Other Publications (1)
Articles by Chandrashekhar Charavaryamath in JoVE
Evaluation of Stem Cell Therapies in a Bilateral Patellar Tendon Injury Model in Rats John R. Wagner1, Takashi Taguchi1, Jane Y. Cho2, Chandrashekhar Charavaryamath3, Dominique J. Griffon1 1College of Veterinary Medicine, Western University of Health Sciences, 2Applied Medical, 3College of Veterinary Medicine, Iowa State University This paper describes the preparation and evaluation of umbilical cord matrix-derived mesenchymal stem cells spheroids with a bilateral patellar tendon defect model in a rat. This model was associated with an acceptable morbidity and was found to detect differences between untreated and treated tendons, and between the two treatments tested.
Other articles by Chandrashekhar Charavaryamath on PubMed
Pulmonary Innate Inflammatory Responses to Agricultural Occupational Contaminants Cell and Tissue Research. | Pubmed ID: 28168324 Agricultural workers are exposed to many contaminants and suffer from respiratory and other symptoms. Dusts, gases, microbial products and pesticide residues from farms have been linked to effects on the health of agricultural workers. Growing sets of data from in vitro and in vivo models demonstrate the role of the innate immune system, especially Toll-like receptor 4 (TLR4) and TLR9, in lung inflammation induced following exposure to contaminants in agricultural environments. Interestingly, inflammation and lung function changes appear to be discordant indicating the complexity of inflammatory responses to exposures. Whereas the recent development of rodent models and exposure systems have yielded valuable data, we need new systems to examine the combined effects of multiple contaminants in order to increase our understanding of farm-exposure-induced negative health effects.