Christopher G. Tate Laboratory of Molecular Biology Medical Research Council Biography Publications Institution JoVE Articles Christopher G. Tate has not added a biography. If you are Christopher G. Tate and would like to personalize this page please email our Author Liaison for assistance. Publications Cryo-Electron Microscopy: Moving Beyond X-Ray Crystal Structures for Drug Receptors and Drug Development Annual Review of Pharmacology and Toxicology. 01, 2020 | Pubmed ID: 31348870 Molecular Basis for High-affinity Agonist Binding in GPCRs Science (New York, N.Y.). 05, 2019 | Pubmed ID: 31072904 Cryo-EM Structures of GPCRs Coupled to G, G and G Molecular and Cellular Endocrinology. 05, 2019 | Pubmed ID: 30930094 Crystal Structure of Rhodopsin in Complex with a Mini-G Sheds Light on the Principles of G Protein Selectivity Science Advances. 09, 2018 | Pubmed ID: 30255144 Cryo-EM Structure of the Serotonin 5-HT Receptor Coupled to Heterotrimeric G Nature. 06, 2018 | Pubmed ID: 29925951 Insight into Partial Agonism by Observing Multiple Equilibria for Ligand-bound and G-mimetic Nanobody-bound β-adrenergic Receptor Nature Communications. 11, 2017 | Pubmed ID: 29176642 Strategy for the Thermostabilization of an Agonist-Bound GPCR Coupled to a G Protein Methods in Enzymology. 2017 | Pubmed ID: 28779842 Active State Structures of G Protein-coupled Receptors Highlight the Similarities and Differences in the G Protein and Arrestin Coupling Interfaces Current Opinion in Structural Biology. 08, 2017 | Pubmed ID: 28482214 Structural Biology: A Receptor That Might Block Itself Nature. 04, 2017 | Pubmed ID: 28379949 Engineering a Minimal G Protein to Facilitate Crystallisation of G Protein-coupled Receptors in Their Active Conformation Protein Engineering, Design & Selection : PEDS. Dec, 2016 | Pubmed ID: 27672048 Generation of Tetracycline-Inducible Mammalian Cell Lines by Flow Cytometry for Improved Overproduction of Membrane Proteins Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27485330 How Can Mutations Thermostabilize G-Protein-Coupled Receptors? Trends in Pharmacological Sciences. Jan, 2016 | Pubmed ID: 26547284 Ligand Occupancy in Crystal Structure of β1-adrenergic G Protein-coupled Receptor Nature Structural & Molecular Biology. Dec, 2015 | Pubmed ID: 26643842 Identifying Thermostabilizing Mutations in Membrane Proteins by Bioinformatics Biophysical Journal. Oct, 2015 | Pubmed ID: 26445428 Pharmacological Analysis and Structure Determination of 7-Methylcyanopindolol-Bound β1-Adrenergic Receptor Molecular Pharmacology. Dec, 2015 | Pubmed ID: 26385885 Purification and Crystallization of a Thermostabilized Agonist-Bound Conformation of the Human Adenosine A(2A) Receptor Methods in Molecular Biology (Clifton, N.J.). 2015 | Pubmed ID: 26260591 Isolation and Characterisation of Transport-defective Substrate-binding Mutants of the Tetracycline Antiporter TetA(B) Biochimica Et Biophysica Acta. Oct, 2015 | Pubmed ID: 26143388 Molecular Determinants of CGS21680 Binding to the Human Adenosine A2A Receptor Molecular Pharmacology. Jun, 2015 | Pubmed ID: 25762024 Quality Control in Eukaryotic Membrane Protein Overproduction Journal of Molecular Biology. Dec, 2014 | Pubmed ID: 25454020 Editorial Overview: New Constructs and Expression of Proteins: Making Things Better Current Opinion in Structural Biology. Jun, 2014 | Pubmed ID: 24948361 A Crystal Clear Solution for Determining G-protein-coupled Receptor Structures Trends in Biochemical Sciences. Sep, 2012 | Pubmed ID: 22784935 Two Distinct Conformations of Helix 6 Observed in Antagonist-bound Structures of a Beta1-adrenergic Receptor Proceedings of the National Academy of Sciences of the United States of America. May, 2011 | Pubmed ID: 21540331 Biochemistry. Membrane Protein Gymnastics Science (New York, N.Y.). Jun, 2010 | Pubmed ID: 20576878 Three-dimensional Structure of TspO by Electron Cryomicroscopy of Helical Crystals Structure (London, England : 1993). Jun, 2010 | Pubmed ID: 20541505 Practical Considerations of Membrane Protein Instability During Purification and Crystallisation Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 20099147 Engineering G Protein-coupled Receptors to Facilitate Their Structure Determination Current Opinion in Structural Biology. Aug, 2009 | Pubmed ID: 19682887 Mass Spectrometry of Membrane Transporters Reveals Subunit Stoichiometry and Interactions Nature Methods. Aug, 2009 | Pubmed ID: 19578383 Co-evolving Stability and Conformational Homogeneity of the Human Adenosine A2a Receptor Proceedings of the National Academy of Sciences of the United States of America. Aug, 2008 | Pubmed ID: 18664584 Conformational Thermostabilization of the Beta1-adrenergic Receptor in a Detergent-resistant Form Proceedings of the National Academy of Sciences of the United States of America. Jan, 2008 | Pubmed ID: 18192400 Comparison of Three Structures of the Multidrug Transporter EmrE Current Opinion in Structural Biology. Aug, 2006 | Pubmed ID: 16828280 Başarılı Kristalizasyon Için Görsel GPCR-mini-G Protein Sinyal Kompleksi Stratejik Tarama ve Karakterizasyonu Filip Pamula1,2, Jonas Mühle1, Alain Blanc3, Rony Nehmé4, Patricia C. Edwards4, Christopher G. Tate4, Ching-Ju Tsai1 1Laboratory of Biomolecular Research, Paul Scherrer Institute, 2Department of Biology, ETH Zürich, 3Center for Radiopharmaceutical Sciences, Paul Scherrer Institute, 4Laboratory of Molecular Biology, Medical Research Council JoVE 60747 Biochemistry
Başarılı Kristalizasyon Için Görsel GPCR-mini-G Protein Sinyal Kompleksi Stratejik Tarama ve Karakterizasyonu Filip Pamula1,2, Jonas Mühle1, Alain Blanc3, Rony Nehmé4, Patricia C. Edwards4, Christopher G. Tate4, Ching-Ju Tsai1 1Laboratory of Biomolecular Research, Paul Scherrer Institute, 2Department of Biology, ETH Zürich, 3Center for Radiopharmaceutical Sciences, Paul Scherrer Institute, 4Laboratory of Molecular Biology, Medical Research Council JoVE 60747 Biochemistry