Clive N. Svendsen The Board of Governors Regenerative Medicine Institute Cedars-Sinai Medical Center Biography Publications Institution JoVE Articles Clive N. Svendsen has not added a biography. If you are Clive N. Svendsen and would like to personalize this page please email our Author Liaison for assistance. Publications Development of Physiologically Responsive Human IPSC-Derived Intestinal Epithelium to Study Barrier Dysfunction in IBD International Journal of Molecular Sciences. Feb, 2020 | Pubmed ID: 32093254 Rejuvenating the Blood and Bone Marrow to Slow Aging-associated Cognitive Decline and Alzheimer's Disease Communications Biology. Feb, 2020 | Pubmed ID: 32054965 IPSC Modeling of Young-onset Parkinson's Disease Reveals a Molecular Signature of Disease and Novel Therapeutic Candidates Nature Medicine. Feb, 2020 | Pubmed ID: 31988461 Huntington's Disease Patient-Derived Astrocytes Display Electrophysiological Impairments and Reduced Neuronal Support Frontiers in Neuroscience. 2019 | Pubmed ID: 31316341 Human IPSC-Derived Blood-Brain Barrier Chips Enable Disease Modeling and Personalized Medicine Applications Cell Stem Cell. 06, 2019 | Pubmed ID: 31173718 Young Bone Marrow Transplantation Preserves Learning and Memory in Old Mice Communications Biology. 2019 | Pubmed ID: 30820468 In Vitro and In Vivo Proteomic Comparison of Human Neural Progenitor Cell-Induced Photoreceptor Survival Proteomics. 02, 2019 | Pubmed ID: 30515959 Report of the International Conference on Manufacturing and Testing of Pluripotent Stem Cells Biologicals : Journal of the International Association of Biological Standardization. Nov, 2018 | Pubmed ID: 30150108 Stem Cell Transplantation for Amyotrophic Lateral Sclerosis Current Opinion in Neurology. 10, 2018 | Pubmed ID: 30080719 Enhanced Utilization of Induced Pluripotent Stem Cell-Derived Human Intestinal Organoids Using Microengineered Chips Cellular and Molecular Gastroenterology and Hepatology. 2018 | Pubmed ID: 29930984 Inducible Expression of GDNF in Transplanted IPSC-Derived Neural Progenitor Cells Stem Cell Reports. 06, 2018 | Pubmed ID: 29706501 Transplantation of Neural Progenitor Cells Expressing Glial Cell Line-Derived Neurotrophic Factor into the Motor Cortex As a Strategy to Treat Amyotrophic Lateral Sclerosis Stem Cells (Dayton, Ohio). 07, 2018 | Pubmed ID: 29656478 Human IPSC-Derived Endothelial Cells and Microengineered Organ-Chip Enhance Neuronal Development Stem Cell Reports. 04, 2018 | Pubmed ID: 29576540 Genome-wide Analyses Identify KIF5A As a Novel ALS Gene Neuron. Mar, 2018 | Pubmed ID: 29566793 Huntington Modeling Improves with Age Nature Neuroscience. 03, 2018 | Pubmed ID: 29476127 The Library of Integrated Network-Based Cellular Signatures NIH Program: System-Level Cataloging of Human Cells Response to Perturbations Cell Systems. Jan, 2018 | Pubmed ID: 29199020 Directed Differentiation of Human Induced Pluripotent Stem Cells into Fallopian Tube Epithelium Scientific Reports. 09, 2017 | Pubmed ID: 28878359 Concise Review: Stem Cells for Corneal Wound Healing Stem Cells (Dayton, Ohio). 10, 2017 | Pubmed ID: 28748596 Patients with ALS Show Highly Correlated Progression Rates in Left and Right Limb Muscles Neurology. Jul, 2017 | Pubmed ID: 28600459 Ex Vivo Gene Therapy for the Treatment of Neurological Disorders Progress in Brain Research. 2017 | Pubmed ID: 28552237 Modeling Psychomotor Retardation Using IPSCs from MCT8-Deficient Patients Indicates a Prominent Role for the Blood-Brain Barrier Cell Stem Cell. 06, 2017 | Pubmed ID: 28526555 Huntington's Disease IPSC-Derived Brain Microvascular Endothelial Cells Reveal WNT-Mediated Angiogenic and Blood-Brain Barrier Deficits Cell Reports. May, 2017 | Pubmed ID: 28514657 Human Neural Progenitor Transplantation Rescues Behavior and Reduces α-Synuclein in a Transgenic Model of Dementia with Lewy Bodies Stem Cells Translational Medicine. 06, 2017 | Pubmed ID: 28225193 Ferumoxytol Labeling of Human Neural Progenitor Cells for Diagnostic Cellular Tracking in the Porcine Spinal Cord with Magnetic Resonance Imaging Stem Cells Translational Medicine. 01, 2017 | Pubmed ID: 28170192 An Isogenic Blood-brain Barrier Model Comprising Brain Endothelial Cells, Astrocytes, and Neurons Derived from Human Induced Pluripotent Stem Cells Journal of Neurochemistry. 03, 2017 | Pubmed ID: 27935037 Modeling Huntington׳s Disease with Patient-derived Neurons Brain Research. 02, 2017 | Pubmed ID: 26459990 A Model of Recurrent Concussion That Leads to Long-term Motor Deficits, CTE-like Tauopathy and Exacerbation of an ALS Phenotype The Journal of Trauma and Acute Care Surgery. 12, 2016 | Pubmed ID: 27602892 Transcriptome and Proteome Characterization of Surface Ectoderm Cells Differentiated from Human IPSCs Scientific Reports. Aug, 2016 | Pubmed ID: 27550649 ALS Disrupts Spinal Motor Neuron Maturation and Aging Pathways Within Gene Co-expression Networks Nature Neuroscience. 09, 2016 | Pubmed ID: 27428653 Cell Freezing Protocol Suitable for ATAC-Seq on Motor Neurons Derived from Human Induced Pluripotent Stem Cells Scientific Reports. 05, 2016 | Pubmed ID: 27146274 Human Neural Progenitors Differentiate into Astrocytes and Protect Motor Neurons in Aging Rats Experimental Neurology. 06, 2016 | Pubmed ID: 27032721 Modeling ALS with Motor Neurons Derived from Human Induced Pluripotent Stem Cells Nature Neuroscience. Apr, 2016 | Pubmed ID: 27021939 In Vivo CRISPR/Cas9 Gene Editing Corrects Retinal Dystrophy in the S334ter-3 Rat Model of Autosomal Dominant Retinitis Pigmentosa Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2016 | Pubmed ID: 26666451 Ex Vivo Gene Therapy Using Human Mesenchymal Stem Cells to Deliver Growth Factors in the Skeletal Muscle of a Familial ALS Rat Model Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 26611598 Regenerative Cellular Therapies for Neurologic Diseases Brain Research. May, 2016 | Pubmed ID: 26239912 In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Magnetic Resonance Imaging Is Not Enhanced by Ferritin Expression Cell Transplantation. 2016 | Pubmed ID: 26160767 Acute Traumatic Brain Injury Does Not Exacerbate Amyotrophic Lateral Sclerosis in the SOD1 (G93A) Rat Model ENeuro. May-Jun, 2015 | Pubmed ID: 26464984 Quantitative High-throughput Gene Expression Profiling of Human Striatal Development to Screen Stem Cell-derived Medium Spiny Neurons Molecular Therapy. Methods & Clinical Development. 2015 | Pubmed ID: 26417608 Low-Dose Irradiation Enhances Gene Targeting in Human Pluripotent Stem Cells Stem Cells Translational Medicine. Sep, 2015 | Pubmed ID: 26185257 Preclinical Validation of Multilevel Intraparenchymal Stem Cell Therapy in the Porcine Spinal Cord Neurosurgery. Oct, 2015 | Pubmed ID: 26134596 Human IPSC-Derived Neural Progenitors Preserve Vision in an AMD-Like Model Stem Cells (Dayton, Ohio). Aug, 2015 | Pubmed ID: 25869002 HD IPSC-derived Neural Progenitors Accumulate in Culture and Are Susceptible to BDNF Withdrawal Due to Glutamate Toxicity Human Molecular Genetics. Jun, 2015 | Pubmed ID: 25740845 Kuwanon V Inhibits Proliferation, Promotes Cell Survival and Increases Neurogenesis of Neural Stem Cells PloS One. 2015 | Pubmed ID: 25706719 A Subsequent Human Neural Progenitor Transplant into the Degenerate Retina Does Not Compromise Initial Graft Survival or Therapeutic Efficacy Translational Vision Science & Technology. Feb, 2015 | Pubmed ID: 25694843 Astrocytes Show Reduced Support of Motor Neurons with Aging That is Accelerated in a Rodent Model of ALS Neurobiology of Aging. Feb, 2015 | Pubmed ID: 25443290 Targeting ATM Ameliorates Mutant Huntingtin Toxicity in Cell and Animal Models of Huntington's Disease Science Translational Medicine. Dec, 2014 | Pubmed ID: 25540325 Delayed Disease Onset and Extended Survival in the SOD1G93A Rat Model of Amyotrophic Lateral Sclerosis After Suppression of Mutant SOD1 in the Motor Cortex The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2014 | Pubmed ID: 25411487 Reliable Generation of Induced Pluripotent Stem Cells from Human Lymphoblastoid Cell Lines Stem Cells Translational Medicine. Dec, 2014 | Pubmed ID: 25298370 Differentiation of Human Limbal-derived Induced Pluripotent Stem Cells into Limbal-like Epithelium Stem Cells Translational Medicine. Sep, 2014 | Pubmed ID: 25069777 In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Bioluminescence Imaging Journal of Neuroscience Methods. May, 2014 | Pubmed ID: 24675049 The Past, Present and Future of Stem Cell Clinical Trials for ALS Experimental Neurology. Mar, 2014 | Pubmed ID: 24613827 Human Induced Pluripotent Stem Cells Are a Novel Source of Neural Progenitor Cells (iNPCs) That Migrate and Integrate in the Rodent Spinal Cord The Journal of Comparative Neurology. Mar, 2014 | Pubmed ID: 24610630 Patient-Derived Skeletal Dysplasia IPSCs Display Abnormal Chondrogenic Marker Expression and Regulation by BMP2 and TGFβ1 Stem Cells and Development. Apr, 2014 | Pubmed ID: 24559391 Neonatal Immune-tolerance in Mice Does Not Prevent Xenograft Rejection Experimental Neurology. Apr, 2014 | Pubmed ID: 24440640 Ocular Changes in TgF344-AD Rat Model of Alzheimer's Disease Investigative Ophthalmology & Visual Science. Jan, 2014 | Pubmed ID: 24398104 Glial Cell Line-derived Neurotrophic Factor-secreting Human Neural Progenitors Show Long-term Survival, Maturation into Astrocytes, and No Tumor Formation Following Transplantation into the Spinal Cord of Immunocompromised Rats Neuroreport. Apr, 2014 | Pubmed ID: 24284956 Stimulation of GABA-induced Ca2+ Influx Enhances Maturation of Human Induced Pluripotent Stem Cell-derived Neurons PloS One. 2013 | Pubmed ID: 24278369 A Simple Alkaline Method for Decellularizing Human Amniotic Membrane for Cell Culture PloS One. 2013 | Pubmed ID: 24236148 Targeting RNA Foci in IPSC-derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion Science Translational Medicine. Oct, 2013 | Pubmed ID: 24154603 Back to the Future: How Human Induced Pluripotent Stem Cells Will Transform Regenerative Medicine Human Molecular Genetics. Oct, 2013 | Pubmed ID: 23945396 EZ Spheres: a Stable and Expandable Culture System for the Generation of Pre-rosette Multipotent Stem Cells from Human ESCs and IPSCs Stem Cell Research. May, 2013 | Pubmed ID: 23474892 Intermittent Hypoxia and Stem Cell Implants Preserve Breathing Capacity in a Rodent Model of Amyotrophic Lateral Sclerosis American Journal of Respiratory and Critical Care Medicine. Mar, 2013 | Pubmed ID: 23220913 The in Vitro Survival of Human Monosomies and Trisomies As Embryonic Stem Cells Stem Cell Research. Nov, 2012 | Pubmed ID: 22892439 Rapid Genetic Targeting of Pial Surface Neural Progenitors and Immature Neurons by Neonatal Electroporation Neural Development. 2012 | Pubmed ID: 22776033 Induced Pluripotent Stem Cells from Patients with Huntington's Disease Show CAG-repeat-expansion-associated Phenotypes Cell Stem Cell. Aug, 2012 | Pubmed ID: 22748968 Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy PloS One. 2012 | Pubmed ID: 22723941 Stem Cell Transplantation for Motor Neuron Disease: Current Approaches and Future Perspectives Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2011 | Pubmed ID: 21904789 Blood-brain Barrier Modeling with Co-cultured Neural Progenitor Cell-derived Astrocytes and Neurons Journal of Neurochemistry. Nov, 2011 | Pubmed ID: 21854389 Induced Pluripotent Stem Cells: a New Revolution for Clinical Neurology? Lancet Neurology. Apr, 2011 | Pubmed ID: 21435601 Gene Therapy-mediated Delivery of Targeted Cytotoxins for Glioma Therapeutics Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010 | Pubmed ID: 21030678 Stem Cell Biologists Sure Play a Mean Pinball Nature Biotechnology. Apr, 2010 | Pubmed ID: 20379177 Generation of a Human iPSC-Based Blood-Brain Barrier Chip Srikanth Jagadeesan1,2,3, Michael J. Workman4, Anna Herland5,6, Clive N. Svendsen4, Gad D. Vatine1,2,3 1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet JoVE 60925 Developmental Biology
Generation of a Human iPSC-Based Blood-Brain Barrier Chip Srikanth Jagadeesan1,2,3, Michael J. Workman4, Anna Herland5,6, Clive N. Svendsen4, Gad D. Vatine1,2,3 1The Department of Physiology and Cell Biology, Faculty of Health Sciences, Ben-Gurion University of the Negev, 2The Regenerative Medicine and Stem Cell (RMSC) Research Center, Ben-Gurion University of the Negev, 3The Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, 4The Board of Governors Regenerative Medicine Institute, Cedars-Sinai Medical Center, 5Division of Micro and Nanosystems, KTH Royal Institute of Technology, 6AIMES, Department of Neuroscience, Karolinska Institutet JoVE 60925 Developmental Biology