Charles L. Sawyers Human Oncology and Pathogenesis Program Memorial Sloan Kettering Cancer Center Biography Publications Institution JoVE Articles Charles L. Sawyers has not added a biography. If you are Charles L. Sawyers and would like to personalize this page please email our Author Liaison for assistance. Publications ARN-509: a Novel Anti-androgen for Prostate Cancer Treatment Cancer Research. Jan, 2012 | Pubmed ID: 22266222 Fitness Conferred by BCR-ABL Kinase Domain Mutations Determines the Risk of Pre-existing Resistance in Chronic Myeloid Leukemia PloS One. 2011 | Pubmed ID: 22140458 TMPRSS2-ERG Status in Circulating Tumor Cells As a Predictive Biomarker of Sensitivity in Castration-resistant Prostate Cancer Patients Treated with Abiraterone Acetate European Urology. Nov, 2011 | Pubmed ID: 21802835 A HIF-regulated VHL-PTP1B-Src Signaling Axis Identifies a Therapeutic Target in Renal Cell Carcinoma Science Translational Medicine. Jun, 2011 | Pubmed ID: 21632985 Noninvasive Measurement of Androgen Receptor Signaling with a Positron-emitting Radiopharmaceutical That Targets Prostate-specific Membrane Antigen Proceedings of the National Academy of Sciences of the United States of America. Jun, 2011 | Pubmed ID: 21606347 Reciprocal Feedback Regulation of PI3K and Androgen Receptor Signaling in PTEN-deficient Prostate Cancer Cancer Cell. May, 2011 | Pubmed ID: 21575859 FAS and NF-κB Signalling Modulate Dependence of Lung Cancers on Mutant EGFR Nature. Mar, 2011 | Pubmed ID: 21430781 MYC Cooperates with AKT in Prostate Tumorigenesis and Alters Sensitivity to MTOR Inhibitors PloS One. 2011 | Pubmed ID: 21394210 Pretreatment EGFR T790M Mutation and BRCA1 MRNA Expression in Erlotinib-treated Advanced Non-small-cell Lung Cancer Patients with EGFR Mutations Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Mar, 2011 | Pubmed ID: 21233402 Drug Discovery: How Melanomas Bypass New Therapy Nature. Dec, 2010 | Pubmed ID: 21164474 ETV1 is a Lineage Survival Factor That Cooperates with KIT in Gastrointestinal Stromal Tumours Nature. Oct, 2010 | Pubmed ID: 20927104 Constitutively Active Androgen Receptor Splice Variants Expressed in Castration-resistant Prostate Cancer Require Full-length Androgen Receptor Proceedings of the National Academy of Sciences of the United States of America. Sep, 2010 | Pubmed ID: 20823238 Integrative Genomic Profiling of Human Prostate Cancer Cancer Cell. Jul, 2010 | Pubmed ID: 20579941 Even Better Kinase Inhibitors for Chronic Myeloid Leukemia The New England Journal of Medicine. Jun, 2010 | Pubmed ID: 20525994 Coordinate Transcriptional Regulation by ERG and Androgen Receptor in Fusion-positive Prostate Cancers Cancer Cell. May, 2010 | Pubmed ID: 20478521 Antitumour Activity of MDV3100 in Castration-resistant Prostate Cancer: a Phase 1-2 Study Lancet. Apr, 2010 | Pubmed ID: 20398925 Structure-activity Relationship for Thiohydantoin Androgen Receptor Antagonists for Castration-resistant Prostate Cancer (CRPC) Journal of Medicinal Chemistry. Apr, 2010 | Pubmed ID: 20218717 Clonal Hematopoiesis in Philadelphia Chromosome-negative Bone Marrow Cells of Chronic Myeloid Leukemia Patients Receiving Dasatinib Leukemia Research. Jun, 2010 | Pubmed ID: 19804904 Lessons Learned from the Development of Kinase Inhibitors Clinical Advances in Hematology & Oncology : H&O. Sep, 2009 | Pubmed ID: 20020670 Shifting Paradigms: the Seeds of Oncogene Addiction Nature Medicine. Oct, 2009 | Pubmed ID: 19812578 Proteasomal and Genetic Inactivation of the NF1 Tumor Suppressor in Gliomagenesis Cancer Cell. Jul, 2009 | Pubmed ID: 19573811 Finding and Drugging the Vulnerabilities of RAS-dependent Cancers Cell. May, 2009 | Pubmed ID: 19490885 Cooperativity of TMPRSS2-ERG with PI3-kinase Pathway Activation in Prostate Oncogenesis Nature Genetics. May, 2009 | Pubmed ID: 19396167 Development of a Second-generation Antiandrogen for Treatment of Advanced Prostate Cancer Science (New York, N.Y.). May, 2009 | Pubmed ID: 19359544 Histone Deacetylases Are Required for Androgen Receptor Function in Hormone-sensitive and Castrate-resistant Prostate Cancer Cancer Research. Feb, 2009 | Pubmed ID: 19176386 Comprehensive Mutational Analysis and MRNA Isoform Quantification of TP63 in Normal and Neoplastic Human Prostate Cells The Prostate. Apr, 2009 | Pubmed ID: 19142959 Transient Potent BCR-ABL Inhibition is Sufficient to Commit Chronic Myeloid Leukemia Cells Irreversibly to Apoptosis Cancer Cell. Dec, 2008 | Pubmed ID: 19061839 Translational Research: Are We on the Right Track? 2008 American Society for Clinical Investigation Presidential Address The Journal of Clinical Investigation. Nov, 2008 | Pubmed ID: 18982165 The Nuclear Factor-kappaB Pathway Controls the Progression of Prostate Cancer to Androgen-independent Growth Cancer Research. Aug, 2008 | Pubmed ID: 18701501 A Prostatic Intraepithelial Neoplasia-dependent P27 Kip1 Checkpoint Induces Senescence and Inhibits Cell Proliferation and Cancer Progression Cancer Cell. Aug, 2008 | Pubmed ID: 18691549 Targeting the Androgen Receptor Pathway in Prostate Cancer Current Opinion in Pharmacology. Aug, 2008 | Pubmed ID: 18674639 The Cancer Biomarker Problem Nature. Apr, 2008 | Pubmed ID: 18385728 Something Lost--something Gained: the ASCI Begins Its Second Century The Journal of Clinical Investigation. Apr, 2008 | Pubmed ID: 18382722 IkappaB Kinase Beta Inhibition Induces Cell Death in Imatinib-resistant and T315I Dasatinib-resistant BCR-ABL+ Cells Molecular Cancer Therapeutics. Feb, 2008 | Pubmed ID: 18245668 Antitumor Activity of Rapamycin in a Phase I Trial for Patients with Recurrent PTEN-deficient Glioblastoma PLoS Medicine. Jan, 2008 | Pubmed ID: 18215105 Nineteenth Annual Pezcoller Symposium: Hypothesis-driven Clinical Investigation in Cancer Cancer Research. Dec, 2007 | Pubmed ID: 18045966 Cancer: Mixing Cocktails Nature. Oct, 2007 | Pubmed ID: 17960228 Where Lies the Blame for Resistance--tumor or Host? Nature Medicine. Oct, 2007 | Pubmed ID: 17917659 Sequential ABL Kinase Inhibitor Therapy Selects for Compound Drug-resistant BCR-ABL Mutations with Altered Oncogenic Potency The Journal of Clinical Investigation. Sep, 2007 | Pubmed ID: 17710227 Murine Cell Lines Derived from Pten Null Prostate Cancer Show the Critical Role of PTEN in Hormone Refractory Prostate Cancer Development Cancer Research. Jul, 2007 | Pubmed ID: 17616663 Identification of the JNK Signaling Pathway As a Functional Target of the Tumor Suppressor PTEN Cancer Cell. Jun, 2007 | Pubmed ID: 17560336 Epidermal Growth Factor Receptor Activation in Glioblastoma Through Novel Missense Mutations in the Extracellular Domain PLoS Medicine. Dec, 2006 | Pubmed ID: 17177598 Phosphorylation of the ATP-binding Loop Directs Oncogenicity of Drug-resistant BCR-ABL Mutants Proceedings of the National Academy of Sciences of the United States of America. Dec, 2006 | Pubmed ID: 17164333 Mammalian Target of Rapamycin Inhibition Promotes Response to Epidermal Growth Factor Receptor Kinase Inhibitors in PTEN-deficient and PTEN-intact Glioblastoma Cells Cancer Research. Aug, 2006 | Pubmed ID: 16912159 Treating Imatinib-resistant Leukemia: the Next Generation Targeted Therapies TheScientificWorldJournal. 2006 | Pubmed ID: 16906325 Will Kinase Inhibitors Have a Dark Side? The New England Journal of Medicine. Jul, 2006 | Pubmed ID: 16855275 Dasatinib in Imatinib-resistant Philadelphia Chromosome-positive Leukemias The New England Journal of Medicine. Jun, 2006 | Pubmed ID: 16775234 Ligand-specific Allosteric Regulation of Coactivator Functions of Androgen Receptor in Prostate Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. Feb, 2006 | Pubmed ID: 16492776 Structure of the Kinase Domain of an Imatinib-resistant Abl Mutant in Complex with the Aurora Kinase Inhibitor VX-680 Cancer Research. Jan, 2006 | Pubmed ID: 16424036 Hypoxia-inducible Factor Determines Sensitivity to Inhibitors of MTOR in Kidney Cancer Nature Medicine. Jan, 2006 | Pubmed ID: 16341243 Context-dependent Hormone-refractory Progression Revealed Through Characterization of a Novel Murine Prostate Cancer Cell Line Cancer Research. Dec, 2005 | Pubmed ID: 16357166 Molecular Determinants of the Response of Glioblastomas to EGFR Kinase Inhibitors The New England Journal of Medicine. Nov, 2005 | Pubmed ID: 16282176 Biology of Progressive, Castration-resistant Prostate Cancer: Directed Therapies Targeting the Androgen-receptor Signaling Axis Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Nov, 2005 | Pubmed ID: 16278481 Update on the Use of Imatinib Mesylate Clinical Advances in Hematology & Oncology : H&O. Oct, 2005 | Pubmed ID: 16258483 Amplification and Overexpression of Prosaposin in Prostate Cancer Genes, Chromosomes & Cancer. Dec, 2005 | Pubmed ID: 16080200 Calculated Resistance in Cancer Nature Medicine. Aug, 2005 | Pubmed ID: 16079872 Inhibition of Drug-resistant Mutants of ABL, KIT, and EGF Receptor Kinases Proceedings of the National Academy of Sciences of the United States of America. Aug, 2005 | Pubmed ID: 16046538 Dynamics of Chronic Myeloid Leukaemia Nature. Jun, 2005 | Pubmed ID: 15988530 Transcriptional Regulation of a Metastasis Suppressor Gene by Tip60 and Beta-catenin Complexes Nature. Apr, 2005 | Pubmed ID: 15829968 Comparative Analysis of Two Clinically Active BCR-ABL Kinase Inhibitors Reveals the Role of Conformation-specific Binding in Resistance Proceedings of the National Academy of Sciences of the United States of America. Mar, 2005 | Pubmed ID: 15705718 Monitoring Antiproliferative Responses to Kinase Inhibitor Therapy in Mice with 3'-deoxy-3'-18F-fluorothymidine PET Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Jan, 2005 | Pubmed ID: 15632041 Cross-species Comparisons of Cancer Signaling Nature Genetics. Jan, 2005 | Pubmed ID: 15624012 Detection of BCR-ABL Kinase Mutations in CD34+ Cells from Chronic Myelogenous Leukemia Patients in Complete Cytogenetic Remission on Imatinib Mesylate Treatment Blood. Mar, 2005 | Pubmed ID: 15345592 Antibody-based Profiling of the Phosphoinositide 3-kinase Pathway in Clinical Prostate Cancer Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Dec, 2004 | Pubmed ID: 15623612 HER2/neu Kinase-dependent Modulation of Androgen Receptor Function Through Effects on DNA Binding and Stability Cancer Cell. Nov, 2004 | Pubmed ID: 15542435 Granulocyte-macrophage Progenitors As Candidate Leukemic Stem Cells in Blast-crisis CML The New England Journal of Medicine. Aug, 2004 | Pubmed ID: 15306667 Overriding Imatinib Resistance with a Novel ABL Kinase Inhibitor Science (New York, N.Y.). Jul, 2004 | Pubmed ID: 15256671 TORward AKTually Useful Mouse Models Nature Medicine. Jun, 2004 | Pubmed ID: 15170198 Pharmacokinetics and Pharmacodynamics of Imatinib in a Phase I Trial with Chronic Myeloid Leukemia Patients Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2004 | Pubmed ID: 14990650 Molecular Determinants of Resistance to Antiandrogen Therapy Nature Medicine. Jan, 2004 | Pubmed ID: 14702632 AKT Activity Determines Sensitivity to Mammalian Target of Rapamycin (mTOR) Inhibitors by Regulating Cyclin D1 and C-myc Expression The Journal of Biological Chemistry. Jan, 2004 | Pubmed ID: 14576155 Opportunities and Challenges in the Development of Kinase Inhibitor Therapy for Cancer Genes & Development. Dec, 2003 | Pubmed ID: 14701871 Will MTOR Inhibitors Make It As Cancer Drugs? Cancer Cell. Nov, 2003 | Pubmed ID: 14667501 Mechanisms of Resistance to STI571 in Philadelphia Chromosome-associated Leukemias Oncogene. Oct, 2003 | Pubmed ID: 14576846 Myc-driven Murine Prostate Cancer Shares Molecular Features with Human Prostate Tumors Cancer Cell. Sep, 2003 | Pubmed ID: 14522256 Analysis of the Phosphatidylinositol 3'-kinase Signaling Pathway in Glioblastoma Patients in Vivo Cancer Research. Jun, 2003 | Pubmed ID: 12782577 A Novel Pyridopyrimidine Inhibitor of Abl Kinase is a Picomolar Inhibitor of Bcr-abl-driven K562 Cells and is Effective Against STI571-resistant Bcr-abl Mutants Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Apr, 2003 | Pubmed ID: 12684394 MicroPET Imaging of Prostate Cancer in LNCAP-SR39TK-GFP Mouse Xenografts The Prostate. Apr, 2003 | Pubmed ID: 12640659 Persistence of Malignant Hematopoietic Progenitors in Chronic Myelogenous Leukemia Patients in Complete Cytogenetic Remission Following Imatinib Mesylate Treatment Blood. Jun, 2003 | Pubmed ID: 12576334 Whole-body Skeletal Imaging in Mice Utilizing MicroPET: Optimization of Reproducibility and Applications in Animal Models of Bone Disease European Journal of Nuclear Medicine and Molecular Imaging. Sep, 2002 | Pubmed ID: 12418463 BCR-ABL Point Mutants Isolated from Patients with Imatinib Mesylate-resistant Chronic Myeloid Leukemia Remain Sensitive to Inhibitors of the BCR-ABL Chaperone Heat Shock Protein 90 Blood. Oct, 2002 | Pubmed ID: 12351420 Growth Inhibitory Effects of the Dual ErbB1/ErbB2 Tyrosine Kinase Inhibitor PKI-166 on Human Prostate Cancer Xenografts Cancer Research. Sep, 2002 | Pubmed ID: 12234993 The Emergence of Resistance to Targeted Cancer Therapeutics Pharmacogenomics. Sep, 2002 | Pubmed ID: 12223047 Multiple BCR-ABL Kinase Domain Mutations Confer Polyclonal Resistance to the Tyrosine Kinase Inhibitor Imatinib (STI571) in Chronic Phase and Blast Crisis Chronic Myeloid Leukemia Cancer Cell. Aug, 2002 | Pubmed ID: 12204532 Chromosomal Aberrations in Prostate Cancer Xenografts Detected by Comparative Genomic Hybridization Genes, Chromosomes & Cancer. Sep, 2002 | Pubmed ID: 12203791 Imatinib GIST Keeps Finding New Indications: Successful Treatment of Dermatofibrosarcoma Protuberans by Targeted Inhibition of the Platelet-derived Growth Factor Receptor Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2002 | Pubmed ID: 12202652 A Phase 2 Study of Imatinib in Patients with Relapsed or Refractory Philadelphia Chromosome-positive Acute Lymphoid Leukemias Blood. Sep, 2002 | Pubmed ID: 12200353 Survival Signaling Mediated by C-Jun NH(2)-terminal Kinase in Transformed B Lymphoblasts Nature Genetics. Sep, 2002 | Pubmed ID: 12161751 Clinical Resistance to the Kinase Inhibitor STI-571 in Chronic Myeloid Leukemia by Mutation of Tyr-253 in the Abl Kinase Domain P-loop Proceedings of the National Academy of Sciences of the United States of America. Aug, 2002 | Pubmed ID: 12149456 Finding the Next Gleevec: FLT3 Targeted Kinase Inhibitor Therapy for Acute Myeloid Leukemia Cancer Cell. Jun, 2002 | Pubmed ID: 12124170 TMEFF2 is an Androgen-regulated Gene Exhibiting Antiproliferative Effects in Prostate Cancer Cells Oncogene. Jul, 2002 | Pubmed ID: 12101412 The Phosphatidylinositol 3-Kinase AKT Pathway in Human Cancer Nature Reviews. Cancer. Jul, 2002 | Pubmed ID: 12094235 Hematopathologic and Cytogenetic Findings in Imatinib Mesylate-treated Chronic Myelogenous Leukemia Patients: 14 Months' Experience Blood. Jul, 2002 | Pubmed ID: 12091333 Disabling Abl-perspectives on Abl Kinase Regulation and Cancer Therapeutics Cancer Cell. Feb, 2002 | Pubmed ID: 12086882 Overview: the Art of Cancer Drug Screening: Molecular Target Versus Milieu-based Screens Current Opinion in Investigational Drugs (London, England : 2000). Mar, 2002 | Pubmed ID: 12054100 Molecular Mechanisms of Resistance to STI571 in Chronic Myeloid Leukemia Current Opinion in Hematology. Jul, 2002 | Pubmed ID: 12042704 Imatinib Mesylate (STI571) Inhibits Growth of Primitive Malignant Progenitors in Chronic Myelogenous Leukemia Through Reversal of Abnormally Increased Proliferation Blood. May, 2002 | Pubmed ID: 11986238 Imatinib Induces Hematologic and Cytogenetic Responses in Patients with Chronic Myelogenous Leukemia in Myeloid Blast Crisis: Results of a Phase II Study Blood. May, 2002 | Pubmed ID: 11986204 NF-kappa B Activates Prostate-specific Antigen Expression and is Upregulated in Androgen-independent Prostate Cancer Molecular and Cellular Biology. Apr, 2002 | Pubmed ID: 11909978 Imatinib Induces Durable Hematologic and Cytogenetic Responses in Patients with Accelerated Phase Chronic Myeloid Leukemia: Results of a Phase 2 Study Blood. Mar, 2002 | Pubmed ID: 11877262 Rational Therapeutic Intervention in Cancer: Kinases As Drug Targets Current Opinion in Genetics & Development. Feb, 2002 | Pubmed ID: 11790564 Visualisatie van de interstitiële cellen van Cajal (ICC) Netwerk in Muizen Yu Chen1,2, Tambudzai Shamu2, Hui Chen3, Peter Besmer3, Charles L. Sawyers2,4, Ping Chi1,5 1Department of Medicine, Memorial Sloan Kettering Cancer Center, 2Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 3Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 4Howard Hughes, Medical Institute, 5Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University JoVE 2802 Biology
Visualisatie van de interstitiële cellen van Cajal (ICC) Netwerk in Muizen Yu Chen1,2, Tambudzai Shamu2, Hui Chen3, Peter Besmer3, Charles L. Sawyers2,4, Ping Chi1,5 1Department of Medicine, Memorial Sloan Kettering Cancer Center, 2Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, 3Developmental Biology Program, Memorial Sloan Kettering Cancer Center, 4Howard Hughes, Medical Institute, 5Laboratory of Chromatin Biology and Epigenetics, The Rockefeller University JoVE 2802 Biology
