Clare L. Hawkins

Publications

• 8-Chloroadenosine Induces Apoptosis in Human Coronary Artery Endothelial Cells Through the Activation of the Unfolded Protein Response
  Redox Biology. 09, 2019  |   Pubmed ID: 31307008
• A Role for Chlorinated Nucleosides in the Perturbation of Macrophage Function and Promotion of Inflammation
  Chemical Research in Toxicology. Jun, 2019  |   Pubmed ID: 31066272
• Oxidation of Human Plasma Fibronectin by Inflammatory Oxidants Perturbs Endothelial Cell Function
  Free Radical Biology & Medicine. May, 2019  |   Pubmed ID: 30959171
• Characterization of the Cellular Effects of Myeloperoxidase-derived Oxidants on H9c2 Cardiac Myoblasts
  Archives of Biochemistry and Biophysics. Apr, 2019  |   Pubmed ID: 30872062
• Hypochlorous Acid-modified Extracellular Matrix Contributes to the Behavioral Switching of Human Coronary Artery Smooth Muscle Cells
  Free Radical Biology & Medicine. 04, 2019  |   Pubmed ID: 30716431
• Role of Hypochlorous Acid (HOCl) and Other Inflammatory Mediators in the Induction of Macrophage Extracellular Trap Formation
  Free Radical Biology & Medicine. 12, 2018  |   Pubmed ID: 30189264
• Protein Carbamylation: a Key Driver of Vascular Calcification During Chronic Kidney Disease
  Kidney International. 07, 2018  |   Pubmed ID: 29933841
• A Pivotal Role for NF-κB in the Macrophage Inflammatory Response to the Myeloperoxidase Oxidant Hypothiocyanous Acid
  Archives of Biochemistry and Biophysics. 03, 2018  |   Pubmed ID: 29410057
• Molecular Alterations in a Mouse Cardiac Model of Friedreich Ataxia: An Impaired Nrf2 Response Mediated Via Upregulation of Keap1 and Activation of the Gsk3β Axis
  The American Journal of Pathology. Dec, 2017  |   Pubmed ID: 28935570
• Low-density Lipoprotein Modified by Myeloperoxidase Oxidants Induces Endothelial Dysfunction
  Redox Biology. 10, 2017  |   Pubmed ID: 28818791
• Catalytic Oxidant Scavenging by Selenium-containing Compounds: Reduction of Selenoxides and N-chloramines by Thiols and Redox Enzymes
  Redox Biology. 08, 2017  |   Pubmed ID: 28458184
• Role of Mitochondrial Reactive Oxygen Species in the Activation of Cellular Signals, Molecules, and Function
  Handbook of Experimental Pharmacology. 2017  |   Pubmed ID: 28176043
• Role of Myeloperoxidase Oxidants in the Modulation of Cellular Lysosomal Enzyme Function: A Contributing Factor to Macrophage Dysfunction in Atherosclerosis?
  PloS One. 2016  |   Pubmed ID: 27997605
• Changes in Mitochondrial Homeostasis and Redox Status in Astronauts Following Long Stays in Space
  Scientific Reports. 12, 2016  |   Pubmed ID: 27982062
• A Nitric Oxide Storage and Transport System That Protects Activated Macrophages from Endogenous Nitric Oxide Cytotoxicity
  The Journal of Biological Chemistry. 12, 2016  |   Pubmed ID: 27866158
• Cross-linking of Lens Crystallin Proteins Induced by Tryptophan Metabolites and Metal Ions: Implications for Cataract Development
  Free Radical Research. Oct, 2016  |   Pubmed ID: 27383194
• Chasing Great Paths of Helmut Sies "Oxidative Stress"
  Archives of Biochemistry and Biophysics. Apr, 2016  |   Pubmed ID: 27095216
• Cellular Targets of the Myeloperoxidase-derived Oxidant Hypothiocyanous Acid (HOSCN) and Its Role in the Inhibition of Glycolysis in Macrophages
  Free Radical Biology & Medicine. 05, 2016  |   Pubmed ID: 26898502
• β3 Adrenergic Stimulation Restores Nitric Oxide/Redox Balance and Enhances Endothelial Function in Hyperglycemia
  Journal of the American Heart Association. Feb, 2016  |   Pubmed ID: 26896479
• Manganese Superoxide Dismutase Promotes Interaction of Actin, S100A4 and Talin, and Enhances Rat Gastric Tumor Cell Invasion
  Journal of Clinical Biochemistry and Nutrition. Jul, 2015  |   Pubmed ID: 26236095
• Reactivity of Selenium-containing Compounds with Myeloperoxidase-derived Chlorinating Oxidants: Second-order Rate Constants and Implications for Biological Damage
  Free Radical Biology & Medicine. Jul, 2015  |   Pubmed ID: 25841785
• Comparative Reactivity of the Myeloperoxidase-derived Oxidants HOCl and HOSCN with Low-density Lipoprotein (LDL): Implications for Foam Cell Formation in Atherosclerosis
  Archives of Biochemistry and Biophysics. May, 2015  |   Pubmed ID: 25795019
• Role of Cyanate in the Induction of Vascular Dysfunction During Uremia: More Than Protein Carbamylation?
  Kidney International. Nov, 2014  |   Pubmed ID: 25360490
• Tryptophan Oxidation in Proteins Exposed to Thiocyanate-derived Oxidants
  Archives of Biochemistry and Biophysics. Dec, 2014  |   Pubmed ID: 25172223
• Comparative Reactivity of Myeloperoxidase-derived Oxidants with Mammalian Cells
  Free Radical Biology & Medicine. Jun, 2014  |   Pubmed ID: 24632382
• Inhibition of Myeloperoxidase- and Neutrophil-mediated Oxidant Production by Tetraethyl and Tetramethyl Nitroxides
  Free Radical Biology & Medicine. May, 2014  |   Pubmed ID: 24566469
• Detection and Characterisation of Radicals in Biological Materials Using EPR Methodology
  Biochimica Et Biophysica Acta. Feb, 2014  |   Pubmed ID: 23567797
• Comparative Reactivity of the Myeloperoxidase-derived Oxidants Hypochlorous Acid and Hypothiocyanous Acid with Human Coronary Artery Endothelial Cells
  Free Radical Biology & Medicine. Dec, 2013  |   Pubmed ID: 24120969
• Myeloperoxidase-derived Oxidants Modify Apolipoprotein A-I and Generate Dysfunctional High-density Lipoproteins: Comparison of Hypothiocyanous Acid (HOSCN) with Hypochlorous Acid (HOCl)
  The Biochemical Journal. Jan, 2013  |   Pubmed ID: 23088652
• Identification of Proteins Susceptible to Thiol Oxidation in Endothelial Cells Exposed to Hypochlorous Acid and N-chloramines
  Biochemical and Biophysical Research Communications. Aug, 2012  |   Pubmed ID: 22819842
• Reduced Circulating Oxidized LDL is Associated with Hypocholesterolemia and Enhanced Thiol Status in Gilbert Syndrome
  Free Radical Biology & Medicine. May, 2012  |   Pubmed ID: 22521902
• Reactions and Reactivity of Myeloperoxidase-derived Oxidants: Differential Biological Effects of Hypochlorous and Hypothiocyanous Acids
  Free Radical Research. Aug, 2012  |   Pubmed ID: 22348603
• Inactivation of Thiol-dependent Enzymes by Hypothiocyanous Acid: Role of Sulfenyl Thiocyanate and Sulfenic Acid Intermediates
  Free Radical Biology & Medicine. Mar, 2012  |   Pubmed ID: 22248862
• Nitric Oxide Storage and Transport in Cells Are Mediated by Glutathione S-transferase P1-1 and Multidrug Resistance Protein 1 Via Dinitrosyl Iron Complexes
  The Journal of Biological Chemistry. Jan, 2012  |   Pubmed ID: 22084240
• Hypothiocyanous Acid: Benign or Deadly?
  Chemical Research in Toxicology. Feb, 2012  |   Pubmed ID: 22053976
• High Plasma Thiocyanate Levels in Smokers Are a Key Determinant of Thiol Oxidation Induced by Myeloperoxidase
  Free Radical Biology & Medicine. Nov, 2011  |   Pubmed ID: 21884783
• Amino Acid, Peptide, and Protein Hydroperoxides and Their Decomposition Products Modify the Activity of the 26S Proteasome
  Free Radical Biology & Medicine. Jan, 2011  |   Pubmed ID: 21111806
• Cellular Effects of Photogenerated Oxidants and Long-lived, Reactive, Hydroperoxide Photoproducts
  Free Radical Biology & Medicine. Nov, 2010  |   Pubmed ID: 20708682
• Ability of Hypochlorous Acid and N-chloramines to Chlorinate DNA and Its Constituents
  Chemical Research in Toxicology. Jul, 2010  |   Pubmed ID: 20593802
• The Myeloperoxidase-derived Oxidant HOSCN Inhibits Protein Tyrosine Phosphatases and Modulates Cell Signalling Via the Mitogen-activated Protein Kinase (MAPK) Pathway in Macrophages
  The Biochemical Journal. Aug, 2010  |   Pubmed ID: 20528774
• Cellular Effects of Peptide and Protein Hydroperoxides
  Free Radical Biology & Medicine. Apr, 2010  |   Pubmed ID: 20109544
• Acetaminophen (paracetamol) Inhibits Myeloperoxidase-catalyzed Oxidant Production and Biological Damage at Therapeutically Achievable Concentrations
  Biochemical Pharmacology. Apr, 2010  |   Pubmed ID: 19968966
• The Role of Hypothiocyanous Acid (HOSCN) in Biological Systems
  Free Radical Research. Dec, 2009  |   Pubmed ID: 19905977
• Quantification of Protein Modification by Oxidants
  Free Radical Biology & Medicine. Apr, 2009  |   Pubmed ID: 19439229
• Singlet-oxygen-mediated Amino Acid and Protein Oxidation: Formation of Tryptophan Peroxides and Decomposition Products
  Free Radical Biology & Medicine. Jul, 2009  |   Pubmed ID: 19375501
• What Are the Plasma Targets of the Oxidant Hypochlorous Acid? A Kinetic Modeling Approach
  Chemical Research in Toxicology. May, 2009  |   Pubmed ID: 19326902
• Separation, Detection, and Quantification of Hydroperoxides Formed at Side-chain and Backbone Sites on Amino Acids, Peptides, and Proteins
  Free Radical Biology & Medicine. Nov, 2008  |   Pubmed ID: 18762246
• Identification of Plasma Proteins That Are Susceptible to Thiol Oxidation by Hypochlorous Acid and N-chloramines
  Chemical Research in Toxicology. Sep, 2008  |   Pubmed ID: 18698849
• Tryptophan Residues Are Targets in Hypothiocyanous Acid-mediated Protein Oxidation
  The Biochemical Journal. Dec, 2008  |   Pubmed ID: 18652572
• Hypothiocyanous Acid is a More Potent Inducer of Apoptosis and Protein Thiol Depletion in Murine Macrophage Cells Than Hypochlorous Acid or Hypobromous Acid
  The Biochemical Journal. Sep, 2008  |   Pubmed ID: 18459943
• Mammalian Heme Peroxidases: from Molecular Mechanisms to Health Implications
  Antioxidants & Redox Signaling. Jul, 2008  |   Pubmed ID: 18331199
• Hypochlorous Acid-mediated Protein Oxidation: How Important Are Chloramine Transfer Reactions and Protein Tertiary Structure?
  Biochemistry. Aug, 2007  |   Pubmed ID: 17676767
• Sensitizer-mediated Photooxidation of Histidine Residues: Evidence for the Formation of Reactive Side-chain Peroxides
  Free Radical Biology & Medicine. Feb, 2006  |   Pubmed ID: 16458201
• Inactivation of Protease Inhibitors and Lysozyme by Hypochlorous Acid: Role of Side-chain Oxidation and Protein Unfolding in Loss of Biological Function
  Chemical Research in Toxicology. Oct, 2005  |   Pubmed ID: 16533025
• The Role of Aromatic Amino Acid Oxidation, Protein Unfolding, and Aggregation in the Hypobromous Acid-induced Inactivation of Trypsin Inhibitor and Lysozyme
  Chemical Research in Toxicology. Nov, 2005  |   Pubmed ID: 16300375
• The Role of Reactive N-bromo Species and Radical Intermediates in Hypobromous Acid-induced Protein Oxidation
  Free Radical Biology & Medicine. Oct, 2005  |   Pubmed ID: 16140210
• EPR Spin Trapping of Protein Radicals
  Free Radical Biology & Medicine. May, 2004  |   Pubmed ID: 15082061
• Hypochlorite and Superoxide Radicals Can Act Synergistically to Induce Fragmentation of Hyaluronan and Chondroitin Sulphates
  The Biochemical Journal. Jul, 2004  |   Pubmed ID: 15078224
• Hypochlorite-mediated Fragmentation of Hyaluronan, Chondroitin Sulfates, and Related N-acetyl Glycosamines: Evidence for Chloramide Intermediates, Free Radical Transfer Reactions, and Site-specific Fragmentation
  Journal of the American Chemical Society. Nov, 2003  |   Pubmed ID: 14599211
• Hypochlorous Acid-mediated Oxidation of Lipid Components and Antioxidants Present in Low-density Lipoproteins: Absolute Rate Constants, Product Analysis, and Computational Modeling
  Chemical Research in Toxicology. Apr, 2003  |   Pubmed ID: 12703960
• Photo-oxidation of Cells Generates Long-lived Intracellular Protein Peroxides
  Free Radical Biology & Medicine. Mar, 2003  |   Pubmed ID: 12633741
• Singlet Oxygen-mediated Protein Oxidation: Evidence for the Formation of Reactive Side Chain Peroxides on Tyrosine Residues
  Photochemistry and Photobiology. Jul, 2002  |   Pubmed ID: 12126305
• Reaction of Protein Chloramines with DNA and Nucleosides: Evidence for the Formation of Radicals, Protein-DNA Cross-links and DNA Fragmentation
  The Biochemical Journal. Aug, 2002  |   Pubmed ID: 12010123
• Hypochlorite-induced Damage to DNA, RNA, and Polynucleotides: Formation of Chloramines and Nitrogen-centered Radicals
  Chemical Research in Toxicology. Jan, 2002  |   Pubmed ID: 11800600
• Superoxide Radicals Can Act Synergistically with Hypochlorite to Induce Damage to Proteins
  FEBS Letters. Jan, 2002  |   Pubmed ID: 11755528