Christopher J.H. Porter Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences Monash University (Parkville Campus) Biography Publications Institution JoVE Articles Christopher J.H. Porter has not added a biography. If you are Christopher J.H. Porter and would like to personalize this page please email our Author Liaison for assistance. Publications PEGylation Does Not Significantly Change the Initial Intravenous or Subcutaneous Pharmacokinetics or Lymphatic Exposure of Trastuzumab in Rats but Increases Plasma Clearance After Subcutaneous Administration Molecular Pharmaceutics. Mar, 2015 | Pubmed ID: 25644368 Size and Rigidity of Cylindrical Polymer Brushes Dictate Long Circulating Properties in Vivo ACS Nano. Feb, 2015 | Pubmed ID: 25634484 Optimal PEGylation Can Improve the Exposure of Interferon in the Lungs Following Pulmonary Administration Journal of Pharmaceutical Sciences. Jan, 2015 | Pubmed ID: 25631360 Methotrexate-conjugated PEGylated Dendrimers Show Differential Patterns of Deposition and Activity in Tumour-burdened Lymph Nodes After Intravenous and Subcutaneous Administration in Rats Molecular Pharmaceutics. Dec, 2014 | Pubmed ID: 25485615 Profiling the Role of Deacylation-Reacylation in the Lymphatic Transport of a Triglyceride-Mimetic Prodrug Pharmaceutical Research. Dec, 2014 | Pubmed ID: 25446770 Toward the Establishment of Standardized In Vitro Tests for Lipid-Based Formulations. 5. Lipolysis of Representative Formulations by Gastric Lipase Pharmaceutical Research. Oct, 2014 | Pubmed ID: 25288015 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 6: Effects of Varying Pancreatin and Calcium Levels The AAPS Journal. Nov, 2014 | Pubmed ID: 25274609 An in Vitro Digestion Test That Reflects Rat Intestinal Conditions to Probe the Importance of Formulation Digestion Vs First Pass Metabolism in Danazol Bioavailability from Lipid Based Formulations Molecular Pharmaceutics. Nov, 2014 | Pubmed ID: 25265395 In Vitro-in Vivo Evaluation of Lipid Based Formulations of the CETP Inhibitors CP-529,414 (torcetrapib) and CP-532,623 European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V. Nov, 2014 | Pubmed ID: 25152213 Characterization of Two Distinct Modes of Drug Binding to Human Intestinal Fatty Acid Binding Protein ACS Chemical Biology. Nov, 2014 | Pubmed ID: 25144524 'Stealth' Lipid-based Formulations: Poly(ethylene Glycol)-mediated Digestion Inhibition Improves Oral Bioavailability of a Model Poorly Water Soluble Drug Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2014 | Pubmed ID: 25058571 Digestion of Phospholipids After Secretion of Bile into the Duodenum Changes the Phase Behavior of Bile Components Molecular Pharmaceutics. Aug, 2014 | Pubmed ID: 24987935 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 4: Proposing a New Lipid Formulation Performance Classification System Journal of Pharmaceutical Sciences. Aug, 2014 | Pubmed ID: 24985238 The Influence of Intestinal Lymphatic Transport on the Systemic Exposure and Brain Deposition of a Novel Highly Lipophilic Compound with Structural Similarity to Cholesterol The Journal of Pharmacy and Pharmacology. Oct, 2014 | Pubmed ID: 24821499 Nano-chemotherapeutics: Maximising Lymphatic Drug Exposure to Improve the Treatment of Lymph-metastatic Cancers Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2014 | Pubmed ID: 24801249 Lipid-based Formulations Solidified Via Adsorption Onto the Mesoporous Carrier Neusilin® US2: Effect of Drug Type and Formulation Composition on in Vitro Pharmaceutical Performance Journal of Pharmaceutical Sciences. Jun, 2014 | Pubmed ID: 24740767 Pulmonary Administration of a Doxorubicin-conjugated Dendrimer Enhances Drug Exposure to Lung Metastases and Improves Cancer Therapy Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2014 | Pubmed ID: 24637466 Pulmonary and Systemic Pharmacokinetics of Inhaled and Intravenous Colistin Methanesulfonate in Cystic Fibrosis Patients: Targeting Advantage of Inhalational Administration Antimicrobial Agents and Chemotherapy. May, 2014 | Pubmed ID: 24550334 Non-linear Increases in Danazol Exposure with Dose in Older Vs. Younger Beagle Dogs: the Potential Role of Differences in Bile Salt Concentration, Thermodynamic Activity, and Formulation Digestion Pharmaceutical Research. Jun, 2014 | Pubmed ID: 24477676 Choice of Nonionic Surfactant Used to Formulate Type IIIA Self-emulsifying Drug Delivery Systems and the Physicochemical Properties of the Drug Have a Pronounced Influence on the Degree of Drug Supersaturation That Develops During in Vitro Digestion Journal of Pharmaceutical Sciences. Apr, 2014 | Pubmed ID: 24470073 Targeted Delivery of a Model Immunomodulator to the Lymphatic System: Comparison of Alkyl Ester Versus Triglyceride Mimetic Lipid Prodrug Strategies Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2014 | Pubmed ID: 24398334 Ionic Liquids Provide Unique Opportunities for Oral Drug Delivery: Structure Optimization and in Vivo Evidence of Utility Chemical Communications (Cambridge, England). Feb, 2014 | Pubmed ID: 24394756 The Lymphatic System Plays a Major Role in the Intravenous and Subcutaneous Pharmacokinetics of Trastuzumab in Rats Molecular Pharmaceutics. Feb, 2014 | Pubmed ID: 24350780 Recent Advances in Lipid-based Formulation Technology Pharmaceutical Research. Dec, 2013 | Pubmed ID: 24158727 Gastric Pre-processing is an Important Determinant of the Ability of Medium-chain Lipid Solution Formulations to Enhance Oral Bioavailability in Rats Journal of Pharmaceutical Sciences. Nov, 2013 | Pubmed ID: 23983139 PEGylated Polylysine Dendrimers Increase Lymphatic Exposure to Doxorubicin when Compared to PEGylated Liposomal and Solution Formulations of Doxorubicin Journal of Controlled Release : Official Journal of the Controlled Release Society. Nov, 2013 | Pubmed ID: 23954628 Population Pharmacokinetics of Colistin Methanesulfonate in Rats: Achieving Sustained Lung Concentrations of Colistin for Targeting Respiratory Infections Antimicrobial Agents and Chemotherapy. Oct, 2013 | Pubmed ID: 23917323 Lipid-based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/absorption Pathway Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23824582 Lipid Absorption Triggers Drug Supersaturation at the Intestinal Unstirred Water Layer and Promotes Drug Absorption from Mixed Micelles Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23793990 Computational Prediction of Drug Solubility in Lipid Based Formulation Excipients Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23771564 Pulmonary Administration of PEGylated Polylysine Dendrimers: Absorption from the Lung Versus Retention Within the Lung is Highly Size-dependent Molecular Pharmaceutics. Aug, 2013 | Pubmed ID: 23750747 A Simple Quantitative Approach for the Determination of Long and Medium Chain Lipids in Bio-relevant Matrices by High Performance Liquid Chromatography with Refractive Index Detection AAPS PharmSciTech. Sep, 2013 | Pubmed ID: 23733513 The Potential for Drug Supersaturation During Intestinal Processing of Lipid-based Formulations May Be Enhanced for Basic Drugs Molecular Pharmaceutics. Jul, 2013 | Pubmed ID: 23697606 The Impact of Lymphatic Transport on the Systemic Disposition of Lipophilic Drugs Journal of Pharmaceutical Sciences. Jul, 2013 | Pubmed ID: 23696002 In Vitro Assessment of Drug-free and Fenofibrate-containing Lipid Formulations Using Dispersion and Digestion Testing Gives Detailed Insights into the Likely Fate of Formulations in the Intestine European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2013 | Pubmed ID: 23684915 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the in Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-based Formulations Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23661145 Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis Molecular Pharmaceutics. Aug, 2013 | Pubmed ID: 23631696 PEGylation of Interferon α2 Improves Lymphatic Exposure After Subcutaneous and Intravenous Administration and Improves Antitumour Efficacy Against Lymphatic Breast Cancer Metastases Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2013 | Pubmed ID: 23499718 Intestinal Bile Secretion Promotes Drug Absorption from Lipid Colloidal Phases Via Induction of Supersaturation Molecular Pharmaceutics. May, 2013 | Pubmed ID: 23480483 A Mouse Model to Evaluate the Impact of Species, Sex, and Lipid Load on Lymphatic Drug Transport Pharmaceutical Research. Dec, 2013 | Pubmed ID: 23430484 Strategies to Address Low Drug Solubility in Discovery and Development Pharmacological Reviews. Jan, 2013 | Pubmed ID: 23383426 Silica-lipid Hybrid (SLH) Formulations Enhance the Oral Bioavailability and Efficacy of Celecoxib: An in Vivo Evaluation Journal of Controlled Release : Official Journal of the Controlled Release Society. Apr, 2013 | Pubmed ID: 23353808 The Effect of Administered Dose of Lipid-based Formulations on the in Vitro and in Vivo Performance of Cinnarizine As a Model Poorly Water-soluble Drug Journal of Pharmaceutical Sciences. Feb, 2013 | Pubmed ID: 23242691 In Vitro Digestion Testing of Lipid-based Delivery Systems: Calcium Ions Combine with Fatty Acids Liberated from Triglyceride Rich Lipid Solutions to Form Soaps and Reduce the Solubilization Capacity of Colloidal Digestion Products International Journal of Pharmaceutics. Jan, 2013 | Pubmed ID: 23178598 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations During in Vitro Digestion Molecular Pharmaceutics. Nov, 2012 | Pubmed ID: 23030411 Incomplete Desorption of Liquid Excipients Reduces the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems Solidified by Adsorption Onto an Inorganic Mesoporous Carrier Molecular Pharmaceutics. Sep, 2012 | Pubmed ID: 22870936 Lipid Digestion As a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems Molecular Pharmaceutics. Jul, 2012 | Pubmed ID: 22656917 Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 1: Method Parameterization and Comparison of in Vitro Digestion Profiles Across a Range of Representative Formulations Journal of Pharmaceutical Sciences. Sep, 2012 | Pubmed ID: 22644939 Intravenous Dosing Conditions May Affect Systemic Clearance for Highly Lipophilic Drugs: Implications for Lymphatic Transport and Absolute Bioavailability Studies Journal of Pharmaceutical Sciences. Sep, 2012 | Pubmed ID: 22623170 Association of Chemotherapeutic Drugs with Dendrimer Nanocarriers: An Assessment of the Merits of Covalent Conjugation Compared to Noncovalent Encapsulation Molecular Pharmaceutics. Jan, 2012 | Pubmed ID: 22250750 Doxorubicin-Conjugated PEGylated Dendrimers Show Similar Tumoricidal Activity but Lower Systemic Toxicity When Compared to PEGylated Liposome and Solution Formulations in Mouse and Rat Tumor Models Molecular Pharmaceutics. Jan, 2012 | Pubmed ID: 22233281 A Comparison of Changes to Doxorubicin Pharmacokinetics, Antitumor Activity, and Toxicity Mediated by PEGylated Dendrimer and PEGylated Liposome Drug Delivery Systems Nanomedicine : Nanotechnology, Biology, and Medicine. Jan, 2012 | Pubmed ID: 21704192 Correction to "targeted Drug Delivery to Lymphocytes: a Route to Site-specific Immunomodulation?" Molecular Pharmaceutics. Dec, 2011 | Pubmed ID: 21995681 Dendrimer Pharmacokinetics: the Effect of Size, Structure and Surface Characteristics on ADME Properties Nanomedicine (London, England). Aug, 2011 | Pubmed ID: 21955077 Differences in Colloidal Structure of PEGylated Nanomaterials Dictate the Likelihood of Accelerated Blood Clearance Journal of Pharmaceutical Sciences. Nov, 2011 | Pubmed ID: 21721002 Targeting the Lymphatics Using Dendritic Polymers (dendrimers) Advanced Drug Delivery Reviews. Sep, 2011 | Pubmed ID: 21683746 Acute Hypertriglyceridemia Promotes Intestinal Lymphatic Lipid and Drug Transport: a Positive Feedback Mechanism in Lipid and Drug Absorption Molecular Pharmaceutics. Aug, 2011 | Pubmed ID: 21604764 Fatty Acid Binding Proteins: Potential Chaperones of Cytosolic Drug Transport in the Enterocyte? Pharmaceutical Research. Sep, 2011 | Pubmed ID: 21523511 Nanostructured Liquid Crystalline Particles Provide Long Duration Sustained-release Effect for a Poorly Water Soluble Drug After Oral Administration Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2011 | Pubmed ID: 21497623 Characterisation and Tumour Targeting of PEGylated Polylysine Dendrimers Bearing Doxorubicin Via a PH Labile Linker Journal of Controlled Release : Official Journal of the Controlled Release Society. Jun, 2011 | Pubmed ID: 21315119 Preparation, Crystallization and Preliminary X-ray Diffraction Analysis of Two Intestinal Fatty-acid Binding Proteins in the Presence of 11-(dansylamino)undecanoic Acid Acta Crystallographica. Section F, Structural Biology and Crystallization Communications. Feb, 2011 | Pubmed ID: 21301109 Capping Methotrexate α-carboxyl Groups Enhances Systemic Exposure and Retains the Cytotoxicity of Drug Conjugated PEGylated Polylysine Dendrimers Molecular Pharmaceutics. Apr, 2011 | Pubmed ID: 21171585 Using Polymeric Precipitation Inhibitors to Improve the Absorption of Poorly Water-soluble Drugs: A Mechanistic Basis for Utility Journal of Drug Targeting. Dec, 2010 | Pubmed ID: 20973755 Targeted Drug Delivery to Lymphocytes: a Route to Site-specific Immunomodulation? Molecular Pharmaceutics. Dec, 2010 | Pubmed ID: 20958081 Phytantriol and Glyceryl Monooleate Cubic Liquid Crystalline Phases As Sustained-release Oral Drug Delivery Systems for Poorly Water-soluble Drugs II. In-vivo Evaluation The Journal of Pharmacy and Pharmacology. Jul, 2010 | Pubmed ID: 20636873 Phytantriol and Glyceryl Monooleate Cubic Liquid Crystalline Phases As Sustained-release Oral Drug Delivery Systems for Poorly Water Soluble Drugs I. Phase Behaviour in Physiologically-relevant Media The Journal of Pharmacy and Pharmacology. Jul, 2010 | Pubmed ID: 20636872 The Mechanism of Lymphatic Access of Two Cholesteryl Ester Transfer Protein Inhibitors (CP524,515 and CP532,623) and Evaluation of Their Impact on Lymph Lipoprotein Profiles Pharmaceutical Research. Sep, 2010 | Pubmed ID: 20635194 The Role of the Intestinal Lymphatics in the Absorption of Two Highly Lipophilic Cholesterol Ester Transfer Protein Inhibitors (CP524,515 and CP532,623) Pharmaceutical Research. May, 2010 | Pubmed ID: 20221896 Lymphatic Transport of Methylnortestosterone Undecanoate (MU) and the Bioavailability of Methylnortestosterone Are Highly Sensitive to the Mass of Coadministered Lipid After Oral Administration of MU The Journal of Pharmacology and Experimental Therapeutics. Nov, 2009 | Pubmed ID: 19696095 Probing the Fibrate Binding Specificity of Rat Liver Fatty Acid Binding Protein Journal of Medicinal Chemistry. Sep, 2009 | Pubmed ID: 19663428 Oral Bioavailability Assessment and Intestinal Lymphatic Transport of Org 45697 and Org 46035, Two Highly Lipophilic Novel Immunomodulator Analogues Current Drug Delivery. Aug, 2009 | Pubmed ID: 19534711 Pharmacokinetics and Tumor Disposition of PEGylated, Methotrexate Conjugated Poly-l-lysine Dendrimers Molecular Pharmaceutics. Jul-Aug, 2009 | Pubmed ID: 19453158 Intestinal Lymphatic Transport Enhances the Post-prandial Oral Bioavailability of a Novel Cannabinoid Receptor Agonist Via Avoidance of First-pass Metabolism Pharmaceutical Research. Jun, 2009 | Pubmed ID: 19280324 Characterization of Lipophilic Drug Binding to Rat Intestinal Fatty Acid Binding Protein Molecular and Cellular Biochemistry. Jun, 2009 | Pubmed ID: 19160019 An Evaluation of the Relative Roles of the Unstirred Water Layer and Receptor Sink in Limiting the In-vitro Intestinal Permeability of Drug Compounds of Varying Lipophilicity The Journal of Pharmacy and Pharmacology. Oct, 2008 | Pubmed ID: 18812024 Characterization of the Drug Binding Specificity of Rat Liver Fatty Acid Binding Protein Journal of Medicinal Chemistry. Jul, 2008 | Pubmed ID: 18533710 The Impact of Molecular Weight and PEG Chain Length on the Systemic Pharmacokinetics of PEGylated Poly L-lysine Dendrimers Molecular Pharmaceutics. May-Jun, 2008 | Pubmed ID: 18393438 Lipid-based Systems for the Enhanced Delivery of Poorly Water Soluble Drugs Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18160174 Enhancing Intestinal Drug Solubilisation Using Lipid-based Delivery Systems Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18155801 Lipid-based Delivery Systems and Intestinal Lymphatic Drug Transport: a Mechanistic Update Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18155316 Formulation of Lipid-based Delivery Systems for Oral Administration: Materials, Methods and Strategies Advanced Drug Delivery Reviews. Mar, 2008 | Pubmed ID: 18068260 Evaluation of the Impact of Surfactant Digestion on the Bioavailability of Danazol After Oral Administration of Lipidic Self-emulsifying Formulations to Dogs Journal of Pharmaceutical Sciences. Feb, 2008 | Pubmed ID: 18064698 Use of Plasma Proteins As Solubilizing Agents in in Vitro Permeability Experiments: Correction for Unbound Drug Concentration Using the Reciprocal Permeability Approach Journal of Pharmaceutical Sciences. Jan, 2008 | Pubmed ID: 17585392 Impact of Surface Derivatization of Poly-L-lysine Dendrimers with Anionic Arylsulfonate or Succinate Groups on Intravenous Pharmacokinetics and Disposition Molecular Pharmaceutics. Nov-Dec, 2007 | Pubmed ID: 17953445 Lymphatic Absorption of Subcutaneously Administered Proteins: Influence of Different Injection Sites on the Absorption of Darbepoetin Alfa Using a Sheep Model Drug Metabolism and Disposition: the Biological Fate of Chemicals. Dec, 2007 | Pubmed ID: 17875672 Low Dose Lipid Formulations: Effects on Gastric Emptying and Biliary Secretion Pharmaceutical Research. Nov, 2007 | Pubmed ID: 17657595 A Lipid-based Liquid Crystalline Matrix That Provides Sustained Release and Enhanced Oral Bioavailability for a Model Poorly Water Soluble Drug in Rats International Journal of Pharmaceutics. Aug, 2007 | Pubmed ID: 17467935 Examination of the Role of Intestinal Fatty Acid-binding Protein in Drug Absorption Using a Parallel Artificial Membrane Permeability Assay Chemistry & Biology. Apr, 2007 | Pubmed ID: 17462580 Increasing the Proportional Content of Surfactant (Cremophor EL) Relative to Lipid in Self-emulsifying Lipid-based Formulations of Danazol Reduces Oral Bioavailability in Beagle Dogs Pharmaceutical Research. Apr, 2007 | Pubmed ID: 17372700 Lipids and Lipid-based Formulations: Optimizing the Oral Delivery of Lipophilic Drugs Nature Reviews. Drug Discovery. Mar, 2007 | Pubmed ID: 17330072 Impact of Cremophor-EL and Polysorbate-80 on Digoxin Permeability Across Rat Jejunum: Delineation of Thermodynamic and Transporter Related Events Using the Reciprocal Permeability Approach Journal of Pharmaceutical Sciences. Feb, 2007 | Pubmed ID: 17051595 Cationic Poly-L-lysine Dendrimers: Pharmacokinetics, Biodistribution, and Evidence for Metabolism and Bioresorption After Intravenous Administration to Rats Molecular Pharmaceutics. Sep-Oct, 2006 | Pubmed ID: 17009860 The Absorption of Darbepoetin Alfa Occurs Predominantly Via the Lymphatics Following Subcutaneous Administration to Sheep Pharmaceutical Research. Sep, 2006 | Pubmed ID: 16951999 Permeability Assessment of Poorly Water-soluble Compounds Under Solubilizing Conditions: the Reciprocal Permeability Approach Journal of Pharmaceutical Sciences. Oct, 2006 | Pubmed ID: 16883557 An Acute and Coincident Increase in FABP Expression and Lymphatic Lipid and Drug Transport Occurs During Intestinal Infusion of Lipid-based Drug Formulations to Rats Pharmaceutical Research. Aug, 2006 | Pubmed ID: 16858652 Examination of the Impact of a Range of Pluronic Surfactants on the In-vitro Solubilisation Behaviour and Oral Bioavailability of Lipidic Formulations of Atovaquone The Journal of Pharmacy and Pharmacology. Jun, 2006 | Pubmed ID: 16734982 An Examination of the Interplay Between Enterocyte-based Metabolism and Lymphatic Drug Transport in the Rat Drug Metabolism and Disposition: the Biological Fate of Chemicals. May, 2006 | Pubmed ID: 16467133 The Lymph Lipid Precursor Pool is a Key Determinant of Intestinal Lymphatic Drug Transport The Journal of Pharmacology and Experimental Therapeutics. Feb, 2006 | Pubmed ID: 16249368 Tissue Uptake of DDT is Independent of Chylomicron Metabolism Archives of Toxicology. Apr, 2006 | Pubmed ID: 16180009 Subcutaneous Drug Delivery and the Role of the Lymphatics Drug Discovery Today. Technologies. 2005 | Pubmed ID: 24981760 Bile Increases Intestinal Lymphatic Drug Transport in the Fasted Rat Pharmaceutical Research. Nov, 2005 | Pubmed ID: 16132351 An Improved Method for the Purification of Rat Liver-type Fatty Acid Binding Protein from Escherichia Coli Protein Expression and Purification. Nov, 2005 | Pubmed ID: 15914028 The Interaction of Lipophilic Drugs with Intestinal Fatty Acid-binding Protein The Journal of Biological Chemistry. May, 2005 | Pubmed ID: 15722357 Influence of the Intermediate Digestion Phases of Common Formulation Lipids on the Absorption of a Poorly Water-soluble Drug Journal of Pharmaceutical Sciences. Mar, 2005 | Pubmed ID: 15619248 Lymphatic Absorption is the Primary Contributor to the Systemic Availability of Epoetin Alfa Following Subcutaneous Administration to Sheep The Journal of Pharmacology and Experimental Therapeutics. Apr, 2005 | Pubmed ID: 15579493 A Novel Cubic Phase of Medium Chain Lipid Origin for the Delivery of Poorly Water Soluble Drugs Journal of Controlled Release : Official Journal of the Controlled Release Society. Sep, 2004 | Pubmed ID: 15380632 Susceptibility to Lipase-mediated Digestion Reduces the Oral Bioavailability of Danazol After Administration As a Medium-chain Lipid-based Microemulsion Formulation Pharmaceutical Research. Aug, 2004 | Pubmed ID: 15359575 Use of in Vitro Lipid Digestion Data to Explain the in Vivo Performance of Triglyceride-based Oral Lipid Formulations of Poorly Water-soluble Drugs: Studies with Halofantrine Journal of Pharmaceutical Sciences. May, 2004 | Pubmed ID: 15067688 Drug Solubilization Behavior During in Vitro Digestion of Suspension Formulations of Poorly Water-soluble Drugs in Triglyceride Lipids Pharmaceutical Research. Feb, 2004 | Pubmed ID: 15032306 Drug Solubilization Behavior During in Vitro Digestion of Simple Triglyceride Lipid Solution Formulations Pharmaceutical Research. Feb, 2004 | Pubmed ID: 15032305 Influence of Physicochemical Properties on the Patterns of Association of a Series of Aliphatic Esters of Halofantrine with Plasma Lipoproteins Journal of Controlled Release : Official Journal of the Controlled Release Society. Mar, 2004 | Pubmed ID: 14980776 Evaluation of the Impact of Altered Lipoprotein Binding Conditions on Halofantrine Induced QTc Interval Prolongation in an Anaesthetized Rabbit Model The Journal of Pharmacy and Pharmacology. Jan, 2004 | Pubmed ID: 14980003 Pharmacokinetics of Recombinant Human Leukemia Inhibitory Factor in Sheep The Journal of Pharmacology and Experimental Therapeutics. Jun, 2004 | Pubmed ID: 14872093 Probing Drug Solubilization Patterns in the Gastrointestinal Tract After Administration of Lipid-based Delivery Systems: a Phase Diagram Approach Journal of Pharmaceutical Sciences. Feb, 2004 | Pubmed ID: 14705191 Intestinal Lymphatic Transport of Halofantrine Occurs After Oral Administration of a Unit-dose Lipid-based Formulation to Fasted Dogs Pharmaceutical Research. Sep, 2003 | Pubmed ID: 14567642 Examination of Oral Absorption and Lymphatic Transport of Halofantrine in a Triple-cannulated Canine Model After Administration in Self-microemulsifying Drug Delivery Systems (SMEDDS) Containing Structured Triglycerides European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Sep, 2003 | Pubmed ID: 13678797 Pharmacokinetic Model to Describe the Lymphatic Absorption of R-metHu-leptin After Subcutaneous Injection to Sheep Pharmaceutical Research. Aug, 2003 | Pubmed ID: 12948012 Application of Compartmental Modeling to an Examination of in Vitro Intestinal Permeability Data: Assessing the Impact of Tissue Uptake, P-glycoprotein, and CYP3A Drug Metabolism and Disposition: the Biological Fate of Chemicals. Sep, 2003 | Pubmed ID: 12920171 Contribution of Lymphatically Transported Testosterone Undecanoate to the Systemic Exposure of Testosterone After Oral Administration of Two Andriol Formulations in Conscious Lymph Duct-cannulated Dogs The Journal of Pharmacology and Experimental Therapeutics. Sep, 2003 | Pubmed ID: 12807999 Using the Polymer Partitioning Method to Probe the Thermodynamic Activity of Poorly Water-soluble Drugs Solubilized in Model Lipid Digestion Products Journal of Pharmaceutical Sciences. Jun, 2003 | Pubmed ID: 12761815 Does Stereoselective Lymphatic Absorption Contribute to the Enantioselective Pharmacokinetics of Halofantrine In Vivo? Biopharmaceutics & Drug Disposition. May, 2003 | Pubmed ID: 12698498 A Kinetic Evaluation of the Absorption, Efflux, and Metabolism of Verapamil in the Autoperfused Rat Jejunum The Journal of Pharmacology and Experimental Therapeutics. Apr, 2003 | Pubmed ID: 12649363 Desbutylhalofantrine: Evaluation of QT Prolongation and Other Cardiovascular Effects After Intravenous Administration in Vivo Journal of Cardiovascular Pharmacology. Mar, 2003 | Pubmed ID: 12605019 Separation and Characterization of the Colloidal Phases Produced on Digestion of Common Formulation Lipids and Assessment of Their Impact on the Apparent Solubility of Selected Poorly Water-soluble Drugs Journal of Pharmaceutical Sciences. Mar, 2003 | Pubmed ID: 12587125 An in Vitro Examination of the Impact of Polyethylene Glycol 400, Pluronic P85, and Vitamin E D-alpha-tocopheryl Polyethylene Glycol 1000 Succinate on P-glycoprotein Efflux and Enterocyte-based Metabolism in Excised Rat Intestine AAPS PharmSci. 2002 | Pubmed ID: 12646011 Structured Triglyceride Vehicles for Oral Delivery of Halofantrine: Examination of Intestinal Lymphatic Transport and Bioavailability in Conscious Rats Pharmaceutical Research. Sep, 2002 | Pubmed ID: 12403073 A Physicochemical Basis for the Extensive Intestinal Lymphatic Transport of a Poorly Lipid Soluble Antimalarial, Halofantrine Hydrochloride, After Postprandial Administration to Dogs Journal of Pharmaceutical Sciences. Mar, 2002 | Pubmed ID: 11920750 Evaluation of the In-vitro Digestion Profiles of Long and Medium Chain Glycerides and the Phase Behaviour of Their Lipolytic Products The Journal of Pharmacy and Pharmacology. Jan, 2002 | Pubmed ID: 11833493 Mezenterik Lenf Kanal Kanüllü Rat Modeli: Bağırsak Lenfatik İlaç Ulaştırma Değerlendirilmesine Uygulaması Natalie L. Trevaskis1, Luojuan Hu1, Suzanne M. Caliph1, Sifei Han1, Christopher J.H. Porter1 1Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) Immunology and Infection
Mezenterik Lenf Kanal Kanüllü Rat Modeli: Bağırsak Lenfatik İlaç Ulaştırma Değerlendirilmesine Uygulaması Natalie L. Trevaskis1, Luojuan Hu1, Suzanne M. Caliph1, Sifei Han1, Christopher J.H. Porter1 1Drug Delivery, Disposition, and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus) Immunology and Infection