Christine L. Mummery

Publications

• Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts
  Current Protocols in Human Genetics. Oct, 2018  |   Pubmed ID: 30253059
• Advanced in Vitro Models of Vascular Biology: Human Induced Pluripotent Stem Cells and Organ-on-chip Technology
  Advanced Drug Delivery Reviews. Jun, 2018  |   Pubmed ID: 29944904
• Inflammatory Responses and Barrier Function of Endothelial Cells Derived from Human Induced Pluripotent Stem Cells
  Stem Cell Reports. May, 2018  |   Pubmed ID: 29657098
• NKX2-5 Regulates Human Cardiomyogenesis Via a HEY2 Dependent Transcriptional Network
  Nature Communications. 04, 2018  |   Pubmed ID: 29636455
• Squaramide-Based Supramolecular Materials for Three-Dimensional Cell Culture of Human Induced Pluripotent Stem Cells and Their Derivatives
  Biomacromolecules. Apr, 2018  |   Pubmed ID: 29528623
• MUSCLEMOTION: A Versatile Open Software Tool to Quantify Cardiomyocyte and Cardiac Muscle Contraction In Vitro and In Vivo
  Circulation Research. Feb, 2018  |   Pubmed ID: 29282212
• Executive Summary of the 12th HHT International Scientific Conference
  Angiogenesis. Feb, 2018  |   Pubmed ID: 29147802
• Interpretation of Field Potentials Measured on a Multi Electrode Array in Pharmacological Toxicity Screening on Primary and Human Pluripotent Stem Cell-derived Cardiomyocytes
  Biochemical and Biophysical Research Communications. 03, 2018  |   Pubmed ID: 28153730
• Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells
  Stem Cell Reports. 12, 2017  |   Pubmed ID: 29173898
• A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes
  Stem Cell Reports. 12, 2017  |   Pubmed ID: 29173897
• Co-Differentiation of Human Pluripotent Stem Cells-Derived Cardiomyocytes and Endothelial Cells from Cardiac Mesoderm Provides a Three-Dimensional Model of Cardiac Microtissue
  Current Protocols in Human Genetics. 10, 2017  |   Pubmed ID: 29044469
• DNA Methylation and Transcriptional Trajectories During Human Development and Reprogramming of Isogenic Pluripotent Stem Cells
  Nature Communications. 10, 2017  |   Pubmed ID: 29030611
• Human Pluripotent Stem Cell Models of Cardiac Disease: from Mechanisms to Therapies
  Disease Models & Mechanisms. 09, 2017  |   Pubmed ID: 28883014
• FANTOM5 CAGE Profiles of Human and Mouse Samples
  Scientific Data. 08, 2017  |   Pubmed ID: 28850106
• Differentiation-Defective Human Induced Pluripotent Stem Cells Reveal Strengths and Limitations of the Teratoma Assay and In Vitro Pluripotency Assays
  Stem Cell Reports. 05, 2017  |   Pubmed ID: 28494940
• Three-dimensional Cardiac Microtissues Composed of Cardiomyocytes and Endothelial Cells Co-differentiated from Human Pluripotent Stem Cells
  Development (Cambridge, England). Mar, 2017  |   Pubmed ID: 28279973
• Subtype-specific Promoter-driven Action Potential Imaging for Precise Disease Modelling and Drug Testing in HiPSC-derived Cardiomyocytes
  European Heart Journal. Jan, 2017  |   Pubmed ID: 28182242
• Small Molecule Absorption by PDMS in the Context of Drug Response Bioassays
  Biochemical and Biophysical Research Communications. Jan, 2017  |   Pubmed ID: 27856254
• Cytostretch, an Organ-on-Chip Platform
  Micromachines. Jul, 2016  |   Pubmed ID: 30404293
• TECRL, a New Life-threatening Inherited Arrhythmia Gene Associated with Overlapping Clinical Features of Both LQTS and CPVT
  EMBO Molecular Medicine. 12, 2016  |   Pubmed ID: 27861123
• Readthrough-Promoting Drugs Gentamicin and PTC124 Fail to Rescue Nav1.5 Function of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes Carrying Nonsense Mutations in the Sodium Channel Gene SCN5A
  Circulation. Arrhythmia and Electrophysiology. Nov, 2016  |   Pubmed ID: 27784737
• Integrating Cardiomyocytes from Human Pluripotent Stem Cells in Safety Pharmacology: Has the Time Come?
  British Journal of Pharmacology. Sep, 2016  |   Pubmed ID: 27641943
• A New HERG Allosteric Modulator Rescues Genetic and Drug-induced Long-QT Syndrome Phenotypes in Cardiomyocytes from Isogenic Pairs of Patient Induced Pluripotent Stem Cells
  EMBO Molecular Medicine. 09, 2016  |   Pubmed ID: 27470144
• Inherited Heart Disease - What Can We Expect from the Second Decade of Human IPS Cell Research?
  FEBS Letters. Aug, 2016  |   Pubmed ID: 27391414
• Concise Review: Measuring Physiological Responses of Human Pluripotent Stem Cell Derived Cardiomyocytes to Drugs and Disease
  Stem Cells (Dayton, Ohio). Aug, 2016  |   Pubmed ID: 27250776
• Stem Cells: The Cancer's Gone, but Did Chemotherapy Damage Your Heart?
  Nature Reviews. Cardiology. Jul, 2016  |   Pubmed ID: 27226155
• Position Paper of the European Society of Cardiology Working Group Cellular Biology of the Heart: Cell-based Therapies for Myocardial Repair and Regeneration in Ischemic Heart Disease and Heart Failure
  European Heart Journal. Apr, 2016  |   Pubmed ID: 27055812
• Complex Tissue and Disease Modeling Using HiPSCs
  Cell Stem Cell. Mar, 2016  |   Pubmed ID: 26942851
• The Avian Embryo to Study Development of the Cardiac Conduction System
  Differentiation; Research in Biological Diversity. Apr-Jun, 2016  |   Pubmed ID: 26856662
• Interaction Between ALK1 Signaling and Connexin40 in the Development of Arteriovenous Malformations
  Arteriosclerosis, Thrombosis, and Vascular Biology. Apr, 2016  |   Pubmed ID: 26821948
• The Composition and Differentiation Potential of the Duodenal Intraepithelial Innate Lymphocyte Compartment is Altered in Coeliac Disease
  Gut. Aug, 2016  |   Pubmed ID: 25966995
• Differentiation of Human Pluripotent Stem Cells to Cardiomyocytes Under Defined Conditions
  Methods in Molecular Biology (Clifton, N.J.). 2016  |   Pubmed ID: 25626427
• Advantages of the Avian Model for Human Ovarian Cancer
  Molecular and Clinical Oncology. Nov, 2015  |   Pubmed ID: 26807219
• Induced Pluripotent Stem Cells to Model Human Fibrodysplasia Ossificans Progressiva
  Stem Cell Reports. Dec, 2015  |   Pubmed ID: 26626181
• Contractile Defect Caused by Mutation in MYBPC3 Revealed Under Conditions Optimized for Human PSC-Cardiomyocyte Function
  Cell Reports. Oct, 2015  |   Pubmed ID: 26489474
• Altered Calcium Handling and Increased Contraction Force in Human Embryonic Stem Cell Derived Cardiomyocytes Following Short Term Dexamethasone Exposure
  Biochemical and Biophysical Research Communications. Nov, 2015  |   Pubmed ID: 26456652
• Transcriptome of Human Foetal Heart Compared with Cardiomyocytes from Pluripotent Stem Cells
  Development (Cambridge, England). Sep, 2015  |   Pubmed ID: 26209647
• Expansion and Patterning of Cardiovascular Progenitors Derived from Human Pluripotent Stem Cells
  Nature Biotechnology. Sep, 2015  |   Pubmed ID: 26192318
• KeyGenes, a Tool to Probe Tissue Differentiation Using a Human Fetal Transcriptional Atlas
  Stem Cell Reports. Jun, 2015  |   Pubmed ID: 26028532
• What Endothelial Cells from Patient IPSCs Can Tell Us About Aortic Valve Disease
  Cell Stem Cell. May, 2015  |   Pubmed ID: 25957898
• Reply to Christ Et Al.: LQT1 and JLNS Phenotypes in HiPSC-derived Cardiomyocytes Are Due to KCNQ1 Mutations
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2015  |   Pubmed ID: 25795241
• Functional Maturation of Human Pluripotent Stem Cell Derived Cardiomyocytes in Vitro--correlation Between Contraction Force and Electrophysiology
  Biomaterials. May, 2015  |   Pubmed ID: 25771005
• Atrial-like Cardiomyocytes from Human Pluripotent Stem Cells Are a Robust Preclinical Model for Assessing Atrial-selective Pharmacology
  EMBO Molecular Medicine. Apr, 2015  |   Pubmed ID: 25700171
• Pluripotent Stem Cell Derived Cardiovascular Progenitors--a Developmental Perspective
  Developmental Biology. Apr, 2015  |   Pubmed ID: 25624264
• Lymphangiogenesis and Angiogenesis During Human Fetal Pancreas Development
  Vascular Cell. 2014  |   Pubmed ID: 25785186
• Recessive Cardiac Phenotypes in Induced Pluripotent Stem Cell Models of Jervell and Lange-Nielsen Syndrome: Disease Mechanisms and Pharmacological Rescue
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2014  |   Pubmed ID: 25453094
• A Case for Crowd Sourcing in Stem Cell Research
  Stem Cells Translational Medicine. Nov, 2014  |   Pubmed ID: 25232185
• Assessment of Functional Competence of Endothelial Cells from Human Pluripotent Stem Cells in Zebrafish Embryos
  Methods in Molecular Biology (Clifton, N.J.). 2014  |   Pubmed ID: 25173378
• Cell Replacement Therapies: is It Time to Reprogram?
  Human Gene Therapy. Oct, 2014  |   Pubmed ID: 25141889
• Serum Supplemented Culture Medium Masks Hypertrophic Phenotypes in Human Pluripotent Stem Cell Derived Cardiomyocytes
  Journal of Cellular and Molecular Medicine. Aug, 2014  |   Pubmed ID: 24981391
• SIRPA, VCAM1 and CD34 Identify Discrete Lineages During Early Human Cardiovascular Development
  Stem Cell Research. Jul, 2014  |   Pubmed ID: 24968096
• Generation, Expansion and Functional Analysis of Endothelial Cells and Pericytes Derived from Human Pluripotent Stem Cells
  Nature Protocols. 2014  |   Pubmed ID: 24874816
• Strategies for Rapidly Mapping Proviral Integration Sites and Assessing Cardiogenic Potential of Nascent Human Induced Pluripotent Stem Cell Clones
  Experimental Cell Research. Oct, 2014  |   Pubmed ID: 24836851
• Functionality of Endothelial Cells and Pericytes from Human Pluripotent Stem Cells Demonstrated in Cultured Vascular Plexus and Zebrafish Xenografts
  Arteriosclerosis, Thrombosis, and Vascular Biology. Jan, 2014  |   Pubmed ID: 24158517
• PGC-1α and Reactive Oxygen Species Regulate Human Embryonic Stem Cell-derived Cardiomyocyte Function
  Stem Cell Reports. 2013  |   Pubmed ID: 24371810
• Isogenic Human Pluripotent Stem Cell Pairs Reveal the Role of a KCNH2 Mutation in Long-QT Syndrome
  The EMBO Journal. Dec, 2013  |   Pubmed ID: 24213244
• Direct Cardiomyocyte Reprogramming: a New Direction for Cardiovascular Regenerative Medicine
  Cold Spring Harbor Perspectives in Medicine. Sep, 2013  |   Pubmed ID: 24003244
• Generation of Induced Pluripotent Stem Cells from Human Foetal Fibroblasts Using the Sleeping Beauty Transposon Gene Delivery System
  Differentiation; Research in Biological Diversity. Jul-Sep, 2013  |   Pubmed ID: 23933400
• Conversion of Mature Human β-cells into Glucagon-producing α-cells
  Diabetes. Jul, 2013  |   Pubmed ID: 23569174
• Is Heart Regeneration on the Right Track?
  Nature Medicine. Apr, 2013  |   Pubmed ID: 23558629
• Model Systems for Cardiovascular Regenerative Biology
  Cold Spring Harbor Perspectives in Medicine. Apr, 2013  |   Pubmed ID: 23545574
• Induced Pluripotent Stem Cells: the New Patient?
  Nature Reviews. Molecular Cell Biology. Nov, 2012  |   Pubmed ID: 23034453
• Cardiomyocytes Derived from Pluripotent Stem Cells Recapitulate Electrophysiological Characteristics of an Overlap Syndrome of Cardiac Sodium Channel Disease
  Circulation. Jun, 2012  |   Pubmed ID: 22647976
• Smooth Muscle Diversity from Human Pluripotent Cells
  Nature Biotechnology. Feb, 2012  |   Pubmed ID: 22318032
• New Perspectives on Regeneration of the Heart
  Circulation Research. Sep, 2011  |   Pubmed ID: 21960722
• Human Embryonic and Fetal Mesenchymal Stem Cells Differentiate Toward Three Different Cardiac Lineages in Contrast to Their Adult Counterparts
  PloS One. 2011  |   Pubmed ID: 21931658
• Shedding New Light on the Mechanism Underlying Stem Cell Therapy for the Heart
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2011  |   Pubmed ID: 21720378
• Pluripotent Stem Cell Models of Cardiac Disease and Their Implication for Drug Discovery and Development
  Trends in Molecular Medicine. Sep, 2011  |   Pubmed ID: 21703926
• Cardiomyocyte Differentiation of Pluripotent Stem Cells and Their Use As Cardiac Disease Models
  The Biochemical Journal. Feb, 2011  |   Pubmed ID: 21269276
• Challenges in Using Stem Cells for Cardiac Repair
  Science Translational Medicine. Apr, 2010  |   Pubmed ID: 20393186
• Extracellular Matrix Formation After Transplantation of Human Embryonic Stem Cell-derived Cardiomyocytes
  Cellular and Molecular Life Sciences : CMLS. Jan, 2010  |   Pubmed ID: 19844658
• Prospects for Pluripotent Stem Cell-derived Cardiomyocytes in Cardiac Cell Therapy and As Disease Models
  Journal of Cellular Biochemistry. Jul, 2009  |   Pubmed ID: 19449339
• SOST Expression is Restricted to the Great Arteries During Embryonic and Neonatal Cardiovascular Development
  Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2007  |   Pubmed ID: 17195180