Chuan-ju Liu Department of Orthopaedic Surgery & Department of Cell Biology NYU School of Medicine Biography Publications Institution JoVE Articles Chuan-ju LiuProfessor of Orthopaedic Surgery and Cell Biology Dr. Chuanju Liu held a dual appointment as an Assistant Professor from Department of Orthopaedic Surgery and Department of Cell Biology at NYU School of Medicine since 2002, and was promoted to Associate Professor with Tenure and Professor with Tenure in 2007 and 2013, respectively. He is the current Editor-in-Chief of Clinical Medicine Insights: Arthritis and Musculoskeletal Disorders and Rheumatology Research and Review, and serves on a number of Editorial Boards. He is also an active participant in peer review of grant applications to various agencies (NIH, DOD, VA, etc.). His current research focuses on inflammatory and degenerative arthritis, cartilage/bone regeneration, and autoimmune diseases. He has published over 140 papers in prestigious journals, including Science, ARD, EMBO J, and PNAS. He is the recipient of numerous awards, including the ASBMR's Harold M. Frost Award, the Arthritis Foundation's Dorothy W. Goldstein Award, the NIH Career Development Award, the Kappa Delta Award from the ORS and AAOS, the Innovative Research Award from the American College of Rheumatology, and the STAR Award from NIH/NIAMS. Publications Progranulin Promotes Diabetic Fracture Healing in Mice with Type 1 Diabetes Annals of the New York Academy of Sciences. Aug, 2019 | Pubmed ID: 31423598 Fexofenadine Inhibits TNF Signaling Through Targeting to Cytosolic Phospholipase A2 and is Therapeutic Against Inflammatory Arthritis Annals of the Rheumatic Diseases. Jul, 2019 | Pubmed ID: 31302596 Progranulin: A Conductor of Receptors Orchestra, a Chaperone of Lysosomal Enzymes and a Therapeutic Target for Multiple Diseases Cytokine & Growth Factor Reviews. 02, 2019 | Pubmed ID: 30733059 Clinical Application of Teriparatide in Fracture Prevention: A Systematic Review JBJS Reviews. Jan, 2019 | Pubmed ID: 30694878 Targeting Tumor Necrosis Factor Receptors in Ankylosing Spondylitis Annals of the New York Academy of Sciences. Apr, 2019 | Pubmed ID: 30008173 Brain-penetrant Heat Shock Protein Amplifier Arimoclomol Enhances GCase Activity in in Vitro Gaucher Disease Models EBioMedicine. 12, 2018 | Pubmed ID: 30522930 Progranulin Associates with Hexosaminidase A and Ameliorates GM2 Ganglioside Accumulation and Lysosomal Storage in Tay-Sachs Disease Journal of Molecular Medicine (Berlin, Germany). Dec, 2018 | Pubmed ID: 30341570 Establishment of a Modified Collagen-Induced Arthritis Mouse Model to Investigate the Anti-inflammatory Activity of Progranulin in Inflammatory Arthritis Methods in Molecular Biology (Clifton, N.J.). 2018 | Pubmed ID: 29956284 Role of ADAMTS-12 in Protecting Against Inflammatory Arthritis in Mice By Interacting With and Inactivating Proinflammatory Connective Tissue Growth Factor Arthritis & Rheumatology (Hoboken, N.J.). 11, 2018 | Pubmed ID: 29750395 Molecular Regulations and Therapeutic Targets of Gaucher Disease Cytokine & Growth Factor Reviews. 06, 2018 | Pubmed ID: 29699937 P204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice EBioMedicine. Mar, 2018 | Pubmed ID: 29472103 Chitinase-3-like Protein 1: A Progranulin Downstream Molecule and Potential Biomarker for Gaucher Disease EBioMedicine. Feb, 2018 | Pubmed ID: 29396296 Multifunctional Molecule ERp57: From Cancer to Neurodegenerative Diseases Pharmacology & Therapeutics. 01, 2018 | Pubmed ID: 28723413 Progranulin: A Key Player in Autoimmune Diseases Cytokine. 01, 2018 | Pubmed ID: 27527809 Progranulin Derivative Atsttrin Protects Against Early Osteoarthritis in Mouse and Rat Models Arthritis Research & Therapy. Dec, 2017 | Pubmed ID: 29258611 Progranulin Acts As a Shared Chaperone and Regulates Multiple Lysosomal Enzymes Genes & Diseases. Sep, 2017 | Pubmed ID: 28944282 Foxo4- and Stat3-dependent IL-10 Production by Progranulin in Regulatory T Cells Restrains Inflammatory Arthritis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 04, 2017 | Pubmed ID: 28011648 Progranulin Recruits HSP70 to β-Glucocerebrosidase and Is Therapeutic Against Gaucher Disease EBioMedicine. Nov, 2016 | Pubmed ID: 27789271 Association Between Progranulin and Gaucher Disease EBioMedicine. Sep, 2016 | Pubmed ID: 27515686 Review: Novel Insights Into Tumor Necrosis Factor Receptor, Death Receptor 3, and Progranulin Pathways in Arthritis and Bone Remodeling Arthritis & Rheumatology (Hoboken, N.J.). 12, 2016 | Pubmed ID: 27428882 Extracellular Matrix Protein 1, a Direct Targeting Molecule of Parathyroid Hormone-related Peptide, Negatively Regulates Chondrogenesis and Endochondral Ossification Via Associating with Progranulin Growth Factor FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. 08, 2016 | Pubmed ID: 27075243 Progranulin Suppresses Titanium Particle Induced Inflammatory Osteolysis by Targeting TNFα Signaling Scientific Reports. Feb, 2016 | Pubmed ID: 26864916 Does Progranulin Account for the Opposite Effects of Etanercept and Infliximab/adalimumab in Osteoarthritis?: Comment on Olson Et Al.: "Therapeutic Opportunities to Prevent Post-Traumatic Arthritis: Lessons From the Natural History of Arthritis After Articular Fracture" Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jan, 2016 | Pubmed ID: 26519939 Progranulin Knockout Accelerates Intervertebral Disc Degeneration in Aging Mice Scientific Reports. Mar, 2015 | Pubmed ID: 25777988 Overexpression of ADAMTS-7 Leads to Accelerated Initiation and Progression of Collagen-induced Arthritis in Mice Molecular and Cellular Biochemistry. Jun, 2015 | Pubmed ID: 25742929 Progranulin Protects Against Osteoarthritis Through Interacting with TNF-α and β-Catenin Signalling Annals of the Rheumatic Diseases. Dec, 2015 | Pubmed ID: 25169730 Progranulin Facilitates Conversion and Function of Regulatory T Cells Under Inflammatory Conditions PloS One. 2014 | Pubmed ID: 25393765 PGRN Protects Against Colitis Progression in Mice in an IL-10 and TNFR2 Dependent Manner Scientific Reports. Nov, 2014 | Pubmed ID: 25387791 ADAMTS-18: a Metalloproteinase with Multiple Functions Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896365 Three TNFR-binding Domains of PGRN Act Independently in Inhibition of TNF-alpha Binding and Activity Frontiers in Bioscience (Landmark Edition). Jun, 2014 | Pubmed ID: 24896343 Progranulin Inhibition of TNFα Immunology and Cell Biology. Feb, 2014 | Pubmed ID: 24518982 Progranulin Directly Binds to the CRD2 and CRD3 of TNFR Extracellular Domains FEBS Letters. Nov, 2013 | Pubmed ID: 24070898 ADAMTS-7 Forms a Positive Feedback Loop with TNF-α in the Pathogenesis of Osteoarthritis Annals of the Rheumatic Diseases. Dec, 2013 | Pubmed ID: 23928557 The Promotion of Bone Healing by Progranulin, a Downstream Molecule of BMP-2, Through Interacting with TNF/TNFR Signaling Biomaterials. Sep, 2013 | Pubmed ID: 23746860 Progranulin Deficiency Exaggerates, Whereas Progranulin-derived Atsttrin Attenuates, Severity of Dermatitis in Mice FEBS Letters. Jun, 2013 | Pubmed ID: 23669357 Prevention of Atrophic Nonunion by the Systemic Administration of Parathyroid Hormone (PTH 1-34) in an Experimental Animal Model Journal of Orthopaedic Trauma. Dec, 2012 | Pubmed ID: 22932751 Progranulina: Un Factor De Crecimiento, Un Nuevo Ligando TNFR Y Un Objetivo De Drogas Pharmacology & Therapeutics. Jan, 2012 | Pubmed ID: 22008260 GEP Constituye Un Bucle De Retroalimentación Negativa Con MyoD Y Actúa Como Un Nuevo Mediador En El Control De La Diferenciación Del Músculo Esquelético Cellular and Molecular Life Sciences : CMLS. Dec, 2011 | Pubmed ID: 22179841 Progranulina: Una Prometedora Diana Terapéutica Para La Artritis Reumatoide FEBS Letters. Dec, 2011 | Pubmed ID: 21550343 El Factor De Crecimiento Progranulina Se Une a Receptores De TNF Y Es Terapéutico Para La Artritis Inflamatoria En Ratones Science (New York, N.Y.). Apr, 2011 | Pubmed ID: 21393509 Cartílago De Proteína De La Matriz Oligomérica Inhibe La Calcificación Del Músculo Liso Vascular Mediante La Interacción Con La Proteína Morfogenética ósea 2 Circulation Research. Apr, 2011 | Pubmed ID: 21350216 El Papel De La ADAMTSs En La Artritis Protein & Cell. Jan, 2010 | Pubmed ID: 21203996 GEP, Un Factor De Crecimiento Local, Es Fundamental Para Odontogénesis Y Amelogénesis International Journal of Biological Sciences. 2010 | Pubmed ID: 21152114 Metaloproteinasas De La Matriz Que Se Asocian Con Y Se Unirá La Proteína Morfogenética ósea 2 in Vitro Son Elevados En Los Tejidos De Fractura Seudoartrosis Hipertrófica Journal of Orthopaedic Trauma. Sep, 2010 | Pubmed ID: 20736794 La Interacción Entre La Proteína Matriz Oligomérica De Cartílago Y La Proteína De Matriz Extracelular 1 Media De Crecimiento De Hueso Endocondral Matrix Biology : Journal of the International Society for Matrix Biology. May, 2010 | Pubmed ID: 20138147 Granulina Epithelin Precursor: Una Proteína Morfogenética ósea 2-inducible Factor De Crecimiento Que Activa ERK1 / 2 Señalización Y Factores De Transcripción En El JunB Condrogénesis FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2010 | Pubmed ID: 20124436 Cartílago Oligomeric Proteína De La Matriz Mantiene El Fenotipo Contráctil De Células Musculares Lisas Vasculares Mediante La Interacción Con Alpha (7) Beta (1) Integrina Circulation Research. Feb, 2010 | Pubmed ID: 20019333 Los Niveles De Expresión De BMP-7 Y Varios Antagonistas De BMP Pueden Desempeñar Un Papel Integral En Una Fractura De Falta De Unión: Un Estudio Piloto Clinical Orthopaedics and Related Research. Dec, 2009 | Pubmed ID: 19597895 ADAMTS-7, Un Objetivo Directo De La PTHrP, Que Perjudica Regula El Crecimiento De Hueso Endocondral Al Asociarse Con E Inactivación Del Factor De Crecimiento GEP Molecular and Cellular Biology. Aug, 2009 | Pubmed ID: 19487464 Los MicroARNs En Skeletogenesis Frontiers in Bioscience : a Journal and Virtual Library. 2009 | Pubmed ID: 19273234 MiR-199a, Una Proteína Morfogenética ósea 2-responde MicroARN, Regula Condrogénesis Vía De Atacar Directamente a La Smad1 The Journal of Biological Chemistry. Apr, 2009 | Pubmed ID: 19251704 ADAMTS-7 Media La Migración Vascular Células Musculares Lisas Y La Formación De Neoíntima En Las Arterias De Ratas Lesionadas Con Balón Circulation Research. Mar, 2009 | Pubmed ID: 19168437 El Papel De La ADAMTS-7 Y ADAMTS 12 En La Patogénesis De La Artritis Nature Clinical Practice. Rheumatology. Jan, 2009 | Pubmed ID: 19098927 P204, P200 Una Proteína De La Familia, Como Un Regulador Multifuncional De La Proliferación Y Diferenciación Celular Cytokine & Growth Factor Reviews. Oct-Dec, 2008 | Pubmed ID: 19027346 Inhibition of ADAMTS-7 and ADAMTS-12 Degradation of Cartilage Oligomeric Matrix Protein by Alpha-2-macroglobulin Osteoarthritis and Cartilage. Nov, 2008 | Pubmed ID: 18485748 La Proteína P204 Supera La Inhibición De La Central De Alfa-1 Mediada Por La Unión Del Factor De Diferenciación Osteogénica Por ID De La Hélice-hélice-bucle De Proteínas Molecular Biology of the Cell. May, 2008 | Pubmed ID: 18287524 RbAp48 Es Un Mediador Crítico Que Controla La Actividad De Transformación Del Papiloma Humano Tipo 16 En El Cáncer De Cuello Uterino The Journal of Biological Chemistry. Sep, 2007 | Pubmed ID: 17616526 IFI16 Inhibits Tumorigenicity and Cell Proliferation of Bone and Cartilage Tumor Cells Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17569615 La Activación Transcripcional De La Proteína Matriz Oligomérica De Cartílago Por Sox9, SOX5, Y SOX6 Factores De Transcripción Y Coactivadores CBP/p300 Frontiers in Bioscience : a Journal and Virtual Library. 2007 | Pubmed ID: 17485346 La Proteína Del Retinoblastoma Es Un Mediador Esencial De La Osteogénesis Que Une La Proteína P204 Con El Factor De Transcripción Cbfa1 Lo Que Aumenta Su Actividad The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17439944 Interacciones Proteína-proteína Y Localización En La Membrana Del Transportador Humano De Solutos Orgánicos American Journal of Physiology. Gastrointestinal and Liver Physiology. Jun, 2007 | Pubmed ID: 17332473 El Cartílago Matriz Oligomérica Proteína Se Asocia Con Granulina-epithelin Precursor (GEP) Y Potencia GEP-estimuló La Proliferación De Condrocitos The Journal of Biological Chemistry. Apr, 2007 | Pubmed ID: 17307734 ADAMTS-12 Con Los Asociados Y Degrada El Cartílago Proteína De La Matriz Oligomérica The Journal of Biological Chemistry. Jun, 2006 | Pubmed ID: 16611630 ADAMTS-7: Una Metaloproteinasa Que Directamente Se Une Y Degrada El Cartílago Proteína De La Matriz Oligomérica FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. May, 2006 | Pubmed ID: 16585064 La Proteína P204 Supera La Inhibición De La Diferenciación De Las Células Murinas P19 Carcinoma Embrionario Para Vencer Miocitos Cardiacos Por Proteínas Id The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556596 P204 Es Necesario Para La Diferenciación De Las Células Murinas P19 Carcinoma Embrionario Para Vencer Miocitos Cardiacos: Su Expresión Es Activada Por El Gata4 Cardiaca, Nkx2.5 Y Proteínas TBX5 The Journal of Biological Chemistry. May, 2006 | Pubmed ID: 16556595 El Suero De Interleucina-6 Como Marcador De Infección Periprotésica Después De Artroplastia De Cadera Y Rodilla The Journal of Bone and Joint Surgery. American Volume. Sep, 2005 | Pubmed ID: 16140805 El Interferón-inducible P204 Proteína Actúa Como Un Coactivador Transcripcional De Cbfa1 Y Mejora La Diferenciación Osteoblástica The Journal of Biological Chemistry. Jan, 2005 | Pubmed ID: 15557274 Leucemia / Linfoma Relacionado Con Factor, Un POZ De Dominio Que Contienen Represor Transcripcional, Interacciona Con La Histona Deacetilasa-1 Inhibe La Expresión Y La Matriz Del Cartílago Oligomérica Gen De La Proteína Y Condrogénesis The Journal of Biological Chemistry. Nov, 2004 | Pubmed ID: 15337766 Un Elemento Silenciador En El Gen Oligomérica Del Cartílago Proteína De La Matriz Regula La Expresión Específica De Los Condrocitos Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. Jul, 2004 | Pubmed ID: 15183430 Asociación De La Subunidad C De 16-kDa De La Bomba De Protones Vacuolar Con La Na +-dependiente Ileal Transportador De ácidos Biliares: Interacción Proteína-proteína Y El Tráfico Intracelular The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14752118 La Modulación Del Canal De Sodio Cardiaco Nav1.5 Por El Factor De Crecimiento Fibroblástico Homóloga 1B Factor The Journal of Biological Chemistry. Jan, 2003 | Pubmed ID: 12401812 El MyoD Inducible Proteína P204 Supera La Inhibición De La Diferenciación De Mioblastos Por Proteínas Id Molecular and Cellular Biology. May, 2002 | Pubmed ID: 11940648 Un ensayo semicuantitativo de estabilidad de objetivos sensibles a la afinidad de drogas (DARTS, por sus) para estudiar la interacción con Rapamicina/mTOR Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemistry Establecimiento de un modelo quirúrgicamente inducida en ratones para investigar el papel de protección de progranulina en la osteoartritis Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioengineering Modificado levadura sistema híbrido de dos para identificar proteínas que interactúan con el factor de crecimiento progranulina Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biology
Un ensayo semicuantitativo de estabilidad de objetivos sensibles a la afinidad de drogas (DARTS, por sus) para estudiar la interacción con Rapamicina/mTOR Chen Zhang*1, Min Cui*1, Yazhou Cui1, Aubryanna Hettinghouse1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, New York University Medical Center, 2Department of Cell Biology, New York University School of Medicine JoVE 59656 Biochemistry
Establecimiento de un modelo quirúrgicamente inducida en ratones para investigar el papel de protección de progranulina en la osteoartritis Yunpeng Zhao1, Ben Liu1, Chuan-ju Liu2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Orthopaedic Surgery, New York University Medical Center JoVE 50924 Bioengineering
Modificado levadura sistema híbrido de dos para identificar proteínas que interactúan con el factor de crecimiento progranulina Qing-Yun Tian1, Yun-Peng Zhao1, Chuan-ju Liu1,2 1Department of Orthopaedic Surgery, NYU Hospital for Joint Diseases, 2Department of Cell Biology, New York University School of Medicine JoVE 3562 Biology