Christoph Korbmacher

Publications

• Sensitisation of TRPV4 by PAR2 is Independent of Intracellular Calcium Signalling and Can Be Mediated by the Biased Agonist Neutrophil Elastase
  Pflugers Archiv : European Journal of Physiology. Jun, 2014  |   Pubmed ID: 24906497
• Proteolytic Activation of the Human Epithelial Sodium Channel by Trypsin IV and Trypsin I Involves Distinct Cleavage Sites
  The Journal of Biological Chemistry. May, 2014  |   Pubmed ID: 24841206
• Pharmacological and Electrophysiological Characterization of the Human Bile Acid-sensitive Ion Channel (hBASIC)
  Pflügers Archiv : European Journal of Physiology. Feb, 2014  |   Pubmed ID: 23842738
• The Bile Acid Receptor TGR5 Does Not Interact with β-arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts
  The Journal of Biological Chemistry. Aug, 2013  |   Pubmed ID: 23818521
• Characterization of the Mouse ClC-K1/Barttin Chloride Channel
  Biochimica Et Biophysica Acta. Nov, 2013  |   Pubmed ID: 23791703
• A Mutation in the β-subunit of ENaC Identified in a Patient with Cystic Fibrosis-like Symptoms Has a Gain-of-function Effect
  American Journal of Physiology. Lung Cellular and Molecular Physiology. Jan, 2013  |   Pubmed ID: 23087020
• Plasmin and Chymotrypsin Have Distinct Preferences for Channel Activating Cleavage Sites in the γ Subunit of the Human Epithelial Sodium Channel
  The Journal of General Physiology. Oct, 2012  |   Pubmed ID: 22966015
• Aldosterone-dependent and -independent Regulation of the Epithelial Sodium Channel (ENaC) in Mouse Distal Nephron
  American Journal of Physiology. Renal Physiology. Nov, 2012  |   Pubmed ID: 22933298
• Proteolytic Activation of the Epithelial Sodium Channel (ENaC) by the Cysteine Protease Cathepsin-S
  Pflügers Archiv : European Journal of Physiology. Oct, 2012  |   Pubmed ID: 22864553
• An Inhibitory Peptide Derived from the α-subunit of the Epithelial Sodium Channel (ENaC) Shows a Helical Conformation
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2012  |   Pubmed ID: 22613977
• Four Subunits (αβγδ) of the Epithelial Sodium Channel (ENaC) Are Expressed in the Human Eye in Various Locations
  Investigative Ophthalmology & Visual Science. Feb, 2012  |   Pubmed ID: 22167092
• Atomic Force Microscopy Reveals the Architecture of the Epithelial Sodium Channel (ENaC)
  The Journal of Biological Chemistry. Sep, 2011  |   Pubmed ID: 21775436
• Protein Kinase B Alpha (PKBα) Stimulates the Epithelial Sodium Channel (ENaC) Heterologously Expressed in Xenopus Laevis Oocytes by Two Distinct Mechanisms
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2010  |   Pubmed ID: 21220922
• A Mutation of the Epithelial Sodium Channel Associated with Atypical Cystic Fibrosis Increases Channel Open Probability and Reduces Na+ Self Inhibition
  The Journal of Physiology. Apr, 2010  |   Pubmed ID: 20194130
• Functional Characterization of a Partial Loss-of-function Mutation of the Epithelial Sodium Channel (ENaC) Associated with Atypical Cystic Fibrosis
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2010  |   Pubmed ID: 20054153
• Proteolytic Activation of the Epithelial Sodium Channel (ENaC) in Health and Disease
  The Journal of Medical Investigation : JMI. 2009  |   Pubmed ID: 20224211
• Cholesterol Depletion of the Plasma Membrane Prevents Activation of the Epithelial Sodium Channel (ENaC) by SGK1
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2009  |   Pubmed ID: 19910701
• The Delta-subunit of the Epithelial Sodium Channel (ENaC) Enhances Channel Activity and Alters Proteolytic ENaC Activation
  The Journal of Biological Chemistry. Oct, 2009  |   Pubmed ID: 19717556
• Mutations in the Amiloride-sensitive Epithelial Sodium Channel in Patients with Cystic Fibrosis-like Disease
  Human Mutation. Jul, 2009  |   Pubmed ID: 19462466
• HIF-prolyl Hydroxylases in the Rat Kidney: Physiologic Expression Patterns and Regulation in Acute Kidney Injury
  The American Journal of Pathology. May, 2009  |   Pubmed ID: 19349364
• Regulated Sodium Transport in the Renal Connecting Tubule (CNT) Via the Epithelial Sodium Channel (ENaC)
  Pflügers Archiv : European Journal of Physiology. May, 2009  |   Pubmed ID: 19277701
• Plasmin in Nephrotic Urine Activates the Epithelial Sodium Channel
  Journal of the American Society of Nephrology : JASN. Feb, 2009  |   Pubmed ID: 19073825
• Cleavage in the {gamma}-subunit of the Epithelial Sodium Channel (ENaC) Plays an Important Role in the Proteolytic Activation of Near-silent Channels
  The Journal of Physiology. Oct, 2008  |   Pubmed ID: 18669538
• Trypsin Can Activate the Epithelial Sodium Channel (ENaC) in Microdissected Mouse Distal Nephron
  American Journal of Physiology. Renal Physiology. Oct, 2008  |   Pubmed ID: 18653483
• Aldosterone Responsiveness of the Epithelial Sodium Channel (ENaC) in Colon is Increased in a Mouse Model for Liddle's Syndrome
  The Journal of Physiology. Jan, 2008  |   Pubmed ID: 18006588
• (NDRG2) Stimulates Amiloride-sensitive Na+ Currents in Xenopus Laevis Oocytes and Fisher Rat Thyroid Cells
  The Journal of Biological Chemistry. Sep, 2007  |   Pubmed ID: 17652085
• Functional Characterization of a Novel CFTR Mutation P67S Identified in a Patient with Atypical Cystic Fibrosis
  Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology. 2007  |   Pubmed ID: 17495464
• Stimulation of the Epithelial Sodium Channel (ENaC) by CAMP Involves Putative ERK Phosphorylation Sites in the C Termini of the Channel's Beta- and Gamma-subunit
  The Journal of Biological Chemistry. Apr, 2006  |   Pubmed ID: 16476738
• Stimulation of the Epithelial Sodium Channel (ENaC) by the Serum- and Glucocorticoid-inducible Kinase (Sgk) Involves the PY Motifs of the Channel but is Independent of Sodium Feedback Inhibition
  Pflügers Archiv : European Journal of Physiology. Jun, 2006  |   Pubmed ID: 16416336
• A Novel Pathway of Epithelial Sodium Channel Activation Involves a Serum- and Glucocorticoid-inducible Kinase Consensus Motif in the C Terminus of the Channel's Alpha-subunit
  The Journal of Biological Chemistry. Sep, 2004  |   Pubmed ID: 15234985
• PGE2 Stimulates Cl- Secretion in Murine M-1 Cortical Collecting Duct Cells in an Autocrine Manner
  Pflügers Archiv : European Journal of Physiology. Jul, 2004  |   Pubmed ID: 15127302
• Additional Disruption of the ClC-2 Cl(-) Channel Does Not Exacerbate the Cystic Fibrosis Phenotype of Cystic Fibrosis Transmembrane Conductance Regulator Mouse Models
  The Journal of Biological Chemistry. May, 2004  |   Pubmed ID: 15007059
• Extracellular Na+ Removal Attenuates Rundown of the Epithelial Na+-channel (ENaC) by Reducing the Rate of Channel Retrieval
  Pflügers Archiv : European Journal of Physiology. Mar, 2004  |   Pubmed ID: 14704795
• CAMP-dependent Activation of CFTR Inhibits the Epithelial Sodium Channel (ENaC) Without Affecting Its Surface Expression
  Pflügers Archiv : European Journal of Physiology. Jan, 2003  |   Pubmed ID: 12548398
• The Gamma-subunit of ENaC is More Important for Channel Surface Expression Than the Beta-subunit
  American Journal of Physiology. Cell Physiology. Feb, 2003  |   Pubmed ID: 12529252
• Identification of Domains That Control the Heteromeric Assembly of Kir5.1/Kir4.0 Potassium Channels
  American Journal of Physiology. Cell Physiology. Apr, 2003  |   Pubmed ID: 12456399
• The Role of Individual Nedd4-2 (KIAA0439) WW Domains in Binding and Regulating Epithelial Sodium Channels
  FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jan, 2003  |   Pubmed ID: 12424229
• Basolateral Adrenoceptor Activation Mediates Noradrenaline-induced Cl- Secretion in M-1 Mouse Cortical Collecting Duct Cells
  Pflügers Archiv : European Journal of Physiology. Dec, 2002  |   Pubmed ID: 12466941
• The Serum and Glucocorticoid-inducible Kinase SGK1 and the Na+/H+ Exchange Regulating Factor NHERF2 Synergize to Stimulate the Renal Outer Medullary K+ Channel ROMK1
  Journal of the American Society of Nephrology : JASN. Dec, 2002  |   Pubmed ID: 12444200
• Regulation of the Epithelial Sodium Channel by N4WBP5A, a Novel Nedd4/Nedd4-2-interacting Protein
  The Journal of Biological Chemistry. Aug, 2002  |   Pubmed ID: 12050153
• Cystic Fibrosis Transmembrane Conductance Regulator-dependent Up-regulation of Kir1.1 (ROMK) Renal K+ Channels by the Epithelial Sodium Channel
  The Journal of Biological Chemistry. Jul, 2002  |   Pubmed ID: 11994290
• Intrinsic Sensitivity of Kir1.1 (ROMK) to Glibenclamide in the Absence of SUR2B. Implications for the Identity of the Renal ATP-regulated Secretory K+ Channel
  The Journal of Biological Chemistry. Jun, 2002  |   Pubmed ID: 11927600
• Basolateral PAR-2 Receptors Mediate KCl Secretion and Inhibition of Na+ Absorption in the Mouse Distal Colon
  The Journal of Physiology. Feb, 2002  |   Pubmed ID: 11850514