Celina G. Kleer Department of Pathology University of Michigan Comprehensive Cancer Center Biography Publications Institution JoVE Articles Celina G. Kleer has not added a biography. If you are Celina G. Kleer and would like to personalize this page please email our Author Liaison for assistance. Publications EZH2 Expands Breast Stem Cells Through Activation of NOTCH1 Signaling Proceedings of the National Academy of Sciences of the United States of America. Feb, 2014 | Pubmed ID: 24516139 Poised Chromatin at the ZEB1 Promoter Enables Breast Cancer Cell Plasticity and Enhances Tumorigenicity Cell. Jul, 2013 | Pubmed ID: 23827675 EZH2 and ALDH1 Expression in Ductal Carcinoma in Situ: Complex Association with Recurrence and Progression to Invasive Breast Cancer Cell Cycle (Georgetown, Tex.). Jul, 2013 | Pubmed ID: 23759596 Tissue-based Identification of Stem Cells and Epithelial-to-mesenchymal Transition in Breast Cancer Human Pathology. Aug, 2013 | Pubmed ID: 23574782 EZH2 Inhibition Decreases P38 Signaling and Suppresses Breast Cancer Motility and Metastasis Breast Cancer Research and Treatment. Apr, 2013 | Pubmed ID: 23539298 Invasive Ductal Carcinoma with Lobular Features: a Comparison Study to Invasive Ductal and Invasive Lobular Carcinomas of the Breast Breast Cancer Research and Treatment. Apr, 2013 | Pubmed ID: 23535842 HER2 Drives Luminal Breast Cancer Stem Cells in the Absence of HER2 Amplification: Implications for Efficacy of Adjuvant Trastuzumab Cancer Research. Mar, 2013 | Pubmed ID: 23442322 Expression of Aldehyde Dehydrogenase 1 As a Marker of Mammary Stem Cells in Benign and Malignant Breast Lesions of Ghanaian Women Cancer. Feb, 2013 | Pubmed ID: 22930220 CCN6 Knockdown Disrupts Acinar Organization of Breast Cells in Three-dimensional Cultures Through Up-regulation of Type III TGF-β Receptor Neoplasia (New York, N.Y.). Nov, 2012 | Pubmed ID: 23226100 Canonical Wnt Signaling Regulates Slug Activity and Links Epithelial-mesenchymal Transition with Epigenetic Breast Cancer 1, Early Onset (BRCA1) Repression Proceedings of the National Academy of Sciences of the United States of America. Oct, 2012 | Pubmed ID: 23011797 RhoC Impacts the Metastatic Potential and Abundance of Breast Cancer Stem Cells PloS One. 2012 | Pubmed ID: 22911725 Metaplastic Carcinomas of the Breast: Diagnostic Challenges and New Translational Insights Archives of Pathology & Laboratory Medicine. Aug, 2012 | Pubmed ID: 22849737 CCN6 Modulates BMP Signaling Via the Smad-independent TAK1/p38 Pathway, Acting to Suppress Metastasis of Breast Cancer Cancer Research. Sep, 2012 | Pubmed ID: 22805309 Invasive Breast Carcinomas in Ghana: High Frequency of High Grade, Basal-like Histology and High EZH2 Expression Breast Cancer Research and Treatment. Aug, 2012 | Pubmed ID: 22527102 Discoidin Domain Receptor Tyrosine Kinases: New Players in Cancer Progression Cancer Metastasis Reviews. Jun, 2012 | Pubmed ID: 22366781 Metaplastic Breast Carcinomas Are Enriched in Markers of Tumor-initiating Cells and Epithelial to Mesenchymal Transition Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2012 | Pubmed ID: 22080057 On How CCN6 Suppresses Breast Cancer Growth and Invasion Journal of Cell Communication and Signaling. Mar, 2012 | Pubmed ID: 21842227 Increased Risk for Distant Metastasis in Patients with Familial Early-stage Breast Cancer and High EZH2 Expression Breast Cancer Research and Treatment. Apr, 2012 | Pubmed ID: 21614565 Inflammatory Breast Cancer in North Africa: Comparison of Clinical and Molecular Epidemiologic Characteristics of Patients from Egypt, Tunisia, and Morocco Breast Disease. 2011-2012 | Pubmed ID: 23001584 Functionally Recurrent Rearrangements of the MAST Kinase and Notch Gene Families in Breast Cancer Nature Medicine. Dec, 2011 | Pubmed ID: 22101766 P38γ Promotes Breast Cancer Cell Motility and Metastasis Through Regulation of RhoC GTPase, Cytoskeletal Architecture, and a Novel Leading Edge Behavior Cancer Research. Oct, 2011 | Pubmed ID: 21862636 Survival of Inflammatory Breast Cancer Patients Compared to Non-inflammatory Breast Cancer Patients in Egypt The Breast Journal. Sep-Oct, 2011 | Pubmed ID: 21827567 CCN6 (WISP3) Decreases ZEB1-mediated EMT and Invasion by Attenuation of IGF-1 Receptor Signaling in Breast Cancer Journal of Cell Science. May, 2011 | Pubmed ID: 21525039 Histone Methyltransferase EZH2 Induces Akt-dependent Genomic Instability and BRCA1 Inhibition in Breast Cancer Cancer Research. Mar, 2011 | Pubmed ID: 21406404 EZH2 and ALDH-1 Mark Breast Epithelium at Risk for Breast Cancer Development Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jun, 2011 | Pubmed ID: 21399615 Membrane Localization of Insulin Receptor Substrate-2 (IRS-2) is Associated with Decreased Overall Survival in Breast Cancer Breast Cancer Research and Treatment. Dec, 2011 | Pubmed ID: 21258861 Breast Cancer Stem Cells Are Regulated by Mesenchymal Stem Cells Through Cytokine Networks Cancer Research. Jan, 2011 | Pubmed ID: 21224357 African Ancestry and Higher Prevalence of Triple-negative Breast Cancer: Findings from an International Study Cancer. Nov, 2010 | Pubmed ID: 20629078 Implications of Enhancer of Zeste Homologue 2 Expression in Pancreatic Ductal Adenocarcinoma Human Pathology. Sep, 2010 | Pubmed ID: 20573371 Blockade of CCN6 (WISP3) Activates Growth Factor-independent Survival and Resistance to Anoikis in Human Mammary Epithelial Cells Cancer Research. Apr, 2010 | Pubmed ID: 20395207 Antiangiogenic Tetrathiomolybdate Protects Against Her2/neu-induced Breast Carcinoma by Hypoplastic Remodeling of the Mammary Gland Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2009 | Pubmed ID: 19934283 Carcinoma of the Breast with Medullary-like Features: Diagnostic Challenges and Relationship with BRCA1 and EZH2 Functions Archives of Pathology & Laboratory Medicine. Nov, 2009 | Pubmed ID: 19886718 Targeted Overexpression of EZH2 in the Mammary Gland Disrupts Ductal Morphogenesis and Causes Epithelial Hyperplasia The American Journal of Pathology. Sep, 2009 | Pubmed ID: 19661437 AGTR1 Overexpression Defines a Subset of Breast Cancer and Confers Sensitivity to Losartan, an AGTR1 Antagonist Proceedings of the National Academy of Sciences of the United States of America. Jun, 2009 | Pubmed ID: 19487683 Towards a New "stromal-based" Classification System for Human Breast Cancer Prognosis and Therapy Cell Cycle (Georgetown, Tex.). Jun, 2009 | Pubmed ID: 19448435 An Absence of Stromal Caveolin-1 Expression Predicts Early Tumor Recurrence and Poor Clinical Outcome in Human Breast Cancers The American Journal of Pathology. Jun, 2009 | Pubmed ID: 19411448 Analysis of RhoC Expression and Lymphovascular Emboli in Inflammatory Vs Non-inflammatory Breast Cancers in Egyptian Patients Breast (Edinburgh, Scotland). Feb, 2009 | Pubmed ID: 19157876 Residual Disease After Re-excision Lumpectomy for Close Margins Journal of Surgical Oncology. Feb, 2009 | Pubmed ID: 19065638 Tubular Carcinoma and Grade 1 (well-differentiated) Invasive Ductal Carcinoma: Comparison of Flat Epithelial Atypia and Other Intra-epithelial Lesions Pathology International. Oct, 2008 | Pubmed ID: 18801081 Axillary Staging Prior to Neoadjuvant Chemotherapy for Breast Cancer: Predictors of Recurrence Annals of Surgical Oncology. Nov, 2008 | Pubmed ID: 18784961 Epithelial and Stromal Cathepsin K and CXCL14 Expression in Breast Tumor Progression Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2008 | Pubmed ID: 18765527 Genetic Changes of Wnt Pathway Genes Are Common Events in Metaplastic Carcinomas of the Breast Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jul, 2008 | Pubmed ID: 18593979 Inhibition of CCN6 (Wnt-1-induced Signaling Protein 3) Down-regulates E-cadherin in the Breast Epithelium Through Induction of Snail and ZEB1 The American Journal of Pathology. Apr, 2008 | Pubmed ID: 18321996 BRCA1 Regulates Human Mammary Stem/progenitor Cell Fate Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18230721 Molecular Epidemiologic Features of Inflammatory Breast Cancer: a Comparison Between Egyptian and US Patients Breast Cancer Research and Treatment. Nov, 2008 | Pubmed ID: 18058225 ALDH1 is a Marker of Normal and Malignant Human Mammary Stem Cells and a Predictor of Poor Clinical Outcome Cell Stem Cell. Nov, 2007 | Pubmed ID: 18371393 CXCR7 (RDC1) Promotes Breast and Lung Tumor Growth in Vivo and is Expressed on Tumor-associated Vasculature Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17898181 Sentinel Lymph Node Biopsy for Breast Cancer: How Many Nodes Are Enough? Journal of Surgical Oncology. Dec, 2007 | Pubmed ID: 17685432 Expression of Polycomb Group Protein EZH2 in Nevi and Melanoma Journal of Cutaneous Pathology. Aug, 2007 | Pubmed ID: 17640228 Altered Expression of the Early Mitotic Checkpoint Protein, CHFR, in Breast Cancers: Implications for Tumor Suppression Cancer Research. Jul, 2007 | Pubmed ID: 17596595 CCN6 (WISP3) As a New Regulator of the Epithelial Phenotype in Breast Cancer Cells, Tissues, Organs. 2007 | Pubmed ID: 17587813 Breast Tumor Kinase (protein Tyrosine Kinase 6) Regulates Heregulin-induced Activation of ERK5 and P38 MAP Kinases in Breast Cancer Cells Cancer Research. May, 2007 | Pubmed ID: 17483331 Significance of Flat Epithelial Atypia on Mammotome Core Needle Biopsy: Should It Be Excised? Human Pathology. Jan, 2007 | Pubmed ID: 17095049 Enhancer of Zeste 2 As a Marker of Preneoplastic Progression in the Breast Cancer Research. Oct, 2006 | Pubmed ID: 17018586 Changes in Surgical Management Resulting from Case Review at a Breast Cancer Multidisciplinary Tumor Board Cancer. Nov, 2006 | Pubmed ID: 16998942 RhoC GTPase Expression As a Potential Marker of Lymph Node Metastasis in Squamous Cell Carcinomas of the Head and Neck Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Aug, 2006 | Pubmed ID: 16899593 The Polycomb Group Protein Enhancer of Zeste 2: Its Links to DNA Repair and Breast Cancer Journal of Molecular Histology. Sep, 2006 | Pubmed ID: 16855786 ADAM15 Disintegrin is Associated with Aggressive Prostate and Breast Cancer Disease Neoplasia (New York, N.Y.). Apr, 2006 | Pubmed ID: 16756724 Identification of EZH2 As a Molecular Marker for a Precancerous State in Morphologically Normal Breast Tissues Cancer Research. Apr, 2006 | Pubmed ID: 16618729 Interobserver Reproducibility in the Diagnosis of Flat Epithelial Atypia of the Breast Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Feb, 2006 | Pubmed ID: 16424892 Is Lobular Carcinoma in Situ As a Component of Breast Carcinoma a Risk Factor for Local Failure After Breast-conserving Therapy? Results of a Matched Pair Analysis Cancer. Jan, 2006 | Pubmed ID: 16329136 Inhibition of CCN6 (WISP3) Expression Promotes Neoplastic Progression and Enhances the Effects of Insulin-like Growth Factor-1 on Breast Epithelial Cells Breast Cancer Research : BCR. 2005 | Pubmed ID: 16457688 A Putative Role for Psoriasin in Breast Tumor Progression Cancer Research. Dec, 2005 | Pubmed ID: 16357139 Identification of GATA3 As a Breast Cancer Prognostic Marker by Global Gene Expression Meta-analysis Cancer Research. Dec, 2005 | Pubmed ID: 16357129 The Polycomb Group Protein EZH2 Impairs DNA Repair in Breast Epithelial Cells Neoplasia (New York, N.Y.). Nov, 2005 | Pubmed ID: 16331887 RhoC-GTPase is a Novel Tissue Biomarker Associated with Biologically Aggressive Carcinomas of the Breast Breast Cancer Research and Treatment. Sep, 2005 | Pubmed ID: 16187229 Protein Kinase C Epsilon is a Predictive Biomarker of Aggressive Breast Cancer and a Validated Target for RNA Interference Anticancer Therapy Cancer Research. Sep, 2005 | Pubmed ID: 16166314 Clinical and Radiologic Assessments to Predict Breast Cancer Pathologic Complete Response to Neoadjuvant Chemotherapy Breast Cancer Research and Treatment. Aug, 2005 | Pubmed ID: 16155794 Comprehensive Axillary Evaluation in Neoadjuvant Chemotherapy Patients with Ultrasonography and Sentinel Lymph Node Biopsy Annals of Surgical Oncology. Sep, 2005 | Pubmed ID: 16079956 Alpha-methylacyl-CoA Racemase Protein Expression is Associated with the Degree of Differentiation in Breast Cancer Using Quantitative Image Analysis Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology. Jun, 2005 | Pubmed ID: 15941950 Pathologic Features of Breast Cancer Associated with Complete Response to Neoadjuvant Chemotherapy: Importance of Tumor Necrosis The American Journal of Surgical Pathology. Mar, 2005 | Pubmed ID: 15725804 A Pilot Study to Establish a Clinical Model to Perform Phase II Studies of Breast Cancer Chemopreventive Agents in Women at High Risk with Biomarkers As Surrogate Endpoints for Activity Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2004 | Pubmed ID: 15623610 WISP3 and RhoC Guanosine Triphosphatase Cooperate in the Development of Inflammatory Breast Cancer Breast Cancer Research : BCR. 2004 | Pubmed ID: 15602803 Small (< 2.0-cm) Breast Cancers: Mammographic and US Findings at US-guided Cryoablation--initial Experience Radiology. Dec, 2004 | Pubmed ID: 15567802 P63 Expression in Breast Cancer: a Highly Sensitive and Specific Marker of Metaplastic Carcinoma The American Journal of Surgical Pathology. Nov, 2004 | Pubmed ID: 15489655 WISP3 (CCN6) is a Secreted Tumor-suppressor Protein That Modulates IGF Signaling in Inflammatory Breast Cancer Neoplasia (New York, N.Y.). Mar-Apr, 2004 | Pubmed ID: 15140407 Genomic and Expression Analysis of the 8p11-12 Amplicon in Human Breast Cancer Cell Lines Cancer Research. Jan, 2004 | Pubmed ID: 14729606 WISP3 and RhoC Guanosine Triphosphatase Cooperate in the Development of Inflammatory Breast Cancer Breast Cancer Research : BCR. 2004 | Pubmed ID: 14696649 E-cadherin Expression in Primary Carcinomas of the Breast and Its Distant Metastases Breast Cancer Research : BCR. 2003 | Pubmed ID: 14580257 EZH2 is a Marker of Aggressive Breast Cancer and Promotes Neoplastic Transformation of Breast Epithelial Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2003 | Pubmed ID: 14500907 Sentinel Node Biopsy Prior to Neoadjuvant Chemotherapy American Journal of Surgery. Aug, 2003 | Pubmed ID: 12885598 Antiangiogenic Tetrathiomolybdate Enhances the Efficacy of Doxorubicin Against Breast Carcinoma Molecular Cancer Therapeutics. Jul, 2003 | Pubmed ID: 12883034 Altered Receptor Trafficking in Huntingtin Interacting Protein 1-transformed Cells Cancer Cell. May, 2003 | Pubmed ID: 12781365 Lymphocytic Mastitis and Diabetic Mastopathy: a Molecular, Immunophenotypic, and Clinicopathologic Evaluation of 11 Cases Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Mar, 2003 | Pubmed ID: 12640102 Copper Deficiency Induced by Tetrathiomolybdate Suppresses Tumor Growth and Angiogenesis Cancer Research. Sep, 2002 | Pubmed ID: 12208730 Alpha-Methylacyl-CoA Racemase: a Novel Tumor Marker Over-expressed in Several Human Cancers and Their Precursor Lesions The American Journal of Surgical Pathology. Jul, 2002 | Pubmed ID: 12131161 Detection of Epstein-Barr Virus in Rapidly Growing Fibroadenomas of the Breast in Immunosuppressed Hosts Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc. Jul, 2002 | Pubmed ID: 12118114 WISP3 is a Novel Tumor Suppressor Gene of Inflammatory Breast Cancer Oncogene. May, 2002 | Pubmed ID: 12082632 Characterization of RhoC Expression in Benign and Malignant Breast Disease: a Potential New Marker for Small Breast Carcinomas with Metastatic Ability The American Journal of Pathology. Feb, 2002 | Pubmed ID: 11839578 Genetic Changes in Chromosomes 1p and 17p in Thyroid Cancer Progression Endocrine Pathology. 2000 | Pubmed ID: 12114819 तीन आयामी संस्कृति: स्तन कोशिकाओं की घातक परिवर्तन बनाम सामान्य कोष्ठकी संरचना का अध्ययन करने के लिए एक उपकरण Anupama Pal1, Celina G. Kleer2 1Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 2Department of Pathology, University of Michigan Comprehensive Cancer Center JoVE 51311 Medicine
तीन आयामी संस्कृति: स्तन कोशिकाओं की घातक परिवर्तन बनाम सामान्य कोष्ठकी संरचना का अध्ययन करने के लिए एक उपकरण Anupama Pal1, Celina G. Kleer2 1Department of Internal Medicine, University of Michigan Comprehensive Cancer Center, 2Department of Pathology, University of Michigan Comprehensive Cancer Center JoVE 51311 Medicine
