Chrisostomos Prodromou

Publications

• HSP70-HSP90 Chaperone Networking in Protein-Misfolding Disease
  Sub-cellular Biochemistry. 2023  |   Pubmed ID: 36520314
• Recognition of BRAF by CDC37 and Re-Evaluation of the Activation Mechanism for the Class 2 BRAF-L597R Mutant
  Biomolecules. Jun, 2022  |   Pubmed ID: 35883461
• Advances Towards Understanding the Mechanism of Action of the Hsp90 Complex
  Biomolecules. Apr, 2022  |   Pubmed ID: 35625528
• Two-colour Single-molecule Photoinduced Electron Transfer Fluorescence Imaging Microscopy of Chaperone Dynamics
  Nature Communications. Nov, 2021  |   Pubmed ID: 34845214
• Structure of the TELO2-TTI1-TTI2 Complex and Its Function in TOR Recruitment to the R2TP Chaperone
  Cell Reports. Jul, 2021  |   Pubmed ID: 34233195
• The Structure-function Relationship of Oncogenic LMTK3
  Science Advances. Nov, 2020  |   Pubmed ID: 33188023
• Clinical and Functional Analyses of AIPL1 Variants Reveal Mechanisms of Pathogenicity Linked to Different Forms of Retinal Degeneration
  Scientific Reports. Oct, 2020  |   Pubmed ID: 33067476
• Editorial: The Role of Heat Shock Proteins in Neuroprotection
  Frontiers in Pharmacology. 2020  |   Pubmed ID: 32848805
• Chemical Perturbation of Oncogenic Protein Folding: from the Prediction of Locally Unstable Structures to the Design of Disruptors of Hsp90-Client Interactions
  Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2020  |   Pubmed ID: 32167602
• Structural Mechanism for Regulation of the AAA-ATPases RUVBL1-RUVBL2 in the R2TP Co-chaperone Revealed by Cryo-EM
  Science Advances. May, 2019  |   Pubmed ID: 31049401
• Post-translational Regulation of FNIP1 Creates a Rheostat for the Molecular Chaperone Hsp90
  Cell Reports. Jan, 2019  |   Pubmed ID: 30699359
• Advances on the Structure of the R2TP/Prefoldin-like Complex
  Advances in Experimental Medicine and Biology. 2018  |   Pubmed ID: 30484153
• Author Correction: RPAP3 Provides a Flexible Scaffold for Coupling HSP90 to the Human R2TP Co-chaperone Complex
  Nature Communications. Jul, 2018  |   Pubmed ID: 30065299
• Dihydropyridines Allosterically Modulate Hsp90 Providing a Novel Mechanism for Heat Shock Protein Co-induction and Neuroprotection
  Frontiers in Molecular Biosciences. 2018  |   Pubmed ID: 29930942
• RPAP3 Provides a Flexible Scaffold for Coupling HSP90 to the Human R2TP Co-chaperone Complex
  Nature Communications. Apr, 2018  |   Pubmed ID: 29662061
• Bioassay to Test the Pathogenicity of Missense Human Variants
  Journal of Medical Genetics. Aug, 2018  |   Pubmed ID: 29632148
• Multi-chaperone Function Modulation and Association with Cytoskeletal Proteins Are Key Features of the Function of AIP in the Pituitary Gland
  Oncotarget. Feb, 2018  |   Pubmed ID: 29507682
• The Integrity and Organization of the Human AIPL1 Functional Domains is Critical for Its Role As a HSP90-dependent Co-chaperone for Rod PDE6
  Human Molecular Genetics. Apr, 2018  |   Pubmed ID: 29351602
• The Stoichiometric Interaction of the Hsp90-Sgt1-Rar1 Complex by CD and SRCD Spectroscopy
  Frontiers in Molecular Biosciences. 2017  |   Pubmed ID: 29387685
• Tumor Suppressor Tsc1 is a New Hsp90 Co-chaperone That Facilitates Folding of Kinase and Non-kinase Clients
  The EMBO Journal. 12, 2017  |   Pubmed ID: 29127155
• Differential Regulation of G1 CDK Complexes by the Hsp90-Cdc37 Chaperone System
  Cell Reports. Oct, 2017  |   Pubmed ID: 29091774
• The Integrity and Organization of the Human AIPL1 Functional Domains is Critical for Its Role As a HSP90-dependent Co-chaperone for Rod PDE6
  Human Molecular Genetics. Nov, 2017  |   Pubmed ID: 28973376
• The Structure of the R2TP Complex Defines a Platform for Recruiting Diverse Client Proteins to the HSP90 Molecular Chaperone System
  Structure (London, England : 1993). Jul, 2017  |   Pubmed ID: 28648606
• HECTD3 Mediates an HSP90-Dependent Degradation Pathway for Protein Kinase Clients
  Cell Reports. Jun, 2017  |   Pubmed ID: 28636940
• The Structure of FKBP38 in Complex with the MEEVD Tetratricopeptide Binding-motif of Hsp90
  PloS One. 2017  |   Pubmed ID: 28278223
• Mechanisms of Hsp90 Regulation
  The Biochemical Journal. Aug, 2016  |   Pubmed ID: 27515256
• The FNIP Co-chaperones Decelerate the Hsp90 Chaperone Cycle and Enhance Drug Binding
  Nature Communications. 06, 2016  |   Pubmed ID: 27353360
• Cooperation of Local Motions in the Hsp90 Molecular Chaperone ATPase Mechanism
  Nature Chemical Biology. Aug, 2016  |   Pubmed ID: 27322067
• Rapid Proteasomal Degradation of Mutant Proteins Is the Primary Mechanism Leading to Tumorigenesis in Patients With Missense AIP Mutations
  The Journal of Clinical Endocrinology and Metabolism. Aug, 2016  |   Pubmed ID: 27253664
• Dihydropyridine Derivatives Modulate Heat Shock Responses and Have a Neuroprotective Effect in a Transgenic Mouse Model of Alzheimer's Disease
  Journal of Alzheimer's Disease : JAD. May, 2016  |   Pubmed ID: 27163800
• Mps1 Mediated Phosphorylation of Hsp90 Confers Renal Cell Carcinoma Sensitivity and Selectivity to Hsp90 Inhibitors
  Cell Reports. Feb, 2016  |   Pubmed ID: 26804907
• C-Abl Mediated Tyrosine Phosphorylation of Aha1 Activates Its Co-chaperone Function in Cancer Cells
  Cell Reports. Aug, 2015  |   Pubmed ID: 26235616
• Tah1 Helix-swap Dimerization Prevents Mixed Hsp90 Co-chaperone Complexes
  Acta Crystallographica. Section D, Biological Crystallography. May, 2015  |   Pubmed ID: 25945584
• Structural Basis for Phosphorylation-dependent Recruitment of Tel2 to Hsp90 by Pih1
  Structure (London, England : 1993). Jun, 2014  |   Pubmed ID: 24794838
• Asymmetric Hsp90 N Domain SUMOylation Recruits Aha1 and ATP-competitive Inhibitors
  Molecular Cell. Jan, 2014  |   Pubmed ID: 24462205
• Synthesis of 19-substituted Geldanamycins with Altered Conformations and Their Binding to Heat Shock Protein Hsp90
  Nature Chemistry. Apr, 2013  |   Pubmed ID: 23511419
• ATP-competitive Inhibitors Block Protein Kinase Recruitment to the Hsp90-Cdc37 System
  Nature Chemical Biology. May, 2013  |   Pubmed ID: 23502424
• Structure of the TPR Domain of AIP: Lack of Client Protein Interaction with the C-terminal α-7 Helix of the TPR Domain of AIP is Sufficient for Pituitary Adenoma Predisposition
  PloS One. 2012  |   Pubmed ID: 23300914
• CDK-dependent Hsp70 Phosphorylation Controls G1 Cyclin Abundance and Cell-cycle Progression
  Cell. Dec, 2012  |   Pubmed ID: 23217712
• Co-crystalization and in Vitro Biological Characterization of 5-aryl-4-(5-substituted-2-4-dihydroxyphenyl)-1,2,3-thiadiazole Hsp90 Inhibitors
  PloS One. 2012  |   Pubmed ID: 22984537
• Dynamic Tyrosine Phosphorylation Modulates Cycling of the HSP90-P50(CDC37)-AHA1 Chaperone Machine
  Molecular Cell. Aug, 2012  |   Pubmed ID: 22727666
• Charged Linker Sequence Modulates Eukaryotic Heat Shock Protein 90 (Hsp90) Chaperone Activity
  Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012  |   Pubmed ID: 22315411
• The 'active Life' of Hsp90 Complexes
  Biochimica Et Biophysica Acta. Mar, 2012  |   Pubmed ID: 21840346
• Threonine 22 Phosphorylation Attenuates Hsp90 Interaction with Cochaperones and Affects Its Chaperone Activity
  Molecular Cell. Mar, 2011  |   Pubmed ID: 21419342
• Structural Basis for Assembly of Hsp90-Sgt1-CHORD Protein Complexes: Implications for Chaperoning of NLR Innate Immunity Receptors
  Molecular Cell. Jul, 2010  |   Pubmed ID: 20670895