Clayton E. Mathews Department of Pathology, Immunology, and Laboratory Medicine University of Florida Biography Publications Institution JoVE Articles Clayton E. Mathews has not added a biography. If you are Clayton E. Mathews and would like to personalize this page please email our Author Liaison for assistance. Publications Islet Sympathetic Innervation and Islet Neuropathology in Patients with Type 1 Diabetes Scientific Reports. Mar, 2021 | Pubmed ID: 33753784 Influence of Allotypes on Innate and Adaptive Immune Function in Health and Disease Frontiers in Immunology. 2021 | Pubmed ID: 33717184 Low-dose ATG/GCSF in Established Type 1 Diabetes: A Five-Year Follow-up Report Diabetes. Feb, 2021 | Pubmed ID: 33632742 Mitochondrial Haplogroup G is Associated with Nonalcoholic Fatty Liver Disease, While Haplogroup A Mitigates the Effects of PNPLA3 Endocrinology, Diabetes & Metabolism. Jan, 2021 | Pubmed ID: 33532620 Branched Chain Amino Acids and Carbohydrate Restriction Exacerbate Ketogenesis and Hepatic Mitochondrial Oxidative Dysfunction During NAFLD FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Nov, 2020 | Pubmed ID: 32918763 Comparing Beta Cell Preservation Across Clinical Trials in Recent-Onset Type 1 Diabetes Diabetes Technology & Therapeutics. 12, 2020 | Pubmed ID: 32833543 Lipid Mediators and Biomarkers Associated with Type 1 Diabetes Development JCI Insight. 08, 2020 | Pubmed ID: 32814707 NKG2D Signaling Within the Pancreatic Islets Reduces NOD Diabetes and Increases Protective Central Memory CD8 T-Cell Numbers Diabetes. 08, 2020 | Pubmed ID: 32535552 Disruption of Hepatic One-carbon Metabolism Impairs Mitochondrial Function and Enhances Macrophage Activity in Methionine-choline-deficient Mice The Journal of Nutritional Biochemistry. 07, 2020 | Pubmed ID: 32422424 Innate Inflammation Drives NK Cell Activation to Impair Treg Activity Journal of Autoimmunity. 03, 2020 | Pubmed ID: 32035746 Neutrophil Cytosolic Factor 1 in Dendritic Cells Promotes Autoreactive CD8 T Cell Activation Via Cross-Presentation in Type 1 Diabetes Frontiers in Immunology. 2019 | Pubmed ID: 31118934 Boosting to Amplify Signal with Isobaric Labeling (BASIL) Strategy for Comprehensive Quantitative Phosphoproteomic Characterization of Small Populations of Cells Analytical Chemistry. May, 2019 | Pubmed ID: 30843680 Sixteen Diverse Laboratory Mouse Reference Genomes Define Strain-specific Haplotypes and Novel Functional Loci Nature Genetics. 11, 2018 | Pubmed ID: 30275530 Nanowell-mediated Two-dimensional Liquid Chromatography Enables Deep Proteome Profiling of <1000 Mammalian Cells Chemical Science. Sep, 2018 | Pubmed ID: 30210768 Correction To: Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 09, 2018 | Pubmed ID: 30173405 Protective Role of Myeloid Cells Expressing a G-CSF Receptor Polymorphism in an Induced Model of Lupus Frontiers in Immunology. 2018 | Pubmed ID: 29868014 Abnormal Islet Sphingolipid Metabolism in Type 1 Diabetes Diabetologia. 07, 2018 | Pubmed ID: 29671030 The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future Frontiers in Endocrinology. 2018 | Pubmed ID: 29527189 Nanodroplet Processing Platform for Deep and Quantitative Proteome Profiling of 10-100 Mammalian Cells Nature Communications. 02, 2018 | Pubmed ID: 29491378 Loss of B-Cell Anergy in Type 1 Diabetes Is Associated With High-Risk HLA and Non-HLA Disease Susceptibility Alleles Diabetes. 04, 2018 | Pubmed ID: 29343548 Mitochondrial Reactive Oxygen Species and Type 1 Diabetes Antioxidants & Redox Signaling. 11, 2018 | Pubmed ID: 29295631 Avidity and Bystander Suppressive Capacity of Human Regulatory T Cells Expressing Autoreactive T-Cell Receptors in Type 1 Diabetes Frontiers in Immunology. 2017 | Pubmed ID: 29123516 The Type 1 Diabetes-Resistance Locus Controls Trafficking of Autoreactive CTLs into the Pancreatic Islets of NOD Mice Journal of Immunology (Baltimore, Md. : 1950). 12, 2017 | Pubmed ID: 29109122 Type I Interferon Is a Catastrophic Feature of the Diabetic Islet Microenvironment Frontiers in Endocrinology. 2017 | Pubmed ID: 28959234 T Cells Display Mitochondria Hyperpolarization in Human Type 1 Diabetes Scientific Reports. 09, 2017 | Pubmed ID: 28883439 Type 1 Interferons Potentiate Human CD8 T-Cell Cytotoxicity Through a STAT4- and Granzyme B-Dependent Pathway Diabetes. 12, 2017 | Pubmed ID: 28877912 Mitochondrial ATP Transporter Depletion Protects Mice Against Liver Steatosis and Insulin Resistance Nature Communications. 02, 2017 | Pubmed ID: 28205519 Interferon-γ Limits Diabetogenic CD8 T-Cell Effector Responses in Type 1 Diabetes Diabetes. 03, 2017 | Pubmed ID: 27920091 Human Pancreatic Cancer Cells Induce a MyD88-Dependent Stromal Response to Promote a Tumor-Tolerant Immune Microenvironment Cancer Research. 02, 2017 | Pubmed ID: 27864347 Genetic Risk Analysis of a Patient with Fulminant Autoimmune Type 1 Diabetes Mellitus Secondary to Combination Ipilimumab and Nivolumab Immunotherapy Journal for Immunotherapy of Cancer. 2016 | Pubmed ID: 28031819 Islet-derived CD4 T-cells Targeting Proinsulin in Human Autoimmune Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27920090 Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes Diabetes. Dec, 2016 | Pubmed ID: 27669730 Islet Cell Hyperexpression of HLA Class I Antigens: a Defining Feature in Type 1 Diabetes Diabetologia. 11, 2016 | Pubmed ID: 27506584 Liquid Chromatography-Mass Spectrometry Metabolic and Lipidomic Sample Preparation Workflow for Suspension-Cultured Mammalian Cells Using Jurkat T Lymphocyte Cells Journal of Proteomics & Bioinformatics. Jun, 2015 | Pubmed ID: 26401069 Respiration and Substrate Transport Rates As Well As Reactive Oxygen Species Production Distinguish Mitochondria from Brain and Liver BMC Biochemistry. Sep, 2015 | Pubmed ID: 26358560 Loss of NOX-Derived Superoxide Exacerbates Diabetogenic CD4 T-Cell Effector Responses in Type 1 Diabetes Diabetes. Dec, 2015 | Pubmed ID: 26269022 Acute Versus Progressive Onset of Diabetes in NOD Mice: Potential Implications for Therapeutic Interventions in Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26216853 Combination Therapy Reverses Hyperglycemia in NOD Mice With Established Type 1 Diabetes Diabetes. Nov, 2015 | Pubmed ID: 26185279 Distinct Differences in the Responses of the Human Pancreatic β-cell Line EndoC-βH1 and Human Islets to Proinflammatory Cytokines American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Sep, 2015 | Pubmed ID: 26084699 Reply to Gurgul-Convey and Lenzen: Cytokines, Nitric Oxide, and β-cells The Journal of Biological Chemistry. Apr, 2015 | Pubmed ID: 26065037 How the Location of Superoxide Generation Influences the β-cell Response to Nitric Oxide The Journal of Biological Chemistry. Mar, 2015 | Pubmed ID: 25648890 TRIF-dependent Innate Immune Activation is Critical for Survival to Neonatal Gram-negative Sepsis Journal of Immunology (Baltimore, Md. : 1950). Feb, 2015 | Pubmed ID: 25548220 Association of the Mt-ND2 5178A/C Polymorphism with Parkinson's Disease Neuroscience Letters. Feb, 2015 | Pubmed ID: 25511548 Anti-thymocyte Globulin/G-CSF Treatment Preserves β Cell Function in Patients with Established Type 1 Diabetes The Journal of Clinical Investigation. Jan, 2015 | Pubmed ID: 25500887 Mechanisms of Tumor Necrosis Factor α Antagonist-induced Lupus in a Murine Model Arthritis & Rheumatology (Hoboken, N.J.). Jan, 2015 | Pubmed ID: 25252121 Metabolic Abnormalities in the Pathogenesis of Type 1 Diabetes Current Diabetes Reports. 2014 | Pubmed ID: 25023213 In Search of a Surrogate: Engineering Human Beta Cell Lines for Therapy Trends in Endocrinology and Metabolism: TEM. Aug, 2014 | Pubmed ID: 24958526 Use of Chemical Probes to Detect Mitochondrial ROS by Flow Cytometry and Spectrofluorometry Methods in Enzymology. 2014 | Pubmed ID: 24862269 Do β-cells Generate Peroxynitrite in Response to Cytokine Treatment? The Journal of Biological Chemistry. Dec, 2013 | Pubmed ID: 24194521 Comparative Genetics: Synergizing Human and NOD Mouse Studies for Identifying Genetic Causation of Type 1 Diabetes The Review of Diabetic Studies : RDS. 2012 | Pubmed ID: 23804259 Oxidative Stress and Beta Cell Dysfunction Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22933078 Immune-mediated β-cell Death in Type 1 Diabetes: Lessons from Human β-cell Lines European Journal of Clinical Investigation. Nov, 2012 | Pubmed ID: 22924552 Inherited β-cell Dysfunction in Lean Individuals with Type 2 Diabetes Diabetes. Jul, 2012 | Pubmed ID: 22723272 Pleiotropic IFN-dependent and -independent Effects of IRF5 on the Pathogenesis of Experimental Lupus Journal of Immunology (Baltimore, Md. : 1950). Apr, 2012 | Pubmed ID: 22422888 Die Verwendung Von Leptin Als Behandlung Für Typ 1 Diabetes Mellitus: Kontrapunkt Pediatric Diabetes. Feb, 2012 | Pubmed ID: 21884562 Rolle Der Genetik in Widerstand Gegen Typ-1-Diabetes Diabetes/metabolism Research and Reviews. Nov, 2011 | Pubmed ID: 22069272 Erhöhte Superoxid-Akkumulation in Pyruvat Dehydrogenase Komplex Mangelhaft Fibroblasten Molecular Genetics and Metabolism. Nov, 2011 | Pubmed ID: 21846590 Entwicklung Von Diabetes in Den Mageren Ncb5or-Null-Mäusen Ist Manifestationen Des Endoplasmatischen Retikulum Und Oxidativen Stress in Beta-Zellen Zugeordnet Biochimica Et Biophysica Acta. Nov, 2011 | Pubmed ID: 21839170 Rolle Der Mitochondrien Immunvermittelte Apoptotic Tod Die Menschliche Pankreatische β-Zelle-Linie-βLox5 PloS One. 2011 | Pubmed ID: 21738580 Superoxid-Produktion Von Makrophagen Und T-Zellen Ist Entscheidend Für Die Induktion Von Autoreactivity Und Typ 1 Diabetes Diabetes. Aug, 2011 | Pubmed ID: 21715554 Neutrophil Mobilisierung Aus Dem Knochenmark Während Der Polymikrobiellen Sepsis Ist Abhängig Von CXCL12 Signalisieren Journal of Immunology (Baltimore, Md. : 1950). Jul, 2011 | Pubmed ID: 21690321 Fortschreitende Aushöhlung Der β-Zelle-Funktion Wird in Der NOD-Maus-Modell Des Typ 1 Diabetes Beginn Der Hyperglykämie Vorangestellt Diabetes. Aug, 2011 | Pubmed ID: 21659497 Entscheidende Rolle Für CXC Ligand 10/CXC-Rezeptor 3 Signalisierung in Der Murinen Neonatale Antwort an Sepsis Infection and Immunity. Jul, 2011 | Pubmed ID: 21518789 Sepsis Induziert Frühe Veränderungen in Der Angeborenen Immunität, Die Sterblichkeit Auf Eine Sekundäre Infektion Auswirken Journal of Immunology (Baltimore, Md. : 1950). Jan, 2011 | Pubmed ID: 21106855 Mt-Nd2(a) ändert Widerstand Gegen Autoimmune Typ 1-Diabetes in NOD-Mäuse Auf Der Ebene Der Pankreatische β-Zelle Diabetes. Jan, 2011 | Pubmed ID: 20980458 NADPH Oxidasemangel Regelt Th Linie Engagement Und Moduliert Autoimmunität Journal of Immunology (Baltimore, Md. : 1950). Nov, 2010 | Pubmed ID: 20881184 Einsatz Von Nonobese Diabetischen Mäusen Menschliche Typ 1 Diabetes Zu Verstehen Endocrinology and Metabolism Clinics of North America. Sep, 2010 | Pubmed ID: 20723819 Immun Raubbau Mit Zellulären Mobilisierung Immunoregulation Vermittelt Und Kehrt Autoimmune Diabetes Nonobese Diabetischen Mäusen Diabetes. Oct, 2009 | Pubmed ID: 19628781 Auswertung Der Protokolle Für Die Embryonalen Stammzellen Differenzierung in Beta-Zellen Insulin-sezernierende Mit Insulin II-GFP Als Spezifische Und Nicht-invasive Reporter Cloning and Stem Cells. Jun, 2009 | Pubmed ID: 19508115 Rolle Der SREBP-1 in Der Entwicklung Der Parasympathische Dysfunktion in Den Herzen Der Typ 1 Diabetiker Akita Mäuse Circulation Research. Jul, 2009 | Pubmed ID: 19423844 Kapitel 24 Quantifizierung, Lokalisierung Und Gewebe Besonderheiten Der Maus Mitochondriale Reaktive Sauerstoff Spezies Produktion Methods in Enzymology. 2009 | Pubmed ID: 19348903 MerTK Regelt Thymom Auswahl Von Autoreaktive T-Zellen Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19251650 Rolle Der Erhöhten ROS Dissipation in Der Prävention Von T1D Annals of the New York Academy of Sciences. Dec, 2008 | Pubmed ID: 19120287 Gemeinsamkeiten Der Genetische Resistenz Gegen Spontane Autoimmune Und Freie Radikale--vermittelten Diabetes Free Radical Biology & Medicine. Nov, 2008 | Pubmed ID: 18718526 MT-Nd2a Unterdrückt Reaktive Sauerstoff Spezies Produktion Von Mitochondrialen Komplexe I Und III The Journal of Biological Chemistry. Apr, 2008 | Pubmed ID: 18281288 MerTK Ist Für Apoptotic Zellen Induziert T-Zell-Toleranz Erforderlich The Journal of Experimental Medicine. Jan, 2008 | Pubmed ID: 18195070 Autoreaktive T-Zell-Antworten: Neue Technologie Zur Erreichung Einer Enteignung Pediatric Diabetes. Oct, 2007 | Pubmed ID: 17850466 Nuclear and Mitochondrial Interaktion Mit Mt-Nd2 Führt Zu Erhöhten Mitochondrialen Reaktive Sauerstoff Spezies Produktion The Journal of Biological Chemistry. Feb, 2007 | Pubmed ID: 17189252 Apoptotic Zellen Induzieren Mer Tyrosin Kinase-abhängigen Blockade Der NF-KappaB Aktivierung Dendritischer Zellen Blood. Jan, 2007 | Pubmed ID: 17008547 Modulierende Rolle Der DR4 Auf DQ8 Beschränkt CD4-T-Zell-Antworten Und Typ 1 Diabetes Anfälligkeit Diabetes. Dec, 2006 | Pubmed ID: 17130492 HLA-A * 0201 Eingeschränkten T-Zellen Von Humanisierten NOD-Mäuse Erkennen Autoantigene Der Potenzielle Klinische Relevanz Für Typ 1-Diabetes Journal of Immunology (Baltimore, Md. : 1950). Mar, 2006 | Pubmed ID: 16493087 Nutzen Der Murinen Modellen Für Die Untersuchung Der Spontanen Typ-1-Diabetes Pediatric Diabetes. Sep, 2005 | Pubmed ID: 16109074 Mechanismen Widerstand Pankreasinseln Von ALR / Lt Mäusen, Die Cytokin-induzierte Zerstörung Journal of Immunology (Baltimore, Md. : 1950). Jul, 2005 | Pubmed ID: 16002729 Haupthistokompatibilitätskomplex-linked Anfälligkeit Diabetes in NOD / Lt-Mäuse: Subcongenic Analyse Lokalisiert Eine Komponente Idd16 an Der H2-D Ende Des Diabetogene H2 (G7)-Komplex Diabetes. May, 2005 | Pubmed ID: 15855353 Proteasominhibition ändert Glukose-stimulierten (pro) Insulinsekretion Und Umsatz Im Pankreas {beta}-Zellen The Journal of Biological Chemistry. Apr, 2005 | Pubmed ID: 15705591 ALS / Lt: Ein Neuer Typ 2 Diabetes Mausmodell Mit Niedrigen Radikalfänger Potential Verbunden Sind Diabetes. Feb, 2004 | Pubmed ID: 14749277 Genetische Analyse Der Resistenz Gegen Typ-1 Diabetes in ALR / Lt-Mäuse, Eine NOD-verwandter Stamm Mit Abwehrmechanismen Gegen Autoimmun-vermittelten Diabetogene Stress Immunogenetics. Oct, 2003 | Pubmed ID: 14513297 Rodent Models for the Study of Type 2 Diabetes in Children (juvenile Diabesity) Pediatric Diabetes. Sep, 2002 | Pubmed ID: 15016157 Neue Mausmodell Inseltransplantation Bei Insulin-abhängigen Diabetes Mellitus Zu Untersuchen Transplantation. Apr, 2002 | Pubmed ID: 11981430 Genetische Kontrolle Der Neutrophilen Superoxid-Produktion in Der Diabetes-resistenten ALR / Lt Mäusen Free Radical Biology & Medicine. Apr, 2002 | Pubmed ID: 11937300 Beobachtung der Inselfunktion und der Wechselwirkungen zwischen Insel-Immunzellen in lebenden Pankreasgewebeschnitten Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection Methoden zur Beta Cell Death vermittelt durch zytotoxische T-Lymphozyten Beurteilung Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection
Beobachtung der Inselfunktion und der Wechselwirkungen zwischen Insel-Immunzellen in lebenden Pankreasgewebeschnitten Mollie K. Huber1, Denise M. Drotar2,3,4, Helmut Hiller1, Maria L. Beery1, Paul Joseph1, Irina Kusmartseva1, Stephan Speier2,3,4, Mark A. Atkinson1, Clayton E. Mathews1, Edward A. Phelps5 1Department of Pathology, Immunology, and Laboratory Medicine, University of Florida, 2Paul Langerhans Institute Dresden (PLID) of the Helmholtz Zentrum München at the University Clinic Carl Gustav Carus of Technische Universität Dresden, 3Institute of Physiology, Faculty of Medicine, Technische Universität Dresden, 4German Center for Diabetes Research (DZD), 5J. Crayton Pruitt Family Department of Biomedical Engineering, University of Florida JoVE 62207 Immunology and Infection
Methoden zur Beta Cell Death vermittelt durch zytotoxische T-Lymphozyten Beurteilung Jing Chen1, Scott Grieshaber1, Clayton E. Mathews1 1Departments of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida JoVE 2724 Immunology and Infection