Christoph Korbmacher Institut für Zelluläre und Molekulare Physiologie Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) Biography Publications Institution JoVE Articles Christoph Korbmacher has not added a biography. If you are Christoph Korbmacher and would like to personalize this page please email our Author Liaison for assistance. Publications Sensitisation of TRPV4 by PAR2 is Independent of Intracellular Calcium Signalling and Can Be Mediated by the Biased Agonist Neutrophil Elastase Pflugers Archiv : European Journal of Physiology. Jun, 2014 | Pubmed ID: 24906497 Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites The Journal of Biological Chemistry. May, 2014 | Pubmed ID: 24841206 Pharmacological and Electrophysiological Characterization of the Human Bile Acid-sensitive Ion Channel (hBASIC) Pflügers Archiv : European Journal of Physiology. Feb, 2014 | Pubmed ID: 23842738 The Bile Acid Receptor TGR5 Does Not Interact with β-arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts The Journal of Biological Chemistry. Aug, 2013 | Pubmed ID: 23818521 Characterization of the Mouse ClC-K1/Barttin Chloride Channel Biochimica Et Biophysica Acta. Nov, 2013 | Pubmed ID: 23791703 A Mutation in the β-subunit of ENaC Identified in a Patient with Cystic Fibrosis-like Symptoms Has a Gain-of-function Effect American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2013 | Pubmed ID: 23087020 Plasmin and Chymotrypsin Have Distinct Preferences for Channel Activating Cleavage Sites in the γ Subunit of the Human Epithelial Sodium Channel The Journal of General Physiology. Oct, 2012 | Pubmed ID: 22966015 Aldosterone-dependent and -independent Regulation of the Epithelial Sodium Channel (ENaC) in Mouse Distal Nephron American Journal of Physiology. Renal Physiology. Nov, 2012 | Pubmed ID: 22933298 Proteolytic Activation of the Epithelial Sodium Channel (ENaC) by the Cysteine Protease Cathepsin-S Pflügers Archiv : European Journal of Physiology. Oct, 2012 | Pubmed ID: 22864553 An Inhibitory Peptide Derived from the α-subunit of the Epithelial Sodium Channel (ENaC) Shows a Helical Conformation Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2012 | Pubmed ID: 22613977 Four Subunits (αβγδ) of the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various Locations Investigative Ophthalmology & Visual Science. Feb, 2012 | Pubmed ID: 22167092 Atomic Force Microscopy Reveals the Architecture of the Epithelial Sodium Channel (ENaC) The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21775436 Protein Kinase B Alpha (PKBα) Stimulates the Epithelial Sodium Channel (ENaC) Heterologously Expressed in Xenopus Laevis Oocytes by Two Distinct Mechanisms Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2010 | Pubmed ID: 21220922 A Mutation of the Epithelial Sodium Channel Associated with Atypical Cystic Fibrosis Increases Channel Open Probability and Reduces Na+ Self Inhibition The Journal of Physiology. Apr, 2010 | Pubmed ID: 20194130 Functional Characterization of a Partial Loss-of-function Mutation of the Epithelial Sodium Channel (ENaC) Associated with Atypical Cystic Fibrosis Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2010 | Pubmed ID: 20054153 Proteolytic Activation of the Epithelial Sodium Channel (ENaC) in Health and Disease The Journal of Medical Investigation : JMI. 2009 | Pubmed ID: 20224211 Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1 Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2009 | Pubmed ID: 19910701 The Delta-subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19717556 Mutations in the Amiloride-sensitive Epithelial Sodium Channel in Patients with Cystic Fibrosis-like Disease Human Mutation. Jul, 2009 | Pubmed ID: 19462466 HIF-prolyl Hydroxylases in the Rat Kidney: Physiologic Expression Patterns and Regulation in Acute Kidney Injury The American Journal of Pathology. May, 2009 | Pubmed ID: 19349364 Regulated Sodium Transport in the Renal Connecting Tubule (CNT) Via the Epithelial Sodium Channel (ENaC) Pflügers Archiv : European Journal of Physiology. May, 2009 | Pubmed ID: 19277701 Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel Journal of the American Society of Nephrology : JASN. Feb, 2009 | Pubmed ID: 19073825 Cleavage in the {gamma}-subunit of the Epithelial Sodium Channel (ENaC) Plays an Important Role in the Proteolytic Activation of Near-silent Channels The Journal of Physiology. Oct, 2008 | Pubmed ID: 18669538 Trypsin Can Activate the Epithelial Sodium Channel (ENaC) in Microdissected Mouse Distal Nephron American Journal of Physiology. Renal Physiology. Oct, 2008 | Pubmed ID: 18653483 Aldosterone Responsiveness of the Epithelial Sodium Channel (ENaC) in Colon is Increased in a Mouse Model for Liddle's Syndrome The Journal of Physiology. Jan, 2008 | Pubmed ID: 18006588 (NDRG2) Stimulates Amiloride-sensitive Na+ Currents in Xenopus Laevis Oocytes and Fisher Rat Thyroid Cells The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17652085 Functional Characterization of a Novel CFTR Mutation P67S Identified in a Patient with Atypical Cystic Fibrosis Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2007 | Pubmed ID: 17495464 Stimulation of the Epithelial Sodium Channel (ENaC) by CAMP Involves Putative ERK Phosphorylation Sites in the C Termini of the Channel's Beta- and Gamma-subunit The Journal of Biological Chemistry. Apr, 2006 | Pubmed ID: 16476738 Stimulation of the Epithelial Sodium Channel (ENaC) by the Serum- and Glucocorticoid-inducible Kinase (Sgk) Involves the PY Motifs of the Channel but is Independent of Sodium Feedback Inhibition Pflügers Archiv : European Journal of Physiology. Jun, 2006 | Pubmed ID: 16416336 A Novel Pathway of Epithelial Sodium Channel Activation Involves a Serum- and Glucocorticoid-inducible Kinase Consensus Motif in the C Terminus of the Channel's Alpha-subunit The Journal of Biological Chemistry. Sep, 2004 | Pubmed ID: 15234985 PGE2 Stimulates Cl- Secretion in Murine M-1 Cortical Collecting Duct Cells in an Autocrine Manner Pflügers Archiv : European Journal of Physiology. Jul, 2004 | Pubmed ID: 15127302 Additional Disruption of the ClC-2 Cl(-) Channel Does Not Exacerbate the Cystic Fibrosis Phenotype of Cystic Fibrosis Transmembrane Conductance Regulator Mouse Models The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 15007059 Extracellular Na+ Removal Attenuates Rundown of the Epithelial Na+-channel (ENaC) by Reducing the Rate of Channel Retrieval Pflügers Archiv : European Journal of Physiology. Mar, 2004 | Pubmed ID: 14704795 CAMP-dependent Activation of CFTR Inhibits the Epithelial Sodium Channel (ENaC) Without Affecting Its Surface Expression Pflügers Archiv : European Journal of Physiology. Jan, 2003 | Pubmed ID: 12548398 The Gamma-subunit of ENaC is More Important for Channel Surface Expression Than the Beta-subunit American Journal of Physiology. Cell Physiology. Feb, 2003 | Pubmed ID: 12529252 Identification of Domains That Control the Heteromeric Assembly of Kir5.1/Kir4.0 Potassium Channels American Journal of Physiology. Cell Physiology. Apr, 2003 | Pubmed ID: 12456399 The Role of Individual Nedd4-2 (KIAA0439) WW Domains in Binding and Regulating Epithelial Sodium Channels FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2003 | Pubmed ID: 12424229 Basolateral Adrenoceptor Activation Mediates Noradrenaline-induced Cl- Secretion in M-1 Mouse Cortical Collecting Duct Cells Pflügers Archiv : European Journal of Physiology. Dec, 2002 | Pubmed ID: 12466941 The Serum and Glucocorticoid-inducible Kinase SGK1 and the Na+/H+ Exchange Regulating Factor NHERF2 Synergize to Stimulate the Renal Outer Medullary K+ Channel ROMK1 Journal of the American Society of Nephrology : JASN. Dec, 2002 | Pubmed ID: 12444200 Regulation of the Epithelial Sodium Channel by N4WBP5A, a Novel Nedd4/Nedd4-2-interacting Protein The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12050153 Cystic Fibrosis Transmembrane Conductance Regulator-dependent Up-regulation of Kir1.1 (ROMK) Renal K+ Channels by the Epithelial Sodium Channel The Journal of Biological Chemistry. Jul, 2002 | Pubmed ID: 11994290 Intrinsic Sensitivity of Kir1.1 (ROMK) to Glibenclamide in the Absence of SUR2B. Implications for the Identity of the Renal ATP-regulated Secretory K+ Channel The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11927600 Basolateral PAR-2 Receptors Mediate KCl Secretion and Inhibition of Na+ Absorption in the Mouse Distal Colon The Journal of Physiology. Feb, 2002 | Pubmed ID: 11850514 مظاهرة من بروتين تفعيل قناة الصوديوم الظهارية (عناق) من خلال الجمع بين المقاييس الحالية مع الكشف عن الشق شظايا Matteus Krappitz1, Christoph Korbmacher1, Silke Haerteis1 1Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) JoVE 51582 Biology
مظاهرة من بروتين تفعيل قناة الصوديوم الظهارية (عناق) من خلال الجمع بين المقاييس الحالية مع الكشف عن الشق شظايا Matteus Krappitz1, Christoph Korbmacher1, Silke Haerteis1 1Institut für Zelluläre und Molekulare Physiologie, Friedrich-Alexander-Universität Erlangen-Nürnberg (FAU) JoVE 51582 Biology