In JoVE (1)
Other Publications (1)
Articles by Chun Chieh Chen in JoVE
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods Chun Chieh Chen*1, Marie Stark*1, Mo Baikoghli1, R. Holland Cheng1 1Department of Molecular and Cellular Biology, University of California Davis We have engineered the capsid protein of hepatitis E virus as a theranostic nanoparticle (HEVNP). HEVNP self-assembles into a stable icosahedral cage in mucosal delivery. Here, we describe the modification of HEVNPs for tumor targeting by mutating surface-exposed residues to cysteines, which conjugate synthetic ligands that specifically bind tumor cells.
Other articles by Chun Chieh Chen on PubMed
Chemically Activatable Viral Capsid Functionalized for Cancer Targeting Nanomedicine (London, England). Feb, 2016 | Pubmed ID: 26786134 To design a theranostic capsule using the virus-like nanoparticle of the hepatitis E virus modified to display breast cancer cell targeting functional group (LXY30).