Christopher James Thibodeaux Chemistry McGill University Biography Publications Institution JoVE Articles Christopher James ThibodeauxAssistant Professor Christopher J. Thibodeaux is a native of Louisiana, where he graduated valedictorian with bachelor's degrees in Biochemistry, Botany, and Chemistry from Louisiana State University. He then entered graduate school in the lab of Hung-wen Liu at the University of Texas, Austin, where his Ph.D. focused on elucidating the chemical and kinetic mechanisms of enzyme catalysis. Following graduation, he had postdoctoral stints in the labs of Taekjip Ha and Wilfred van der Donk at the University of Illinois, Urbana-Champaign, where he studied biomolecular single molecule fluorescence spectroscopy and peptide natural product biosynthesis, respectively. In 2016, he began his independent career in the Chemistry Department at McGill University, where he is currently an assistant professor. His research is broadly aimed at combatting the problem of antimicrobial resistance by understanding the detailed molecular mechanisms of enzymes that synthesize structurally complex antimicrobial compounds, discovering novel antimicrobial compounds by genome mining, and by investigating the mechanisms used by bacteria to establish biofilms. In his spare time, he enjoys the outdoors, cooking and eating spicy food, large family gatherings, watching (American) football and baseball, and spending time with his wife and three daughters. Publications Compartmentalized Processing of Catechols During Mussel Byssus Fabrication Determines the Destiny of DOPA Proceedings of the National Academy of Sciences of the United States of America. Apr, 2020 | Pubmed ID: 32209666 Insights into the Dynamic Structural Properties of a Lanthipeptide Synthetase Using Hydrogen-Deuterium Exchange Mass Spectrometry Journal of the American Chemical Society. Sep, 2019 | Pubmed ID: 31449409 Unraveling Flavoenzyme Reaction Mechanisms Using Flavin Analogues and Linear Free Energy Relationships Methods in Enzymology. Month, 2019 | Pubmed ID: 31072486 The Type II Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase (IDI-2): A Model for Acid/base Chemistry in Flavoenzyme Catalysis Archives of Biochemistry and Biophysics. 10, 2017 | Pubmed ID: 28577910 A Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Platform for Investigating Peptide Biosynthetic Enzymes Yeganeh Habibi1, Christopher J. Thibodeaux1 1Department of Chemistry, McGill University JoVE 61053 Biochemistry
A Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) Platform for Investigating Peptide Biosynthetic Enzymes Yeganeh Habibi1, Christopher J. Thibodeaux1 1Department of Chemistry, McGill University JoVE 61053 Biochemistry