Christopher Heeschen

Publications

• The MiR-17-92 Cluster Counteracts Quiescence and Chemoresistance in a Distinct Subpopulation of Pancreatic Cancer Stem Cells
  Gut. Apr, 2015  |   Pubmed ID: 25887381
• Microenvironmental HCAP-18/LL-37 Promotes Pancreatic Ductal Adenocarcinoma by Activating Its Cancer Stem Cell Compartment
  Gut. Apr, 2015  |   Pubmed ID: 25841238
• Inhibition of CD47 Effectively Targets Pancreatic Cancer Stem Cells Via Dual Mechanisms
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. May, 2015  |   Pubmed ID: 25717063
• ISG15 is a Critical Microenvironmental Factor for Pancreatic Cancer Stem Cells
  Cancer Research. Dec, 2014  |   Pubmed ID: 25368022
• K-RasV14I Recapitulates Noonan Syndrome in Mice
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2014  |   Pubmed ID: 25359213
• Intracellular Autofluorescence: a Biomarker for Epithelial Cancer Stem Cells
  Nature Methods. Nov, 2014  |   Pubmed ID: 25262208
• Nicotine Promotes Initiation and Progression of KRAS-Induced Pancreatic Cancer Via Gata6-Dependent Dedifferentiation of Acinar Cells in Mice
  Gastroenterology. Nov, 2014  |   Pubmed ID: 25127677
• Chloroquine Targets Pancreatic Cancer Stem Cells Via Inhibition of CXCR4 and Hedgehog Signaling
  Molecular Cancer Therapeutics. Jul, 2014  |   Pubmed ID: 24785258
• Metformin Targets the Metabolic Achilles Heel of Human Pancreatic Cancer Stem Cells
  PloS One. 2013  |   Pubmed ID: 24204632
• Multimodal Treatment Eliminates Cancer Stem Cells and Leads to Long-Term Survival in Primary Human Pancreatic Cancer Tissue Xenografts
  PloS One. 2013  |   Pubmed ID: 23825539
• Standing out from the Crowd: Cancer Stem Cells in Hepatocellular Carcinoma
  Cancer Cell. Apr, 2013  |   Pubmed ID: 23597561
• Stem Cells & Pancreatic Cancer
  Pancreatology : Official Journal of the International Association of Pancreatology (IAP) ... [et Al.]. Mar-Apr, 2013  |   Pubmed ID: 23561967
• Aurora B Prevents Delayed DNA Replication and Premature Mitotic Exit by Repressing P21(Cip1)
  Cell Cycle (Georgetown, Tex.). Apr, 2013  |   Pubmed ID: 23428904
• Metastatic Cancer Stem Cells--quo Vadis?
  Clinical Chemistry. Aug, 2013  |   Pubmed ID: 23288488
• Immuno-targeting of Pancreatic Cancer Stem Cells: A New Therapeutic Strategy Against a Devastating Disease?
  Oncoimmunology. Jul, 2012  |   Pubmed ID: 22754787
• Pancreatic Stellate Cells Form a Niche for Cancer Stem Cells and Promote Their Self-renewal and Invasiveness
  Cell Cycle (Georgetown, Tex.). Apr, 2012  |   Pubmed ID: 22421149
• Vascular Incorporation of Endothelial Colony-forming Cells is Essential for Functional Recovery of Murine Ischemic Tissue Following Cell Therapy
  Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2012  |   Pubmed ID: 22199368
• Stem Cells As the Root of Pancreatic Ductal Adenocarcinoma
  Experimental Cell Research. Apr, 2012  |   Pubmed ID: 22119145
• EpCAM/CD3-Bispecific T-cell Engaging Antibody MT110 Eliminates Primary Human Pancreatic Cancer Stem Cells
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Jan, 2012  |   Pubmed ID: 22096026
• Nodal/Activin Signaling Drives Self-renewal and Tumorigenicity of Pancreatic Cancer Stem Cells and Provides a Target for Combined Drug Therapy
  Cell Stem Cell. Nov, 2011  |   Pubmed ID: 22056140
• Pancreatic Cancer Stem Cells: New Insights and Perspectives
  Journal of Gastroenterology. Aug, 2011  |   Pubmed ID: 21698355
• Inhibition of Ataxia Telangiectasia- and Rad3-related Function Abrogates the in Vitro and in Vivo Tumorigenicity of Human Colon Cancer Cells Through Depletion of the CD133(+) Tumor-initiating Cell Fraction
  Stem Cells (Dayton, Ohio). Mar, 2011  |   Pubmed ID: 21308861
• Adiponectin Pretreatment Counteracts the Detrimental Effect of a Diabetic Environment on Endothelial Progenitors
  Diabetes. Feb, 2011  |   Pubmed ID: 21270275
• Combination of Injectable Multiple Growth Factor-releasing Scaffolds and Cell Therapy As an Advanced Modality to Enhance Tissue Neovascularization
  Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2010  |   Pubmed ID: 20689075
• Pancreatic Cancer Stem Cells - Update and Future Perspectives
  Molecular Oncology. Oct, 2010  |   Pubmed ID: 20580623
• Cancer Stem Cells in Solid Tumors
  Seminars in Cancer Biology. Apr, 2010  |   Pubmed ID: 20371287
• Cancer Stem Cells As New Therapeutic Target to Prevent Tumour Progression and Metastasis
  Frontiers in Bioscience (Elite Edition). 2010  |   Pubmed ID: 20036905
• Pancreatic Cancer Stem Cells--insights and Perspectives
  Expert Opinion on Biological Therapy. Oct, 2009  |   Pubmed ID: 19723015
• Add Some Fat to Vascular Progenitor Cell Therapy
  Circulation Research. Jun, 2009  |   Pubmed ID: 19542018
• Combined Targeted Treatment to Eliminate Tumorigenic Cancer Stem Cells in Human Pancreatic Cancer
  Gastroenterology. Sep, 2009  |   Pubmed ID: 19501590
• CGMP-dependent Protein Kinase I is Crucial for Angiogenesis and Postnatal Vasculogenesis
  PloS One. 2009  |   Pubmed ID: 19287493
• Prostaglandin E Positively Modulates Endothelial Progenitor Cell Homeostasis: an Advanced Treatment Modality for Autologous Cell Therapy
  Journal of Vascular Research. 2009  |   Pubmed ID: 19142013
• The Wnt Antagonist Dickkopf-1 Mobilizes Vasculogenic Progenitor Cells Via Activation of the Bone Marrow Endosteal Stem Cell Niche
  Circulation Research. Oct, 2008  |   Pubmed ID: 18776043
• More Good Reasons for Adherence to Statin Therapy During Acute Coronary Syndromes
  European Heart Journal. Sep, 2008  |   Pubmed ID: 18676969
• Concentration of Bone Marrow Total Nucleated Cells by a Point-of-care Device Provides a High Yield and Preserves Their Functional Activity
  Cell Transplantation. 2008  |   Pubmed ID: 18351022
• Metastatic Cancer Stem Cells: a New Target for Anti-cancer Therapy?
  Cell Cycle (Georgetown, Tex.). Jan, 2008  |   Pubmed ID: 18256530
• Quantitation of Myocardial Borderzone Using Reconstructive 3-D Echocardiography After Chronic Infarction in Rats: Incremental Value of Low-dose Dobutamine
  Ultrasound in Medicine & Biology. Apr, 2008  |   Pubmed ID: 17996357
• Distinct Populations of Cancer Stem Cells Determine Tumor Growth and Metastatic Activity in Human Pancreatic Cancer
  Cell Stem Cell. Sep, 2007  |   Pubmed ID: 18371365
• Genetically Engineered Stem Cells for Therapeutic Gene Delivery
  Current Gene Therapy. Aug, 2007  |   Pubmed ID: 17969558
• Nonbone Marrow-derived Endothelial Progenitor Cells: What is Their Exact Location?
  Circulation Research. Oct, 2007  |   Pubmed ID: 17967790
• Selective Functional Exhaustion of Hematopoietic Progenitor Cells in the Bone Marrow of Patients with Postinfarction Heart Failure
  Journal of the American College of Cardiology. Jun, 2007  |   Pubmed ID: 17572250
• Influence of Sample Type on Soluble CD40 Ligand Assessment in Patients with Acute Coronary Syndromes
  Thrombosis Research. 2007  |   Pubmed ID: 17337289
• Nonbone Marrow-derived Circulating Progenitor Cells Contribute to Postnatal Neovascularization Following Tissue Ischemia
  Circulation Research. Mar, 2007  |   Pubmed ID: 17272807
• The Immunosuppressant FTY720 Inhibits Tumor Angiogenesis Via the Sphingosine 1-phosphate Receptor 1
  Journal of Cellular Biochemistry. May, 2007  |   Pubmed ID: 17203465
• Endothelial Progenitor Cells Participate in Nicotine-mediated Angiogenesis
  Journal of the American College of Cardiology. Dec, 2006  |   Pubmed ID: 17174197
• Low-energy Shock Wave for Enhancing Recruitment of Endothelial Progenitor Cells: a New Modality to Increase Efficacy of Cell Therapy in Chronic Hind Limb Ischemia
  Circulation. Dec, 2006  |   Pubmed ID: 17145991
• Ex Vivo Pretreatment of Bone Marrow Mononuclear Cells with Endothelial NO Synthase Enhancer AVE9488 Enhances Their Functional Activity for Cell Therapy
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2006  |   Pubmed ID: 16983080
• Effects of Granulocyte Colony Simulating Factor on Functional Activities of Endothelial Progenitor Cells in Patients with Chronic Ischemic Heart Disease
  Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2006  |   Pubmed ID: 16902165
• Differential Effects of Short-term Lipid Lowering with Ezetimibe and Statins on Endothelial Function in Patients with CAD: Clinical Evidence for 'pleiotropic' Functions of Statin Therapy
  European Heart Journal. May, 2006  |   Pubmed ID: 16621868
• Influence of Sample Type and Storage Conditions on Soluble CD40 Ligand Assessment
  Clinical Chemistry. May, 2006  |   Pubmed ID: 16527885
• Elevated Placental Growth Factor Levels Are Associated with Adverse Outcomes at Four-year Follow-up in Patients with Acute Coronary Syndromes
  Journal of the American College of Cardiology. Jan, 2006  |   Pubmed ID: 16412852
• Biomarkers in Acute Coronary Syndromes and Their Role in Diabetic Patients
  Diabetes & Vascular Disease Research. Oct, 2005  |   Pubmed ID: 16334593
• Biochemical Monitoring of MTOR Inhibitor-based Immunosuppression Following Kidney Transplantation: a Novel Approach for Tailored Immunosuppressive Therapy
  Kidney International. Dec, 2005  |   Pubmed ID: 16316335
• Impaired CXCR4 Signaling Contributes to the Reduced Neovascularization Capacity of Endothelial Progenitor Cells from Patients with Coronary Artery Disease
  Circulation Research. Nov, 2005  |   Pubmed ID: 16254213
• Soluble Factors Released by Endothelial Progenitor Cells Promote Migration of Endothelial Cells and Cardiac Resident Progenitor Cells
  Journal of Molecular and Cellular Cardiology. Nov, 2005  |   Pubmed ID: 16199052
• Involvement of Foxo Transcription Factors in Angiogenesis and Postnatal Neovascularization
  The Journal of Clinical Investigation. Sep, 2005  |   Pubmed ID: 16100571
• Histone Deacetylase Activity is Essential for the Expression of HoxA9 and for Endothelial Commitment of Progenitor Cells
  The Journal of Experimental Medicine. Jun, 2005  |   Pubmed ID: 15928198
• Cathepsin L is Required for Endothelial Progenitor Cell-induced Neovascularization
  Nature Medicine. Feb, 2005  |   Pubmed ID: 15665831
• Pregnancy-associated Plasma Protein-A Levels in Patients with Acute Coronary Syndromes: Comparison with Markers of Systemic Inflammation, Platelet Activation, and Myocardial Necrosis
  Journal of the American College of Cardiology. Jan, 2005  |   Pubmed ID: 15653020
• Role of Beta2-integrins for Homing and Neovascularization Capacity of Endothelial Progenitor Cells
  The Journal of Experimental Medicine. Jan, 2005  |   Pubmed ID: 15623573
• N-terminal Pro-B-type Natriuretic Peptide Levels for Dynamic Risk Stratification of Patients with Acute Coronary Syndromes
  Circulation. Nov, 2004  |   Pubmed ID: 15533869
• The Pro-apoptotic Serum Activity is an Independent Mortality Predictor of Patients with Heart Failure
  European Heart Journal. Sep, 2004  |   Pubmed ID: 15351161
• The Role of NOS3 in Stem Cell Mobilization
  Trends in Molecular Medicine. Sep, 2004  |   Pubmed ID: 15350893
• Interleukin-10 Serum Levels and Systemic Endothelial Vasoreactivity in Patients with Coronary Artery Disease
  Journal of the American College of Cardiology. Jul, 2004  |   Pubmed ID: 15234404
• Inflammatory Markers and Coronary Artery Disease
  Current Opinion in Pharmacology. Apr, 2004  |   Pubmed ID: 15063355
• Profoundly Reduced Neovascularization Capacity of Bone Marrow Mononuclear Cells Derived from Patients with Chronic Ischemic Heart Disease
  Circulation. Apr, 2004  |   Pubmed ID: 15037527
• 111In-labeled CD34+ Hematopoietic Progenitor Cells in a Rat Myocardial Infarction Model
  Journal of Nuclear Medicine : Official Publication, Society of Nuclear Medicine. Mar, 2004  |   Pubmed ID: 15001696
• Quantitative Bedside Testing of Troponin T: is It Equal to Laboratory Testing? The Cardiac Reader Troponin T (CARE T) Study
  Clinical Laboratory. 2004  |   Pubmed ID: 15000216
• P21Cip1 Levels Differentially Regulate Turnover of Mature Endothelial Cells, Endothelial Progenitor Cells, and in Vivo Neovascularization
  Circulation Research. Mar, 2004  |   Pubmed ID: 14752032
• Prognostic Value of Placental Growth Factor in Patients with Acute Chest Pain
  JAMA. Jan, 2004  |   Pubmed ID: 14747500
• Relevance of Monocytic Features for Neovascularization Capacity of Circulating Endothelial Progenitor Cells
  Circulation. Nov, 2003  |   Pubmed ID: 14581410
• Essential Role of Endothelial Nitric Oxide Synthase for Mobilization of Stem and Progenitor Cells
  Nature Medicine. Nov, 2003  |   Pubmed ID: 14556003
• Second Hand Smoke Stimulates Tumor Angiogenesis and Growth
  Cancer Cell. Sep, 2003  |   Pubmed ID: 14522253
• Myeloperoxidase Serum Levels Predict Risk in Patients with Acute Coronary Syndromes
  Circulation. Sep, 2003  |   Pubmed ID: 12952835
• Erythropoietin is a Potent Physiologic Stimulus for Endothelial Progenitor Cell Mobilization
  Blood. Aug, 2003  |   Pubmed ID: 12702503
• Serum Level of the Antiinflammatory Cytokine Interleukin-10 is an Important Prognostic Determinant in Patients with Acute Coronary Syndromes
  Circulation. Apr, 2003  |   Pubmed ID: 12668510
• Soluble CD40 Ligand in Acute Coronary Syndromes
  The New England Journal of Medicine. Mar, 2003  |   Pubmed ID: 12646667
• Nicotine Promotes Arteriogenesis
  Journal of the American College of Cardiology. Feb, 2003  |   Pubmed ID: 12575981
• Nicotine Strongly Activates Dendritic Cell-mediated Adaptive Immunity: Potential Role for Progression of Atherosclerotic Lesions
  Circulation. Feb, 2003  |   Pubmed ID: 12566374
• Prognostic Significance of Angiogenic Growth Factor Serum Levels in Patients with Acute Coronary Syndromes
  Circulation. Feb, 2003  |   Pubmed ID: 12566361
• Withdrawal of Statins in Patients with Acute Coronary Syndromes
  Circulation. Jan, 2003  |   Pubmed ID: 12551886
• A Novel Angiogenic Pathway Mediated by Non-neuronal Nicotinic Acetylcholine Receptors
  The Journal of Clinical Investigation. Aug, 2002  |   Pubmed ID: 12189247
• Withdrawal of Statins Increases Event Rates in Patients with Acute Coronary Syndromes
  Circulation. Mar, 2002  |   Pubmed ID: 11914253
• Statins Have Biphasic Effects on Angiogenesis
  Circulation. Feb, 2002  |   Pubmed ID: 11839631