Christian Siebold Division of Structural Biology, Wellcome Centre Human Genetics University of Oxford Biography Publications Institution JoVE Articles Christian Siebold has not added a biography. If you are Christian Siebold and would like to personalize this page please email our Author Liaison for assistance. Publications A Calcium-sensing Receptor Mutation Causing Hypocalcemia Disrupts a Transmembrane Salt Bridge to Activate β-arrestin-biased Signaling Science Signaling. Feb, 2018 | Pubmed ID: 29463778 Multiple Ligand Binding Sites Regulate the Hedgehog Signal Transducer Smoothened in Vertebrates Current Opinion in Cell Biology. Apr, 2018 | Pubmed ID: 29268141 RGMs: Structural Insights, Molecular Regulation, and Downstream Signaling Trends in Cell Biology. 05, 2017 | Pubmed ID: 28007423 Cholesterol Activates the G-protein Coupled Receptor Smoothened to Promote Hedgehog Signaling ELife. 10, 2016 | Pubmed ID: 27705744 Structural Basis of Smoothened Regulation by Its Extracellular Domains Nature. 07, 2016 | Pubmed ID: 27437577 Structural Basis for Integration of GluD Receptors Within Synaptic Organizer Complexes Science (New York, N.Y.). Jul, 2016 | Pubmed ID: 27418511 Initiation of T Cell Signaling by CD45 Segregation at 'close Contacts' Nature Immunology. May, 2016 | Pubmed ID: 26998761 Lrig2 Negatively Regulates Ectodomain Shedding of Axon Guidance Receptors by ADAM Proteases Developmental Cell. Dec, 2015 | Pubmed ID: 26651291 Secreted HHIP1 Interacts with Heparan Sulfate and Regulates Hedgehog Ligand Localization and Function The Journal of Cell Biology. Jun, 2015 | Pubmed ID: 26056142 Repulsive Guidance Molecule is a Structural Bridge Between Neogenin and Bone Morphogenetic Protein Nature Structural & Molecular Biology. Jun, 2015 | Pubmed ID: 25938661 Structure and Function of the Smoothened Extracellular Domain in Vertebrate Hedgehog Signaling ELife. Oct, 2013 | Pubmed ID: 24171105 Structural Insights into Proteoglycan-shaped Hedgehog Signaling Proceedings of the National Academy of Sciences of the United States of America. Oct, 2013 | Pubmed ID: 24062467 Structure of the Repulsive Guidance Molecule (RGM)-neogenin Signaling Hub Science (New York, N.Y.). Jul, 2013 | Pubmed ID: 23744777 Restoring P53 Function in Human Melanoma Cells by Inhibiting MDM2 and Cyclin B1/CDK1-phosphorylated Nuclear IASPP Cancer Cell. May, 2013 | Pubmed ID: 23623661 Structural Insights into Semaphorins and Their Receptors Seminars in Cell & Developmental Biology. Mar, 2013 | Pubmed ID: 23253452 Neuropilins Lock Secreted Semaphorins Onto Plexins in a Ternary Signaling Complex Nature Structural & Molecular Biology. Dec, 2012 | Pubmed ID: 23104057 Structural and Functional Studies of LRP6 Ectodomain Reveal a Platform for Wnt Signaling Developmental Cell. Nov, 2011 | Pubmed ID: 22000855 A Dual Binding Mode for RhoGTPases in Plexin Signalling PLoS Biology. Aug, 2011 | Pubmed ID: 21912513 Modular Mechanism of Wnt Signaling Inhibition by Wnt Inhibitory Factor 1 Nature Structural & Molecular Biology. Jul, 2011 | Pubmed ID: 21743455 Recording Information on Protein Complexes in an Information Management System Journal of Structural Biology. Aug, 2011 | Pubmed ID: 21605682 Automation of Large Scale Transient Protein Expression in Mammalian Cells Journal of Structural Biology. Aug, 2011 | Pubmed ID: 21571074 Structure of HLA-A*0301 in Complex with a Peptide of Proteolipid Protein: Insights into the Role of HLA-A Alleles in Susceptibility to Multiple Sclerosis Acta Crystallographica. Section D, Biological Crystallography. May, 2011 | Pubmed ID: 21543847 Proteoglycan-specific Molecular Switch for RPTPσ Clustering and Neuronal Extension Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21454754 Structural Basis of Semaphorin-plexin Signalling Nature. Oct, 2010 | Pubmed ID: 20877282 Interactions Between Hedgehog Proteins and Their Binding Partners Come into View Genes & Development. Sep, 2010 | Pubmed ID: 20844013 Structural Plasticity of Eph Receptor A4 Facilitates Cross-class Ephrin Signaling Structure (London, England : 1993). Oct, 2009 | Pubmed ID: 19836338 Crystal Structure of the GluR2 Amino-terminal Domain Provides Insights into the Architecture and Assembly of Ionotropic Glutamate Receptors Journal of Molecular Biology. Oct, 2009 | Pubmed ID: 19651138 Structural Insights into Hedgehog Ligand Sequestration by the Human Hedgehog-interacting Protein HHIP Nature Structural & Molecular Biology. Jul, 2009 | Pubmed ID: 19561611 Receptor Protein Tyrosine Phosphatase Micro: Measuring Where to Stick Biochemical Society Transactions. Apr, 2008 | Pubmed ID: 18363557 Biochemical and Structural Studies of ASPP Proteins Reveal Differential Binding to P53, P63, and P73 Structure (London, England : 1993). Feb, 2008 | Pubmed ID: 18275817 Structure and Functional Analysis of the IGF-II/IGF2R Interaction The EMBO Journal. Jan, 2008 | Pubmed ID: 18046459 Structure of a Tyrosine Phosphatase Adhesive Interaction Reveals a Spacer-clamp Mechanism Science (New York, N.Y.). Aug, 2007 | Pubmed ID: 17761881 Structure of the Fungal Beta-glucan-binding Immune Receptor Dectin-1: Implications for Function Protein Science : a Publication of the Protein Society. Jun, 2007 | Pubmed ID: 17473009 Mutations in Alpha-tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans Cell. Jan, 2007 | Pubmed ID: 17218254 MHC Class II Proteins and Disease: a Structural Perspective Nature Reviews. Immunology. Apr, 2006 | Pubmed ID: 16557259 Molecular Analysis of Receptor Protein Tyrosine Phosphatase Mu-mediated Cell Adhesion The EMBO Journal. Feb, 2006 | Pubmed ID: 16456543 High-resolution Structure of the Catalytic Region of MICAL (molecule Interacting with CasL), a Multidomain Flavoenzyme-signaling Molecule Proceedings of the National Academy of Sciences of the United States of America. Nov, 2005 | Pubmed ID: 16275925 Multiple Sclerosis: MHC Associations and Therapeutic Implications Expert Reviews in Molecular Medicine. Feb, 2005 | Pubmed ID: 15710050 Crystal Structure of HLA-DQ0602 That Protects Against Type 1 Diabetes and Confers Strong Susceptibility to Narcolepsy Proceedings of the National Academy of Sciences of the United States of America. Feb, 2004 | Pubmed ID: 14769912 Kalibrering-fri In Vitro kvantificering af Protein Homo-oligomerisering ved hjælp af kommercielle instrumentering og gratis, Open Source lysstyrke analyse Software Rory Nolan1, Luis A. Alvarez1, Samuel C. Griffiths2, Jonathan Elegheert2, Christian Siebold2, Sergi Padilla-Parra1,2,3,4 1Cellular Imaging Group, Wellcome Centre Human Genetics, University of Oxford, 2Division of Structural Biology, Wellcome Centre Human Genetics, University of Oxford, 3Dynamic Structural Virology Group, Biocruces Health Research Centre, 4IKERBASQUE, Basque Foundation for Science JoVE 58157 Biochemistry
Kalibrering-fri In Vitro kvantificering af Protein Homo-oligomerisering ved hjælp af kommercielle instrumentering og gratis, Open Source lysstyrke analyse Software Rory Nolan1, Luis A. Alvarez1, Samuel C. Griffiths2, Jonathan Elegheert2, Christian Siebold2, Sergi Padilla-Parra1,2,3,4 1Cellular Imaging Group, Wellcome Centre Human Genetics, University of Oxford, 2Division of Structural Biology, Wellcome Centre Human Genetics, University of Oxford, 3Dynamic Structural Virology Group, Biocruces Health Research Centre, 4IKERBASQUE, Basque Foundation for Science JoVE 58157 Biochemistry
