Christopher J.H. Porter Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences Monash University (Parkville Campus) Biography Publications Institution JoVE Articles Christopher J.H. Porter has not added a biography. If you are Christopher J.H. Porter and would like to personalize this page please email our Author Liaison for assistance. Publications PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance After Subcutaneous Administration Molecular Pharmaceutics. Mar, 2015 | Pubmed ID: 25644368 Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties in Vivo ACS Nano. Feb, 2015 | Pubmed ID: 25634484 Optimal PEGylation Can Improve the Exposure of Interferon in the Lungs Following Pulmonary Administration Journal of Pharmaceutical Sciences. Jan, 2015 | Pubmed ID: 25631360 Methotrexate-conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumour-burdened Lymph Nodes After Intravenous and Subcutaneous Administration in Rats Molecular Pharmaceutics. Dec, 2014 | Pubmed ID: 25485615 Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug Pharmaceutical Research. Dec, 2014 | Pubmed ID: 25446770 Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase Pharmaceutical Research. Oct, 2014 | Pubmed ID: 25288015 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels The AAPS Journal. Nov, 2014 | Pubmed ID: 25274609 An in Vitro Digestion Test That Reflects Rat Intestinal Conditions to Probe the Importance of Formulation Digestion Vs First Pass Metabolism in Danazol Bioavailability from Lipid Based Formulations Molecular Pharmaceutics. Nov, 2014 | Pubmed ID: 25265395 In Vitro-in Vivo Evaluation of Lipid Based Formulations of the CETP Inhibitors CP-529,414 (torcetrapib) and CP-532,623 European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2014 | Pubmed ID: 25152213 Characterization of Two Distinct Modes of Drug Binding to Human Intestinal Fatty Acid Binding Protein ACS Chemical Biology. Nov, 2014 | Pubmed ID: 25144524 'Stealth' Lipid-based Formulations: Poly(ethylene Glycol)-mediated Digestion Inhibition Improves Oral Bioavailability of a Model Poorly Water Soluble Drug Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2014 | Pubmed ID: 25058571 Digestion of Phospholipids After Secretion of Bile into the Duodenum Changes the Phase Behavior of Bile Components Molecular Pharmaceutics. Aug, 2014 | Pubmed ID: 24987935 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 4: Proposing a New Lipid Formulation Performance Classification System Journal of Pharmaceutical Sciences. Aug, 2014 | Pubmed ID: 24985238 The Influence of Intestinal Lymphatic Transport on the Systemic Exposure and Brain Deposition of a Novel Highly Lipophilic Compound with Structural Similarity to Cholesterol The Journal of Pharmacy and Pharmacology. Oct, 2014 | Pubmed ID: 24821499 Nano-chemotherapeutics: Maximising Lymphatic Drug Exposure to Improve the Treatment of Lymph-metastatic Cancers Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2014 | Pubmed ID: 24801249 Lipid-based Formulations Solidified Via Adsorption Onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on in Vitro Pharmaceutical Performance Journal of Pharmaceutical Sciences. Jun, 2014 | Pubmed ID: 24740767 Pulmonary Administration of a Doxorubicin-conjugated Dendrimer Enhances Drug Exposure to Lung Metastases and Improves Cancer Therapy Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2014 | Pubmed ID: 24637466 Pulmonary and Systemic Pharmacokinetics of Inhaled and Intravenous Colistin Methanesulfonate in Cystic Fibrosis Patients: Targeting Advantage of Inhalational Administration Antimicrobial Agents and Chemotherapy. May, 2014 | Pubmed ID: 24550334 Non-linear Increases in Danazol Exposure with Dose in Older Vs. Younger Beagle Dogs: the Potential Role of Differences in Bile Salt Concentration, Thermodynamic Activity, and Formulation Digestion Pharmaceutical Research. Jun, 2014 | Pubmed ID: 24477676 Choice of Nonionic Surfactant Used to Formulate Type IIIA Self-emulsifying Drug Delivery Systems and the Physicochemical Properties of the Drug Have a Pronounced Influence on the Degree of Drug Supersaturation That Develops During in Vitro Digestion Journal of Pharmaceutical Sciences. Apr, 2014 | Pubmed ID: 24470073 Targeted Delivery of a Model Immunomodulator to the Lymphatic System: Comparison of Alkyl Ester Versus Triglyceride Mimetic Lipid Prodrug Strategies Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2014 | Pubmed ID: 24398334 Ionic Liquids Provide Unique Opportunities for Oral Drug Delivery: Structure Optimization and in Vivo Evidence of Utility Chemical Communications (Cambridge, England). Feb, 2014 | Pubmed ID: 24394756 The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats Molecular Pharmaceutics. Feb, 2014 | Pubmed ID: 24350780 Recent Advances in Lipid-based Formulation Technology Pharmaceutical Research. Dec, 2013 | Pubmed ID: 24158727 Gastric Pre-processing is an Important Determinant of the Ability of Medium-chain Lipid Solution Formulations to Enhance Oral Bioavailability in Rats Journal of Pharmaceutical Sciences. Nov, 2013 | Pubmed ID: 23983139 PEGylated Polylysine Dendrimers Increase Lymphatic Exposure to Doxorubicin when Compared to PEGylated Liposomal and Solution Formulations of Doxorubicin Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2013 | Pubmed ID: 23954628 Population Pharmacokinetics of Colistin Methanesulfonate in Rats: Achieving Sustained Lung Concentrations of Colistin for Targeting Respiratory Infections Antimicrobial Agents and Chemotherapy. Oct, 2013 | Pubmed ID: 23917323 Lipid-based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/absorption Pathway Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23824582 Lipid Absorption Triggers Drug Supersaturation at the Intestinal Unstirred Water Layer and Promotes Drug Absorption from Mixed Micelles Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23793990 Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23771564 Pulmonary Administration of PEGylated Polylysine Dendrimers: Absorption from the Lung Versus Retention Within the Lung is Highly Size-dependent Molecular Pharmaceutics. Aug, 2013 | Pubmed ID: 23750747 A Simple Quantitative Approach for the Determination of Long and Medium Chain Lipids in Bio-relevant Matrices by High Performance Liquid Chromatography with Refractive Index Detection AAPS PharmSciTech. Sep, 2013 | Pubmed ID: 23733513 The Potential for Drug Supersaturation During Intestinal Processing of Lipid-based Formulations May Be Enhanced for Basic Drugs Molecular Pharmaceutics. Jul, 2013 | Pubmed ID: 23697606 The Impact of Lymphatic Transport on the Systemic Disposition of Lipophilic Drugs Journal of Pharmaceutical Sciences. Jul, 2013 | Pubmed ID: 23696002 In Vitro Assessment of Drug-free and Fenofibrate-containing Lipid Formulations Using Dispersion and Digestion Testing Gives Detailed Insights into the Likely Fate of Formulations in the Intestine European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2013 | Pubmed ID: 23684915 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the in Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-based Formulations Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23661145 Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis Molecular Pharmaceutics. Aug, 2013 | Pubmed ID: 23631696 PEGylation of Interferon α2 Improves Lymphatic Exposure After Subcutaneous and Intravenous Administration and Improves Antitumour Efficacy Against Lymphatic Breast Cancer Metastases Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2013 | Pubmed ID: 23499718 Intestinal Bile Secretion Promotes Drug Absorption from Lipid Colloidal Phases Via Induction of Supersaturation Molecular Pharmaceutics. May, 2013 | Pubmed ID: 23480483 A Mouse Model to Evaluate the Impact of Species, Sex, and Lipid Load on Lymphatic Drug Transport Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23430484 Strategies to Address Low Drug Solubility in Discovery and Development Pharmacological Reviews. Jan, 2013 | Pubmed ID: 23383426 Silica-lipid Hybrid (SLH) Formulations Enhance the Oral Bioavailability and Efficacy of Celecoxib: An in Vivo Evaluation Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2013 | Pubmed ID: 23353808 The Effect of Administered Dose of Lipid-based Formulations on the in Vitro and in Vivo Performance of Cinnarizine As a Model Poorly Water-soluble Drug Journal of Pharmaceutical Sciences. Feb, 2013 | Pubmed ID: 23242691 In Vitro Digestion Testing of Lipid-based Delivery Systems: Calcium Ions Combine with Fatty Acids Liberated from Triglyceride Rich Lipid Solutions to Form Soaps and Reduce the Solubilization Capacity of Colloidal Digestion Products International Journal of Pharmaceutics. Jan, 2013 | Pubmed ID: 23178598 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations During in Vitro Digestion Molecular Pharmaceutics. Nov, 2012 | Pubmed ID: 23030411 Incomplete Desorption of Liquid Excipients Reduces the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems Solidified by Adsorption Onto an Inorganic Mesoporous Carrier Molecular Pharmaceutics. Sep, 2012 | Pubmed ID: 22870936 Lipid Digestion As a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems Molecular Pharmaceutics. Jul, 2012 | Pubmed ID: 22656917 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 1: Method Parameterization and Comparison of in Vitro Digestion Profiles Across a Range of Representative Formulations Journal of Pharmaceutical Sciences. Sep, 2012 | Pubmed ID: 22644939 Intravenous Dosing Conditions May Affect Systemic Clearance for Highly Lipophilic Drugs: Implications for Lymphatic Transport and Absolute Bioavailability Studies Journal of Pharmaceutical Sciences. Sep, 2012 | Pubmed ID: 22623170 デンドリマーナノキャリアを持つ化学療法薬との関連:非共有結合カプセルに比べて共有結合のメリットの評価 Molecular Pharmaceutics. Jan, 2012 | Pubmed ID: 22250750 マウスおよびラット腫瘍モデルにおけるPEG化リポソーム溶液製剤と比較するとドキソルビシン共役PEG化デンドリマーは、同様の殺腫瘍活性が低い全身毒性を表示する Molecular Pharmaceutics. Jan, 2012 | Pubmed ID: 22233281 ドキソルビシンの薬物動態への変更は、抗腫瘍活性、および毒性の比較PEG化デンドリマーおよびPEGリポソームのドラッグデリバリーシステムによって媒介される Nanomedicine : Nanotechnology, Biology, and Medicine. Jan, 2012 | Pubmed ID: 21704192 訂正 "リンパ球への標的ドラッグデリバリー:サイト固有の免疫調節へのルート?" Molecular Pharmaceutics. Dec, 2011 | Pubmed ID: 21995681 デンドリマー薬物動態:ADME特性に及ぼすサイズ、構造、表面特性の影響 Nanomedicine (London, England). Aug, 2011 | Pubmed ID: 21955077 PEG化ナノ材料のコロイド構造の違いは加速血中クリアランスの可能性を指示する Journal of Pharmaceutical Sciences. Nov, 2011 | Pubmed ID: 21721002 樹状ポリマー(デンドリマー)を使用してリンパ管を標的と Advanced Drug Delivery Reviews. Sep, 2011 | Pubmed ID: 21683746 脂質および薬物吸収に正のフィードバック機構:急性血症は、腸リンパ脂質および薬物輸送を促進する Molecular Pharmaceutics. Aug, 2011 | Pubmed ID: 21604764 脂肪酸結合タンパク質:腸の細胞質薬物輸送の潜在的なシャペロン? Pharmaceutical Research. Sep, 2011 | Pubmed ID: 21523511 ナノ構造の液晶粒子は、経口投与後、難水溶性薬物のために長い時間徐放効果を提供する Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2011 | Pubmed ID: 21497623 PH不安定性リンカーを介して特性評価とドキソルビシンを有するPEG化ポリリジンデンドリマーの標的腫瘍 Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2011 | Pubmed ID: 21315119 Preparation, Crystallization and Preliminary X-ray Diffraction Analysis of Two Intestinal Fatty-acid Binding Proteins in the Presence of 11-(dansylamino)undecanoic Acid Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2011 | Pubmed ID: 21301109 メトトレキサートのα-カルボキシル基をキャッピング全身曝露を強化し、薬物共役PEG化ポリリジンデンドリマーの細胞毒性を保持します Molecular Pharmaceutics. Apr, 2011 | Pubmed ID: 21171585 難水溶性薬物の吸収を向上させるためのポリマー沈殿剤を使用する:ユーティリティの基本メカニズム Journal of Drug Targeting. Dec, 2010 | Pubmed ID: 20973755 リンパ球の標的ドラッグデリバリー:サイト固有の免疫調節へのルート? Molecular Pharmaceutics. Dec, 2010 | Pubmed ID: 20958081 難水溶性薬物IIの放経口ドラッグデリバリーシステムとして、フィタントリオールおよびグリセリルモノオレエートキュービック液晶相。生体内評価 The Journal of Pharmacy and Pharmacology. Jul, 2010 | Pubmed ID: 20636873 生理学的に関連のメディアにおける難水溶性薬物I.位相行動のためのフィタントリオールと放経口ドラッグデリバリーシステムとしてグリセリルモノオレエートキュービック液晶相 The Journal of Pharmacy and Pharmacology. Jul, 2010 | Pubmed ID: 20636872 二つのコレステリルエステル転送蛋白質阻害剤のリンパアクセスのメカニズム(CP524、515とCP532、623)とリンパリポ蛋白プロファイルに及ぼす影響の評価 Pharmaceutical Research. Sep, 2010 | Pubmed ID: 20635194 二つの高親油性コレステロールエステル転送蛋白阻害剤の吸収腸リンパ管の役割(CP524、515とCP532、623) Pharmaceutical Research. May, 2010 | Pubmed ID: 20221896 リンパMethylnortestosteroneのウンの輸送(MU)とMethylnortestosteroneのバイオアベイラビリティは、MUの経口投与後、併用脂質のマスに非常に敏感 The Journal of Pharmacology and Experimental Therapeutics. Nov, 2009 | Pubmed ID: 19696095 ラット肝脂肪酸結合タンパク質のフィブラート結合特異性を探る Journal of Medicinal Chemistry. Sep, 2009 | Pubmed ID: 19663428 経口バイオアベイラビリティ評価と組織45697およびOrg 46035、二つの腸リンパ輸送高親油性の新規免疫調節の類縁 Current Drug Delivery. Aug, 2009 | Pubmed ID: 19534711 薬物動態およびPEG、メトトレキサート共役ポリ-L-リジンデンドリマーの腫瘍処分 Molecular Pharmaceutics. Jul-Aug, 2009 | Pubmed ID: 19453158 腸のリンパ輸送は初回通過代謝の回避経由で新規カンナビノイド受容体アゴニストの食後経口バイオアベイラビリティを強化 Pharmaceutical Research. Jun, 2009 | Pubmed ID: 19280324 腸脂肪酸結合タンパク質をラットに親油性薬物の結合のキャラクタリゼーション Molecular and Cellular Biochemistry. Jun, 2009 | Pubmed ID: 19160019 親油性を変化させる薬剤化合物のIn-vitroで腸透過性を制限することでかくはんされていない水層と受容体のシンクの相対的な役割の評価 The Journal of Pharmacy and Pharmacology. Oct, 2008 | Pubmed ID: 18812024 ラット肝脂肪酸結合タンパク質の薬物結合特異性のキャラクタリゼーション Journal of Medicinal Chemistry. Jul, 2008 | Pubmed ID: 18533710 PEG化ポリL-リジンデンドリマーの全身薬物動態に及ぼす分子量とPEG鎖長の影響 Molecular Pharmaceutics. May-Jun, 2008 | Pubmed ID: 18393438 難水溶性薬物の強化された配信のための脂質ベースのシステム Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18160174 脂質ベースのデリバリーシステムを用いた腸内薬物可溶化を高める Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18155801 脂質ベースのデリバリーシステムと腸リンパ薬物輸送:反応機構の更新 Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18155316 材料、方法と戦略:経口投与のための脂質ベースのデリバリーシステムの定式化 Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18068260 犬への脂質の自己乳化製剤の経口投与後、ダナゾールのバイオアベイラビリティに対する界面活性剤の消化に及ぼす影響の評価 Journal of Pharmaceutical Sciences. Feb, 2008 | Pubmed ID: 18064698 体外透水実験において可溶化剤として血漿タンパク質の使用:相互浸透性アプローチを用いた非結合型薬物濃度の補正 Journal of Pharmaceutical Sciences. Jan, 2008 | Pubmed ID: 17585392 静脈内薬物動態および処分に関するアニオンアリールスルホン酸またはコハク酸基を有するポリ-L-リジンデンドリマーの表面誘導体化の影響 Molecular Pharmaceutics. Nov-Dec, 2007 | Pubmed ID: 17953445 皮下投与したタンパク質のリンパ管吸収:羊モデルを用いたダルベポエチンアルファの吸収上の異なる注射部位の影響 Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2007 | Pubmed ID: 17875672 低線量脂質製剤:胃排出および胆汁分泌に及ぼす影響 Pharmaceutical Research. Nov, 2007 | Pubmed ID: 17657595 モデルのための徐放性と強化された経口生物学的利用能ラットにおける難水溶性薬物を提供します。脂質ベースの液晶マトリックス International Journal of Pharmaceutics. Aug, 2007 | Pubmed ID: 17467935 並列人工膜透過性アッセイを用いた薬物吸収の腸内脂肪酸結合タンパク質の役割の検討 Chemistry & Biology. Apr, 2007 | Pubmed ID: 17462580 ダナゾールの自己乳化型脂質ベース製剤中の脂質への相対界面活性剤の比例コンテンツ(クレモフォールEL)を増やすと、ビーグル犬に経口バイオアベイラビリティを削減 Pharmaceutical Research. Apr, 2007 | Pubmed ID: 17372700 脂質および脂質ベース製剤:親油性薬物の経口デリバリーの最適化 Nature Reviews. Drug Discovery. Mar, 2007 | Pubmed ID: 17330072 ラットの空腸間ジゴキシン透水性にクレモファー-ELとポリソルベート80の影響:相互浸透性アプローチを用いた熱力学とトランスポーター関連イベントの輪郭線抽出 Journal of Pharmaceutical Sciences. Feb, 2007 | Pubmed ID: 17051595 カチオン性ポリ-L-リジンデンドリマー:薬物動態、体内分布、およびラットに静脈内投与後の代謝とBioresorptionの証拠 Molecular Pharmaceutics. Sep-Oct, 2006 | Pubmed ID: 17009860 ダルベポエチンアルファの吸収は羊に皮下投与後のリンパ管経由で主に発生します。 Pharmaceutical Research. Sep, 2006 | Pubmed ID: 16951999 可溶化条件下で難水溶性化合物の透水性の評価:相互浸透性のアプローチ Journal of Pharmaceutical Sciences. Oct, 2006 | Pubmed ID: 16883557 FABPの発現とリンパ脂質および薬物輸送における急性および同時増加はラットに脂質ベースの薬物製剤の腸内注入中に発生します Pharmaceutical Research. Aug, 2006 | Pubmed ID: 16858652 インビトロ可溶化挙動とアトバコンの脂質製剤の経口バイオアベイラビリティにプルロニック界面活性剤の範囲に与える影響の検討 The Journal of Pharmacy and Pharmacology. Jun, 2006 | Pubmed ID: 16734982 ラット腸細胞ベースの代謝とリンパ薬物輸送との間の相互作用の検討 Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2006 | Pubmed ID: 16467133 リンパ脂質前駆プールは腸リンパ薬物輸送の重要な決定要因である The Journal of Pharmacology and Experimental Therapeutics. Feb, 2006 | Pubmed ID: 16249368 DDTの組織取り込みは、カイロミクロン代謝の独立です。 Archives of Toxicology. Apr, 2006 | Pubmed ID: 16180009 Subcutaneous Drug Delivery and the Role of the Lymphatics Drug Discovery Today. Technologies. 2005 | Pubmed ID: 24981760 胆汁は、絶食ラットにおける腸管リンパ薬物輸送を増加させる Pharmaceutical Research. Nov, 2005 | Pubmed ID: 16132351 大腸菌由来のラット肝型脂肪酸結合タンパク質の精製のための改良法 Protein Expression and Purification. Nov, 2005 | Pubmed ID: 15914028 腸脂肪酸結合タンパク質との親油性薬物の相互作用 The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15722357 難水溶性薬物の吸収での一般的な定式化脂質の中間消化フェーズの影響 Journal of Pharmaceutical Sciences. Mar, 2005 | Pubmed ID: 15619248 リンパ吸収は羊に皮下投与後のエポエチンアルファの全身状況に主な要因です。 The Journal of Pharmacology and Experimental Therapeutics. Apr, 2005 | Pubmed ID: 15579493 難水溶性薬物の送達のために中鎖脂質由来の新規なキュービック相 Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2004 | Pubmed ID: 15380632 リパーゼ媒介消化に対する感受性は、中鎖脂質ベースのマイクロエマルジョン製剤として投与後ダナゾールの経口バイオアベイラビリティを削減 Pharmaceutical Research. Aug, 2004 | Pubmed ID: 15359575 難水溶性薬物のトリグリセリドベースオーラル脂質製剤の生体内でのパフォーマンスで説明する体外脂質消化のデータでの使用:ハロファントリンを用いた研究 Journal of Pharmaceutical Sciences. May, 2004 | Pubmed ID: 15067688 トリグリセリド脂質の難水溶性薬物の懸濁製剤のin Vitro消化中の薬物可溶化挙動 Pharmaceutical Research. Feb, 2004 | Pubmed ID: 15032306 シンプルなトリグリセリド脂質溶液製剤のin Vitro消化中の薬物可溶化挙動 Pharmaceutical Research. Feb, 2004 | Pubmed ID: 15032305 プラズマリポタンパク質とハロファントリンの脂肪族エステルのシリーズの協会のパターン上に物理化学的性質に及ぼす影響 Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2004 | Pubmed ID: 14980776 麻酔ウサギモデルにおけるハロファントリン誘導QTc間隔の延長上で改変されたリポタンパク質の結合条件の影響の評価 The Journal of Pharmacy and Pharmacology. Jan, 2004 | Pubmed ID: 14980003 羊の組換えヒト白血病抑制因子の動態 The Journal of Pharmacology and Experimental Therapeutics. Jun, 2004 | Pubmed ID: 14872093 脂質ベースのデリバリーシステムの投与後の消化管における薬物の可溶化パターンを探る:フェーズダイアグラムのアプローチ Journal of Pharmaceutical Sciences. Feb, 2004 | Pubmed ID: 14705191 ハロファントリンの腸リンパ輸送は絶食犬に単位用量の脂質ベース製剤の経口投与後に発生します。 Pharmaceutical Research. Sep, 2003 | Pubmed ID: 14567642 ストラクチャード·トリグリセリドを含む自己microemulsifyingドラッグデリバリーシステムで管理した後トリプルカニューレイヌモデル(SMEDDS)のハロファントリンの経口吸収およびリンパ輸送の検討 European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Sep, 2003 | Pubmed ID: 13678797 羊に皮下注射後のR-metHu-レプチンのリンパ吸収を記述するための薬物動態学的モデル Pharmaceutical Research. Aug, 2003 | Pubmed ID: 12948012 In Vitroで腸透過性データの検討にコンパートメントモデルの適用:組織取り込み、P-糖タンパク質、およびCYP3Aの影響を評価する Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2003 | Pubmed ID: 12920171 に配慮したリンパ管、カニューレ犬の2つのAndriol製剤の経口投与後のテストステロンの全身曝露にLymphatically輸送されるテストステロンウンデカン酸の寄与 The Journal of Pharmacology and Experimental Therapeutics. Sep, 2003 | Pubmed ID: 12807999 モデル脂質消化産物中に可溶化難水溶性薬物の熱力学的活性を調べるために高分子分割法を使用して Journal of Pharmaceutical Sciences. Jun, 2003 | Pubmed ID: 12761815 立体選択的リンパ吸収は、in Vivoでハロファントリンのエナンチオ選択的体内動態に貢献していますか? Biopharmaceutics & Drug Disposition. May, 2003 | Pubmed ID: 12698498 Autoperfusedラット空腸における吸収、流出、およびベラパミルの代謝の速度論的評価 The Journal of Pharmacology and Experimental Therapeutics. Apr, 2003 | Pubmed ID: 12649363 Desbutylhalofantrine:QT延長およびin Vivoで静脈内投与後に他の心血管系への影響の評価 Journal of Cardiovascular Pharmacology. Mar, 2003 | Pubmed ID: 12605019 一般的な定式化脂質と選択した難水溶性薬物の見かけの溶解度に及ぼす影響の評価の消化で生成コロイド相分離とキャラクタリゼーション Journal of Pharmaceutical Sciences. Mar, 2003 | Pubmed ID: 12587125 An in Vitro Examination of the Impact of Polyethylene Glycol 400, Pluronic P85, and Vitamin E D-alpha-tocopheryl Polyethylene Glycol 1000 Succinate on P-glycoprotein Efflux and Enterocyte-based Metabolism in Excised Rat Intestine AAPS PharmSci. 2002 | Pubmed ID: 12646011 ハロファントリンの経口送達のために構造化されたトリグリセリド車:覚醒ラットにおける腸管リンパ輸送および生物学的利用能の検討 Pharmaceutical Research. Sep, 2002 | Pubmed ID: 12403073 犬に食後投与後の不十分な脂溶性抗マラリア、ハロファントリン塩酸の広範な腸リンパ輸送のための物理化学的基礎、 Journal of Pharmaceutical Sciences. Mar, 2002 | Pubmed ID: 11920750 ロングと中鎖グリセリドのin Vitro消化プロファイルとその脂肪分解製品の相挙動の評価 The Journal of Pharmacy and Pharmacology. Jan, 2002 | Pubmed ID: 11833493 腸間膜リンパダクトカニューレを挿入ラットモデル:腸のリンパ医薬品輸送の評価への応用 Natalie L. Trevaskis1, Luojuan Hu1, Suzanne M. Caliph1, Sifei Han1, Christopher J.H. Porter1 1Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) Immunology and Infection
腸間膜リンパダクトカニューレを挿入ラットモデル:腸のリンパ医薬品輸送の評価への応用 Natalie L. Trevaskis1, Luojuan Hu1, Suzanne M. Caliph1, Sifei Han1, Christopher J.H. Porter1 1Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) Immunology and Infection