Celina G. Kleer

Publications

• EZH2 Expands Breast Stem Cells Through Activation of NOTCH1 Signaling
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014  |   Pubmed ID: 24516139
• Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity
  Cell. Jul, 2013  |   Pubmed ID: 23827675
• EZH2 and ALDH1 Expression in Ductal Carcinoma in Situ: Complex Association with Recurrence and Progression to Invasive Breast Cancer
  Cell Cycle (Georgetown, Tex.). Jul, 2013  |   Pubmed ID: 23759596
• Tissue-based Identification of Stem Cells and Epithelial-to-mesenchymal Transition in Breast Cancer
  Human Pathology. Aug, 2013  |   Pubmed ID: 23574782
• EZH2 Inhibition Decreases P38 Signaling and Suppresses Breast Cancer Motility and Metastasis
  Breast Cancer Research and Treatment. Apr, 2013  |   Pubmed ID: 23539298
• Invasive Ductal Carcinoma with Lobular Features: a Comparison Study to Invasive Ductal and Invasive Lobular Carcinomas of the Breast
  Breast Cancer Research and Treatment. Apr, 2013  |   Pubmed ID: 23535842
• HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab
  Cancer Research. Mar, 2013  |   Pubmed ID: 23442322
• Expression of Aldehyde Dehydrogenase 1 As a Marker of Mammary Stem Cells in Benign and Malignant Breast Lesions of Ghanaian Women
  Cancer. Feb, 2013  |   Pubmed ID: 22930220
• CCN6 Knockdown Disrupts Acinar Organization of Breast Cells in Three-dimensional Cultures Through Up-regulation of Type III TGF-β Receptor
  Neoplasia (New York, N.Y.). Nov, 2012  |   Pubmed ID: 23226100
• Canonical Wnt Signaling Regulates Slug Activity and Links Epithelial-mesenchymal Transition with Epigenetic Breast Cancer 1, Early Onset (BRCA1) Repression
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012  |   Pubmed ID: 23011797
• RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells
  PloS One. 2012  |   Pubmed ID: 22911725
• Metaplastic Carcinomas of the Breast: Diagnostic Challenges and New Translational Insights
  Archives of Pathology & Laboratory Medicine. Aug, 2012  |   Pubmed ID: 22849737
• CCN6 Modulates BMP Signaling Via the Smad-independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer
  Cancer Research. Sep, 2012  |   Pubmed ID: 22805309
• Invasive Breast Carcinomas in Ghana: High Frequency of High Grade, Basal-like Histology and High EZH2 Expression
  Breast Cancer Research and Treatment. Aug, 2012  |   Pubmed ID: 22527102
• Discoidin Domain Receptor Tyrosine Kinases: New Players in Cancer Progression
  Cancer Metastasis Reviews. Jun, 2012  |   Pubmed ID: 22366781
• Metaplastic Breast Carcinomas Are Enriched in Markers of Tumor-initiating Cells and Epithelial to Mesenchymal Transition
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2012  |   Pubmed ID: 22080057
• On How CCN6 Suppresses Breast Cancer Growth and Invasion
  Journal of Cell Communication and Signaling. Mar, 2012  |   Pubmed ID: 21842227
• Increased Risk for Distant Metastasis in Patients with Familial Early-stage Breast Cancer and High EZH2 Expression
  Breast Cancer Research and Treatment. Apr, 2012  |   Pubmed ID: 21614565
• Inflammatory Breast Cancer in North Africa: Comparison of Clinical and Molecular Epidemiologic Characteristics of Patients from Egypt, Tunisia, and Morocco
  Breast Disease. 2011-2012  |   Pubmed ID: 23001584
• Functionally Recurrent Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer
  Nature Medicine. Dec, 2011  |   Pubmed ID: 22101766
• P38γ Promotes Breast Cancer Cell Motility and Metastasis Through Regulation of RhoC GTPase, Cytoskeletal Architecture, and a Novel Leading Edge Behavior
  Cancer Research. Oct, 2011  |   Pubmed ID: 21862636
• Survival of Inflammatory Breast Cancer Patients Compared to Non-inflammatory Breast Cancer Patients in Egypt
  The Breast Journal. Sep-Oct, 2011  |   Pubmed ID: 21827567
• CCN6 (WISP3) Decreases ZEB1-mediated EMT and Invasion by Attenuation of IGF-1 Receptor Signaling in Breast Cancer
  Journal of Cell Science. May, 2011  |   Pubmed ID: 21525039
• Histone Methyltransferase EZH2 Induces Akt-dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer
  Cancer Research. Mar, 2011  |   Pubmed ID: 21406404
• EZH2 and ALDH-1 Mark Breast Epithelium at Risk for Breast Cancer Development
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jun, 2011  |   Pubmed ID: 21399615
• Membrane Localization of Insulin Receptor Substrate-2 (IRS-2) is Associated with Decreased Overall Survival in Breast Cancer
  Breast Cancer Research and Treatment. Dec, 2011  |   Pubmed ID: 21258861
• Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells Through Cytokine Networks
  Cancer Research. Jan, 2011  |   Pubmed ID: 21224357
• African Ancestry and Higher Prevalence of Triple-negative Breast Cancer: Findings from an International Study
  Cancer. Nov, 2010  |   Pubmed ID: 20629078
• Implications of Enhancer of Zeste Homologue 2 Expression in Pancreatic Ductal Adenocarcinoma
  Human Pathology. Sep, 2010  |   Pubmed ID: 20573371
• Blockade of CCN6 (WISP3) Activates Growth Factor-independent Survival and Resistance to Anoikis in Human Mammary Epithelial Cells
  Cancer Research. Apr, 2010  |   Pubmed ID: 20395207
• Antiangiogenic Tetrathiomolybdate Protects Against Her2/neu-induced Breast Carcinoma by Hypoplastic Remodeling of the Mammary Gland
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2009  |   Pubmed ID: 19934283
• Carcinoma of the Breast with Medullary-like Features: Diagnostic Challenges and Relationship with BRCA1 and EZH2 Functions
  Archives of Pathology & Laboratory Medicine. Nov, 2009  |   Pubmed ID: 19886718
• Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia
  The American Journal of Pathology. Sep, 2009  |   Pubmed ID: 19661437
• AGTR1 Overexpression Defines a Subset of Breast Cancer and Confers Sensitivity to Losartan, an AGTR1 Antagonist
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009  |   Pubmed ID: 19487683
• Towards a New "stromal-based" Classification System for Human Breast Cancer Prognosis and Therapy
  Cell Cycle (Georgetown, Tex.). Jun, 2009  |   Pubmed ID: 19448435
• An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers
  The American Journal of Pathology. Jun, 2009  |   Pubmed ID: 19411448
• Analysis of RhoC Expression and Lymphovascular Emboli in Inflammatory Vs Non-inflammatory Breast Cancers in Egyptian Patients
  Breast (Edinburgh, Scotland). Feb, 2009  |   Pubmed ID: 19157876
• Residual Disease After Re-excision Lumpectomy for Close Margins
  Journal of Surgical Oncology. Feb, 2009  |   Pubmed ID: 19065638
• Tubular Carcinoma and Grade 1 (well-differentiated) Invasive Ductal Carcinoma: Comparison of Flat Epithelial Atypia and Other Intra-epithelial Lesions
  Pathology International. Oct, 2008  |   Pubmed ID: 18801081
• Axillary Staging Prior to Neoadjuvant Chemotherapy for Breast Cancer: Predictors of Recurrence
  Annals of Surgical Oncology. Nov, 2008  |   Pubmed ID: 18784961
• Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2008  |   Pubmed ID: 18765527
• Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2008  |   Pubmed ID: 18593979
• Inhibition of CCN6 (Wnt-1-induced Signaling Protein 3) Down-regulates E-cadherin in the Breast Epithelium Through Induction of Snail and ZEB1
  The American Journal of Pathology. Apr, 2008  |   Pubmed ID: 18321996
• BRCA1 Regulates Human Mammary Stem/progenitor Cell Fate
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008  |   Pubmed ID: 18230721
• Molecular Epidemiologic Features of Inflammatory Breast Cancer: a Comparison Between Egyptian and US Patients
  Breast Cancer Research and Treatment. Nov, 2008  |   Pubmed ID: 18058225
• ALDH1 is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome
  Cell Stem Cell. Nov, 2007  |   Pubmed ID: 18371393
• CXCR7 (RDC1) Promotes Breast and Lung Tumor Growth in Vivo and is Expressed on Tumor-associated Vasculature
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007  |   Pubmed ID: 17898181
• Sentinel Lymph Node Biopsy for Breast Cancer: How Many Nodes Are Enough?
  Journal of Surgical Oncology. Dec, 2007  |   Pubmed ID: 17685432
• Expression of Polycomb Group Protein EZH2 in Nevi and Melanoma
  Journal of Cutaneous Pathology. Aug, 2007  |   Pubmed ID: 17640228
• Altered Expression of the Early Mitotic Checkpoint Protein, CHFR, in Breast Cancers: Implications for Tumor Suppression
  Cancer Research. Jul, 2007  |   Pubmed ID: 17596595
• CCN6 (WISP3) As a New Regulator of the Epithelial Phenotype in Breast Cancer
  Cells, Tissues, Organs. 2007  |   Pubmed ID: 17587813
• Breast Tumor Kinase (protein Tyrosine Kinase 6) Regulates Heregulin-induced Activation of ERK5 and P38 MAP Kinases in Breast Cancer Cells
  Cancer Research. May, 2007  |   Pubmed ID: 17483331
• Significance of Flat Epithelial Atypia on Mammotome Core Needle Biopsy: Should It Be Excised?
  Human Pathology. Jan, 2007  |   Pubmed ID: 17095049
• Enhancer of Zeste 2 As a Marker of Preneoplastic Progression in the Breast
  Cancer Research. Oct, 2006  |   Pubmed ID: 17018586
• Changes in Surgical Management Resulting from Case Review at a Breast Cancer Multidisciplinary Tumor Board
  Cancer. Nov, 2006  |   Pubmed ID: 16998942
• RhoC GTPase Expression As a Potential Marker of Lymph Node Metastasis in Squamous Cell Carcinomas of the Head and Neck
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2006  |   Pubmed ID: 16899593
• The Polycomb Group Protein Enhancer of Zeste 2: Its Links to DNA Repair and Breast Cancer
  Journal of Molecular Histology. Sep, 2006  |   Pubmed ID: 16855786
• ADAM15 Disintegrin is Associated with Aggressive Prostate and Breast Cancer Disease
  Neoplasia (New York, N.Y.). Apr, 2006  |   Pubmed ID: 16756724
• Identification of EZH2 As a Molecular Marker for a Precancerous State in Morphologically Normal Breast Tissues
  Cancer Research. Apr, 2006  |   Pubmed ID: 16618729
• Interobserver Reproducibility in the Diagnosis of Flat Epithelial Atypia of the Breast
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2006  |   Pubmed ID: 16424892
• Is Lobular Carcinoma in Situ As a Component of Breast Carcinoma a Risk Factor for Local Failure After Breast-conserving Therapy? Results of a Matched Pair Analysis
  Cancer. Jan, 2006  |   Pubmed ID: 16329136
• Inhibition of CCN6 (WISP3) Expression Promotes Neoplastic Progression and Enhances the Effects of Insulin-like Growth Factor-1 on Breast Epithelial Cells
  Breast Cancer Research : BCR. 2005  |   Pubmed ID: 16457688
• A Putative Role for Psoriasin in Breast Tumor Progression
  Cancer Research. Dec, 2005  |   Pubmed ID: 16357139
• Identification of GATA3 As a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis
  Cancer Research. Dec, 2005  |   Pubmed ID: 16357129
• The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells
  Neoplasia (New York, N.Y.). Nov, 2005  |   Pubmed ID: 16331887
• RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast
  Breast Cancer Research and Treatment. Sep, 2005  |   Pubmed ID: 16187229
• Protein Kinase C Epsilon is a Predictive Biomarker of Aggressive Breast Cancer and a Validated Target for RNA Interference Anticancer Therapy
  Cancer Research. Sep, 2005  |   Pubmed ID: 16166314
• Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy
  Breast Cancer Research and Treatment. Aug, 2005  |   Pubmed ID: 16155794
• Comprehensive Axillary Evaluation in Neoadjuvant Chemotherapy Patients with Ultrasonography and Sentinel Lymph Node Biopsy
  Annals of Surgical Oncology. Sep, 2005  |   Pubmed ID: 16079956
• Alpha-methylacyl-CoA Racemase Protein Expression is Associated with the Degree of Differentiation in Breast Cancer Using Quantitative Image Analysis
  Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jun, 2005  |   Pubmed ID: 15941950
• Pathologic Features of Breast Cancer Associated with Complete Response to Neoadjuvant Chemotherapy: Importance of Tumor Necrosis
  The American Journal of Surgical Pathology. Mar, 2005  |   Pubmed ID: 15725804
• A Pilot Study to Establish a Clinical Model to Perform Phase II Studies of Breast Cancer Chemopreventive Agents in Women at High Risk with Biomarkers As Surrogate Endpoints for Activity
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2004  |   Pubmed ID: 15623610
• WISP3 and RhoC Guanosine Triphosphatase Cooperate in the Development of Inflammatory Breast Cancer
  Breast Cancer Research : BCR. 2004  |   Pubmed ID: 15602803
• Small (< 2.0-cm) Breast Cancers: Mammographic and US Findings at US-guided Cryoablation--initial Experience
  Radiology. Dec, 2004  |   Pubmed ID: 15567802
• P63 Expression in Breast Cancer: a Highly Sensitive and Specific Marker of Metaplastic Carcinoma
  The American Journal of Surgical Pathology. Nov, 2004  |   Pubmed ID: 15489655
• WISP3 (CCN6) is a Secreted Tumor-suppressor Protein That Modulates IGF Signaling in Inflammatory Breast Cancer
  Neoplasia (New York, N.Y.). Mar-Apr, 2004  |   Pubmed ID: 15140407
• Genomic and Expression Analysis of the 8p11-12 Amplicon in Human Breast Cancer Cell Lines
  Cancer Research. Jan, 2004  |   Pubmed ID: 14729606
• WISP3 and RhoC Guanosine Triphosphatase Cooperate in the Development of Inflammatory Breast Cancer
  Breast Cancer Research : BCR. 2004  |   Pubmed ID: 14696649
• E-cadherin Expression in Primary Carcinomas of the Breast and Its Distant Metastases
  Breast Cancer Research : BCR. 2003  |   Pubmed ID: 14580257
• EZH2 is a Marker of Aggressive Breast Cancer and Promotes Neoplastic Transformation of Breast Epithelial Cells
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003  |   Pubmed ID: 14500907
• Sentinel Node Biopsy Prior to Neoadjuvant Chemotherapy
  American Journal of Surgery. Aug, 2003  |   Pubmed ID: 12885598
• Antiangiogenic Tetrathiomolybdate Enhances the Efficacy of Doxorubicin Against Breast Carcinoma
  Molecular Cancer Therapeutics. Jul, 2003  |   Pubmed ID: 12883034
• Altered Receptor Trafficking in Huntingtin Interacting Protein 1-transformed Cells
  Cancer Cell. May, 2003  |   Pubmed ID: 12781365
• Lymphocytic Mastitis and Diabetic Mastopathy: a Molecular, Immunophenotypic, and Clinicopathologic Evaluation of 11 Cases
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2003  |   Pubmed ID: 12640102
• Copper Deficiency Induced by Tetrathiomolybdate Suppresses Tumor Growth and Angiogenesis
  Cancer Research. Sep, 2002  |   Pubmed ID: 12208730
• Alpha-Methylacyl-CoA Racemase: a Novel Tumor Marker Over-expressed in Several Human Cancers and Their Precursor Lesions
  The American Journal of Surgical Pathology. Jul, 2002  |   Pubmed ID: 12131161
• Detection of Epstein-Barr Virus in Rapidly Growing Fibroadenomas of the Breast in Immunosuppressed Hosts
  Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2002  |   Pubmed ID: 12118114
• WISP3 is a Novel Tumor Suppressor Gene of Inflammatory Breast Cancer
  Oncogene. May, 2002  |   Pubmed ID: 12082632
• Characterization of RhoC Expression in Benign and Malignant Breast Disease: a Potential New Marker for Small Breast Carcinomas with Metastatic Ability
  The American Journal of Pathology. Feb, 2002  |   Pubmed ID: 11839578
• Genetic Changes in Chromosomes 1p and 17p in Thyroid Cancer Progression
  Endocrine Pathology. 2000  |   Pubmed ID: 12114819