Christoph Handschin Biozentrum University of Basel Biography Publications Institution JoVE Articles Christoph Handschin has not added a biography. If you are Christoph Handschin and would like to personalize this page please email our Author Liaison for assistance. Publications PGC-1α Determines Light Damage Susceptibility of the Murine Retina PloS One. 2012 | Pubmed ID: 22348062 Remodeling of Calcium Handling in Skeletal Muscle Through PGC-1α: Impact on Force, Fatigability, and Fiber Type American Journal of Physiology. Cell Physiology. Jan, 2012 | Pubmed ID: 21918181 Myopathy Caused by Mammalian Target of Rapamycin Complex 1 (mTORC1) Inactivation is Not Reversed by Restoring Mitochondrial Function Proceedings of the National Academy of Sciences of the United States of America. Dec, 2011 | Pubmed ID: 22143799 Coordinated Balancing of Muscle Oxidative Metabolism Through PGC-1α Increases Metabolic Flexibility and Preserves Insulin Sensitivity Biochemical and Biophysical Research Communications. Apr, 2011 | Pubmed ID: 21501593 PGC-1 Coactivators and the Regulation of Skeletal Muscle Fiber-type Determination Cell Metabolism. Apr, 2011 | Pubmed ID: 21459315 PGC-1α and Myokines in the Aging Muscle - a Mini-review Gerontology. 2011 | Pubmed ID: 20134150 ApoE-/- PGC-1α-/- Mice Display Reduced IL-18 Levels and Do Not Develop Enhanced Atherosclerosis PloS One. 2010 | Pubmed ID: 21042583 Peroxisome Proliferator-activated Receptor {gamma} Coactivator 1{alpha} (PGC-1{alpha}) Promotes Skeletal Muscle Lipid Refueling in Vivo by Activating De Novo Lipogenesis and the Pentose Phosphate Pathway The Journal of Biological Chemistry. Oct, 2010 | Pubmed ID: 20716531 SIRT1 Reduces Endothelial Activation Without Affecting Vascular Function in ApoE-/- Mice Aging. Jun, 2010 | Pubmed ID: 20606253 Electric Pulse Stimulation of Cultured Murine Muscle Cells Reproduces Gene Expression Changes of Trained Mouse Muscle PloS One. 2010 | Pubmed ID: 20532042 Regulation of Skeletal Muscle Cell Plasticity by the Peroxisome Proliferator-activated Receptor γ Coactivator 1α Journal of Receptor and Signal Transduction Research. Dec, 2010 | Pubmed ID: 20178454 For a Pragmatic Approach to Exercise Studies Journal of Applied Physiology (Bethesda, Md. : 1985). Jan, 2010 | Pubmed ID: 20066760 Peroxisome Proliferator-activated Receptor-gamma Coactivator-1alpha in Muscle Links Metabolism to Inflammation Clinical and Experimental Pharmacology & Physiology. Dec, 2009 | Pubmed ID: 19671064 The Biology of PGC-1α and Its Therapeutic Potential Trends in Pharmacological Sciences. Jun, 2009 | Pubmed ID: 19446346 A High-mobility, Low-cost Phenotype Defines Human Effector-memory CD8+ T Cells Blood. Jan, 2009 | Pubmed ID: 18845792 Paradoxical Effects of Increased Expression of PGC-1alpha on Muscle Mitochondrial Function and Insulin-stimulated Muscle Glucose Metabolism Proceedings of the National Academy of Sciences of the United States of America. Dec, 2008 | Pubmed ID: 19066218 The Role of Exercise and PGC1alpha in Inflammation and Chronic Disease Nature. Jul, 2008 | Pubmed ID: 18650917 Abnormal Glucose Homeostasis in Skeletal Muscle-specific PGC-1alpha Knockout Mice Reveals Skeletal Muscle-pancreatic Beta Cell Crosstalk The Journal of Clinical Investigation. Nov, 2007 | Pubmed ID: 17932564 Skeletal Muscle Fiber-type Switching, Exercise Intolerance, and Myopathy in PGC-1alpha Muscle-specific Knock-out Animals The Journal of Biological Chemistry. Oct, 2007 | Pubmed ID: 17702743 AMP-activated Protein Kinase (AMPK) Action in Skeletal Muscle Via Direct Phosphorylation of PGC-1alpha Proceedings of the National Academy of Sciences of the United States of America. Jul, 2007 | Pubmed ID: 17609368 A Fundamental System of Cellular Energy Homeostasis Regulated by PGC-1alpha Proceedings of the National Academy of Sciences of the United States of America. May, 2007 | Pubmed ID: 17470778 PGC-1alpha Regulates the Neuromuscular Junction Program and Ameliorates Duchenne Muscular Dystrophy Genes & Development. Apr, 2007 | Pubmed ID: 17403779 RANTES (regulated on Activation, Normal T Cell Expressed and Secreted), Inflammation, Obesity, and the Metabolic Syndrome Circulation. Feb, 2007 | Pubmed ID: 17325252 Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators Cell. Oct, 2006 | Pubmed ID: 17055439 PGC-1alpha Protects Skeletal Muscle from Atrophy by Suppressing FoxO3 Action and Atrophy-specific Gene Transcription Proceedings of the National Academy of Sciences of the United States of America. Oct, 2006 | Pubmed ID: 17053067 Transducer of Regulated CREB-binding Proteins (TORCs) Induce PGC-1alpha Transcription and Mitochondrial Biogenesis in Muscle Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006 | Pubmed ID: 16980408 Partnership of PGC-1alpha and HNF4alpha in the Regulation of Lipoprotein Metabolism The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16574644 Nutritional Regulation of Hepatic Heme Biosynthesis and Porphyria Through PGC-1alpha Cell. Aug, 2005 | Pubmed ID: 16122419 Metabolic Control Through the PGC-1 Family of Transcription Coactivators Cell Metabolism. Jun, 2005 | Pubmed ID: 16054085 Transcriptional Coactivator PGC-1 Alpha Controls the Energy State and Contractile Function of Cardiac Muscle Cell Metabolism. Apr, 2005 | Pubmed ID: 16054070 LXR Deficiency and Cholesterol Feeding Affect the Expression and Phenobarbital-mediated Induction of Cytochromes P450 in Mouse Liver Journal of Lipid Research. Aug, 2005 | Pubmed ID: 15930522 Hyperlipidemic Effects of Dietary Saturated Fats Mediated Through PGC-1beta Coactivation of SREBP Cell. Jan, 2005 | Pubmed ID: 15680331 Species-specific Mechanisms for Cholesterol 7alpha-hydroxylase (CYP7A1) Regulation by Drugs and Bile Acids Archives of Biochemistry and Biophysics. Feb, 2005 | Pubmed ID: 15629111 Regulatory Network of Lipid-sensing Nuclear Receptors: Roles for CAR, PXR, LXR, and FXR Archives of Biochemistry and Biophysics. Jan, 2005 | Pubmed ID: 15581595 The Evolution of Drug-activated Nuclear Receptors: One Ancestral Gene Diverged into Two Xenosensor Genes in Mammals Nuclear Receptor. 10, 2004 | Pubmed ID: 15479477 Identification of the Xenosensors Regulating Human 5-aminolevulinate Synthase Proceedings of the National Academy of Sciences of the United States of America. Jun, 2004 | Pubmed ID: 15178759 Erralpha and Gabpa/b Specify PGC-1alpha-dependent Oxidative Phosphorylation Gene Expression That is Altered in Diabetic Muscle Proceedings of the National Academy of Sciences of the United States of America. Apr, 2004 | Pubmed ID: 15100410 Suppression of Mitochondrial Respiration Through Recruitment of P160 Myb Binding Protein to PGC-1alpha: Modulation by P38 MAPK Genes & Development. Feb, 2004 | Pubmed ID: 14744933 In Silico Approaches, and in Vitro and in Vivo Experiments to Predict Induction of Drug Metabolism Drug News & Perspectives. Sep, 2003 | Pubmed ID: 14668938 Induction of Drug Metabolism: the Role of Nuclear Receptors Pharmacological Reviews. Dec, 2003 | Pubmed ID: 14657421 An Autoregulatory Loop Controls Peroxisome Proliferator-activated Receptor Gamma Coactivator 1alpha Expression in Muscle Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12764228 Cholesterol and Bile Acids Regulate Xenosensor Signaling in Drug-mediated Induction of Cytochromes P450 The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12045201 NUBIScan, an in Silico Approach for Prediction of Nuclear Receptor Response Elements Molecular Endocrinology (Baltimore, Md.). Jun, 2002 | Pubmed ID: 12040014 A Link Between Cholesterol Levels and Phenobarbital Induction of Cytochromes P450 Biochemical and Biophysical Research Communications. Feb, 2002 | Pubmed ID: 11846416 En funktionel Motor enhed i Kultur Dish: Co-kultur for Rygmarvsskader eksplantater og muskelceller Anne-Sophie Arnold1, Martine Christe1, Christoph Handschin1 1Biozentrum, University of Basel JoVE 3616 Neuroscience
En funktionel Motor enhed i Kultur Dish: Co-kultur for Rygmarvsskader eksplantater og muskelceller Anne-Sophie Arnold1, Martine Christe1, Christoph Handschin1 1Biozentrum, University of Basel JoVE 3616 Neuroscience