Christoph Winkler Department of Biological Sciences National University of Singapore Biography Publications Institution JoVE Articles Christoph Winkler has not added a biography. If you are Christoph Winkler and would like to personalize this page please email our Author Liaison for assistance. Publications A Vertebrate Specific and Essential Role for Sp7/osterix in Osteogenesis Revealed by Gene Knock-out in the Teleost Medaka Development (Cambridge, England). Dec, 2016 | Pubmed ID: 27993982 Transcriptional Enhancement of Smn Levels in Motoneurons is Crucial for Proper Axon Morphology in Zebrafish Scientific Reports. Jun, 2016 | Pubmed ID: 27273160 Trametes Versicolor Carboxylate Reductase Uncovered Monatshefte Fur Chemie. 2016 | Pubmed ID: 27069283 Live Imaging of Osteoclast Inhibition by Bisphosphonates in a Medaka Osteoporosis Model Disease Models & Mechanisms. Feb, 2016 | Pubmed ID: 26704995 An Adult Osteopetrosis Model in Medaka Reveals the Importance of Osteoclast Function for Bone Remodeling in Teleost Fish Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP. Dec, 2015 | Pubmed ID: 26334373 The Wnt Co-Receptor Lrp5 Is Required for Cranial Neural Crest Cell Migration in Zebrafish PloS One. 2015 | Pubmed ID: 26121341 The Flatness of Lamellipodia Explained by the Interaction Between Actin Dynamics and Membrane Deformation Journal of Theoretical Biology. Sep, 2015 | Pubmed ID: 26002996 A Multifunctional Mutagenesis System for Analysis of Gene Function in Zebrafish G3 (Bethesda, Md.). Apr, 2015 | Pubmed ID: 25840430 Effect of Rubber Flooring on Dairy Cattle Stepping Behavior and Muscle Activity Journal of Dairy Science. Apr, 2015 | Pubmed ID: 25648801 Dmrt5 Controls Corticotrope and Gonadotrope Differentiation in the Zebrafish Pituitary Molecular Endocrinology (Baltimore, Md.). Feb, 2015 | Pubmed ID: 25489906 Nitrile As Activating Group in the Asymmetric Bioreduction of β-Cyanoacrylic Acids Catalyzed by Ene-Reductases Advanced Synthesis & Catalysis. May, 2014 | Pubmed ID: 26190962 Identification of a PRPF4 Loss-of-function Variant That Abrogates U4/U6.U5 Tri-snRNP Integration and is Associated with Retinitis Pigmentosa PloS One. 2014 | Pubmed ID: 25383878 Identification of Promiscuous Ene-reductase Activity by Mining Structural Databases Using Active Site Constellations Nature Communications. Jun, 2014 | Pubmed ID: 24954722 Bioreduction and Disproportionation of Cyclohex-2-enone Catalyzed by Ene-reductase OYE-1 in 'micro-aqueous' Organic Solvents Biotechnology Letters. Jun, 2014 | Pubmed ID: 24563324 Electron Tomography and Simulation of Baculovirus Actin Comet Tails Support a Tethered Filament Model of Pathogen Propulsion PLoS Biology. Jan, 2014 | Pubmed ID: 24453943 Osterix/Sp7 Regulates Biomineralization of Otoliths and Bone in Medaka (Oryzias Latipes) Matrix Biology : Journal of the International Society for Matrix Biology. Feb, 2014 | Pubmed ID: 24407212 NAD(P)H-independent Asymmetric C=C Bond Reduction Catalyzed by Ene Reductases by Using Artificial Co-substrates As the Hydrogen Donor Chemistry (Weinheim an Der Bergstrasse, Germany). Jan, 2014 | Pubmed ID: 24382795 SMN Deficiency Alters Nrxn2 Expression and Splicing in Zebrafish and Mouse Models of Spinal Muscular Atrophy Human Molecular Genetics. Apr, 2014 | Pubmed ID: 24218366 Arp2/3 Complex is Essential for Actin Network Treadmilling As Well As for Targeting of Capping Protein and Cofilin Molecular Biology of the Cell. Sep, 2013 | Pubmed ID: 23885122 Overcoming Co-product Inhibition in the Nicotinamide Independent Asymmetric Bioreduction of Activated C=C-bonds Using Flavin-dependent Ene-reductases Biotechnology and Bioengineering. Dec, 2013 | Pubmed ID: 23794404 A Col10a1:nlGFP Transgenic Line Displays Putative Osteoblast Precursors at the Medaka Notochordal Sheath Prior to Mineralization Developmental Biology. Sep, 2013 | Pubmed ID: 23769979 Two Isoforms of Sister-Of-Mammalian Grainyhead Have Opposing Functions in Endothelial Cells and in Vivo Arteriosclerosis, Thrombosis, and Vascular Biology. Jul, 2013 | Pubmed ID: 23685552 Anaplastic Lymphoma Kinase is Required for Neurogenesis in the Developing Central Nervous System of Zebrafish PloS One. 2013 | Pubmed ID: 23667670 Zebrafish Hoxd4a Acts Upstream of Meis1.1 to Direct Vasculogenesis, Angiogenesis and Hematopoiesis PloS One. 2013 | Pubmed ID: 23554940 全长中期因子的结构与功能分析揭示出新型残留的肝素结合和斑马鱼胚胎发生重要。 The Biochemical Journal. Feb, 2013 | Pubmed ID: 23418741 Chemoenzymatic Asymmetric Synthesis of Pregabalin Precursors Via Asymmetric Bioreduction of β-cyanoacrylate Esters Using Ene-reductases The Journal of Organic Chemistry. Feb, 2013 | Pubmed ID: 23316696 Dynamic Microtubules at the Vegetal Cortex Predict the Embryonic Axis in Zebrafish Development (Cambridge, England). Oct, 2012 | Pubmed ID: 22949618 The 1D4 Antibody Labels Outer Segments of Long Double Cone but Not Rod Photoreceptors in Zebrafish Investigative Ophthalmology & Visual Science. Jul, 2012 | Pubmed ID: 22743318 A Substrate-driven Approach to Determine Reactivities of α,β-unsaturated Carboxylic Esters Towards Asymmetric Bioreduction Chemistry (Weinheim an Der Bergstrasse, Germany). Aug, 2012 | Pubmed ID: 22736443 Asymmetric Bioreduction of Activated Alkenes to Industrially Relevant Optically Active Compounds Journal of Biotechnology. Dec, 2012 | Pubmed ID: 22498437 Actin Branching in the Initiation and Maintenance of Lamellipodia Journal of Cell Science. Jun, 2012 | Pubmed ID: 22431015 Actin Filament Tracking in Electron Tomograms of Negatively Stained Lamellipodia Using the Localized Radon Transform Journal of Structural Biology. Apr, 2012 | Pubmed ID: 22387240 Conditional Ablation of Osteoblasts in Medaka Developmental Biology. Apr, 2012 | Pubmed ID: 22326228 The Popeye Domain Containing 2 (popdc2) Gene in Zebrafish is Required for Heart and Skeletal Muscle Development Developmental Biology. Mar, 2012 | Pubmed ID: 22290329 Rankl-induced Osteoclastogenesis Leads to Loss of Mineralization in a Medaka Osteoporosis Model Development (Cambridge, England). Jan, 2012 | Pubmed ID: 22096076 Mutant Prpf31 Causes Pre-mRNA Splicing Defects and Rod Photoreceptor Cell Degeneration in a Zebrafish Model for Retinitis Pigmentosa Molecular Neurodegeneration. Jul, 2011 | Pubmed ID: 21801444 Asymmetric Bioreduction of Alkenes Using Ene-reductases YersER and KYE1 and Effects of Organic Solvents Organic Letters. May, 2011 | Pubmed ID: 21510626 Combined in Vivo Imaging and Omics Approaches Reveal Metabolism of Icaritin and Its Glycosides in Zebrafish Larvae Molecular BioSystems. Jul, 2011 | Pubmed ID: 21445457 Systemic Splicing Factor Deficiency Causes Tissue-specific Defects: a Zebrafish Model for Retinitis Pigmentosa Human Molecular Genetics. Jan, 2011 | Pubmed ID: 21051334 Bioreduction of Alpha-methylcinnamaldehyde Derivatives: Chemo-enzymatic Asymmetric Synthesis of Lilial and Helional Dalton Transactions (Cambridge, England : 2003). Sep, 2010 | Pubmed ID: 20461254 Tgfbeta3 Regulation of Chondrogenesis and Osteogenesis in Zebrafish is Mediated Through Formation and Survival of a Subpopulation of the Cranial Neural Crest Mechanisms of Development. Jul-Aug, 2010 | Pubmed ID: 20406684 Accessibility of Host Cell Lineages to Medaka Stem Cells Depends on Genetic Background and Irradiation of Recipient Embryos Cellular and Molecular Life Sciences : CMLS. Apr, 2010 | Pubmed ID: 20238480 异构核核糖核蛋白-R 是脊髓运动神经元轴突 β-肌动蛋白 MRNA 易位的必要条件。 Human Molecular Genetics. May, 2010 | Pubmed ID: 20167579 Phylogenetic and Evolutionary Relationships and Developmental Expression Patterns of the Zebrafish Twist Gene Family Development Genes and Evolution. Jun, 2009 | Pubmed ID: 19565261 Osterix-mCherry Transgenic Medaka for in Vivo Imaging of Bone Formation Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jan, 2009 | Pubmed ID: 19097055 Genetic Analysis of Somite Formation in Laboratory Fish Models Advances in Experimental Medicine and Biology. 2008 | Pubmed ID: 21038770 Retinoic Acid and Cyp26b1 Are Critical Regulators of Osteogenesis in the Axial Skeleton Development (Cambridge, England). Nov, 2008 | Pubmed ID: 18927155 An Asymmetric Distribution of Positrons in the Galactic Disk Revealed by Gamma-rays Nature. Jan, 2008 | Pubmed ID: 18185581 Midkine-b Regulates Cell Specification at the Neural Plate Border in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Jan, 2008 | Pubmed ID: 18058915 Influence of Verapamil on Tachycardia-induced Alterations of PP1 and PP2A in Rabbit Atrium Experimental and Clinical Cardiology. 2007 | Pubmed ID: 18651001 Effect of Verapamil on Tachycardia-induced Early Cellular Electrical Remodeling in Rabbit Atrium Naunyn-Schmiedeberg's Archives of Pharmacology. Dec, 2007 | Pubmed ID: 17874072 Inhibition of Primordial Germ Cell Proliferation by the Medaka Male Determining Gene Dmrt I BY BMC Developmental Biology. Aug, 2007 | Pubmed ID: 17760954 Pituitary-interrenal Interaction in Zebrafish Interrenal Organ Development Molecular Endocrinology (Baltimore, Md.). Feb, 2007 | Pubmed ID: 17082325 Discontinuous Organization and Specification of the Lateral Floor Plate in Zebrafish Developmental Biology. Jan, 2007 | Pubmed ID: 17045256 Tissue-specific Expression of Dmrt Genes in Embryos and Adults of the Platyfish Xiphophorus Maculatus Zebrafish. 2006 | Pubmed ID: 18377213 Structural and Functional Characterization of the Zebrafish Lamin B Receptor European Journal of Cell Biology. Aug, 2006 | Pubmed ID: 16759737 Dynamic Expression of Sparc Precedes Formation of Skeletal Elements in the Medaka (Oryzias Latipes) Gene. May, 2006 | Pubmed ID: 16545530 Her1 and Her13.2 Are Jointly Required for Somitic Border Specification Along the Entire Axis of the Fish Embryo Developmental Biology. May, 2006 | Pubmed ID: 16545363 Comparative Analysis of Her Genes During Fish Somitogenesis Suggests a Mouse/chick-like Mode of Oscillation in Medaka Development Genes and Evolution. Jun, 2006 | Pubmed ID: 16544152 Radioactive 26Al from Massive Stars in the Galaxy Nature. Jan, 2006 | Pubmed ID: 16397491 Identification and Comparative Expression Analysis of a Second Wt1 Gene in Zebrafish Developmental Dynamics : an Official Publication of the American Association of Anatomists. Feb, 2006 | Pubmed ID: 16292775 Reduced U SnRNP Assembly Causes Motor Axon Degeneration in an Animal Model for Spinal Muscular Atrophy Genes & Development. Oct, 2005 | Pubmed ID: 16204184 Medial Floor Plate Formation in Zebrafish Consists of Two Phases and Requires Trunk-derived Midkine-a Genes & Development. Apr, 2005 | Pubmed ID: 15833916 Hedgehog and Retinoid Signalling Confines Nkx2.2b Expression to the Lateral Floor Plate of the Zebrafish Trunk Mechanisms of Development. Jan, 2005 | Pubmed ID: 15582776 The Lamina-associated Polypeptide 2 (LAP2) Genes of Zebrafish and Chicken: No LAP2alpha Isoform is Synthesised by Non-mammalian Vertebrates European Journal of Cell Biology. Aug, 2004 | Pubmed ID: 15506564 Her7 and Hey1, but Not Lunatic Fringe Show Dynamic Expression During Somitogenesis in Medaka (Oryzias Latipes) Gene Expression Patterns : GEP. Sep, 2004 | Pubmed ID: 15261833 Developmentally Regulated and Non-sex-specific Expression of Autosomal Dmrt Genes in Embryos of the Medaka Fish (Oryzias Latipes) Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210205 Activation of the Mouse Oct4 Promoter in Medaka Embryonic Stem Cells and Its Use for Ablation of Spontaneous Differentiation Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210197 影响视网膜发展的次突变。 Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210178 影响中 (对镧) 次体节形成的突变。 Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210175 基因突变影响器官发生在次,对镧屏幕系统全基因组。 Mechanisms of Development. Jul, 2004 | Pubmed ID: 15210174 Characterization of Hey BHLH Genes in Teleost Fish Development Genes and Evolution. Nov, 2003 | Pubmed ID: 14593478 Functional Divergence of Two Zebrafish Midkine Growth Factors Following Fish-specific Gene Duplication Genome Research. Jun, 2003 | Pubmed ID: 12743018 The Lamina-associated Polypeptide 2 (LAP2) Isoforms Beta, Gamma and Omega of Zebrafish: Developmental Expression and Behavior During the Cell Cycle Journal of Cell Science. Jun, 2003 | Pubmed ID: 12734396 The Pro-opiomelanocortin Gene of the Zebrafish (Danio Rerio) Biochemical and Biophysical Research Communications. Apr, 2003 | Pubmed ID: 12684052 A Duplicated Copy of DMRT1 in the Sex-determining Region of the Y Chromosome of the Medaka, Oryzias Latipes Proceedings of the National Academy of Sciences of the United States of America. Sep, 2002 | Pubmed ID: 12193652 戒毒治疗和 Tingsheng Yu1,2, Christoph Winkler1,2 1Department of Biological Sciences, National University of Singapore, 2NUS Centre for Bioimaging Sciences (CBIS), National University of Singapore Developmental Biology
戒毒治疗和 Tingsheng Yu1,2, Christoph Winkler1,2 1Department of Biological Sciences, National University of Singapore, 2NUS Centre for Bioimaging Sciences (CBIS), National University of Singapore Developmental Biology