In JoVE (1)
Other Publications (1)
Articles by Chun Chieh Chen in JoVE
Surface Functionalization of Hepatitis E Virus Nanoparticles Using Chemical Conjugation Methods Chun Chieh Chen*1, Marie Stark*1, Mo Baikoghli1, R. Holland Cheng1 1Department of Molecular and Cellular Biology, University of California Davis We have engineered the capsid protein of hepatitis E virus as a theranostic nanoparticle (HEVNP). HEVNP self-assembles into a stable icosahedral cage in mucosal delivery. Here, we describe the modification of HEVNPs for tumor targeting by mutating surface-exposed residues to cysteines, which conjugate synthetic ligands that specifically bind tumor cells.