Clive N. Svendsen

Publications

• In Vivo Tracking of Human Neural Progenitor Cells in the Rat Brain Using Bioluminescence Imaging
  Journal of Neuroscience Methods. May, 2014  |   Pubmed ID: 24675049
• The Past, Present and Future of Stem Cell Clinical Trials for ALS
  Experimental Neurology. Mar, 2014  |   Pubmed ID: 24613827
• Human Induced Pluripotent Stem Cells Are a Novel Source of Neural Progenitor Cells (iNPCs) That Migrate and Integrate in the Rodent Spinal Cord
  The Journal of Comparative Neurology. Mar, 2014  |   Pubmed ID: 24610630
• Patient-Derived Skeletal Dysplasia IPSCs Display Abnormal Chondrogenic Marker Expression and Regulation by BMP2 and TGFβ1
  Stem Cells and Development. Apr, 2014  |   Pubmed ID: 24559391
• Neonatal Immune-tolerance in Mice Does Not Prevent Xenograft Rejection
  Experimental Neurology. Apr, 2014  |   Pubmed ID: 24440640
• Ocular Changes in TgF344-AD Rat Model of Alzheimer's Disease
  Investigative Ophthalmology & Visual Science. Jan, 2014  |   Pubmed ID: 24398104
• Glial Cell Line-derived Neurotrophic Factor-secreting Human Neural Progenitors Show Long-term Survival, Maturation into Astrocytes, and No Tumor Formation Following Transplantation into the Spinal Cord of Immunocompromised Rats
  Neuroreport. Apr, 2014  |   Pubmed ID: 24284956
• Stimulation of GABA-induced Ca2+ Influx Enhances Maturation of Human Induced Pluripotent Stem Cell-derived Neurons
  PloS One. 2013  |   Pubmed ID: 24278369
• A Simple Alkaline Method for Decellularizing Human Amniotic Membrane for Cell Culture
  PloS One. 2013  |   Pubmed ID: 24236148
• Targeting RNA Foci in IPSC-derived Motor Neurons from ALS Patients with a C9ORF72 Repeat Expansion
  Science Translational Medicine. Oct, 2013  |   Pubmed ID: 24154603
• Back to the Future: How Human Induced Pluripotent Stem Cells Will Transform Regenerative Medicine
  Human Molecular Genetics. Oct, 2013  |   Pubmed ID: 23945396
• Synergistic Effects of GDNF and VEGF on Lifespan and Disease Progression in a Familial ALS Rat Model
  Molecular Therapy : the Journal of the American Society of Gene Therapy. May, 2013  |   Pubmed ID: 23712039
• EZ Spheres: a Stable and Expandable Culture System for the Generation of Pre-rosette Multipotent Stem Cells from Human ESCs and IPSCs
  Stem Cell Research. May, 2013  |   Pubmed ID: 23474892
• Intermittent Hypoxia and Stem Cell Implants Preserve Breathing Capacity in a Rodent Model of Amyotrophic Lateral Sclerosis
  American Journal of Respiratory and Critical Care Medicine. Mar, 2013  |   Pubmed ID: 23220913
• The in Vitro Survival of Human Monosomies and Trisomies As Embryonic Stem Cells
  Stem Cell Research. Nov, 2012  |   Pubmed ID: 22892439
• Gene Expression Changes in the MAPK Pathway in Both Fragile X and Down Syndrome Human Neural Progenitor Cells
  American Journal of Stem Cells. Jun, 2012  |   Pubmed ID: 22822472
• Rapid Genetic Targeting of Pial Surface Neural Progenitors and Immature Neurons by Neonatal Electroporation
  Neural Development. 2012  |   Pubmed ID: 22776033
• Inhibition of Apoptosis Blocks Human Motor Neuron Cell Death in a Stem Cell Model of Spinal Muscular Atrophy
  PloS One. 2012  |   Pubmed ID: 22723941
• Gonadectomy and Dehydroepiandrosterone (DHEA) Do Not Modulate Disease Progression in the G93A Mutant SOD1 Rat Model of Amyotrophic Lateral Sclerosis
  Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. May, 2012  |   Pubmed ID: 22409357
• Clinical Translation of Stem Cells in Neurodegenerative Disorders
  Cell Stem Cell. Feb, 2012  |   Pubmed ID: 22305565
• BDNF-, IGF-1- and GDNF-secreting Human Neural Progenitor Cells Rescue Amyloid β-induced Toxicity in Cultured Rat Septal Neurons
  Neurochemical Research. Jan, 2012  |   Pubmed ID: 21909955
• Stem Cell Transplantation for Motor Neuron Disease: Current Approaches and Future Perspectives
  Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics. Oct, 2011  |   Pubmed ID: 21904789
• Blood-brain Barrier Modeling with Co-cultured Neural Progenitor Cell-derived Astrocytes and Neurons
  Journal of Neurochemistry. Nov, 2011  |   Pubmed ID: 21854389
• Human Neural Stem Cells Enhance Structural Plasticity and Axonal Transport in the Ischaemic Brain
  Brain : a Journal of Neurology. Jun, 2011  |   Pubmed ID: 21616972
• Induced Pluripotent Stem Cells: a New Revolution for Clinical Neurology?
  Lancet Neurology. Apr, 2011  |   Pubmed ID: 21435601
• Transplantation of Human Glial-restricted Neural Precursors into Injured Spinal Cord Promotes Functional and Sensory Recovery Without Causing Allodynia
  Cytotherapy. Jan, 2011  |   Pubmed ID: 20735167
• Gene Therapy-mediated Delivery of Targeted Cytotoxins for Glioma Therapeutics
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2010  |   Pubmed ID: 21030678
• Real Time Imaging of Human Progenitor Neurogenesis
  PloS One. 2010  |   Pubmed ID: 20949053
• Stem Cell Model of Spinal Muscular Atrophy
  Archives of Neurology. Jun, 2010  |   Pubmed ID: 20558385
• Stem Cell Biologists Sure Play a Mean Pinball
  Nature Biotechnology. Apr, 2010  |   Pubmed ID: 20379177
• Human Stem Cells and Drug Screening: Opportunities and Challenges
  Nature Reviews. Drug Discovery. May, 2010  |   Pubmed ID: 20339370
• Ex Vivo Delivery of GDNF Maintains Motor Function and Prevents Neuronal Loss in a Transgenic Mouse Model of Huntington's Disease
  Experimental Neurology. Jul, 2010  |   Pubmed ID: 20227407
• Acute Glial Activation by Stab Injuries Does Not Lead to Overt Damage or Motor Neuron Degeneration in the G93A Mutant SOD1 Rat Model of Amyotrophic Lateral Sclerosis
  Experimental Neurology. Feb, 2010  |   Pubmed ID: 20005223
• Chromosome 7 and 19 Trisomy in Cultured Human Neural Progenitor Cells
  PloS One. 2009  |   Pubmed ID: 19898616
• A Critical Period in Cortical Interneuron Neurogenesis in Down Syndrome Revealed by Human Neural Progenitor Cells
  Developmental Neuroscience. 2009  |   Pubmed ID: 19738365
• Induced Pluripotent Stem Cells from a Spinal Muscular Atrophy Patient
  Nature. Jan, 2009  |   Pubmed ID: 19098894
• Regionally Specified Human Neural Progenitor Cells Derived from the Mesencephalon and Forebrain Undergo Increased Neurogenesis Following Overexpression of ASCL1
  Stem Cells (Dayton, Ohio). Feb, 2009  |   Pubmed ID: 19008346
• Lesion-induced Increase in Survival and Migration of Human Neural Progenitor Cells Releasing GDNF
  Cell Transplantation. 2008  |   Pubmed ID: 19044202
• Isolating, Expanding, and Infecting Human and Rodent Fetal Neural Progenitor Cells
  Current Protocols in Stem Cell Biology. Sep, 2008  |   Pubmed ID: 18819085
• Regulation of Prenatal Human Retinal Neurosphere Growth and Cell Fate Potential by Retinal Pigment Epithelium and Mash1
  Stem Cells (Dayton, Ohio). Dec, 2008  |   Pubmed ID: 18802035
• Direct Muscle Delivery of GDNF with Human Mesenchymal Stem Cells Improves Motor Neuron Survival and Function in a Rat Model of Familial ALS
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Dec, 2008  |   Pubmed ID: 18797452
• Long-term Vision Rescue by Human Neural Progenitors in a Rat Model of Photoreceptor Degeneration
  Investigative Ophthalmology & Visual Science. Jul, 2008  |   Pubmed ID: 18579765
• GDNF-secreting Human Neural Progenitor Cells Increase Tyrosine Hydroxylase and VMAT2 Expression in MPTP-treated Cynomolgus Monkeys
  Cell Transplantation. 2008  |   Pubmed ID: 18522241
• Combining Growth Factor and Stem Cell Therapy for Amyotrophic Lateral Sclerosis
  Trends in Neurosciences. Apr, 2008  |   Pubmed ID: 18329734
• A Novel Serum-free Method for Culturing Human Prenatal Retinal Pigment Epithelial Cells
  Investigative Ophthalmology & Visual Science. Feb, 2008  |   Pubmed ID: 18235029
• Normal Neurogenesis but Abnormal Gene Expression in Human Fragile X Cortical Progenitor Cells
  Stem Cells and Development. Feb, 2008  |   Pubmed ID: 18225979
• Human Neural Progenitor Cells Over-expressing IGF-1 Protect Dopamine Neurons and Restore Function in a Rat Model of Parkinson's Disease
  Experimental Neurology. Jan, 2008  |   Pubmed ID: 18061591
• A High Concentration of Epidermal Growth Factor Increases the Growth and Survival of Neurogenic Radial Glial Cells Within Human Neurosphere Cultures
  Stem Cells (Dayton, Ohio). Feb, 2008  |   Pubmed ID: 18032704
• GDNF Secreting Human Neural Progenitor Cells Protect Dying Motor Neurons, but Not Their Projection to Muscle, in a Rat Model of Familial ALS
  PloS One. 2007  |   Pubmed ID: 17668067
• Lentiviral Vector-mediated Genetic Modification of Human Neural Progenitor Cells for Ex Vivo Gene Therapy
  Journal of Neuroscience Methods. Jul, 2007  |   Pubmed ID: 17397931
• Protection of Visual Functions by Human Neural Progenitors in a Rat Model of Retinal Disease
  PloS One. 2007  |   Pubmed ID: 17396165
• Sexual Dimorphism in Disease Onset and Progression of a Rat Model of ALS
  Amyotrophic Lateral Sclerosis : Official Publication of the World Federation of Neurology Research Group on Motor Neuron Diseases. Feb, 2007  |   Pubmed ID: 17364431
• Over-expression of Alpha-synuclein in Human Neural Progenitors Leads to Specific Changes in Fate and Differentiation
  Human Molecular Genetics. Mar, 2007  |   Pubmed ID: 17309880
• Differentiating Embryonic Neural Progenitor Cells Induce Blood-brain Barrier Properties
  Journal of Neurochemistry. Apr, 2007  |   Pubmed ID: 17254017
• Control of Neurogenesis and Tyrosine Hydroxylase Expression in Neural Progenitor Cells Through BHLH Proteins and Nurr1
  Experimental Neurology. Feb, 2007  |   Pubmed ID: 17034791
• Low Concentrations of Extracellular FGF-2 Are Sufficient but Not Essential for Neurogenesis from Human Neural Progenitor Cells
  Molecular and Cellular Neurosciences. Sep, 2006  |   Pubmed ID: 16860999
• Glutamate Enhances Proliferation and Neurogenesis in Human Neural Progenitor Cell Cultures Derived from the Fetal Cortex
  The European Journal of Neuroscience. Aug, 2006  |   Pubmed ID: 16848797
• Musashi1 Antigen Expression in Human Fetal Germinal Matrix Development
  Experimental Neurology. Oct, 2006  |   Pubmed ID: 16777095
• Massively Parallel Signature Sequencing Profiling of Fetal Human Neural Precursor Cells
  Stem Cells and Development. Apr, 2006  |   Pubmed ID: 16646669
• Human Progenitor Cells Isolated from the Developing Cortex Undergo Decreased Neurogenesis and Eventual Senescence Following Expansion in Vitro
  Experimental Cell Research. Jul, 2006  |   Pubmed ID: 16631163
• Crossroads in GDNF Therapy for Parkinson's Disease
  Movement Disorders : Official Journal of the Movement Disorder Society. Feb, 2006  |   Pubmed ID: 16470786
• EGF and FGF-2 Responsiveness of Rat and Mouse Neural Precursors Derived from the Embryonic CNS
  Brain Research Bulletin. Dec, 2005  |   Pubmed ID: 16325008
• 5-Bromo-2'-deoxyuridine is Selectively Toxic to Neuronal Precursors in Vitro
  The European Journal of Neuroscience. Dec, 2005  |   Pubmed ID: 16324131
• A New Tool in the Battle Against Alzheimer's Disease and Aging: Ex Vivo Gene Therapy
  Rejuvenation Research. 2005  |   Pubmed ID: 16144466
• Human Retinal Progenitor Cells Grown As Neurospheres Demonstrate Time-dependent Changes in Neuronal and Glial Cell Fate Potential
  Annals of the New York Academy of Sciences. May, 2005  |   Pubmed ID: 15965111
• GDNF Delivery Using Human Neural Progenitor Cells in a Rat Model of ALS
  Human Gene Therapy. Apr, 2005  |   Pubmed ID: 15871682
• Stem Cells in the Injured Spinal Cord: Reducing the Pain and Increasing the Gain
  Nature Neuroscience. Mar, 2005  |   Pubmed ID: 15746908
• Intraputamenal Infusion of Glial Cell Line-derived Neurotrophic Factor in PD: a Two-year Outcome Study
  Annals of Neurology. Feb, 2005  |   Pubmed ID: 15668979
• Rotenone-induced Caspase 9/3-independent and -dependent Cell Death in Undifferentiated and Differentiated Human Neural Stem Cells
  Journal of Neurochemistry. Feb, 2005  |   Pubmed ID: 15659217
• Requirement for Neurogenesis to Proceed Through the Division of Neuronal Progenitors Following Differentiation of Epidermal Growth Factor and Fibroblast Growth Factor-2-responsive Human Neural Stem Cells
  Stem Cells (Dayton, Ohio). 2004  |   Pubmed ID: 15342944
• Combining Growth Factors, Stem Cells, and Gene Therapy for the Aging Brain
  Annals of the New York Academy of Sciences. Jun, 2004  |   Pubmed ID: 15246984
• Heparin Stabilizes FGF-2 and Modulates Striatal Precursor Cell Behavior in Response to EGF
  Experimental Neurology. Aug, 2004  |   Pubmed ID: 15246840
• Human Neural Stem Cell Transplants Improve Motor Function in a Rat Model of Huntington's Disease
  The Journal of Comparative Neurology. Jul, 2004  |   Pubmed ID: 15211462
• Stem Cells As a Potential Treatment of Neurological Disorders
  Current Opinion in Pharmacology. Feb, 2004  |   Pubmed ID: 15018846
• Differentiation and Migration of Long Term Expanded Human Neural Progenitors in a Partial Lesion Model of Parkinson's Disease
  The International Journal of Biochemistry & Cell Biology. Apr, 2004  |   Pubmed ID: 15010333
• Stem Cells for Parkinson Disease and ALS: Replacement or Protection?
  Nature Medicine. Mar, 2004  |   Pubmed ID: 14991036
• Mitotic and Neurogenic Effects of Dehydroepiandrosterone (DHEA) on Human Neural Stem Cell Cultures Derived from the Fetal Cortex
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 14973190
• Using Human Neural Stem Cells to Model Neurological Disease
  Nature Reviews. Genetics. Feb, 2004  |   Pubmed ID: 14735124
• FGF-dependent Generation of Oligodendrocytes by a Hedgehog-independent Pathway
  Development (Cambridge, England). Dec, 2003  |   Pubmed ID: 14660548
• Gene Expression in Human Neural Stem Cells: Effects of Leukemia Inhibitory Factor
  Journal of Neurochemistry. Jul, 2003  |   Pubmed ID: 12807438
• Direct Brain Infusion of Glial Cell Line-derived Neurotrophic Factor in Parkinson Disease
  Nature Medicine. May, 2003  |   Pubmed ID: 12669033
• Stem Cells for Neurodegenerative Disorders: Where Can We Go from Here?
  BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. 2002  |   Pubmed ID: 12463763
• Neurospheres Modified to Produce Glial Cell Line-derived Neurotrophic Factor Increase the Survival of Transplanted Dopamine Neurons
  Journal of Neuroscience Research. Sep, 2002  |   Pubmed ID: 12205689
• The Amazing Astrocyte
  Nature. May, 2002  |   Pubmed ID: 11986650
• Neuronal Target Genes of the Neuron-restrictive Silencer Factor in Neurospheres Derived from Fetuses with Down's Syndrome: a Gene Expression Study
  Lancet. Jan, 2002  |   Pubmed ID: 11830198