Christopher Chen Memory Aging and Cognition Centre National University Health System Biography Publications Institution JoVE Articles Christopher Chen has not added a biography. If you are Christopher Chen and would like to personalize this page please email our Author Liaison for assistance. Publications Influence of Cerebrovascular Disease on Brain Networks in Prodromal and Clinical Alzheimer's Disease Brain : a Journal of Neurology. Nov, 2017 | Pubmed ID: 29053778 Repeatability and Reproducibility of Retinal Neuronal and Axonal Measures on Spectral-Domain Optical Coherence Tomography in Patients with Cognitive Impairment Frontiers in Neurology. Month, 2017 | Pubmed ID: 28861029 Distinct White Matter Microstructural Abnormalities and Extracellular Water Increases Relate to Cognitive Impairment in Alzheimer's Disease with and Without Cerebrovascular Disease Alzheimer's Research & Therapy. Aug, 2017 | Pubmed ID: 28818116 Detection, Risk Factors, and Functional Consequences of Cerebral Microinfarcts The Lancet. Neurology. Sep, 2017 | Pubmed ID: 28716371 Ankle Brachial Index, MRI Markers and Cognition: The Epidemiology of Dementia in Singapore Study Atherosclerosis. Aug, 2017 | Pubmed ID: 28709046 Prevalence, Risk Factors and Consequences of Cerebral Small Vessel Diseases: Data from Three Asian Countries Journal of Neurology, Neurosurgery, and Psychiatry. Aug, 2017 | Pubmed ID: 28600443 Decline in Changing Montreal Cognitive Assessment (MoCA) Scores is Associated with Post-stroke Cognitive Decline Determined by a Formal Neuropsychological Evaluation PloS One. Month, 2017 | Pubmed ID: 28346532 Serum IL-8 is a Marker of White-matter Hyperintensities in Patients with Alzheimer's Disease Alzheimer's & Dementia (Amsterdam, Netherlands). Month, 2017 | Pubmed ID: 28239640 Association Between Subclinical Cardiac Biomarkers and Clinically Manifest Cardiac Diseases With Cortical Cerebral Microinfarcts JAMA Neurology. Apr, 2017 | Pubmed ID: 28166312 Evidence That NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke Molecular Neurobiology. Jan, 2017 | Pubmed ID: 28092085 Imaging Retina to Study Dementia and Stroke Progress in Retinal and Eye Research. Mar, 2017 | Pubmed ID: 28057562 Prognostic Factors and Pattern of Long-Term Recovery with MLC601 (NeuroAiD™) in the Chinese Medicine NeuroAiD Efficacy on Stroke Recovery - Extension Study Cerebrovascular Diseases (Basel, Switzerland). Month, 2017 | Pubmed ID: 27846631 Evaluation of an FMRI USPIO-based Assay in Healthy Human Volunteers Journal of Magnetic Resonance Imaging : JMRI. Jul, 2017 | Pubmed ID: 27775841 Poststroke Cognitive Decline is Independent of Longitudinal Changes in Cerebral Hemodynamics Parameters Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging. May, 2017 | Pubmed ID: 27623192 Intracranial Stenosis in Cognitive Impairment and Dementia Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. Jun, 2017 | Pubmed ID: 27488908 Cerebral Microbleeds and Neuropsychiatric Symptoms in an Elderly Asian Cohort Journal of Neurology, Neurosurgery, and Psychiatry. Jan, 2017 | Pubmed ID: 27261503 Prevalence of Cognitive Impairment and Dementia in Malays - Epidemiology of Dementia in Singapore Study Current Alzheimer Research. Month, 2017 | Pubmed ID: 26428410 Impact of Strategically Located White Matter Hyperintensities on Cognition in Memory Clinic Patients with Small Vessel Disease PloS One. Month, 2016 | Pubmed ID: 27824925 Novel Genetic Loci Underlying Human Intracranial Volume Identified Through Genome-wide Association Nature Neuroscience. Dec, 2016 | Pubmed ID: 27694991 Muscarinic M1 Receptor Coupling to G-protein is Intact in Parkinson's Disease Dementia Journal of Parkinson's Disease. Oct, 2016 | Pubmed ID: 27662332 Increased Phosphorylation of Collapsin Response Mediator Protein-2 at Thr514 Correlates with β-amyloid Burden and Synaptic Deficits in Lewy Body Dementias Molecular Brain. 09, 2016 | Pubmed ID: 27609071 Cortical Cerebral Microinfarcts on 3T MRI: A Novel Marker of Cerebrovascular Disease Neurology. Oct, 2016 | Pubmed ID: 27590296 Inter-hemispheric Functional Dysconnectivity Mediates the Association of Corpus Callosum Degeneration with Memory Impairment in AD and Amnestic MCI Scientific Reports. Sep, 2016 | Pubmed ID: 27581062 The Association Between Retinal Neuronal Layer and Brain Structure is Disrupted In Patients with Cognitive Impairment And Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Sep, 2016 | Pubmed ID: 27567815 Growth Differentiation Factor-15 and White Matter Hyperintensities in Cognitive Impairment and Dementia Medicine. Aug, 2016 | Pubmed ID: 27537582 The Diagnostic Utility of the NINDS-CSN Neuropsychological Battery in Memory Clinics Dementia and Geriatric Cognitive Disorders Extra. May-Aug, 2016 | Pubmed ID: 27504116 Changing Patterns of Patient Characteristics in a Memory Clinic in Singapore Journal of the American Medical Directors Association. Sep, 2016 | Pubmed ID: 27449635 ApoE4 Expression Accelerates Hippocampus-dependent Cognitive Deficits by Enhancing Aβ Impairment of Insulin Signaling in an Alzheimer's Disease Mouse Model Scientific Reports. May, 2016 | Pubmed ID: 27189808 Validation of the Total Cerebrovascular Disease Burden Scale in a Community Sample Journal of Alzheimer's Disease : JAD. Apr, 2016 | Pubmed ID: 27079726 The Montreal Cognitive Assessment is Superior to National Institute of Neurological Disease and Stroke-Canadian Stroke Network 5-minute Protocol in Predicting Vascular Cognitive Impairment at 1 Year BMC Neurology. Apr, 2016 | Pubmed ID: 27067253 Gender Differences in White Matter Pathology and Mitochondrial Dysfunction in Alzheimer's Disease with Cerebrovascular Disease Molecular Brain. Mar, 2016 | Pubmed ID: 26983404 Apolipoprotein ɛ4 is Associated with Dementia and Cognitive Impairment Predominantly Due to Alzheimer's Disease and Not with Vascular Cognitive Impairment: A Singapore-Based Cohort Journal of Alzheimer's Disease : JAD. Month, 2016 | Pubmed ID: 26923016 The Combined Utility of a Brief Functional Measure and Performance-Based Screening Test for Case Finding of Cognitive Impairment in Primary Healthcare Journal of the American Medical Directors Association. Apr, 2016 | Pubmed ID: 26857297 Risk Factors of Cognitive Impairment and Brief Cognitive Tests To Predict Cognitive Performance Determined by a Formal Neuropsychological Evaluation of Primary Health Care Patients Journal of the American Medical Directors Association. Apr, 2016 | Pubmed ID: 26785695 Clinical Utility of the Informant AD8 As a Dementia Case Finding Instrument in Primary Healthcare Journal of Alzheimer's Disease : JAD. Month, 2016 | Pubmed ID: 26444776 A Priori Collaboration in Population Imaging: The Uniform Neuro-Imaging of Virchow-Robin Spaces Enlargement Consortium Alzheimer's & Dementia (Amsterdam, Netherlands). Dec, 2015 | Pubmed ID: 27239529 Beyond Screening: Can the Mini-Mental State Examination Be Used As an Exclusion Tool in a Memory Clinic? Diagnostics (Basel, Switzerland). Nov, 2015 | Pubmed ID: 26854165 Rapid Screening for Cognitive Impairment in Parkinson's Disease: A Pilot Study Parkinson's Disease. Month, 2015 | Pubmed ID: 26713170 Inter-Dependent Mechanisms Behind Cognitive Dysfunction, Vascular Biology and Alzheimer's Dementia in Down Syndrome: Multi-Faceted Roles of APP Frontiers in Behavioral Neuroscience. Month, 2015 | Pubmed ID: 26648852 Ocular Fundus Photography As a Tool to Study Stroke and Dementia Seminars in Neurology. Oct, 2015 | Pubmed ID: 26444393 Extracellular Vesicles Are Rapidly Purified from Human Plasma by PRotein Organic Solvent PRecipitation (PROSPR) Scientific Reports. Sep, 2015 | Pubmed ID: 26419333 Subcortical Atrophy in Cognitive Impairment and Dementia Journal of Alzheimer's Disease : JAD. Month, 2015 | Pubmed ID: 26402115 Differential Interaction of Apolipoprotein-E Isoforms with Insulin Receptors Modulates Brain Insulin Signaling in Mutant Human Amyloid Precursor Protein Transgenic Mice Scientific Reports. Sep, 2015 | Pubmed ID: 26346625 Association of Magnetic Resonance Imaging Markers of Cerebrovascular Disease Burden and Cognition Stroke. Oct, 2015 | Pubmed ID: 26330446 Prevalence and Risk Factors of Acute Incidental Infarcts Stroke. Oct, 2015 | Pubmed ID: 26294677 Association of Neuropsychiatric Symptoms and Sub-syndromes with Cognitive Impairment in Community-dwelling Asian Elderly International Psychogeriatrics. Nov, 2015 | Pubmed ID: 26201550 Risk Factors and Consequences of Cortical Thickness in an Asian Population Medicine. Jun, 2015 | Pubmed ID: 26061305 Cortical Microinfarcts on 3T MRI: Clinical Correlates In memory-clinic patients Alzheimer's & Dementia : the Journal of the Alzheimer's Association. May, 2015 | Pubmed ID: 25956990 Markers of Cardiac Dysfunction in Cognitive Impairment and Dementia Medicine. Jan, 2015 | Pubmed ID: 25569645 Temporal Lobe Proteins Implicated in Synaptic Failure Exhibit Differential Expression and Deamidation in Vascular Dementia Neurochemistry International. Jan, 2015 | Pubmed ID: 25497727 Retinal Neurodegeneration on Optical Coherence Tomography and Cerebral Atrophy Neuroscience Letters. Jan, 2015 | Pubmed ID: 25451722 Retinal Ganglion Cell Analysis Using High-definition Optical Coherence Tomography in Patients with Mild Cognitive Impairment and Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2015 | Pubmed ID: 25428254 Differential Alterations of Neocortical GluN Receptor Subunits in Patients with Mixed Subcortical Ischemic Vascular Dementia and Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2015 | Pubmed ID: 25261450 Intracranial Stenosis, Cerebrovascular Diseases, and Cognitive Impairment in Chinese Alzheimer Disease and Associated Disorders. Jan-Mar, 2015 | Pubmed ID: 24731981 Feasibility and Acceptability of the Informant AD8 for Cognitive Screening in Primary Healthcare: a Pilot Study TheScientificWorldJournal. Month, 2014 | Pubmed ID: 25548780 Retinal Microvasculature in Alzheimer's Disease Journal of Alzheimer's Disease : JAD. Month, 2014 | Pubmed ID: 25351108 Retinal Vascular Fractals and Cognitive Impairment Dementia and Geriatric Cognitive Disorders Extra. May, 2014 | Pubmed ID: 25298774 Microvascular Network Alterations in Retina of Subjects with Cerebral Small Vessel Disease Neuroscience Letters. Aug, 2014 | Pubmed ID: 24937268 A Pilot Study to Examine the Correlation Between Cognition and Blood Biomarkers in a Singapore Chinese Male Cohort with Type 2 Diabetes Mellitus PloS One. Month, 2014 | Pubmed ID: 24816647 Computer Tomography for Prediction of Cognitive Outcomes After Ischemic Cerebrovascular Events Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association. Aug, 2014 | Pubmed ID: 24794946 Discovery of Prognostic Biomarker Candidates of Lacunar Infarction by Quantitative Proteomics of Microvesicles Enriched Plasma PloS One. Month, 2014 | Pubmed ID: 24752076 Brain Lipidomes of Subcortical Ischemic Vascular Dementia and Mixed Dementia Neurobiology of Aging. Oct, 2014 | Pubmed ID: 24684787 Diagnostic Criteria for Vascular Cognitive Disorders: A VASCOG Statement Alzheimer Disease and Associated Disorders. Mar, 2014 | Pubmed ID: 24632990 Novel Pathophysiological Markers Are Revealed by ITRAQ-based Quantitative Clinical Proteomics Approach in Vascular Dementia Journal of Proteomics. Mar, 2014 | Pubmed ID: 24448401 Microvascular Network Alterations in the Retina of Patients with Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Mar, 2014 | Pubmed ID: 24439169 Improving Screening for Vascular Cognitive Impairment at Three to Six Months After Mild Ischemic Stroke and Transient Ischemic Attack International Psychogeriatrics. May, 2014 | Pubmed ID: 24423626 Cerebral Microbleeds and Cognition: the Epidemiology of Dementia in Singapore Study Alzheimer Disease and Associated Disorders. Apr-Jun, 2014 | Pubmed ID: 24322485 Decreased Rabphilin 3A Immunoreactivity in Alzheimer's Disease is Associated with Aβ Burden Neurochemistry International. Jan, 2014 | Pubmed ID: 24200817 Cognitive Screening Improves the Predictive Value of Stroke Severity Scores for Functional Outcome 3-6 Months After Mild Stroke and Transient Ischaemic Attack: an Observational Study BMJ Open. Sep, 2013 | Pubmed ID: 24002980 Patterns of Neuropsychological Impairment in Alzheimer's Disease and Mixed Dementia Journal of the Neurological Sciences. Oct, 2013 | Pubmed ID: 23978422 The NeuroAiD II (MLC901) in Vascular Cognitive Impairment Study (NEURITES) Cerebrovascular Diseases (Basel, Switzerland). Month, 2013 | Pubmed ID: 23548916 The Informant AD8 is Superior to Participant AD8 in Detecting Cognitive Impairment in a Memory Clinic Setting Journal of Alzheimer's Disease : JAD. Month, 2013 | Pubmed ID: 23380993 Changes in Cerebral Hemodynamic and Cognitive Parameters After External Carotid-internal Carotid Bypass Surgery in Patients with Severe Steno-occlusive Disease: a Pilot Study Journal of the Neurological Sciences. Nov, 2012 | Pubmed ID: 22846792 The Montreal Cognitive Assessment is Superior to the Mini-Mental State Examination in Detecting Patients at Higher Risk of Dementia International Psychogeriatrics. Nov, 2012 | Pubmed ID: 22687278 Brief Screening Tests During Acute Admission in Patients with Mild Stroke Are Predictive of Vascular Cognitive Impairment 3-6 Months After Stroke Journal of Neurology, Neurosurgery, and Psychiatry. Jun, 2012 | Pubmed ID: 22496580 Preservation of Cortical Histamine H3 Receptors in Ischemic Vascular and Mixed Dementias Journal of the Neurological Sciences. Apr, 2012 | Pubmed ID: 22129936 Upregulation of AMPA Receptor GluR2 (GluA2) Subunits in Subcortical Ischemic Vascular Dementia is Repressed in the Presence of Alzheimer's Disease Neurochemistry International. Jun, 2011 | Pubmed ID: 21419184 Differential Involvement of Hippocampal Serotonin1A Receptors and Re-uptake Sites in Non-cognitive Behaviors of Alzheimer's Disease Psychopharmacology. Feb, 2011 | Pubmed ID: 20625884 Cortisol Response to Individualised Graded Insulin Infusions: a Reproducible Biomarker for CNS Compounds Inhibiting HPA Activation British Journal of Clinical Pharmacology. Dec, 2010 | Pubmed ID: 21175444 Intact Cannabinoid CB1 Receptors in the Alzheimer's Disease Cortex Neurochemistry International. Dec, 2010 | Pubmed ID: 21034788 Hippocampal Neurofibrillary Tangle Changes and Aggressive Behaviour in Dementia Neuroreport. Dec, 2010 | Pubmed ID: 20890229 The Montreal Cognitive Assessment (MoCA) is Superior to the Mini-Mental State Examination (MMSE) for the Detection of Vascular Cognitive Impairment After Acute Stroke Journal of the Neurological Sciences. Dec, 2010 | Pubmed ID: 20889166 Utilizando imagens da retina para estudar a demência Victor T.T. Chan1, Tiffany H.K. Tso1, Fangyao Tang1, Clement Tham1, Vincent Mok2,3,4, Christopher Chen5,6, Tien Y. Wong7,8, Carol Y. Cheung1 1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 2Department of Medicine & Therapeutics, The Chinese University of Hong Kong, 3Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, 4Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, 5Memory Aging and Cognition Centre, National University Health System, 6Department of Pharmacology, National University of Singapore, 7Singapore Eye Research Institute, Singapore National Eye Centre, 8Duke-NUS Medical School, National University of Singapore JoVE 56137 Medicine
Utilizando imagens da retina para estudar a demência Victor T.T. Chan1, Tiffany H.K. Tso1, Fangyao Tang1, Clement Tham1, Vincent Mok2,3,4, Christopher Chen5,6, Tien Y. Wong7,8, Carol Y. Cheung1 1Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, 2Department of Medicine & Therapeutics, The Chinese University of Hong Kong, 3Therese Pei Fong Chow Research Centre for Prevention of Dementia, The Chinese University of Hong Kong, 4Gerald Choa Neuroscience Centre, The Chinese University of Hong Kong, 5Memory Aging and Cognition Centre, National University Health System, 6Department of Pharmacology, National University of Singapore, 7Singapore Eye Research Institute, Singapore National Eye Centre, 8Duke-NUS Medical School, National University of Singapore JoVE 56137 Medicine
