Charles O. Rock

Publications

• A Fatty Acid Binding Protein of Facilitates the Acquisition of Host Polyunsaturated Fatty Acids
  The Journal of Biological Chemistry. Sep, 2019  |   Pubmed ID: 31530637
• Disruption of Glycolysis by Nutritional Immunity Activates a Two-Component System That Coordinates a Metabolic and Antihost Response by Staphylococcus Aureus
  MBio. Aug, 2019  |   Pubmed ID: 31387906
• Oleate Hydratase from Protects Against Palmitoleic Acid, the Major Antimicrobial Fatty Acid Produced by Mammalian Skin
  The Journal of Biological Chemistry. Jun, 2019  |   Pubmed ID: 31018965
• Human Pantothenate Kinase 4 is a Pseudo-pantothenate Kinase
  Protein Science : a Publication of the Protein Society. Jun, 2019  |   Pubmed ID: 30927326
• Acyl-chain Selectivity and Physiological Roles of Fatty Acid-binding Proteins
  The Journal of Biological Chemistry. 01, 2019  |   Pubmed ID: 30429218
• A Therapeutic Approach to Pantothenate Kinase Associated Neurodegeneration
  Nature Communications. 10, 2018  |   Pubmed ID: 30352999
• Therapeutic Targets in Chlamydial Fatty Acid and Phospholipid Synthesis
  Frontiers in Microbiology. 2018  |   Pubmed ID: 30319589
• The Structural and Functional Basis for Recurring Sulfa Drug Resistance Mutations in Dihydropteroate Synthase
  Frontiers in Microbiology. 2018  |   Pubmed ID: 30065703
• Role of Fatty Acid Kinase in Cellular Lipid Homeostasis and SaeRS-Dependent Virulence Factor Expression in
  MBio. 08, 2017  |   Pubmed ID: 28765222
• A Two-helix Motif Positions the Lysophosphatidic Acid Acyltransferase Active Site for Catalysis Within the Membrane Bilayer
  Nature Structural & Molecular Biology. Aug, 2017  |   Pubmed ID: 28714993
• Exogenous Fatty Acid Metabolism in Bacteria
  Biochimie. Oct, 2017  |   Pubmed ID: 28668270
• Sonic Hedgehog Activates Phospholipase A2 to Enhance Smoothened Ciliary Translocation
  Cell Reports. 06, 2017  |   Pubmed ID: 28591579
• Excess Coenzyme A Reduces Skeletal Muscle Performance and Strength in Mice Overexpressing Human PANK2
  Molecular Genetics and Metabolism. 04, 2017  |   Pubmed ID: 28189602
• T Cells Encountering Myeloid Cells Programmed for Amino Acid-dependent Immunosuppression Use Rictor/mTORC2 Protein for Proliferative Checkpoint Decisions
  The Journal of Biological Chemistry. Jan, 2017  |   Pubmed ID: 27903651
• Bacterial Fatty Acid Metabolism in Modern Antibiotic Discovery
  Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. Nov, 2017  |   Pubmed ID: 27668701
• Pyruvate Oxidase As a Critical Link Between Metabolism and Capsule Biosynthesis in Streptococcus Pneumoniae
  PLoS Pathogens. Oct, 2016  |   Pubmed ID: 27760231
• Enoyl-Acyl Carrier Protein Reductase I (FabI) Is Essential for the Intracellular Growth of Listeria Monocytogenes
  Infection and Immunity. Dec, 2016  |   Pubmed ID: 27736774
• Allosteric Regulation of Mammalian Pantothenate Kinase
  The Journal of Biological Chemistry. Oct, 2016  |   Pubmed ID: 27555321
• A Pathogen-Selective Antibiotic Minimizes Disturbance to the Microbiome
  Antimicrobial Agents and Chemotherapy. 07, 2016  |   Pubmed ID: 27161626
• Resistance Mechanisms and the Future of Bacterial Enoyl-Acyl Carrier Protein Reductase (FabI) Antibiotics
  Cold Spring Harbor Perspectives in Medicine. Mar, 2016  |   Pubmed ID: 26931811
• Biochemical Roles for Conserved Residues in the Bacterial Fatty Acid-binding Protein Family
  The Journal of Biological Chemistry. Mar, 2016  |   Pubmed ID: 26774272
• Activation of Exogenous Fatty Acids to Acyl-Acyl Carrier Protein Cannot Bypass FabI Inhibition in Neisseria
  The Journal of Biological Chemistry. Jan, 2016  |   Pubmed ID: 26567338
• Correction of a Genetic Deficiency in Pantothenate Kinase 1 Using Phosphopantothenate Replacement Therapy
  Molecular Genetics and Metabolism. Dec, 2015  |   Pubmed ID: 26549575
• Maternal Bile Acid Transporter Deficiency Promotes Neonatal Demise
  Nature Communications. Sep, 2015  |   Pubmed ID: 26416771
• Chlamydia Trachomatis Scavenges Host Fatty Acids for Phospholipid Synthesis Via an Acyl-Acyl Carrier Protein Synthetase
  The Journal of Biological Chemistry. Sep, 2015  |   Pubmed ID: 26195634
• Discovery of Bacterial Fatty Acid Synthase Type II Inhibitors Using a Novel Cellular Bioluminescent Reporter Assay
  Antimicrobial Agents and Chemotherapy. Sep, 2015  |   Pubmed ID: 26169404
• Chlamydia Trachomatis Relies on Autonomous Phospholipid Synthesis for Membrane Biogenesis
  The Journal of Biological Chemistry. Jul, 2015  |   Pubmed ID: 25995447
• How Bacterial Pathogens Eat Host Lipids: Implications for the Development of Fatty Acid Synthesis Therapeutics
  The Journal of Biological Chemistry. Mar, 2015  |   Pubmed ID: 25648887
• A High-throughput Screen Reveals New Small-molecule Activators and Inhibitors of Pantothenate Kinases
  Journal of Medicinal Chemistry. Feb, 2015  |   Pubmed ID: 25569308
• A Thioesterase Bypasses the Requirement for Exogenous Fatty Acids in the PlsX Deletion of Streptococcus Pneumoniae
  Molecular Microbiology. Apr, 2015  |   Pubmed ID: 25534847
• FabH Mutations Confer Resistance to FabF-directed Antibiotics in Staphylococcus Aureus
  Antimicrobial Agents and Chemotherapy. Feb, 2015  |   Pubmed ID: 25403676
• Identification of a Two-component Fatty Acid Kinase Responsible for Host Fatty Acid Incorporation by Staphylococcus Aureus
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2014  |   Pubmed ID: 25002480
• Type II Fatty Acid Synthesis is Essential for the Replication of Chlamydia Trachomatis
  The Journal of Biological Chemistry. Aug, 2014  |   Pubmed ID: 24958721
• Pank1 Deletion in Leptin-deficient Mice Reduces Hyperglycaemia and Hyperinsulinaemia and Modifies Global Metabolism Without Affecting Insulin Resistance
  Diabetologia. Jul, 2014  |   Pubmed ID: 24781151
• Discovery of Novel Bacterial Elongation Condensing Enzyme Inhibitors by Virtual Screening
  Bioorganic & Medicinal Chemistry Letters. Jun, 2014  |   Pubmed ID: 24755430
• Incorporation of Extracellular Fatty Acids by a Fatty Acid Kinase-dependent Pathway in Staphylococcus Aureus
  Molecular Microbiology. Apr, 2014  |   Pubmed ID: 24673884
• The Identification, Analysis and Structure-based Development of Novel Inhibitors of 6-hydroxymethyl-7,8-dihydropterin Pyrophosphokinase
  Bioorganic & Medicinal Chemistry. Apr, 2014  |   Pubmed ID: 24613625
• Phosphatidylglycerol Homeostasis in Glycerol-phosphate Auxotrophs of Staphylococcus Aureus
  BMC Microbiology. Nov, 2013  |   Pubmed ID: 24238430
• Resistance to AFN-1252 Arises from Missense Mutations in Staphylococcus Aureus Enoyl-acyl Carrier Protein Reductase (FabI)
  The Journal of Biological Chemistry. Dec, 2013  |   Pubmed ID: 24189061
• Staphylococcus Aureus Fatty Acid Auxotrophs Do Not Proliferate in Mice
  Antimicrobial Agents and Chemotherapy. Nov, 2013  |   Pubmed ID: 23979734
• Bacterial Lipids: Metabolism and Membrane Homeostasis
  Progress in Lipid Research. Jul, 2013  |   Pubmed ID: 23500459
• Perturbation of Staphylococcus Aureus Gene Expression by the Enoyl-acyl Carrier Protein Reductase Inhibitor AFN-1252
  Antimicrobial Agents and Chemotherapy. May, 2013  |   Pubmed ID: 23459481
• Preface: Phospholipids and Phospholipid Metabolism
  Biochimica Et Biophysica Acta. Mar, 2013  |   Pubmed ID: 23369660
• Phosphatidic Acid Synthesis in Bacteria
  Biochimica Et Biophysica Acta. Mar, 2013  |   Pubmed ID: 22981714
• Sustained Generation of Nitric Oxide and Control of Mycobacterial Infection Requires Argininosuccinate Synthase 1
  Cell Host & Microbe. Sep, 2012  |   Pubmed ID: 22980328
• Membrane Disruption by Antimicrobial Fatty Acids Releases Low-molecular-weight Proteins from Staphylococcus Aureus
  Journal of Bacteriology. Oct, 2012  |   Pubmed ID: 22843840
• Will the Initiator of Fatty Acid Synthesis in Pseudomonas Aeruginosa Please Stand Up?
  Journal of Bacteriology. Oct, 2012  |   Pubmed ID: 22821980
• Acyl-sulfamates Target the Essential Glycerol-phosphate Acyltransferase (PlsY) in Gram-positive Bacteria
  Bioorganic & Medicinal Chemistry. Aug, 2012  |   Pubmed ID: 22795901
• Cancer-associated Isocitrate Dehydrogenase Mutations Inactivate NADPH-dependent Reductive Carboxylation
  The Journal of Biological Chemistry. Apr, 2012  |   Pubmed ID: 22442146
• Atg8 Transfer from Atg7 to Atg3: a Distinctive E1-E2 Architecture and Mechanism in the Autophagy Pathway
  Molecular Cell. Nov, 2011  |   Pubmed ID: 22055190
• Metabolic Basis for the Differential Susceptibility of Gram-positive Pathogens to Fatty Acid Synthesis Inhibitors
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2011  |   Pubmed ID: 21876172
• Is Bacterial Fatty Acid Synthesis a Valid Target for Antibacterial Drug Discovery?
  Current Opinion in Microbiology. Oct, 2011  |   Pubmed ID: 21862391
• A σW-dependent Stress Response in Bacillus Subtilis That Reduces Membrane Fluidity
  Molecular Microbiology. Jul, 2011  |   Pubmed ID: 21542858
• A Rainbow Coalition of Lipid Transcriptional Regulators
  Molecular Microbiology. Oct, 2010  |   Pubmed ID: 20941840
• Modulation of Pantothenate Kinase 3 Activity by Small Molecules That Interact with the Substrate/allosteric Regulatory Domain
  Chemistry & Biology. Aug, 2010  |   Pubmed ID: 20797618
• Structural Basis for the Transcriptional Regulation of Membrane Lipid Homeostasis
  Nature Structural & Molecular Biology. Aug, 2010  |   Pubmed ID: 20639888
• Pantothenate Kinase 1 is Required to Support the Metabolic Transition from the Fed to the Fasted State
  PloS One. Jun, 2010  |   Pubmed ID: 20559429
• DesT Coordinates the Expression of Anaerobic and Aerobic Pathways for Unsaturated Fatty Acid Biosynthesis in Pseudomonas Aeruginosa
  Journal of Bacteriology. Jan, 2010  |   Pubmed ID: 19880602
• FabH Selectivity for Anteiso Branched-chain Fatty Acid Precursors in Low-temperature Adaptation in Listeria Monocytogenes
  FEMS Microbiology Letters. Dec, 2009  |   Pubmed ID: 19863661
• Transcriptional Regulation of Membrane Lipid Homeostasis in Escherichia Coli
  The Journal of Biological Chemistry. Dec, 2009  |   Pubmed ID: 19854834
• Opening a New Path to Lipoic Acid
  Journal of Bacteriology. Nov, 2009  |   Pubmed ID: 19734307
• Elimination of the CDP-ethanolamine Pathway Disrupts Hepatic Lipid Homeostasis
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19666474
• Acyl-Acyl Carrier Protein Regulates Transcription of Fatty Acid Biosynthetic Genes Via the FabT Repressor in Streptococcus Pneumoniae
  The Journal of Biological Chemistry. Jun, 2009  |   Pubmed ID: 19376778
• Structural Modification of Acyl Carrier Protein by Butyryl Group
  Protein Science : a Publication of the Protein Society. Jan, 2009  |   Pubmed ID: 19177367
• Molecular Determinants for Interfacial Binding and Conformational Change in a Soluble Diacylglycerol Kinase
  The Journal of Biological Chemistry. Mar, 2009  |   Pubmed ID: 19112175
• Transcriptional Regulation in Bacterial Membrane Lipid Synthesis
  Journal of Lipid Research. Apr, 2009  |   Pubmed ID: 18941141
• Novel Acyl Phosphate Mimics That Target PlsY, an Essential Acyltransferase in Gram-positive Bacteria
  ChemMedChem. Dec, 2008  |   Pubmed ID: 19016283
• PqsD is Responsible for the Synthesis of 2,4-dihydroxyquinoline, an Extracellular Metabolite Produced by Pseudomonas Aeruginosa
  The Journal of Biological Chemistry. Oct, 2008  |   Pubmed ID: 18728009
• Analysis of the Staphylococcus Aureus DgkB Structure Reveals a Common Catalytic Mechanism for the Soluble Diacylglycerol Kinases
  Structure (London, England : 1993). Jul, 2008  |   Pubmed ID: 18611377
• Thematic Review Series: Glycerolipids. Acyltransferases in Bacterial Glycerophospholipid Synthesis
  Journal of Lipid Research. Sep, 2008  |   Pubmed ID: 18369234
• RhlA Converts Beta-hydroxyacyl-acyl Carrier Protein Intermediates in Fatty Acid Synthesis to the Beta-hydroxydecanoyl-beta-hydroxydecanoate Component of Rhamnolipids in Pseudomonas Aeruginosa
  Journal of Bacteriology. May, 2008  |   Pubmed ID: 18326581
• Membrane Lipid Homeostasis in Bacteria
  Nature Reviews. Microbiology. Mar, 2008  |   Pubmed ID: 18264115
• A Pseudomonas Aeruginosa Transcription Factor That Senses Fatty Acid Structure
  Molecular Microbiology. Nov, 2007  |   Pubmed ID: 17877713
• Localization and Regulation of Mouse Pantothenate Kinase 2
  FEBS Letters. Oct, 2007  |   Pubmed ID: 17825826
• Coupling of Fatty Acid and Phospholipid Synthesis in Bacillus Subtilis
  Journal of Bacteriology. Aug, 2007  |   Pubmed ID: 17557823
• Identification of a Soluble Diacylglycerol Kinase Required for Lipoteichoic Acid Production in Bacillus Subtilis
  The Journal of Biological Chemistry. Jul, 2007  |   Pubmed ID: 17535816
• Crystal Structure and Allosteric Regulation of the Cytoplasmic Escherichia Coli L-asparaginase I
  Journal of Molecular Biology. Jun, 2007  |   Pubmed ID: 17451745
• Chemical Knockout of Pantothenate Kinase Reveals the Metabolic and Genetic Program Responsible for Hepatic Coenzyme A Homeostasis
  Chemistry & Biology. Mar, 2007  |   Pubmed ID: 17379144
• Topology and Active Site of PlsY: the Bacterial Acylphosphate:glycerol-3-phosphate Acyltransferase
  The Journal of Biological Chemistry. Apr, 2007  |   Pubmed ID: 17308305
• Activation of Human Mitochondrial Pantothenate Kinase 2 by Palmitoylcarnitine
  Proceedings of the National Academy of Sciences of the United States of America. Jan, 2007  |   Pubmed ID: 17242360
• Acyl-phosphates Initiate Membrane Phospholipid Synthesis in Gram-positive Pathogens
  Molecular Cell. Sep, 2006  |   Pubmed ID: 16949372
• Placental Thrombosis and Spontaneous Fetal Death in Mice Deficient in Ethanolamine Kinase 2
  The Journal of Biological Chemistry. Sep, 2006  |   Pubmed ID: 16861741
• Inhibiting Bacterial Fatty Acid Synthesis
  The Journal of Biological Chemistry. Jun, 2006  |   Pubmed ID: 16648134
• Structure of RhlG, an Essential Beta-ketoacyl Reductase in the Rhamnolipid Biosynthetic Pathway of Pseudomonas Aeruginosa
  The Journal of Biological Chemistry. Jun, 2006  |   Pubmed ID: 16624803
• Roles of the Active Site Water, Histidine 303, and Phenylalanine 396 in the Catalytic Mechanism of the Elongation Condensing Enzyme of Streptococcus Pneumoniae
  The Journal of Biological Chemistry. Jun, 2006  |   Pubmed ID: 16618705
• Two Aerobic Pathways for the Formation of Unsaturated Fatty Acids in Pseudomonas Aeruginosa
  Molecular Microbiology. Apr, 2006  |   Pubmed ID: 16573679
• Structure-activity Relationships at the 5-position of Thiolactomycin: an Intact (5R)-isoprene Unit is Required for Activity Against the Condensing Enzymes from Mycobacterium Tuberculosis and Escherichia Coli
  Journal of Medicinal Chemistry. Jan, 2006  |   Pubmed ID: 16392800
• Biochemical Properties of Human Pantothenate Kinase 2 Isoforms and Mutations Linked to Pantothenate Kinase-associated Neurodegeneration
  The Journal of Biological Chemistry. Jan, 2006  |   Pubmed ID: 16272150
• Feedback Regulation of Murine Pantothenate Kinase 3 by Coenzyme A and Coenzyme A Thioesters
  The Journal of Biological Chemistry. Sep, 2005  |   Pubmed ID: 16040613
• Coenzyme A: Back in Action
  Progress in Lipid Research. Mar-May, 2005  |   Pubmed ID: 15893380
• A Pantothenate Kinase from Staphylococcus Aureus Refractory to Feedback Regulation by Coenzyme A
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15548531
• The Reductase Steps of the Type II Fatty Acid Synthase As Antimicrobial Targets
  Lipids. Nov, 2004  |   Pubmed ID: 15726819
• Acyl Carrier Protein is a Cellular Target for the Antibacterial Action of the Pantothenamide Class of Pantothenate Antimetabolites
  The Journal of Biological Chemistry. Dec, 2004  |   Pubmed ID: 15459190
• Prediction of Mechanisms of Action of Antibacterial Compounds by Gene Expression Profiling
  Antimicrobial Agents and Chemotherapy. Aug, 2004  |   Pubmed ID: 15273089
• The Structure of the Pantothenate Kinase.ADP.pantothenate Ternary Complex Reveals the Relationship Between the Binding Sites for Substrate, Allosteric Regulator, and Antimetabolites
  The Journal of Biological Chemistry. Aug, 2004  |   Pubmed ID: 15136582
• Evaluation of Epigallocatechin Gallate and Related Plant Polyphenols As Inhibitors of the FabG and FabI Reductases of Bacterial Type II Fatty-acid Synthase
  The Journal of Biological Chemistry. Jul, 2004  |   Pubmed ID: 15133034
• Product Diversity and Regulation of Type II Fatty Acid Synthases
  Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Feb, 2004  |   Pubmed ID: 15052334
• Fatty Acid Biosynthesis As a Target for Novel Antibacterials
  Current Opinion in Investigational Drugs (London, England : 2000). Feb, 2004  |   Pubmed ID: 15043388
• Cofactor-induced Conformational Rearrangements Establish a Catalytically Competent Active Site and a Proton Relay Conduit in FabG
  Structure (London, England : 1993). Mar, 2004  |   Pubmed ID: 15016358
• Key Residues Responsible for Acyl Carrier Protein and Beta-ketoacyl-acyl Carrier Protein Reductase (FabG) Interaction
  The Journal of Biological Chemistry. Dec, 2003  |   Pubmed ID: 14527946
• The 1.3-Angstrom-resolution Crystal Structure of Beta-ketoacyl-acyl Carrier Protein Synthase II from Streptococcus Pneumoniae
  Journal of Bacteriology. Jul, 2003  |   Pubmed ID: 12837788
• Crystal Structures of the Dab Homology Domains of Mouse Disabled 1 and 2
  The Journal of Biological Chemistry. Sep, 2003  |   Pubmed ID: 12826668
• Role of Feedback Regulation of Pantothenate Kinase (CoaA) in Control of Coenzyme A Levels in Escherichia Coli
  Journal of Bacteriology. Jun, 2003  |   Pubmed ID: 12754240
• The Application of Computational Methods to Explore the Diversity and Structure of Bacterial Fatty Acid Synthase
  Journal of Lipid Research. Jan, 2003  |   Pubmed ID: 12518017
• Characterization of Streptococcus Pneumoniae Enoyl-(acyl-carrier Protein) Reductase (FabK)
  The Biochemical Journal. Mar, 2003  |   Pubmed ID: 12487627
• The Claisen Condensation in Biology
  Natural Product Reports. Oct, 2002  |   Pubmed ID: 12430724
• A New Mechanism for Anaerobic Unsaturated Fatty Acid Formation in Streptococcus Pneumoniae
  The Journal of Biological Chemistry. Nov, 2002  |   Pubmed ID: 12237320
• The Murine Pantothenate Kinase (Pank1) Gene Encodes Two Differentially Regulated Pantothenate Kinase Isozymes
  Gene. May, 2002  |   Pubmed ID: 12095677
• Forty Years of Bacterial Fatty Acid Synthesis
  Biochemical and Biophysical Research Communications. Apr, 2002  |   Pubmed ID: 11969206
• A Missense Mutation in the FabB (beta-ketoacyl-acyl Carrier Protein Synthase I) Gene Confers Tiolactomycin Resistance to Escherichia Coli
  Antimicrobial Agents and Chemotherapy. May, 2002  |   Pubmed ID: 11959552
• Dual Roles for the Dab2 Adaptor Protein in Embryonic Development and Kidney Transport
  The EMBO Journal. Apr, 2002  |   Pubmed ID: 11927540
• The FabR (YijC) Transcription Factor Regulates Unsaturated Fatty Acid Biosynthesis in Escherichia Coli
  The Journal of Biological Chemistry. May, 2002  |   Pubmed ID: 11859088
• The Solution Structure of Acyl Carrier Protein from Mycobacterium Tuberculosis
  The Journal of Biological Chemistry. May, 2002  |   Pubmed ID: 11825906
• Disabled-2 is Transcriptionally Regulated by ICSBP and Augments Macrophage Spreading and Adhesion
  The EMBO Journal. Feb, 2002  |   Pubmed ID: 11823414
• Structure and Mechanism of CTP:phosphocholine Cytidylyltransferase (LicC) from Streptococcus Pneumoniae
  The Journal of Biological Chemistry. Feb, 2002  |   Pubmed ID: 11706035
• The LicC Gene of Streptococcus Pneumoniae Encodes a CTP:phosphocholine Cytidylyltransferase
  Journal of Bacteriology. Aug, 2001  |   Pubmed ID: 11466299
• Response of Bacillus Subtilis to Cerulenin and Acquisition of Resistance
  Journal of Bacteriology. May, 2001  |   Pubmed ID: 11325930
• Beta-ketoacyl-acyl Carrier Protein Synthase III (FabH) is a Determining Factor in Branched-chain Fatty Acid Biosynthesis
  Journal of Bacteriology. Jan, 2000  |   Pubmed ID: 10629181
• A Missense Mutation Accounts for the Defect in the Glycerol-3-phosphate Acyltransferase Expressed in the PlsB26 Mutant
  Journal of Bacteriology. Mar, 1999  |   Pubmed ID: 10074094
• A Conserved Histidine is Essential for Glycerolipid Acyltransferase Catalysis
  Journal of Bacteriology. Mar, 1998  |   Pubmed ID: 9515909
• Roles of the FabA and FabZ Beta-hydroxyacyl-acyl Carrier Protein Dehydratases in Escherichia Coli Fatty Acid Biosynthesis
  The Journal of Biological Chemistry. Nov, 1996  |   Pubmed ID: 8910376