012 | Pubmed ID: 20434811 Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease PloS One. 2011 | Pubmed ID: 22046234 Dietary and Behavioral Interventions Protect Against Age Related Activation of Caspase Cascades in the Canine Brain PloS One. 2011 | Pubmed ID: 21931796 An Amyloid β(42)-dependent Deficit in Anandamide Mobilization is Associated with Cognitive Dysfunction in Alzheimer's Disease Neurobiology of Aging. May, 2011 | Pubmed ID: 21546126 Common Variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 Are Associated with Late-onset Alzheimer's Disease Nature Genetics. May, 2011 | Pubmed ID: 21460841 Mild Stress Facilitates Learning and Exercise Improves Retention in Aged Mice Experimental Gerontology. Jan, 2011 | Pubmed ID: 20951791 β-Amyloid Impairs Axonal BDNF Retrograde Trafficking Neurobiology of Aging. May, 2011 | Pubmed ID: 19540623 Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease PloS One. 2010 | Pubmed ID: 20838618 Synergistic Effects of Long-term Antioxidant Diet and Behavioral Enrichment on Beta-amyloid Load and Non-amyloidogenic Processing in Aged Canines The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2010 | Pubmed ID: 20660265 Systemic Mitochondrial Dysfunction and the Etiology of Alzheimer's Disease and Down Syndrome Dementia Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20463402 Linear and Conformation Specific Antibodies in Aged Beagles After Prolonged Vaccination with Aggregated Abeta Neurobiology of Disease. Sep, 2010 | Pubmed ID: 20451612 Common Variants at 7p21 Are Associated with Frontotemporal Lobar Degeneration with TDP-43 Inclusions Nature Genetics. Mar, 2010 | Pubmed ID: 20154673 Rescue of Radiation-induced Cognitive Impairment Through Cranial Transplantation of Human Embryonic Stem Cells Proceedings of the National Academy of Sciences of the United States of America. Nov, 2009 | Pubmed ID: 19901336 Short-term Supplementation with Acetyl-L-carnitine and Lipoic Acid Alters Plasma Protein Carbonyl Levels but Does Not Improve Cognition in Aged Beagles Experimental Gerontology. Dec, 2009 | Pubmed ID: 19735717 Exercise Improves Cognition and Hippocampal Plasticity in APOE Epsilon4 Mice Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Jul, 2009 | Pubmed ID: 19560099 Axonal MRNA in Uninjured and Regenerating Cortical Mammalian Axons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2009 | Pubmed ID: 19369540 Mitochondrial Decay in the Brains of Old Rats: Ameliorating Effect of Alpha-lipoic Acid and Acetyl-L-carnitine Neurochemical Research. Apr, 2009 | Pubmed ID: 18846423 The Canine (dog) Model of Human Aging and Disease: Dietary, Environmental and Immunotherapy Approaches Journal of Alzheimer's Disease : JAD. Dec, 2008 | Pubmed ID: 19096165 Healthy Brain Aging: a Meeting Report from the Sylvan M. Cohen Annual Retreat of the University of Pennsylvania Institute on Aging Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Nov, 2008 | Pubmed ID: 18945646 Gene Expression Changes in the Course of Normal Brain Aging Are Sexually Dimorphic Proceedings of the National Academy of Sciences of the United States of America. Oct, 2008 | Pubmed ID: 18832152 Rhinal and Dorsolateral Prefrontal Cortex Lesions Produce Selective Impairments in Object and Spatial Learning and Memory in Canines The Journal of Comparative Neurology. Nov, 2008 | Pubmed ID: 18792072 Exercise Alters the Immune Profile in Tg2576 Alzheimer Mice Toward a Response Coincident with Improved Cognitive Performance and Decreased Amyloid Journal of Neuroinflammation. 2008 | Pubmed ID: 18400101 Lipoamide Protects Retinal Pigment Epithelial Cells from Oxidative Stress and Mitochondrial Dysfunction Free Radical Biology & Medicine. Apr, 2008 | Pubmed ID: 18258206 Voluntary Running Attenuates Age-related Deficits Following SCI Experimental Neurology. Mar, 2008 | Pubmed ID: 18164294 Interleukin-1beta Interferes with Signal Transduction Induced by Neurotrophin-3 in Cortical Neurons Brain Research. Jan, 2008 | Pubmed ID: 18036576 Interleukin-1 Beta Impairs Brain Derived Neurotrophic Factor-induced Signal Transduction Neurobiology of Aging. Sep, 2008 | Pubmed ID: 17467122 Region Specific Neuron Loss in the Aged Canine Hippocampus is Reduced by Enrichment Neurobiology of Aging. Jan, 2008 | Pubmed ID: 17092609 Proteomic Identification of Brain Proteins in the Canine Model of Human Aging Following a Long-term Treatment with Antioxidants and a Program of Behavioral Enrichment: Relevance to Alzheimer's Disease Neurobiology of Aging. Jan, 2008 | Pubmed ID: 17055614 Physical Activity and the Maintenance of Cognition: Learning from Animal Models Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Apr, 2007 | Pubmed ID: 19595972 Fibril Specific, Conformation Dependent Antibodies Recognize a Generic Epitope Common to Amyloid Fibrils and Fibrillar Oligomers That is Absent in Prefibrillar Oligomers Molecular Neurodegeneration. 2007 | Pubmed ID: 17897471 Exercise Builds Brain Health: Key Roles of Growth Factor Cascades and Inflammation Trends in Neurosciences. Sep, 2007 | Pubmed ID: 17765329 Three Weeks of Running Wheel Exposure Improves Cognitive Performance in the Aged Tg2576 Mouse Behavioural Brain Research. Dec, 2007 | Pubmed ID: 17698211 Neurogenesis Decreases with Age in the Canine Hippocampus and Correlates with Cognitive Function Neurobiology of Learning and Memory. Sep, 2007 | Pubmed ID: 17587610 Wheel Running Following Spinal Cord Injury Improves Locomotor Recovery and Stimulates Serotonergic Fiber Growth The European Journal of Neuroscience. Apr, 2007 | Pubmed ID: 17439482 Differential Regulation of Inhibitors of Apoptosis Proteins in Alzheimer's Disease Brains Neurobiology of Disease. Apr, 2007 | Pubmed ID: 17292615 Acrolein, a Toxicant in Cigarette Smoke, Causes Oxidative Damage and Mitochondrial Dysfunction in RPE Cells: Protection by (R)-alpha-lipoic Acid Investigative Ophthalmology & Visual Science. Jan, 2007 | Pubmed ID: 17197552 Effects of Melatonin and Age on Gene Expression in Mouse CNS Using Microarray Analysis Neurochemistry International. Jan, 2007 | Pubmed ID: 17118492 External Force-assisted Cell Positioning Inside Microfluidic Devices Biomedical Microdevices. Feb, 2007 | Pubmed ID: 17091393 Musashi1 Antigen Expression in Human Fetal Germinal Matrix Development Experimental Neurology. Oct, 2006 | Pubmed ID: 16777095 Neurobiology of Exercise Obesity (Silver Spring, Md.). Mar, 2006 | Pubmed ID: 16648603 Visuospatial Function in the Beagle Dog: an Early Marker of Cognitive Decline in a Model of Human Aging and Dementia Neurobiology of Learning and Memory. Sep, 2006 | Pubmed ID: 16616528 Immunization with Fibrillar Abeta(1-42) in Young and Aged Canines: Antibody Generation and Characteristics, and Effects on CSF and Brain Abeta Vaccine. Apr, 2006 | Pubmed ID: 16460841 Effects of Testosterone on Cognition and Mood in Male Patients with Mild Alzheimer Disease and Healthy Elderly Men Archives of Neurology. Feb, 2006 | Pubmed ID: 16344336 BioVision: an Application for the Automated Image Analysis of Histological Sections Neurobiology of Aging. Oct, 2006 | Pubmed ID: 16271803 The Role of Neurotrophins in Brain Aging: a Perspective in Honor of Regino Perez-Polo Neurochemical Research. Jun-Jul, 2005 | Pubmed ID: 16187222 Nutritional Management of Brain Aging in Dogs Journal of the American Veterinary Medical Association. Sep, 2005 | Pubmed ID: 16178393 A Microfluidic Culture Platform for CNS Axonal Injury, Regeneration and Transport Nature Methods. Aug, 2005 | Pubmed ID: 16094385 Caspase-cleaved Tau Accumulation in Neurodegenerative Diseases Associated with Tau and Alpha-synuclein Pathology Acta Neuropathologica. Aug, 2005 | Pubmed ID: 15986225 Exercise-induced Gene Expression Changes in the Rat Spinal Cord Gene Expression. 2005 | Pubmed ID: 15892452 Voluntary Exercise Decreases Amyloid Load in a Transgenic Model of Alzheimer's Disease The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2005 | Pubmed ID: 15858047 Chronic Antioxidant and Mitochondrial Cofactor Administration Improves Discrimination Learning in Aged but Not Young Dogs Progress in Neuro-psychopharmacology & Biological Psychiatry. Mar, 2005 | Pubmed ID: 15795055 A Comparison of Egocentric and Allocentric Age-dependent Spatial Learning in the Beagle Dog Progress in Neuro-psychopharmacology & Biological Psychiatry. Mar, 2005 | Pubmed ID: 15795044 The Role of Caspase Cleavage of Tau in Alzheimer Disease Neuropathology Journal of Neuropathology and Experimental Neurology. Feb, 2005 | Pubmed ID: 15751224 Beta-amyloid Deposition and Tau Phosphorylation in Clinically Characterized Aged Cats Neurobiology of Aging. May, 2005 | Pubmed ID: 15708450 Voluntary Wheel Running Improves Recovery from a Moderate Spinal Cord Injury Journal of Neurotrauma. Jan, 2005 | Pubmed ID: 15665610 The Exercise-induced Expression of BDNF Within the Hippocampus Varies Across Life-span Neurobiology of Aging. Apr, 2005 | Pubmed ID: 15653179 Patterned Cell Culture Inside Microfluidic Devices Lab on a Chip. Jan, 2005 | Pubmed ID: 15616747 Activation of Complement Pathways After Contusion-induced Spinal Cord Injury Journal of Neurotrauma. Dec, 2004 | Pubmed ID: 15684772 Comparison of the Effects of L-carnitine and Acetyl-L-carnitine on Carnitine Levels, Ambulatory Activity, and Oxidative Stress Biomarkers in the Brain of Old Rats Annals of the New York Academy of Sciences. Nov, 2004 | Pubmed ID: 15591009 Frontal Lobe Volume, Function, and Beta-amyloid Pathology in a Canine Model of Aging The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2004 | Pubmed ID: 15385603 Neutralization of the Chemokine CXCL10 Enhances Tissue Sparing and Angiogenesis Following Spinal Cord Injury Journal of Neuroscience Research. Sep, 2004 | Pubmed ID: 15352216 Beta-amyloid Peptide at Sublethal Concentrations Downregulates Brain-derived Neurotrophic Factor Functions in Cultured Cortical Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2004 | Pubmed ID: 15282285 Caspase-cleavage of Tau is an Early Event in Alzheimer Disease Tangle Pathology The Journal of Clinical Investigation. Jul, 2004 | Pubmed ID: 15232619 Concept Abstraction in the Aging Dog: Development of a Protocol Using Successive Discrimination and Size Concept Tasks Behavioural Brain Research. Aug, 2004 | Pubmed ID: 15219721 Isolated Executive Impairment and Associated Frontal Neuropathology Dementia and Geriatric Cognitive Disorders. 2004 | Pubmed ID: 15178954 The Timecourse of Induction of Brain-derived Neurotrophic Factor MRNA and Protein in the Rat Hippocampus Following Voluntary Exercise Neuroscience Letters. Jun, 2004 | Pubmed ID: 15157993 Long-term Treatment with Antioxidants and a Program of Behavioral Enrichment Reduces Age-dependent Impairment in Discrimination and Reversal Learning in Beagle Dogs Experimental Gerontology. May, 2004 | Pubmed ID: 15130670 Microfluidic Multicompartment Device for Neuroscience Research Langmuir : the ACS Journal of Surfaces and Colloids. Mar, 2003 | Pubmed ID: 20725530 Accumulation of Caspase Cleaved Amyloid Precursor Protein Represents an Early Neurodegenerative Event in Aging and in Alzheimer's Disease Neurobiology of Disease. Dec, 2003 | Pubmed ID: 14678756 Response Latency in Canis Familiaris: Mental Ability or Mental Strategy? Behavioral Neuroscience. Oct, 2003 | Pubmed ID: 14570555 Locomotor Activity Rhythms in Dogs Vary with Age and Cognitive Status Behavioral Neuroscience. Aug, 2003 | Pubmed ID: 12931965 Spatial Patterns of Mammalian Brain Aging: Distribution of Cathepsin D-immunoreactive Cell Bodies and Dystrophic Dendrites in Aging Dogs Resembles That in Alzheimer's Disease The Journal of Comparative Neurology. Sep, 2003 | Pubmed ID: 12900930 Fas and Fas Ligand Are Associated with Neuritic Degeneration in the AD Brain and Participate in Beta-amyloid-induced Neuronal Death Neurobiology of Disease. Apr, 2003 | Pubmed ID: 12742739 Exercise Increases the Vulnerability of Rat Hippocampal Neurons to Kainate Lesion Brain Research. May, 2003 | Pubmed ID: 12706240 Common Structure of Soluble Amyloid Oligomers Implies Common Mechanism of Pathogenesis Science (New York, N.Y.). Apr, 2003 | Pubmed ID: 12702875 Adjuvant-dependent Modulation of Th1 and Th2 Responses to Immunization with Beta-amyloid International Immunology. Apr, 2003 | Pubmed ID: 12663680 The Induction of the TNFalpha Death Domain Signaling Pathway in Alzheimer's Disease Brain Neurochemical Research. Feb, 2003 | Pubmed ID: 12608703 Size and Reversal Learning in the Beagle Dog As a Measure of Executive Function and Inhibitory Control in Aging Learning & Memory (Cold Spring Harbor, N.Y.). Jan-Feb, 2003 | Pubmed ID: 12551965 Caspase Activation in the Alzheimer's Disease Brain: Tortuous and Torturous Drug News & Perspectives. Nov, 2002 | Pubmed ID: 12677194 Caspase-9 Activation and Caspase Cleavage of Tau in the Alzheimer's Disease Brain Neurobiology of Disease. Nov, 2002 | Pubmed ID: 12505426 Atherosclerotic Lesions and Mitochondria DNA Deletions in Brain Microvessels As a Central Target for the Development of Human AD and AD-like Pathology in Aged Transgenic Mice Annals of the New York Academy of Sciences. Nov, 2002 | Pubmed ID: 12480733 Brain Aging in the Canine: a Diet Enriched in Antioxidants Reduces Cognitive Dysfunction Neurobiology of Aging. Sep-Oct, 2002 | Pubmed ID: 12392784 Beta-amyloid Deposition and Neurofibrillary Tangle Association with Caspase Activation in Down Syndrome Neuroscience Letters. Sep, 2002 | Pubmed ID: 12213643 Evidence for Decreased DARPP-32 in the Prefrontal Cortex of Patients with Schizophrenia Archives of General Psychiatry. Aug, 2002 | Pubmed ID: 12150646 Hippocampal Brain-derived Neurotrophic Factor Gene Regulation by Exercise and the Medial Septum Journal of Neuroscience Research. Jun, 2002 | Pubmed ID: 12111841 Achieving and Maintaining Cognitive Vitality with Aging Mayo Clinic Proceedings. Mayo Clinic. Jul, 2002 | Pubmed ID: 12108606 Exercise: a Behavioral Intervention to Enhance Brain Health and Plasticity Trends in Neurosciences. Jun, 2002 | Pubmed ID: 12086747 Caspase-cleaved Amyloid Precursor Protein and Activated Caspase-3 Are Co-localized in the Granules of Granulovacuolar Degeneration in Alzheimer's Disease and Down's Syndrome Brain Acta Neuropathologica. Jul, 2002 | Pubmed ID: 12070657 Visuospatial Impairments in Aged Canines (Canis Familiaris): the Role of Cognitive-behavioral Flexibility Behavioral Neuroscience. Jun, 2002 | Pubmed ID: 12049325 The Influence of the Carboxyl Terminus of the Alzheimer Abeta Peptide on Its Conformation, Aggregation, and Neurotoxic Properties Neuromolecular Medicine. 2002 | Pubmed ID: 12025818 Exercise Enhances and Protects Brain Function Exercise and Sport Sciences Reviews. Apr, 2002 | Pubmed ID: 11991541 Memory Loss in Old Rats is Associated with Brain Mitochondrial Decay and RNA/DNA Oxidation: Partial Reversal by Feeding Acetyl-L-carnitine And/or R-alpha -lipoic Acid Proceedings of the National Academy of Sciences of the United States of America. Feb, 2002 | Pubmed ID: 11854529 Microfluidic उपकरणों की सस्ती निर्माण के लिए गैर प्लाज्मा PDMS के संबंध Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Cristina Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 410 Biology एक microfluidic डिवाइस में E18 Compartmentalization के लिए cortical चूहा न्यूरॉन्स की तैयारी Joseph Harris1, Hyuna Lee1, Christina Tu Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 305 Biology एक microfluidic डिवाइस के न्यूरॉन सोमा और axons की Compartmentalization निर्माण के लिए Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Christina Tu2, David Cribbs3, Noo Li Jeon1, Carl Cotman3 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 261 Biology
Microfluidic उपकरणों की सस्ती निर्माण के लिए गैर प्लाज्मा PDMS के संबंध Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Cristina Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 410 Biology
एक microfluidic डिवाइस में E18 Compartmentalization के लिए cortical चूहा न्यूरॉन्स की तैयारी Joseph Harris1, Hyuna Lee1, Christina Tu Tu2, David Cribbs3, Carl Cotman3, Noo Li Jeon1 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 305 Biology
एक microfluidic डिवाइस के न्यूरॉन सोमा और axons की Compartmentalization निर्माण के लिए Joseph Harris1, Hyuna Lee1, Behrad Vahidi1, Christina Tu2, David Cribbs3, Noo Li Jeon1, Carl Cotman3 1Department of Biomedical Engineering, University of California, Irvine (UCI), 2Stem Cell Research Center, University of California, Irvine (UCI), 3Institute for Brain Aging and Dementia, University of California, Irvine (UCI) JoVE 261 Biology
