Clayton E. Mathews Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Clayton E. Mathews has not added a biography. If you are Clayton E. Mathews and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease Frontiers in Immunology. 2021 | Pubmed ID: 33717184 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 Mitochondrial Haplogroup G is Associated with Nonalcoholic Fatty Liver Disease, While Haplogroup A Mitigates the Effects of PNPLA3 Endocrinology, Diabetes & Metabolism. Jan, 2021 | Pubmed ID: 33532620 Branched Chain Amino Acids and Carbohydrate Restriction Exacerbate Ketogenesis and Hepatic Mitochondrial Oxidative Dysfunction During NAFLD FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32918763 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Lipid Mediators and Biomarkers Associated with Type 1 Diabetes Development JCI Insight. 08, 2020 | Pubmed ID: 32814707 NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers Diabetes. 08, 2020 | Pubmed ID: 32535552 Disruption of Hepatic One-carbon Metabolism Impairs Mitochondrial Function and Enhances Macrophage Activity in Methionine-choline-deficient Mice The Journal of Nutritional Biochemistry. 07, 2020 | Pubmed ID: 32422424 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation Via Cross-Presentation in Type 1 Diabetes Frontiers in Immunology. 2019 | Pubmed ID: 31118934 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Sixteen Diverse Laboratory Mouse Reference Genomes Define Strain-specific Haplotypes and Novel Functional Loci Nature Genetics. 11, 2018 | Pubmed ID: 30275530 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Correction To: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 09, 2018 | Pubmed ID: 30173405 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Abnormal Islet Sphingolipid Metabolism in Type 1 Diabetes Diabetologia. 07, 2018 | Pubmed ID: 29671030 The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future Frontiers in Endocrinology. 2018 | Pubmed ID: 29527189 Nanodroplet Processing Platform for Deep and Quantitative Proteome Profiling of 10-100 Mammalian Cells Nature Communications. 02, 2018 | Pubmed ID: 29491378 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Mitochondrial Reactive Oxygen Species and Type 1 Diabetes Antioxidants & Redox Signaling. 11, 2018 | Pubmed ID: 29295631 Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes Frontiers in Immunology. 2017 | Pubmed ID: 29123516 The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29109122 Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment Frontiers in Endocrinology. 2017 | Pubmed ID: 28959234 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Mitochondrial ATP Transporter Depletion Protects Mice Against Liver Steatosis and Insulin Resistance Nature Communications. 02, 2017 | Pubmed ID: 28205519 Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes Diabetes. 03, 2017 | Pubmed ID: 27920091 Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment Cancer Research. 02, 2017 | Pubmed ID: 27864347 Genetic Risk Analysis of a Patient with Fulminant Autoimmune Type 1 Diabetes Mellitus Secondary to Combination Ipilimumab and Nivolumab Immunotherapy Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 28031819 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells Using Jurkat T Lymphocyte Cells Journal of Proteomics & Bioinformatics. Jun, 2015 | Pubmed ID: 26401069 Respiration and Substrate Transport Rates As Well As Reactive Oxygen Species Production Distinguish Mitochondria from Brain and Liver BMC Biochemistry. Sep, 2015 | Pubmed ID: 26358560 Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes Diabetes. Dec, 2015 | Pubmed ID: 26269022 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Distinct Differences in the Responses of the Human Pancreatic β-cell Line EndoC-βH1 and Human Islets to Proinflammatory Cytokines American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26084699 Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-cells The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 26065037 How the Location of Superoxide Generation Influences the β-cell Response to Nitric Oxide The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648890 TRIF-dependent Innate Immune Activation is Critical for Survival to Neonatal Gram-negative Sepsis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25548220 Association of the Mt-ND2 5178A/C Polymorphism with Parkinson's Disease Neuroscience Letters. Feb, 2015 | Pubmed ID: 25511548 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Mechanisms of Tumor Necrosis Factor α Antagonist-induced Lupus in a Murine Model Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25252121 Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 2014 | Pubmed ID: 25023213 In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24958526 Use of Chemical Probes to Detect Mitochondrial ROS by Flow Cytometry and Spectrofluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862269 Do β-cells Generate Peroxynitrite in Response to Cytokine Treatment? The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24194521 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes The Review of Diabetic Studies : RDS. 2012 | Pubmed ID: 23804259 Oxidative Stress and Beta Cell Dysfunction Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22933078 Immune-mediated β-cell Death in Type 1 Diabetes: Lessons from Human β-cell Lines European Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 22924552 Inherited β-cell Dysfunction in Lean Individuals with Type 2 Diabetes Diabetes. Jul, 2012 | Pubmed ID: 22723272 Pleiotropic IFN-dependent and -independent Effects of IRF5 on the Pathogenesis of Experimental Lupus Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012 | Pubmed ID: 22422888 L'utilisation De La Leptine Dans Le Traitement Du Diabète De Type 1: Contrepoint Pediatric Diabetes. Feb, 2012 | Pubmed ID: 21884562 Rôle De La Génétique Dans La Résistance Diabète De Type 1 Diabetes/metabolism Research and Reviews. Nov, 2011 | Pubmed ID: 22069272 Accumulation Superoxyde Accrue Dans Pyruvate Déshydrogénase Complexes Fibroblastes Déficients Molecular Genetics and Metabolism. Nov, 2011 | Pubmed ID: 21846590 Développement Du Diabète Au Lean Ncb5or Souris Nulles Est Associée à Des Manifestations Du Réticulum Endoplasmique Et Le Stress Oxydatif Dans Les Cellules Bêta Biochimica Et Biophysica Acta. Nov, 2011 | Pubmed ID: 21839170 Rôle Des Mitochondries Dans Les Auto-immune La Mort Par Apoptose De La Lignée Cellulaire Pancréatique β Humaines βLox5 PloS One. 2011 | Pubmed ID: 21738580 La Production De Superoxyde Par Les Macrophages Et Les Lymphocytes T Est Critique Pour L'induction De L'Autoréactivité Et Diabète De Type 1 Diabetes. Aug, 2011 | Pubmed ID: 21715554 Mobilisation Des Neutrophiles Dans La Moelle Osseuse Au Cours Du Sepsis Polymicrobienne Dépend CXCL12 Signalisation Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21690321 Érosion Progressive De La β-cellulaire Fonction Précède L'apparition De L'hyperglycémie Dans Le Modèle De Souris NOD De Diabète De Type 1 Diabetes. Aug, 2011 | Pubmed ID: 21659497 Rôle Déterminant Pour CXC Ligand Du Récepteur 10/CXC 3 De Signalisation Dans La Réponse à Une Septicémie Néonatale Murine Infection and Immunity. Jul, 2011 | Pubmed ID: 21518789 Sepsis Provoque Des Altérations Précoces Dans L'immunité Innée Que La Mortalité Impact à Une Infection Secondaire Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21106855 Mt-Nd2 (a) Modifie Résistance Contre Le Diabète De Type 1 Auto-immune Chez La Souris NOD Au Niveau De La β Pancréatique Des Cellules Diabetes. Jan, 2011 | Pubmed ID: 20980458 Déficit De La NADPH Oxydase Régule Engagement Lineage Th Et Module Auto-immunité Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881184 L'utilisation De Souris Diabétiques Non Obèses à Comprendre Humaine De Type 1 Du Diabète Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723819 Déficit Immunitaire Cellulaire Avec La Mobilisation Donne Immunorégulation Et Inverse Diabète Auto-immun Chez Des Souris Diabétiques Non Obèses Diabetes. Oct, 2009 | Pubmed ID: 19628781 L'évaluation Des Protocoles De Différenciation Des Cellules Souches Embryonnaires En Bêta Qui Sécrètent L'insuline Des Cellules Avec De L'insuline II-GFP En Tant Que Journaliste Spécifique Et Non Invasive Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508115 Rôle De SREBP-1 Dans Le Développement De La Dysfonction Parasympathique Dans Les Coeurs De Souris De Type 1 Akita Diabétiques Circulation Research. Jul, 2009 | Pubmed ID: 19423844 Chapitre 24 Quantification, Localisation, Et Les Spécificités Des Tissus De La Souris La Production Mitochondriale Réactives De L'oxygène Methods in Enzymology. 2009 | Pubmed ID: 19348903 MerTK Régule La Sélection Thymique Des Lymphocytes T Autoréactifs Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 Rôle Des ROS Dissipation Accru Dans La Prévention Du DT1 Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120287 Les Points Communs De La Résistance Génétique à Spontanée Auto-immunes Et Free Radical - Médiation Du Diabète Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18718526 Mt-Nd2a Supprime Réactive La Production Des Espèces D'oxygène Par Mitochondrial Complexes I Et III The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18281288 MerTK Est Requis Pour Apoptotique Cellulaire Induite Par La Tolérance Des Cellules T The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 Autoréactifs Des Cellules T Réponses: La Nouvelle Technologie Dans La Poursuite D'un Vieil Ennemi Pediatric Diabetes. Oct, 2007 | Pubmed ID: 17850466 Interaction Nucléaire Et Mitochondrial Impliquer Mt-Nd2 Conduit à Une Augmentation De La Production Mitochondriale Réactives De L'oxygène The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17189252 Cellules Apoptotiques Provoquer Mer Tyrosine Kinase Dépendante De Blocage De NF-kappa B Activation Dans Les Cellules Dendritiques Blood. Jan, 2007 | Pubmed ID: 17008547 Rôle Modulateur De La DR4-DQ8 à Restriction Cellules T CD4 Et Réponses Susceptibilité Au Diabète De Type 1 Diabetes. Dec, 2006 | Pubmed ID: 17130492 HLA-A * 0201-cellules T Restreintes Provenant De Souris NOD Humanisés Reconnaître Autoantigènes D'importance Clinique Potentielle De Diabète De Type 1 Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493087 Utilitaire De Modèles Murins Pour L'étude De Diabète De Type 1 Spontané Auto-immune Pediatric Diabetes. Sep, 2005 | Pubmed ID: 16109074 Résistance Mécanismes Sous-jacents D'îlots Pancréatiques à Partir ALR / Lt Souris à La Destruction Induite Par Les Cytokines Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002729 Major Susceptibilité Au Diabète Histocompatibilité Complexe Lié Au NOD / Lt Souris: Analyse Subcongenic Localise Un Composant De Idd16 à La Fin H2-D De L'H2 Diabétogène (g7) Complexe Diabetes. May, 2005 | Pubmed ID: 15855353 Alters L'inhibition Du Protéasome Glucose Sécrétion D'insuline Stimulée (pro) Et Chiffre D'affaires Du Pancréas {beta}-cellules The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15705591 SLA / Lt: Un Nouveau Type 2 Modèle De Souris Du Diabète Associé à Un Faible Potentiel De Piégeage Des Radicaux Libres Diabetes. Feb, 2004 | Pubmed ID: 14749277 Analyse Génétique De La Résistance à La Diabète De Type 1 Dans ALR / Lt Souris, Une Souche NOD Liée Avec Des Défenses Contre Le Stress Auto-immune à Médiation Diabétogène Immunogenetics. Oct, 2003 | Pubmed ID: 14513297 Des Modèles De Rongeurs Pour L'étude De Diabète De Type 2 Chez Les Enfants (mineurs Diabésité) Pediatric Diabetes. Sep, 2002 | Pubmed ID: 15016157 Nouveau Modèle De Souris Pour étudier La Transplantation D'îlots Dans Le Diabète Sucré Insulino-dépendant Transplantation. Apr, 2002 | Pubmed ID: 11981430 Contrôle Génétique De La Production De Superoxyde Des Neutrophiles Dans Le Diabète Résistant ALR / Lt Souris Free Radical Biology & Medicine. Apr, 2002 | Pubmed ID: 11937300 Observation de la fonction des îlots et des interactions entre les îlots et les cellules immunitaires dans les tranches de tissu pancréatique vivant Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection Méthodes d'évaluation bêta Mediated la mort cellulaire par les lymphocytes T cytotoxiques Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection
Observation de la fonction des îlots et des interactions entre les îlots et les cellules immunitaires dans les tranches de tissu pancréatique vivant Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection
Méthodes d'évaluation bêta Mediated la mort cellulaire par les lymphocytes T cytotoxiques Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection