Carlos A. Guzmán Department of Vaccinology and Applied Microbiology Helmholtz Centre for Infection Research Biography Publications Institution JoVE Articles Carlos A. Guzmán has not added a biography. If you are Carlos A. Guzmán and would like to personalize this page please email our Author Liaison for assistance. Publications Responsiveness to Influenza Vaccination Correlates with NKG2C-Expression on NK Cells Vaccines. Jun, 2020 | Pubmed ID: 32517137 Peptidoglycan-treated Tumor Antigen-pulsed Dendritic Cells Impart Complete Resistance Against Tumor Rechallenge Clinical and Experimental Immunology. May, 2020 | Pubmed ID: 32443171 Mucosal Heterologous Prime/Boost Vaccination Induces Polyfunctional Systemic Immunity, Improving Protection Against Frontiers in Immunology. 2020 | Pubmed ID: 32153562 Knockdown of Virus Antigen Expression Increases Therapeutic Vaccine Efficacy in High-Titer Hepatitis B Virus Carrier Mice Gastroenterology. May, 2020 | Pubmed ID: 32001321 ADAP Promotes Degranulation and Migration of NK Cells Primed During Infection in Mice Frontiers in Immunology. 2019 | Pubmed ID: 32038647 Key Features and Homing Properties of NK Cells in the Liver Are Shaped by Activated INKT Cells Scientific Reports. 11, 2019 | Pubmed ID: 31704965 Mucosal CD8+ T Cell Responses Induced by an MCMV Based Vaccine Vector Confer Protection Against Influenza Challenge PLoS Pathogens. 09, 2019 | Pubmed ID: 31525249 Neutralization of Pro-inflammatory Cytokines During Secondary Infection Post Influenza A Virus Infection Frontiers in Immunology. 2019 | Pubmed ID: 31474978 Neutral Lipopolyplexes for In Vivo Delivery of Conventional and Replicative RNA Vaccine Molecular Therapy. Nucleic Acids. Sep, 2019 | Pubmed ID: 31446119 Invariant NKT Cell-Mediated Modulation of ILC1s As a Tool for Mucosal Immune Intervention Frontiers in Immunology. 2019 | Pubmed ID: 31440243 Self-reported Diabetes and Herpes Zoster Are Associated with a Weak Humoral Response to the Seasonal Influenza A H1N1 Vaccine Antigen Among the Elderly BMC Infectious Diseases. Jul, 2019 | Pubmed ID: 31337344 The STING Activator C-di-AMP Exerts Superior Adjuvant Properties Than the Formulation Poly(I:C)/CpG After Subcutaneous Vaccination with Soluble Protein Antigen or DEC-205-mediated Antigen Targeting to Dendritic Cells Vaccine. 08, 2019 | Pubmed ID: 31320219 Novel Colloidal Associations of Soyasaponins and Lipid Components (DPPC, Cholesterol) As Potential Adjuvants for Vaccines Vaccine. 08, 2019 | Pubmed ID: 31320217 Systems Immunology Characterization of Novel Vaccine Formulations for Bacterins Frontiers in Immunology. 2019 | Pubmed ID: 31178860 Cohort Profile: The LoewenKIDS Study - Life-course Perspective on Infections, the Microbiome and the Development of the Immune System in Early Childhood International Journal of Epidemiology. 08, 2019 | Pubmed ID: 30938437 The Combination Vaccine Adjuvant System Alum/c-di-AMP Results in Quantitative and Qualitative Enhanced Immune Responses Post Immunization Frontiers in Cellular and Infection Microbiology. 2019 | Pubmed ID: 30838180 Cohort Profile: The LoewenKIDS Study - Life-course Perspective on Infections, the Microbiome and the Development of the Immune System in Early Childhood International Journal of Epidemiology. 08, 2019 | Pubmed ID: 30815674 Functional and Immunogenic Characterization of Diverse HCV Glycoprotein E2 Variants Journal of Hepatology. 04, 2019 | Pubmed ID: 30439392 Signatures of T and B Cell Development, Functional Responses and PD-1 Upregulation After HCMV Latent Infections and Reactivations in Nod.Rag.Gamma Mice Humanized With Cord Blood CD34 Cells Frontiers in Immunology. 2018 | Pubmed ID: 30524448 Respiratory Carriage is Associated with Broad Phenotypic Alterations of Peripheral CD4⁺CD25⁺ T Cells and Differentially Affects Immune Responses to Secondary Non-Infectious and Infectious Stimuli in Mice International Journal of Molecular Sciences. Sep, 2018 | Pubmed ID: 30200513 Mannose Metabolism Is Essential for Th1 Cell Differentiation and IFN-γ Production Journal of Immunology (Baltimore, Md. : 1950). 09, 2018 | Pubmed ID: 30030325 Large-scale Production of Megakaryocytes in Microcarrier-supported Stirred Suspension Bioreactors Scientific Reports. 07, 2018 | Pubmed ID: 29977045 Influenza-Activated ILC1s Contribute to Antiviral Immunity Partially Influenced by Differential GITR Expression Frontiers in Immunology. 2018 | Pubmed ID: 29623077 Respiratory Influenza A Virus Infection Triggers Local and Systemic Natural Killer Cell Activation Toll-Like Receptor 7 Frontiers in Immunology. 2018 | Pubmed ID: 29497422 Dual Dye In-vivo Imaging of Differentially Charged PLGA Carriers Reveals Antigen-depot Effect, Leading to Improved Immune Responses in Preclinical Models European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. May, 2018 | Pubmed ID: 29408551 In Silico Vaccine Strain Prediction for Human Influenza Viruses Trends in Microbiology. Feb, 2018 | Pubmed ID: 29032900 Mucosal Administration of Cycle-Di-Nucleotide-Adjuvanted Virosomes Efficiently Induces Protection Against Influenza H5N1 in Mice Frontiers in Immunology. 2017 | Pubmed ID: 29033942 Self-replicating RNA Vaccine Functionality Modulated by Fine-tuning of Polyplex Delivery Vehicle Structure Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2017 | Pubmed ID: 28935594 Bivalent Mucosal Peptide Vaccines Administered Using the LCP Carrier System Stimulate Protective Immune Responses Against Streptococcus Pyogenes Infection Nanomedicine : Nanotechnology, Biology, and Medicine. Nov, 2017 | Pubmed ID: 28887213 Roads to Advanced Vaccines: Influenza Case Study Microbial Biotechnology. Sep, 2017 | Pubmed ID: 28809451 Type I IFN and Not TNF, is Essential for Cyclic Di-nucleotide-elicited CTL by a Cytosolic Cross-presentation Pathway EBioMedicine. Aug, 2017 | Pubmed ID: 28754303 Role of Autophagy in HIV-1 Matrix Protein P17-Driven Lymphangiogenesis Journal of Virology. 08, 2017 | Pubmed ID: 28592537 Anti-nuclear Autoantibodies in the General German Population: Prevalence and Lack of Association with Selected Cardiovascular and Metabolic Disorders-findings of a Multicenter Population-based Study Arthritis Research & Therapy. 06, 2017 | Pubmed ID: 28587625 Intranasal Vaccination with an Adjuvanted Polyphosphazenes Nanoparticle-based Vaccine Formulation Stimulates Protective Immune Responses in Mice Nanomedicine : Nanotechnology, Biology, and Medicine. Oct, 2017 | Pubmed ID: 28579436 Cyclic Dinucleotides Modulate Induced Type I IFN Responses in Innate Immune Cells by Degradation of STING FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 07, 2017 | Pubmed ID: 28396343 Establishment of a Cohort for Deep Phenotyping of the Immune Response to Influenza Vaccination Among Elderly Individuals Recruited from the General Population Human Vaccines & Immunotherapeutics. 07, 2017 | Pubmed ID: 28394705 Targeted Antigen Delivery to Dendritic Cells Elicits Robust Antiviral T Cell-mediated Immunity in the Liver Scientific Reports. Mar, 2017 | Pubmed ID: 28266658 Immunization with Tc52 or Its Amino Terminal Domain Adjuvanted with C-di-AMP Induces Th17+Th1 Specific Immune Responses and Confers Protection Against Trypanosoma Cruzi PLoS Neglected Tropical Diseases. Feb, 2017 | Pubmed ID: 28234897 Motivations for (non)participation in Population-based Health Studies Among the Elderly - Comparison of Participants and Nonparticipants of a Prospective Study on Influenza Vaccination BMC Medical Research Methodology. 02, 2017 | Pubmed ID: 28148221 A New RNA-Based Adjuvant Enhances Virus-Specific Vaccine Responses by Locally Triggering TLR- and RLH-Dependent Effects Journal of Immunology (Baltimore, Md. : 1950). 02, 2017 | Pubmed ID: 28077601 Self-Replicating RNA Vaccine Delivery to Dendritic Cells Methods in Molecular Biology (Clifton, N.J.). 2017 | Pubmed ID: 27987142 Activation of Innate and Adaptive Immunity by a Recombinant Human Cytomegalovirus Strain Expressing an NKG2D Ligand PLoS Pathogens. Dec, 2016 | Pubmed ID: 27907183 The Proneurotrophin Receptor Sortilin is Required for Mycobacterium Tuberculosis Control by Macrophages Scientific Reports. 07, 2016 | Pubmed ID: 27389464 New Horizons in the Development of Novel Needle-Free Immunization Strategies to Increase Vaccination Efficacy Current Topics in Microbiology and Immunology. 2016 | Pubmed ID: 27370343 Generation of HLA-universal IPSCs-derived Megakaryocytes and Platelets for Survival Under Refractoriness Conditions Molecular Medicine (Cambridge, Mass.). May, 2016 | Pubmed ID: 27262025 Modeling Influenza Virus Infection: A Roadmap for Influenza Research Viruses. Oct, 2015 | Pubmed ID: 26473911 Rodents As Pre-clinical Models for Predicting Vaccine Performance in Humans Expert Review of Vaccines. 2015 | Pubmed ID: 26268433 Cohort Study of Airway Mycobiome in Adult Cystic Fibrosis Patients: Differences in Community Structure Between Fungi and Bacteria Reveal Predominance of Transient Fungal Elements Journal of Clinical Microbiology. Sep, 2015 | Pubmed ID: 26135861 Induction of CD4(+) and CD8(+) Anti-tumor Effector T Cell Responses by Bacteria Mediated Tumor Therapy International Journal of Cancer. Oct, 2015 | Pubmed ID: 25868911 Activated NKT Cells Imprint NK-cell Differentiation, Functionality and Education European Journal of Immunology. Jun, 2015 | Pubmed ID: 25808315 Inverse Micellar Sugar Glass (IMSG) Nanoparticles for Transfollicular Vaccination Journal of Controlled Release : Official Journal of the Controlled Release Society. May, 2015 | Pubmed ID: 25795506 High Individuality of Respiratory Bacterial Communities in a Large Cohort of Adult Cystic Fibrosis Patients Under Continuous Antibiotic Treatment PloS One. 2015 | Pubmed ID: 25671713 TRANSVAC Research Infrastructure - Results and Lessons Learned from the European Network of Vaccine Research and Development Vaccine. Oct, 2015 | Pubmed ID: 25667962 Evaluation of Invalid Vaccine Doses in 31 Countries of the WHO African Region Vaccine. Feb, 2015 | Pubmed ID: 25523526 Efficient Nanoparticle-mediated Needle-free Transcutaneous Vaccination Via Hair Follicles Requires Adjuvantation Nanomedicine : Nanotechnology, Biology, and Medicine. Jan, 2015 | Pubmed ID: 25200611 Oral Multicomponent DNA Vaccine Delivered by Attenuated Salmonella Elicited Immunoprotection Against American Trypanosomiasis The Journal of Infectious Diseases. Mar, 2015 | Pubmed ID: 25160983 Gene Expression Driven by a Strong Viral Promoter in MVA Increases Vaccination Efficiency by Enhancing Antibody Responses and Unmasking CD8⁺ T Cell Epitopes Vaccines. Jul, 2014 | Pubmed ID: 26344747 Pegylated Bisacycloxypropylcysteine, a Diacylated Lipopeptide Ligand of TLR6, Plays a Host-protective Role Against Experimental Leishmania Major Infection Journal of Immunology (Baltimore, Md. : 1950). Oct, 2014 | Pubmed ID: 25194056 Use of S-[2,3-bispalmitoyiloxy-(2R)-propyl]-R-cysteinyl-amido-monomethoxy Polyethylene Glycol As an Adjuvant Improved Protective Immunity Associated with a DNA Vaccine Encoding Cu,Zn Superoxide Dismutase of Brucella Abortus in Mice Clinical and Vaccine Immunology : CVI. Nov, 2014 | Pubmed ID: 25165025 Intranasal Delivery of Influenza RNP Adjuvanted with C-di-AMP Induces Strong Humoral and Cellular Immune Responses and Provides Protection Against Virus Challenge PloS One. 2014 | Pubmed ID: 25140692 Tc52 Amino-terminal-domain DNA Carried by Attenuated Salmonella Enterica Serovar Typhimurium Induces Protection Against a Trypanosoma Cruzi Lethal Challenge Infection and Immunity. Oct, 2014 | Pubmed ID: 25069980 Intranasal Formulations: Promising Strategy to Deliver Vaccines Expert Opinion on Drug Delivery. Oct, 2014 | Pubmed ID: 24962722 TRANSVAC Workshop on Standardisation and Harmonisation of Analytical Platforms for HIV, TB and Malaria Vaccines: 'how Can Big Data Help?' Vaccine. Jul, 2014 | Pubmed ID: 24950356 The Mucosal Adjuvant Cyclic Di-AMP Exerts Immune Stimulatory Effects on Dendritic Cells and Macrophages PloS One. 2014 | Pubmed ID: 24755640 A New Adjuvanted Nanoparticle-based H1N1 Influenza Vaccine Induced Antigen-specific Local Mucosal and Systemic Immune Responses After Administration into the Lung Vaccine. Apr, 2014 | Pubmed ID: 24731807 Effects of Aging on Influenza Virus Infection Dynamics Journal of Virology. Apr, 2014 | Pubmed ID: 24478442 Purification of Hepatitis B Surface Antigen Virus-like Particles from Recombinant Pichia Pastoris and in Vivo Analysis of Their Immunogenic Properties Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Dec, 2013 | Pubmed ID: 24141044 Vaccine Adjuvants: Key Tools for Innovative Vaccine Design Current Topics in Medicinal Chemistry. 2013 | Pubmed ID: 24066891 A Study of Chitosan and C-di-GMP As Mucosal Adjuvants for Intranasal Influenza H5N1 Vaccine Influenza and Other Respiratory Viruses. Nov, 2013 | Pubmed ID: 23170900 Development and Characterization of Attenuated Metabolic Mutants of Bordetella Bronchiseptica for Applications in Vaccinology Environmental Microbiology. Jan, 2013 | Pubmed ID: 22676396 Block of Death-receptor Apoptosis Protects Mouse Cytomegalovirus from Macrophages and is a Determinant of Virulence in Immunodeficient Hosts PLoS Pathogens. 2012 | Pubmed ID: 23271968 Vaccines: from Empirical Development to Rational Design PLoS Pathogens. 2012 | Pubmed ID: 23144616 HIV-1 Matrix Protein P17 Promotes Angiogenesis Via Chemokine Receptors CXCR1 and CXCR2 Proceedings of the National Academy of Sciences of the United States of America. Sep, 2012 | Pubmed ID: 22904195 NKT Cell Stimulation with α-galactosylceramide Results in a Block of Th17 Differentiation After Intranasal Immunization in Mice PloS One. 2012 | Pubmed ID: 22291945 Cyclic Di-nucleotides: New Era for Small Molecules As Adjuvants Microbial Biotechnology. Mar, 2012 | Pubmed ID: 21958423 Peritoneal Cavity is Dominated by IFNγ-secreting CXCR3+ Th1 Cells PloS One. 2011 | Pubmed ID: 21789162 Bis-(3',5')-cyclic Dimeric Adenosine Monophosphate: Strong Th1/Th2/Th17 Promoting Mucosal Adjuvant Vaccine. Jul, 2011 | Pubmed ID: 21619907 Exploitation of Prokaryotic Expression Systems Based on the Salicylate-dependent Control Circuit Encompassing NahR/P(sal)::xylS2 for Biotechnological Applications Bioengineered Bugs. Jul-Aug, 2010 | Pubmed ID: 21327056 Generation of Human Antigen-specific Monoclonal IgM Antibodies Using Vaccinated "human Immune System" Mice PloS One. Oct, 2010 | Pubmed ID: 20957227 Modified Vaccinia Virus Ankara Exerts Potent Immune Modulatory Activities in a Murine Model PloS One. Jun, 2010 | Pubmed ID: 20628596 Optimizing Rational Vaccine Design Microbial Biotechnology. Mar, 2009 | Pubmed ID: 21261895 Immune Modulators with Defined Molecular Targets: Cornerstone to Optimize Rational Vaccine Design Advances in Experimental Medicine and Biology. 2009 | Pubmed ID: 20047042 Intranasal Immunization Promotes Th17 Immune Responses Journal of Immunology (Baltimore, Md. : 1950). Dec, 2009 | Pubmed ID: 19890060 The Toll-like Receptor 2/6 Ligand MALP-2 Reduces the Viability of Mycobacterium Tuberculosis in Murine Macrophages The Open Microbiology Journal. Apr, 2009 | Pubmed ID: 19471610 Multiple-locus Variable-number Tandem-repeat Analysis for Clonal Identification of Vibrio Parahaemolyticus Isolates by Using Capillary Electrophoresis Applied and Environmental Microbiology. Jun, 2009 | Pubmed ID: 19376898 A Prime-boost Vaccination Protocol Optimizes Immune Responses Against the Nucleocapsid Protein of the SARS Coronavirus Vaccine. Dec, 2008 | Pubmed ID: 18805454 Immune Modulators with Defined Molecular Targets: Cornerstone to Optimize Rational Vaccine Design Human Vaccines. Jan-Feb, 2008 | Pubmed ID: 18376145 HIV-1 Matrix Protein P17 Induces Human Plasmacytoid Dendritic Cells to Acquire a Migratory Immature Cell Phenotype Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18310327 HIV-1 Matrix Protein P17 Binds to Monocytes and Selectively Stimulates MCP-1 Secretion: Role of Transcriptional Factor AP-1 Cellular Microbiology. Mar, 2008 | Pubmed ID: 18042260 Oral Vaccination with Salmonella Enterica As a Cruzipain-DNA Delivery System Confers Protective Immunity Against Trypanosoma Cruzi Infection and Immunity. Jan, 2008 | Pubmed ID: 17967857 The FAI Protein of Group C Streptococci Acts As a Mucosal Adjuvant by the Specific Targeting and Activation of B Cells International Journal of Medical Microbiology : IJMM. Jan, 2008 | Pubmed ID: 17884726 A Pegylated Derivative of Alpha-galactosylceramide Exhibits Improved Biological Properties Journal of Immunology (Baltimore, Md. : 1950). Aug, 2007 | Pubmed ID: 17675464 The Bacterial Second Messenger CdiGMP Exhibits Promising Activity As a Mucosal Adjuvant Clinical and Vaccine Immunology : CVI. Aug, 2007 | Pubmed ID: 17567766 Immune Modulator Adamantylamide Dipeptide Stimulates Efficient Major Histocompatibility Complex Class I-restricted Responses in Mice Clinical and Vaccine Immunology : CVI. May, 2007 | Pubmed ID: 17344349 The Bacterial Second Messenger Cyclic DiGMP Exhibits Potent Adjuvant Properties Vaccine. Feb, 2007 | Pubmed ID: 17187906 Intranasal Vaccination with Recombinant Outer Membrane Protein CD and Adamantylamide Dipeptide As the Mucosal Adjuvant Enhances Pulmonary Clearance of Moraxella Catarrhalis in an Experimental Murine Model Infection and Immunity. Apr, 2007 | Pubmed ID: 17101651 P. 阿鲁吉诺萨 气液界面中支气皮细胞和巨噬细胞的感染三维共培养，用于抗感染的临床前评估 Carlos Victor Montefusco-Pereira*1,2, Justus C. Horstmann*1,2, Thomas Ebensen3, Christoph Beisswenger4, Robert Bals4, Carlos A. Guzmán3, Nicole Schneider-Daum1, Cristiane de Souza Carvalho-Wodarz1, Claus-Michael Lehr1,2 1Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 2Department of Pharmacy, Saarland University, 3Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 4Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital JoVE 61069 Immunology and Infection 疫苗开发中佐剂细胞毒性 T 淋巴细胞生成能力的快速体内评价 Darío Lirussi1, Thomas Ebensen1, Kai Schulze1, Elena Reinhard1, Stephanie Trittel1, Peggy Riese1, Blair Prochnow1, Carlos A. Guzmán1 1Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research JoVE 57401 Medicine
P. 阿鲁吉诺萨 气液界面中支气皮细胞和巨噬细胞的感染三维共培养，用于抗感染的临床前评估 Carlos Victor Montefusco-Pereira*1,2, Justus C. Horstmann*1,2, Thomas Ebensen3, Christoph Beisswenger4, Robert Bals4, Carlos A. Guzmán3, Nicole Schneider-Daum1, Cristiane de Souza Carvalho-Wodarz1, Claus-Michael Lehr1,2 1Department of Drug Delivery, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), 2Department of Pharmacy, Saarland University, 3Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research, 4Department of Internal Medicine V - Pulmonology, Allergology, Respiratory Intensive Care Medicine, Saarland University Hospital JoVE 61069 Immunology and Infection
疫苗开发中佐剂细胞毒性 T 淋巴细胞生成能力的快速体内评价 Darío Lirussi1, Thomas Ebensen1, Kai Schulze1, Elena Reinhard1, Stephanie Trittel1, Peggy Riese1, Blair Prochnow1, Carlos A. Guzmán1 1Department of Vaccinology and Applied Microbiology, Helmholtz Centre for Infection Research JoVE 57401 Medicine
