Christopher C. Glembotski San Diego State University Heart Institute and the Department of Biology San Diego State University Biography Publications Institution JoVE Articles Christopher C. Glembotski has not added a biography. If you are Christopher C. Glembotski and would like to personalize this page please email our Author Liaison for assistance. Publications Proteomic Analysis of the Cardiac Myocyte Secretome Reveals Extracellular Protective Functions for the ER Stress Response Journal of Molecular and Cellular Cardiology. Apr, 2020 | Pubmed ID: 32339566 Mesencephalic Astrocyte-derived Neurotrophic Factor is an ER-resident Chaperone That Protects Against Reductive Stress in the Heart The Journal of Biological Chemistry. May, 2020 | Pubmed ID: 32327487 ATF6 As a Nodal Regulator of Proteostasis in the Heart Frontiers in Physiology. 2020 | Pubmed ID: 32322217 Reactive Oxygen Species (ROS)-Activatable Prodrug for Selective Activation of ATF6 After Ischemia/Reperfusion Injury ACS Medicinal Chemistry Letters. Mar, 2020 | Pubmed ID: 32184959 Designing Novel Therapies to Mend Broken Hearts: ATF6 and Cardiac Proteostasis Cells. Mar, 2020 | Pubmed ID: 32138230 The ER Unfolded Protein Response Effector, ATF6, Reduces Cardiac Fibrosis and Decreases Activation of Cardiac Fibroblasts International Journal of Molecular Sciences. Feb, 2020 | Pubmed ID: 32085622 Sledgehammer to Scalpel: Broad Challenges to the Heart and Other Tissues Yield Specific Cellular Responses Via Transcriptional Regulation of the ER-Stress Master Regulator ATF6α International Journal of Molecular Sciences. Feb, 2020 | Pubmed ID: 32046286 Integrating ER and Mitochondrial Proteostasis in the Healthy and Diseased Heart Frontiers in Cardiovascular Medicine. 2019 | Pubmed ID: 32010709 Physiological Signaling in the Absence of Amidated Peptides Proceedings of the National Academy of Sciences of the United States of America. 10, 2019 | Pubmed ID: 31515450 Proteostasis and Beyond: ATF6 in Ischemic Disease Trends in Molecular Medicine. 06, 2019 | Pubmed ID: 31078432 Unfolding the Roles of Mitochondria As Therapeutic Targets for Heart Disease Journal of the American College of Cardiology. 04, 2019 | Pubmed ID: 30975298 Pharmacologic ATF6 Activation Confers Global Protection in Widespread Disease Models by Reprograming Cellular Proteostasis Nature Communications. 01, 2019 | Pubmed ID: 30643122 ATF6 Regulates Cardiac Hypertrophy by Transcriptional Induction of the MTORC1 Activator, Rheb Circulation Research. 01, 2019 | Pubmed ID: 30582446 Expanding the Paracrine Hypothesis of Stem Cell-Mediated Repair in the Heart: When the Unconventional Becomes Conventional Circulation Research. 03, 2017 | Pubmed ID: 28254800 CaMKIIδ Subtypes Differentially Regulate Infarct Formation Following Ex Vivo Myocardial Ischemia/reperfusion Through NF-κB and TNF-α Journal of Molecular and Cellular Cardiology. 02, 2017 | Pubmed ID: 28077321 ATF6 Decreases Myocardial Ischemia/Reperfusion Damage and Links ER Stress and Oxidative Stress Signaling Pathways in the Heart Circulation Research. Mar, 2017 | Pubmed ID: 27932512 Activation of the ATF6 Branch of the Unfolded Protein Response in Neurons Improves Stroke Outcome Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Mar, 2017 | Pubmed ID: 27217380 Junctophilin-2 Gene Therapy Rescues Heart Failure by Normalizing RyR2-mediated Ca Release International Journal of Cardiology. Dec, 2016 | Pubmed ID: 27760414 S100A4 Protects the Myocardium Against Ischemic Stress Journal of Molecular and Cellular Cardiology. Nov, 2016 | Pubmed ID: 27721024 Breaking Down the COP9 Signalsome in the Heart: How Inactivating a Protein Ubiquitin Ligase Increases Protein Ubiquitylation and Protects the Heart Circulation Research. Nov, 2015 | Pubmed ID: 26541679 Hrd1 and ER-Associated Protein Degradation, ERAD, Are Critical Elements of the Adaptive ER Stress Response in Cardiac Myocytes Circulation Research. Aug, 2015 | Pubmed ID: 26137860 Finding the Missing Link Between the Unfolded Protein Response and O-GlcNAcylation in the Heart Circulation Research. Aug, 2014 | Pubmed ID: 25170091 Roles for ATF6 and the Sarco/endoplasmic Reticulum Protein Quality Control System in the Heart Journal of Molecular and Cellular Cardiology. Jun, 2014 | Pubmed ID: 24140798 Classic Studies of Cultured Cardiac Myocyte Hypertrophy: Interview with a Transformer Circulation Research. Oct, 2013 | Pubmed ID: 24158575 Mechanistic Target of Rapamycin Complex 2 Protects the Heart from Ischemic Damage Circulation. Nov, 2013 | Pubmed ID: 24008870 Pathological Hypertrophy Amelioration by PRAS40-mediated Inhibition of MTORC1 Proceedings of the National Academy of Sciences of the United States of America. Jul, 2013 | Pubmed ID: 23842089 Regulation of Cardiac Hypertrophic Signaling by Prolyl Isomerase Pin1 Circulation Research. Apr, 2013 | Pubmed ID: 23487407 ATF6 [corrected] and Thrombospondin 4: the Dynamic Duo of the Adaptive Endoplasmic Reticulum Stress Response Circulation Research. Jan, 2013 | Pubmed ID: 23287452 New Concepts of Endoplasmic Reticulum Function in the Heart: Programmed to Conserve Journal of Molecular and Cellular Cardiology. Feb, 2013 | Pubmed ID: 23085588 Roles for the Sarco-/endoplasmic Reticulum in Cardiac Myocyte Contraction, Protein Synthesis, and Protein Quality Control Physiology (Bethesda, Md.). Dec, 2012 | Pubmed ID: 23223628 Clarifying the Cardiac Proteasome Paradox: Protein Quality Control Circulation Research. Aug, 2012 | Pubmed ID: 22904038 Limitation of Individual Folding Resources in the ER Leads to Outcomes Distinct from the Unfolded Protein Response Journal of Cell Science. Oct, 2012 | Pubmed ID: 22854046 Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and is Selectively Secreted Upon Sarco/endoplasmic Reticulum Calcium Depletion The Journal of Biological Chemistry. Jul, 2012 | Pubmed ID: 22637475 Protein Disulfide Isomerase-associated 6 is an ATF6-inducible ER Stress Response Protein That Protects Cardiac Myocytes from Ischemia/reperfusion-mediated Cell Death Journal of Molecular and Cellular Cardiology. Aug, 2012 | Pubmed ID: 22609432 Regulation of MicroRNA Expression in the Heart by the ATF6 Branch of the ER Stress Response Journal of Molecular and Cellular Cardiology. May, 2012 | Pubmed ID: 22326432 The Cardiokine Story Unfolds: Ischemic Stress-induced Protein Secretion in the Heart Trends in Molecular Medicine. Apr, 2011 | Pubmed ID: 21277256 Functions for the Cardiomyokine, MANF, in Cardioprotection, Hypertrophy and Heart Failure Journal of Molecular and Cellular Cardiology. Oct, 2011 | Pubmed ID: 20970425 Pim-1 Kinase Protects Mitochondrial Integrity in Cardiomyocytes Circulation Research. Apr, 2010 | Pubmed ID: 20203306 Roles for Endoplasmic Reticulum-associated Degradation and the Novel Endoplasmic Reticulum Stress Response Gene Derlin-3 in the Ischemic Heart Circulation Research. Feb, 2010 | Pubmed ID: 19940266 La Substitution De Val [67] ATF6-Met Est Associée à Une Augmentation De Cholestérol Plasmatique Arteriosclerosis, Thrombosis, and Vascular Biology. Sep, 2009 | Pubmed ID: 19667116 Ischemia Activates the ATF6 Branch of the Endoplasmic Reticulum Stress Response The Journal of Biological Chemistry. Oct, 2009 | Pubmed ID: 19622751 LPS-induced Autophagy is Mediated by Oxidative Signaling in Cardiomyocytes and is Associated with Cytoprotection American Journal of Physiology. Heart and Circulatory Physiology. Feb, 2009 | Pubmed ID: 19098111 Mesencephalic Astrocyte-derived Neurotrophic Factor is an Ischemia-inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart Circulation Research. Nov, 2008 | Pubmed ID: 18927462 Coordination of Growth and Endoplasmic Reticulum Stress Signaling by Regulator of Calcineurin 1 (RCAN1), a Novel ATF6-inducible Gene The Journal of Biological Chemistry. May, 2008 | Pubmed ID: 18319259 The Role of the Unfolded Protein Response in the Heart Journal of Molecular and Cellular Cardiology. Mar, 2008 | Pubmed ID: 18054039 Pim-1 Regulates Cardiomyocyte Survival Downstream of Akt Nature Medicine. Dec, 2007 | Pubmed ID: 18037896 Endoplasmic Reticulum Stress in the Heart Circulation Research. Nov, 2007 | Pubmed ID: 17991891 Getting a G--RRP on Regulated Exocytosis in the Heart The Journal of Cell Biology. Nov, 2007 | Pubmed ID: 17967951 Effects of the Isoform-specific Characteristics of ATF6 Alpha and ATF6 Beta on Endoplasmic Reticulum Stress Response Gene Expression and Cell Viability The Journal of Biological Chemistry. Aug, 2007 | Pubmed ID: 17522056 Activation of the Unfolded Protein Response in Infarcted Mouse Heart and Hypoxic Cultured Cardiac Myocytes Circulation Research. Aug, 2006 | Pubmed ID: 16794188 Endoplasmic Reticulum Stress Gene Induction and Protection from Ischemia/reperfusion Injury in the Hearts of Transgenic Mice with a Tamoxifen-regulated Form of ATF6 Circulation Research. May, 2006 | Pubmed ID: 16601230 Atrial Natriuretic Peptide Promotes Cardiomyocyte Survival by CGMP-dependent Nuclear Accumulation of Zyxin and Akt The Journal of Clinical Investigation. Oct, 2005 | Pubmed ID: 16200208 Overexpression of Mitogen-activated Protein Kinase Kinase 6 in the Heart Improves Functional Recovery from Ischemia in Vitro and Protects Against Myocardial Infarction in Vivo The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15492008 Opposing Roles for ATF6alpha and ATF6beta in Endoplasmic Reticulum Stress Response Gene Induction The Journal of Biological Chemistry. May, 2004 | Pubmed ID: 14973138 Factor Associated with Neutral Sphingomyelinase Activation and Its Role in Cardiac Cell Death Circulation Research. Apr, 2003 | Pubmed ID: 12637370 Mimicking Phosphorylation of AlphaB-crystallin on Serine-59 is Necessary and Sufficient to Provide Maximal Protection of Cardiac Myocytes from Apoptosis Circulation Research. Feb, 2003 | Pubmed ID: 12574148 Expression and Functional Characterization of SCaMPER: a Sphingolipid-modulated Calcium Channel of Cardiomyocytes American Journal of Physiology. Cell Physiology. Mar, 2003 | Pubmed ID: 12421694 Coordination of ATF6-mediated Transcription and ATF6 Degradation by a Domain That is Shared with the Viral Transcription Factor, VP16 The Journal of Biological Chemistry. Jun, 2002 | Pubmed ID: 11909875 A Role for the P38 Mitogen-activated Protein Kinase Pathway in Myocardial Cell Growth, Sarcomeric Organization, and Cardiac-specific Gene Expression The Journal of Cell Biology. Oct, 1997 | Pubmed ID: 9314533 Isolement et culture simultanés des myocytes auriculaires, des myocytes ventriculaires et des non-myocytes provenant d’un cœur de souris adulte Erik A. Blackwood1, Alina S. Bilal1, Khalid Azizi1, Anup Sarakki1, Christopher C. Glembotski1 1San Diego State University Heart Institute and the Department of Biology, San Diego State University JoVE 61224 Biology
Isolement et culture simultanés des myocytes auriculaires, des myocytes ventriculaires et des non-myocytes provenant d’un cœur de souris adulte Erik A. Blackwood1, Alina S. Bilal1, Khalid Azizi1, Anup Sarakki1, Christopher C. Glembotski1 1San Diego State University Heart Institute and the Department of Biology, San Diego State University JoVE 61224 Biology