Clayton E. Mathews Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Clayton E. Mathews has not added a biography. If you are Clayton E. Mathews and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease Frontiers in Immunology. 2021 | Pubmed ID: 33717184 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 Mitochondrial Haplogroup G is Associated with Nonalcoholic Fatty Liver Disease, While Haplogroup A Mitigates the Effects of PNPLA3 Endocrinology, Diabetes & Metabolism. Jan, 2021 | Pubmed ID: 33532620 Branched Chain Amino Acids and Carbohydrate Restriction Exacerbate Ketogenesis and Hepatic Mitochondrial Oxidative Dysfunction During NAFLD FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32918763 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Lipid Mediators and Biomarkers Associated with Type 1 Diabetes Development JCI Insight. 08, 2020 | Pubmed ID: 32814707 NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers Diabetes. 08, 2020 | Pubmed ID: 32535552 Disruption of Hepatic One-carbon Metabolism Impairs Mitochondrial Function and Enhances Macrophage Activity in Methionine-choline-deficient Mice The Journal of Nutritional Biochemistry. 07, 2020 | Pubmed ID: 32422424 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation Via Cross-Presentation in Type 1 Diabetes Frontiers in Immunology. 2019 | Pubmed ID: 31118934 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Sixteen Diverse Laboratory Mouse Reference Genomes Define Strain-specific Haplotypes and Novel Functional Loci Nature Genetics. 11, 2018 | Pubmed ID: 30275530 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Correction To: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 09, 2018 | Pubmed ID: 30173405 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Abnormal Islet Sphingolipid Metabolism in Type 1 Diabetes Diabetologia. 07, 2018 | Pubmed ID: 29671030 The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future Frontiers in Endocrinology. 2018 | Pubmed ID: 29527189 Nanodroplet Processing Platform for Deep and Quantitative Proteome Profiling of 10-100 Mammalian Cells Nature Communications. 02, 2018 | Pubmed ID: 29491378 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Mitochondrial Reactive Oxygen Species and Type 1 Diabetes Antioxidants & Redox Signaling. 11, 2018 | Pubmed ID: 29295631 Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes Frontiers in Immunology. 2017 | Pubmed ID: 29123516 The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29109122 Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment Frontiers in Endocrinology. 2017 | Pubmed ID: 28959234 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Mitochondrial ATP Transporter Depletion Protects Mice Against Liver Steatosis and Insulin Resistance Nature Communications. 02, 2017 | Pubmed ID: 28205519 Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes Diabetes. 03, 2017 | Pubmed ID: 27920091 Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment Cancer Research. 02, 2017 | Pubmed ID: 27864347 Genetic Risk Analysis of a Patient with Fulminant Autoimmune Type 1 Diabetes Mellitus Secondary to Combination Ipilimumab and Nivolumab Immunotherapy Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 28031819 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells Using Jurkat T Lymphocyte Cells Journal of Proteomics & Bioinformatics. Jun, 2015 | Pubmed ID: 26401069 Respiration and Substrate Transport Rates As Well As Reactive Oxygen Species Production Distinguish Mitochondria from Brain and Liver BMC Biochemistry. Sep, 2015 | Pubmed ID: 26358560 Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes Diabetes. Dec, 2015 | Pubmed ID: 26269022 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Distinct Differences in the Responses of the Human Pancreatic β-cell Line EndoC-βH1 and Human Islets to Proinflammatory Cytokines American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26084699 Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-cells The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 26065037 How the Location of Superoxide Generation Influences the β-cell Response to Nitric Oxide The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648890 TRIF-dependent Innate Immune Activation is Critical for Survival to Neonatal Gram-negative Sepsis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25548220 Association of the Mt-ND2 5178A/C Polymorphism with Parkinson's Disease Neuroscience Letters. Feb, 2015 | Pubmed ID: 25511548 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Mechanisms of Tumor Necrosis Factor α Antagonist-induced Lupus in a Murine Model Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25252121 Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 2014 | Pubmed ID: 25023213 In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24958526 Use of Chemical Probes to Detect Mitochondrial ROS by Flow Cytometry and Spectrofluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862269 Do β-cells Generate Peroxynitrite in Response to Cytokine Treatment? The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24194521 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes The Review of Diabetic Studies : RDS. 2012 | Pubmed ID: 23804259 Oxidative Stress and Beta Cell Dysfunction Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22933078 Immune-mediated β-cell Death in Type 1 Diabetes: Lessons from Human β-cell Lines European Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 22924552 Inherited β-cell Dysfunction in Lean Individuals with Type 2 Diabetes Diabetes. Jul, 2012 | Pubmed ID: 22723272 Pleiotropic IFN-dependent and -independent Effects of IRF5 on the Pathogenesis of Experimental Lupus Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012 | Pubmed ID: 22422888 瘦素用作治疗的 1 型糖尿病: 复调。 Pediatric Diabetes. Feb, 2012 | Pubmed ID: 21884562 遗传学在抵抗 1 型糖尿病中的作用。 Diabetes/metabolism Research and Reviews. Nov, 2011 | Pubmed ID: 22069272 增加超氧丙酮酸盐脱氢酶复杂不足成纤维细胞的积累。 Molecular Genetics and Metabolism. Nov, 2011 | Pubmed ID: 21846590 精益 Ncb5or Null 小鼠糖尿病的发展是与内质网和 Beta 细胞氧化应激的表现相关联。 Biochimica Et Biophysica Acta. Nov, 2011 | Pubmed ID: 21839170 在人类的胰岛 β 细胞线 βLox5 免疫介导的凋亡死亡线粒体的作用。 PloS One. 2011 | Pubmed ID: 21738580 巨噬细胞和 T 细胞超氧离子是关键 Autoreactivity 的感应和 1 型糖尿病。 Diabetes. Aug, 2011 | Pubmed ID: 21715554 Polymicrobial 脓毒症期间从骨髓中性粒细胞动员是依赖 CXCL12 信号。 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21690321 Β 细胞功能的逐步削弱之前在 NOD 小鼠模型的 1 型糖尿病高血糖。 Diabetes. Aug, 2011 | Pubmed ID: 21659497 CXC 配体 10/CXC 受体 3 在脓毒症小鼠的新生儿响应信号的关键作用。 Infection and Immunity. Jul, 2011 | Pubmed ID: 21518789 脓毒症中影响到继发感染死亡率的先天免疫诱导早期改建。 Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21106855 Mt-Nd2(a) 修改抵抗自身免疫性 1 型糖尿病的 NOD 小鼠的胰腺 β-细胞一级。 Diabetes. Jan, 2011 | Pubmed ID: 20980458 NADPH 氧化酶缺乏调节 Th 沿袭承诺和调节自身免疫。 Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881184 使用非肥胖糖尿病小鼠,了解人类的 1 型糖尿病。 Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723819 免疫细胞动员与消耗传授免疫调节和反转肥胖型糖尿病小鼠自身免疫性糖尿病。 Diabetes. Oct, 2009 | Pubmed ID: 19628781 评估用于胚胎干细胞分化为胰岛素分泌 β-细胞的协议使用胰岛素二 GFP 作为特定和无创的记者。 Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508115 固醇-1 在 1 型糖尿病秋田小鼠心脏的副交感神经功能障碍的发展中的作用。 Circulation Research. Jul, 2009 | Pubmed ID: 19423844 章 24 定量化、 本地化和组织特异性的鼠标线粒体的活性氧物种生产。 Methods in Enzymology. 2009 | Pubmed ID: 19348903 MerTK 规管 Autoreactive T 细胞胸腺的选择。 Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 增加 ROS 耗散 T1D 预防中的作用。 Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120287 自发自身免疫性遗传抗性和自由基 — — 介导糖尿病的共同点。 Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18718526 Mt Nd2a 由线粒体复合物抑制活性氧物种生产,一和第三。 The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18281288 MerTK 是必需的凋亡诱导细胞 T 细胞容忍。 The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 Autoreactive T 细胞反应: 追求旧复仇女神的新技术。 Pediatric Diabetes. Oct, 2007 | Pubmed ID: 17850466 涉及山 Nd2 核和线粒体相互作用导致增加线粒体的活性氧物种生产。 The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17189252 细胞凋亡诱导的树突状细胞黏液 Mer 酪氨酸激酶依赖的封锁。 Blood. Jan, 2007 | Pubmed ID: 17008547 DR4-DQ8-限制 CD4 T 细胞反应和 1 型糖尿病易感性的功能的调节作用。 Diabetes. Dec, 2006 | Pubmed ID: 17130492 HLA A * 0201 限制从人性化的 NOD 小鼠的 T 细胞识别抗原的 1 型糖尿病的潜在临床相关性。 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493087 实用程序自身免疫性的自发研究小鼠模型的 1 型糖尿病。 Pediatric Diabetes. Sep, 2005 | Pubmed ID: 16109074 ALR/Lt 小鼠对细胞因子诱导的破坏胰腺胰岛抵抗的基本机制。 Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002729 主要组织相容性复合链接糖尿病易感性点头/Lt 小鼠: Subcongenic 分析本地化 Idd16 H2(g7) 复杂诱发糖尿病 H2 D 末尾的一个组成部分。 Diabetes. May, 2005 | Pubmed ID: 15855353 蛋白酶体抑制改变葡萄糖刺激 (pro) 胰岛素分泌和营业额在胰腺 {beta}-细胞。 The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15705591 ALS/Lt: 新的 2 型糖尿病小鼠模型关联的低自由基的清除的潜力。 Diabetes. Feb, 2004 | Pubmed ID: 14749277 ALR/Lt 小鼠 1 型糖尿病、 点头相关防御自身免疫介导的诱发糖尿病应力与应变的抗性遗传分析。 Immunogenetics. Oct, 2003 | Pubmed ID: 14513297 2 型糖尿病的儿童 (少年肥胖性) 研究的啮齿动物模型。 Pediatric Diabetes. Sep, 2002 | Pubmed ID: 15016157 新的小鼠模型研究胰岛素依赖型糖尿病胰岛移植。 Transplantation. Apr, 2002 | Pubmed ID: 11981430 中性粒细胞超氧生产的抗糖尿病 ALR/Lt 小鼠的遗传控制。 Free Radical Biology & Medicine. Apr, 2002 | Pubmed ID: 11937300 观察活胰腺组织切片中的胰岛功能和胰岛-免疫细胞相互作用 Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection β细胞死亡介导细胞毒性T淋巴细胞的方法来评估 Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection
观察活胰腺组织切片中的胰岛功能和胰岛-免疫细胞相互作用 Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection
β细胞死亡介导细胞毒性T淋巴细胞的方法来评估 Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection