Claes Wahlestedt Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences University of Miami Miller School of Medicine Biography Publications Institution JoVE Articles Claes Wahlestedt has not added a biography. If you are Claes Wahlestedt and would like to personalize this page please email our Author Liaison for assistance. Publications Direct Administration and Gene Modulation Using Antisense Oligonucleotides Within the CNS Cellular and Molecular Neurobiology. Jul, 2020 | Pubmed ID: 32656646 Dipeptide Repeat Proteins Inhibit Homology-directed DNA Double Strand Break Repair in C9ORF72 ALS/FTD Molecular Neurodegeneration. 02, 2020 | Pubmed ID: 32093728 Novel Approach Reveals Genomic Landscapes of Single-strand DNA Breaks with Nucleotide Resolution in Human Cells Nature Communications. 12, 2019 | Pubmed ID: 31862872 The Novel BET-CBP/p300 Dual Inhibitor NEO2734 is Active in SPOP Mutant and Wild-type Prostate Cancer EMBO Molecular Medicine. 11, 2019 | Pubmed ID: 31559706 Dysregulation of the Histone Demethylase KDM6B in Alcohol Dependence is Associated with Epigenetic Regulation of Inflammatory Signaling Pathways Addiction Biology. Aug, 2019 | Pubmed ID: 31373129 Ovarian Cancer Treatment Stratification Using Drug Sensitivity Testing Anticancer Research. Aug, 2019 | Pubmed ID: 31366484 Defective HNF4alpha-dependent Gene Expression As a Driver of Hepatocellular Failure in Alcoholic Hepatitis Nature Communications. 07, 2019 | Pubmed ID: 31311938 Longevity-related Molecular Pathways Are Subject to Midlife "switch" in Humans Aging Cell. 08, 2019 | Pubmed ID: 31168962 Vitamin C Supplementation Expands the Therapeutic Window of BETi for Triple Negative Breast Cancer EBioMedicine. May, 2019 | Pubmed ID: 30975544 HDAC Inhibitors Induce Expression and Promote Neurite Outgrowth in Human Neural Progenitor Cells-Derived Neurons International Journal of Molecular Sciences. Mar, 2019 | Pubmed ID: 30841499 Enhancement of BDNF Expression and Memory by HDAC Inhibition Requires BET Bromodomain Reader Proteins The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. 01, 2019 | Pubmed ID: 30504275 Drug and Disease Signature Integration Identifies Synergistic Combinations in Glioblastoma Nature Communications. 12, 2018 | Pubmed ID: 30552330 Inhibition of HDAC3 Reverses Alzheimer's Disease-related Pathologies in Vitro and in the 3xTg-AD Mouse Model Proceedings of the National Academy of Sciences of the United States of America. Nov, 2018 | Pubmed ID: 30397132 EZH1 is an Antipsychotic-sensitive Epigenetic Modulator of Social and Motivational Behavior That is Dysregulated in Schizophrenia Neurobiology of Disease. Nov, 2018 | Pubmed ID: 30099093 Developments in LncRNA Drug Discovery: Where Are We Heading? Expert Opinion on Drug Discovery. Sep, 2018 | Pubmed ID: 30078338 Strategies to Annotate and Characterize Long Noncoding RNAs: Advantages and Pitfalls Trends in Genetics : TIG. Sep, 2018 | Pubmed ID: 30017313 Serum Long Noncoding RNA HOTAIR As a Novel Diagnostic and Prognostic Biomarker in Glioblastoma Multiforme Molecular Cancer. 03, 2018 | Pubmed ID: 29558959 Cocaine Exposure Increases Blood Pressure and Aortic Stiffness Via the MiR-30c-5p-Malic Enzyme 1-Reactive Oxygen Species Pathway Hypertension (Dallas, Tex. : 1979). Apr, 2018 | Pubmed ID: 29483230 Vitamin C Sensitizes Melanoma to BET Inhibitors Cancer Research. 01, 2018 | Pubmed ID: 29180474 Ex-vivo Sensitivity Profiling to Guide Clinical Decision Making in Acute Myeloid Leukemia: A Pilot Study Leukemia Research. 01, 2018 | Pubmed ID: 29175379 Gain of Function of ASXL1 Truncating Protein in the Pathogenesis of Myeloid Malignancies Blood. Jan, 2018 | Pubmed ID: 29113963 How the Strengths of Lisp-family Languages Facilitate Building Complex and Flexible Bioinformatics Applications Briefings in Bioinformatics. 05, 2018 | Pubmed ID: 28040748 M344 Promotes Nonamyloidogenic Amyloid Precursor Protein Processing While Normalizing Alzheimer's Disease Genes and Improving Memory Proceedings of the National Academy of Sciences of the United States of America. 10, 2017 | Pubmed ID: 29073110 Cocaine Alters Homer1 Natural Antisense Transcript in the Nucleus Accumbens Molecular and Cellular Neurosciences. 12, 2017 | Pubmed ID: 29055697 Oxytocin and Social Functioning Dialogues in Clinical Neuroscience. 06, 2017 | Pubmed ID: 28867943 A C9ORF72 BAC Mouse Model Recapitulates Key Epigenetic Perturbations of ALS/FTD Molecular Neurodegeneration. 06, 2017 | Pubmed ID: 28606110 Shinyheatmap: Ultra Fast Low Memory Heatmap Web Interface for Big Data Genomics PloS One. 2017 | Pubmed ID: 28493881 Oligonucleotide Therapies for Disorders of the Nervous System Nature Biotechnology. 03, 2017 | Pubmed ID: 28244991 Emerging Epigenetic Therapies in Neuroscience: Focus on Bromodomain-Containing Drug Targets Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 01, 2017 | Pubmed ID: 27909334 Orphan Diseases: State of the Drug Discovery Art Wiener Medizinische Wochenschrift (1946). Jun, 2017 | Pubmed ID: 26819216 The FMR1 Promoter is Selectively Hydroxymethylated in Primary Neurons of Fragile X Syndrome Patients Human Molecular Genetics. 11, 2016 | Pubmed ID: 28173181 Ischemic Preconditioning Confers Epigenetic Repression of Mtor and Induction of Autophagy Through G9a-Dependent H3K9 Dimethylation Journal of the American Heart Association. 12, 2016 | Pubmed ID: 28007739 MicroScope: ChIP-seq and RNA-seq Software Analysis Suite for Gene Expression Heatmaps BMC Bioinformatics. Sep, 2016 | Pubmed ID: 27659774 Upregulation of Haploinsufficient Gene Expression in the Brain by Targeting a Long Non-coding RNA Improves Seizure Phenotype in a Model of Dravet Syndrome EBioMedicine. Jul, 2016 | Pubmed ID: 27333023 The BET-Bromodomain Inhibitor JQ1 Reduces Inflammation and Tau Phosphorylation at Ser396 in the Brain of the 3xTg Model of Alzheimer's Disease Current Alzheimer Research. 2016 | Pubmed ID: 27117003 Functional Annotation of the Vlinc Class of Non-coding RNAs Using Systems Biology Approach Nucleic Acids Research. Apr, 2016 | Pubmed ID: 27001520 The Long Non-coding RNA FMR4 Promotes Proliferation of Human Neural Precursor Cells and Epigenetic Regulation of Gene Expression in Trans Molecular and Cellular Neurosciences. 07, 2016 | Pubmed ID: 27001315 Altering the Course of Schizophrenia: Progress and Perspectives Nature Reviews. Drug Discovery. 07, 2016 | Pubmed ID: 26939910 Transcriptomic Profiling of Extracellular RNAs Present in Cerebrospinal Fluid Identifies Differentially Expressed Transcripts in Parkinson's Disease Journal of Parkinson's Disease. 2016 | Pubmed ID: 26889637 C9orf72 Promoter Hypermethylation is Reduced While Hydroxymethylation is Acquired During Reprogramming of ALS Patient Cells Experimental Neurology. Mar, 2016 | Pubmed ID: 26746986 Epigenetic Readers of Lysine Acetylation Regulate Cocaine-Induced Plasticity The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2015 | Pubmed ID: 26558777 Screening for Small-Molecule Modulators of Long Noncoding RNA-Protein Interactions Using AlphaScreen Journal of Biomolecular Screening. Oct, 2015 | Pubmed ID: 26173710 The Bromodomain Protein BRD4 Controls HOTAIR, a Long Noncoding RNA Essential for Glioblastoma Proliferation Proceedings of the National Academy of Sciences of the United States of America. Jul, 2015 | Pubmed ID: 26111795 Bromodomain Inhibitors Regulate the C9ORF72 Locus in ALS Experimental Neurology. Sep, 2015 | Pubmed ID: 26099177 Basic Biology and Therapeutic Implications of LncRNA Advanced Drug Delivery Reviews. Jun, 2015 | Pubmed ID: 26024979 Antisense RNA Controls LRP1 Sense Transcript Expression Through Interaction with a Chromatin-associated Protein, HMGB2 Cell Reports. May, 2015 | Pubmed ID: 25937287 The Landscape of Long Noncoding RNA Classification Trends in Genetics : TIG. May, 2015 | Pubmed ID: 25869999 HeatmapGenerator: High Performance RNAseq and Microarray Visualization Software Suite to Examine Differential Gene Expression Levels Using an R and C++ Hybrid Computational Pipeline Source Code for Biology and Medicine. 2014 | Pubmed ID: 25550709 The BET Bromodomain Inhibitor I-BET151 Acts Downstream of Smoothened Protein to Abrogate the Growth of Hedgehog Protein-driven Cancers The Journal of Biological Chemistry. Dec, 2014 | Pubmed ID: 25355313 Emerging Treatment Strategies for Glioblastoma Multiforme EMBO Molecular Medicine. Nov, 2014 | Pubmed ID: 25312641 Transcriptional Repression of ER Through HMAPK Dependent Histone Deacetylation by Class I HDACs Breast Cancer Research and Treatment. Sep, 2014 | Pubmed ID: 25129342 I-BET151 Selectively Regulates IL-6 Production Biochimica Et Biophysica Acta. Sep, 2014 | Pubmed ID: 24859008 Natural Antisense Transcripts Human Molecular Genetics. Sep, 2014 | Pubmed ID: 24838284 Natural Antisense Transcripts As Therapeutic Targets Drug Discovery Today. Therapeutic Strategies. 2013 | Pubmed ID: 25580147 Regulation of the Apolipoprotein Gene Cluster by a Long Noncoding RNA Cell Reports. Dec, 2013 | Pubmed ID: 24388749 Amygdala-Dependent Fear Is Regulated by Oprl1 in Mice and Humans with PTSD Science Translational Medicine. Jun, 2013 | Pubmed ID: 23740899 Targeting Long Non-coding RNA to Therapeutically Upregulate Gene Expression Nature Reviews. Drug Discovery. Jun, 2013 | Pubmed ID: 23722346 Personalized Medicine in Psychiatry: Problems and Promises BMC Medicine. May, 2013 | Pubmed ID: 23680237 RNAi Joins the "Singles Club" Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2012 | Pubmed ID: 23131851 The Emerging Role of Non-Coding RNAs in Drug Addiction Frontiers in Genetics. 2012 | Pubmed ID: 22737160 Regulation of Chromatin Structure by Long Noncoding RNAs: Focus on Natural Antisense Transcripts Trends in Genetics : TIG. Aug, 2012 | Pubmed ID: 22541732 Inhibition of Natural Antisense Transcripts in Vivo Results in Gene-specific Transcriptional Upregulation Nature Biotechnology. Mar, 2012 | Pubmed ID: 22446693 MicroRNA-132 Disregolazione Nella Schizofrenia Ha Implicazioni Per Sviluppo Neurologico E La Funzione Del Cervello Adulto Proceedings of the National Academy of Sciences of the United States of America. Feb, 2012 | Pubmed ID: 22315408 Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis International Journal of Alzheimer's Disease. 2011 | Pubmed ID: 21785702 Un saggio di escrescenza Neurite e una valutazione della neurotossicità con neuroni derivati dalla cellula del progenitore neurale umano Amir Bagheri1,2, Seyedeh Fatemeh Razavipour3, Claes Wahlestedt2, Seyed Javad Mowla1, Mohammad Ali Faghihi2,4 1Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, 2Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, 3Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 4Persian BayanGene Research and Training Center JoVE 60955 Developmental Biology Purificazione di H3 e H4 proteine istoniche e la quantificazione degli istoni acetilati marchi nelle cellule e tessuto cerebrale Karolina J. Janczura1,2, Claude-Henry Volmar1,2, Claes Wahlestedt1,2 1Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, 2Center for Therapeutic Innovation, University of Miami Miller School of Medicine JoVE 58648 Neuroscience
Un saggio di escrescenza Neurite e una valutazione della neurotossicità con neuroni derivati dalla cellula del progenitore neurale umano Amir Bagheri1,2, Seyedeh Fatemeh Razavipour3, Claes Wahlestedt2, Seyed Javad Mowla1, Mohammad Ali Faghihi2,4 1Department of Molecular Genetics, Faculty of Biological Sciences, Tarbiat Modares University, 2Center for Therapeutic Innovation and Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, 3Department of Biochemistry and Molecular Biology, University of Miami Miller School of Medicine, 4Persian BayanGene Research and Training Center JoVE 60955 Developmental Biology
Purificazione di H3 e H4 proteine istoniche e la quantificazione degli istoni acetilati marchi nelle cellule e tessuto cerebrale Karolina J. Janczura1,2, Claude-Henry Volmar1,2, Claes Wahlestedt1,2 1Department of Psychiatry & Behavioral Sciences, University of Miami Miller School of Medicine, 2Center for Therapeutic Innovation, University of Miami Miller School of Medicine JoVE 58648 Neuroscience
