Christopher Nicchitta

Publications

• Simple and Inexpensive Ribosome Profiling Analysis of MRNA Translation
  Methods (San Diego, Calif.). Jul, 2015  |   Pubmed ID: 26164698
• LOCAL TRANSLATION. Comment on "Principles of ER Cotranslational Translocation Revealed by Proximity-specific Ribosome Profiling"
  Science (New York, N.Y.). Jun, 2015  |   Pubmed ID: 26068841
• Diversity and Selectivity in MRNA Translation on the Endoplasmic Reticulum
  Nature Reviews. Molecular Cell Biology. Apr, 2015  |   Pubmed ID: 25735911
• A Novel Ribosomopathy Caused by Dysfunction of RPL10 Disrupts Neurodevelopment and Causes X-linked Microcephaly in Humans
  Genetics. Oct, 2014  |   Pubmed ID: 25316788
• The Unfolded Protein Response Triggers Selective MRNA Release from the Endoplasmic Reticulum
  Cell. Sep, 2014  |   Pubmed ID: 25215492
• De Novo Translation Initiation on Membrane-bound Ribosomes As a Mechanism for Localization of Cytosolic Protein MRNAs to the Endoplasmic Reticulum
  RNA (New York, N.Y.). Oct, 2014  |   Pubmed ID: 25142066
• Multifunctional Roles for the Protein Translocation Machinery in RNA Anchoring to the Endoplasmic Reticulum
  The Journal of Biological Chemistry. Sep, 2014  |   Pubmed ID: 25063809
• Induction of the Unfolded Protein Response Drives Enhanced Metabolism and Chemoresistance in Glioma Cells
  PloS One. 2013  |   Pubmed ID: 24039668
• Rare Codons Regulate KRas Oncogenesis
  Current Biology : CB. Jan, 2013  |   Pubmed ID: 23246410
• Premature Translational Termination Products Are Rapidly Degraded Substrates for MHC Class I Presentation
  PloS One. 2012  |   Pubmed ID: 23251665
• Translocation of Sickle Cell Erythrocyte MicroRNAs into Plasmodium Falciparum Inhibits Parasite Translation and Contributes to Malaria Resistance
  Cell Host & Microbe. Aug, 2012  |   Pubmed ID: 22901539
• Glycoprotein 96 Perpetuates the Persistent Inflammation of Rheumatoid Arthritis
  Arthritis and Rheumatism. Nov, 2012  |   Pubmed ID: 22777994
• Development of a Grp94 Inhibitor
  Journal of the American Chemical Society. Jun, 2012  |   Pubmed ID: 22642269
• The Enduring Enigma of Nuclear Translation
  The Journal of Cell Biology. Apr, 2012  |   Pubmed ID: 22472436
• Primary Role for Endoplasmic Reticulum-bound Ribosomes in Cellular Translation Identified by Ribosome Profiling
  The Journal of Biological Chemistry. Feb, 2012  |   Pubmed ID: 22199352
• Hierarchical Regulation of MRNA Partitioning Between the Cytoplasm and the Endoplasmic Reticulum of Mammalian Cells
  Molecular Biology of the Cell. Jul, 2011  |   Pubmed ID: 21613539
• Polysome Profiling of the Malaria Parasite Plasmodium Falciparum
  Molecular and Biochemical Parasitology. Sep, 2011  |   Pubmed ID: 21605599
• Out with the Old, in with the New? Comparing Methods for Measuring Protein Degradation
  Cell Biology International. May, 2011  |   Pubmed ID: 21476986
• Analyzing MRNA Localization to the Endoplasmic Reticulum Via Cell Fractionation
  Methods in Molecular Biology (Clifton, N.J.). 2011  |   Pubmed ID: 21431749
• Re-examination of CD91 Function in GRP94 (glycoprotein 96) Surface Binding, Uptake, and Peptide Cross-presentation
  Journal of Immunology (Baltimore, Md. : 1950). Dec, 2010  |   Pubmed ID: 21048103
• Gp93, the Drosophila GRP94 Ortholog, is Required for Gut Epithelial Homeostasis and Nutrient Assimilation-coupled Growth Control
  Developmental Biology. Mar, 2010  |   Pubmed ID: 20044986
• Glioblastoma Proto-oncogene SEC61gamma is Required for Tumor Cell Survival and Response to Endoplasmic Reticulum Stress
  Cancer Research. Dec, 2009  |   Pubmed ID: 19920201
• Efficient Cross-priming of Antiviral CD8+ T Cells by Antigen Donor Cells is GRP94 Independent
  Journal of Immunology (Baltimore, Md. : 1950). Oct, 2009  |   Pubmed ID: 19752220
• Heat Shock Protein 96 is Elevated in Rheumatoid Arthritis and Activates Macrophages Primarily Via TLR2 Signaling
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2009  |   Pubmed ID: 19342676
• Cell Biology: How to Combat Stress
  Nature. Feb, 2009  |   Pubmed ID: 19194438
• The Exception That Reinforces the Rule: Crosspriming by Cytosolic Peptides That Escape Degradation
  Immunity. Jun, 2008  |   Pubmed ID: 18549799
• Redundancy Renders the Glycoprotein 96 Receptor Scavenger Receptor A Dispensable for Cross Priming in Vivo
  Immunology. Dec, 2008  |   Pubmed ID: 18489571
• Analysis of MRNA Partitioning Between the Cytosol and Endoplasmic Reticulum Compartments of Mammalian Cells
  Methods in Molecular Biology (Clifton, N.J.). 2008  |   Pubmed ID: 18369985
• Signal Sequence- and Translation-independent MRNA Localization to the Endoplasmic Reticulum
  RNA (New York, N.Y.). Mar, 2008  |   Pubmed ID: 18192611
• Divergent Regulation of Protein Synthesis in the Cytosol and Endoplasmic Reticulum Compartments of Mammalian Cells
  Molecular Biology of the Cell. Feb, 2008  |   Pubmed ID: 18077556
• In Vitro and Tissue Culture Methods for Analysis of Translation Initiation on the Endoplasmic Reticulum
  Methods in Enzymology. 2007  |   Pubmed ID: 17923230
• The DRiP Hypothesis Decennial: Support, Controversy, Refinement and Extension
  Trends in Immunology. Aug, 2006  |   Pubmed ID: 16815756
• Interaction of TLR2 and TLR4 Ligands with the N-terminal Domain of Gp96 Amplifies Innate and Adaptive Immune Responses
  The Journal of Biological Chemistry. Aug, 2006  |   Pubmed ID: 16754684
• Identification of Novel Quaternary Domain Interactions in the Hsp90 Chaperone, GRP94
  Protein Science : a Publication of the Protein Society. Jun, 2006  |   Pubmed ID: 16731965
• Synthesis of Hsp90 Dimerization Modulators
  Bioorganic & Medicinal Chemistry Letters. Jul, 2006  |   Pubmed ID: 16621545
• MRNA Translation is Compartmentalized to the Endoplasmic Reticulum Following Physiological Inhibition of Cap-dependent Translation
  RNA (New York, N.Y.). May, 2006  |   Pubmed ID: 16540694
• Pathways for Compartmentalizing Protein Synthesis in Eukaryotic Cells: the Template-partitioning Model
  Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. Dec, 2005  |   Pubmed ID: 16333319
• Enhancement of Cancer Radiation Therapy by Use of Adenovirus-mediated Secretable Glucose-regulated Protein 94/gp96 Expression
  Cancer Research. Oct, 2005  |   Pubmed ID: 16230366
• Stable Ribosome Binding to the Endoplasmic Reticulum Enables Compartment-specific Regulation of MRNA Translation
  Molecular Biology of the Cell. Dec, 2005  |   Pubmed ID: 16221886
• HDAC6 Regulates Hsp90 Acetylation and Chaperone-dependent Activation of Glucocorticoid Receptor
  Molecular Cell. May, 2005  |   Pubmed ID: 15916966
• Membrane Topology Mapping of Vitamin K Epoxide Reductase by in Vitro Translation/cotranslocation
  The Journal of Biological Chemistry. Apr, 2005  |   Pubmed ID: 15716279
• Catheter-mediated Subselective Intracoronary Gene Delivery to the Rabbit Heart: Introduction of a Novel Method
  The Journal of Gene Medicine. May, 2005  |   Pubmed ID: 15651066
• The Messenger and the Message: Gp96 (GRP94)-peptide Interactions in Cellular Immunity
  Cell Stress & Chaperones. 2004  |   Pubmed ID: 15633290
• Adenosine Nucleotides and the Regulation of GRP94-client Protein Interactions
  Biochemistry. Jul, 2004  |   Pubmed ID: 15236592
• Glucose-regulated Protein 94/glycoprotein 96 Elicits Bystander Activation of CD4+ T Cell Th1 Cytokine Production in Vivo
  Journal of Immunology (Baltimore, Md. : 1950). Apr, 2004  |   Pubmed ID: 15034032
• Scavenger Receptor-A Mediates Gp96/GRP94 and Calreticulin Internalization by Antigen-presenting Cells
  The EMBO Journal. Nov, 2003  |   Pubmed ID: 14609958
• Structure of the N-terminal Domain of GRP94. Basis for Ligand Specificity and Regulation
  The Journal of Biological Chemistry. Nov, 2003  |   Pubmed ID: 12970348
• Come Forth CD1d: Hsp110 in the Regulation of Intestinal Epithelial CD1d Expression
  The Journal of Clinical Investigation. Sep, 2003  |   Pubmed ID: 12952910
• Partitioning and Translation of MRNAs Encoding Soluble Proteins on Membrane-bound Ribosomes
  RNA (New York, N.Y.). Sep, 2003  |   Pubmed ID: 12923260
• GRP94/gp96 Elicits ERK Activation in Murine Macrophages. A Role for Endotoxin Contamination in NF-kappa B Activation and Nitric Oxide Production
  The Journal of Biological Chemistry. Aug, 2003  |   Pubmed ID: 12805368
• Re-evaluating the Role of Heat-shock Protein-peptide Interactions in Tumour Immunity
  Nature Reviews. Immunology. May, 2003  |   Pubmed ID: 12766764
• ISO: a Critical Evaluation of the Role of Peptides in Heat Shock/chaperone Protein-mediated Tumor Rejection
  Current Opinion in Immunology. Feb, 2003  |   Pubmed ID: 12495739
• GRP94 (gp96) and GRP94 N-terminal Geldanamycin Binding Domain Elicit Tissue Nonrestricted Tumor Suppression
  The Journal of Experimental Medicine. Dec, 2002  |   Pubmed ID: 12461080
• A Platform for Compartmentalized Protein Synthesis: Protein Translation and Translocation in the ER
  Current Opinion in Cell Biology. Aug, 2002  |   Pubmed ID: 12383790
• GRP94-associated Enzymatic Activities. Resolution by Chromatographic Fractionation
  The Journal of Biological Chemistry. Jul, 2002  |   Pubmed ID: 11983709
• Cutting Edge: CD91-independent Cross-presentation of GRP94(gp96)-associated Peptides
  Journal of Immunology (Baltimore, Md. : 1950). May, 2002  |   Pubmed ID: 11970968
• Endoplasmic Reticulum-bound Ribosomes Reside in Stable Association with the Translocon Following Termination of Protein Synthesis
  The Journal of Biological Chemistry. Jun, 2002  |   Pubmed ID: 11964406