Colin W. Pouton

Publications

• 'Stealth' Lipid-based Formulations: Poly(ethylene Glycol)-mediated Digestion Inhibition Improves Oral Bioavailability of a Model Poorly Water Soluble Drug
  Journal of Controlled Release : Official Journal of the Controlled Release Society. Jul, 2014  |   Pubmed ID: 25058571
• Digestion of Phospholipids After Secretion of Bile into the Duodenum Changes the Phase Behavior of Bile Components
  Molecular Pharmaceutics. Aug, 2014  |   Pubmed ID: 24987935
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 4: Proposing a New Lipid Formulation Performance Classification System
  Journal of Pharmaceutical Sciences. Aug, 2014  |   Pubmed ID: 24985238
• SIRPA, VCAM1 and CD34 Identify Discrete Lineages During Early Human Cardiovascular Development
  Stem Cell Research. Jul, 2014  |   Pubmed ID: 24968096
• Human Leukocyte Antigen Haplotype Phasing by Allele-specific Enrichment with Peptide Nucleic Acid Probes
  Molecular Genetics & Genomic Medicine. May, 2014  |   Pubmed ID: 24936514
• Non-linear Increases in Danazol Exposure with Dose in Older Vs. Younger Beagle Dogs: the Potential Role of Differences in Bile Salt Concentration, Thermodynamic Activity, and Formulation Digestion
  Pharmaceutical Research. Jun, 2014  |   Pubmed ID: 24477676
• Choice of Nonionic Surfactant Used to Formulate Type IIIA Self-emulsifying Drug Delivery Systems and the Physicochemical Properties of the Drug Have a Pronounced Influence on the Degree of Drug Supersaturation That Develops During in Vitro Digestion
  Journal of Pharmaceutical Sciences. Apr, 2014  |   Pubmed ID: 24470073
• The Synthesis and Biological Evaluation of Multifunctionalised Derivatives of Noscapine As Cytotoxic Agents
  ChemMedChem. Feb, 2014  |   Pubmed ID: 24339417
• DNA-dependent Protein Kinase is a Context Dependent Regulator of Lmx1a and Midbrain Specification
  PloS One. 2013  |   Pubmed ID: 24194952
• Glyceride Lipid Formulations: Molecular Dynamics Modeling of Phase Behavior During Dispersion and Molecular Interactions Between Drugs and Excipients
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 24092054
• Lipid-based Formulations and Drug Supersaturation: Harnessing the Unique Benefits of the Lipid Digestion/absorption Pathway
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 23824582
• In Vitro Assessment of Drug-free and Fenofibrate-containing Lipid Formulations Using Dispersion and Digestion Testing Gives Detailed Insights into the Likely Fate of Formulations in the Intestine
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Jul, 2013  |   Pubmed ID: 23684915
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 3: Understanding Supersaturation Versus Precipitation Potential During the in Vitro Digestion of Type I, II, IIIA, IIIB and IV Lipid-based Formulations
  Pharmaceutical Research. Dec, 2013  |   Pubmed ID: 23661145
• Evaluation of the Structural Determinants of Polymeric Precipitation Inhibitors Using Solvent Shift Methods and Principle Component Analysis
  Molecular Pharmaceutics. Aug, 2013  |   Pubmed ID: 23631696
• Strategies to Address Low Drug Solubility in Discovery and Development
  Pharmacological Reviews. Jan, 2013  |   Pubmed ID: 23383426
• In Vitro Digestion Testing of Lipid-based Delivery Systems: Calcium Ions Combine with Fatty Acids Liberated from Triglyceride Rich Lipid Solutions to Form Soaps and Reduce the Solubilization Capacity of Colloidal Digestion Products
  International Journal of Pharmaceutics. Jan, 2013  |   Pubmed ID: 23178598
• Synthesis and Biological Evaluation of N-substituted Noscapine Analogues
  ChemMedChem. Dec, 2012  |   Pubmed ID: 23055449
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations. 2. The Effect of Bile Salt Concentration and Drug Loading on the Performance of Type I, II, IIIA, IIIB, and IV Formulations During in Vitro Digestion
  Molecular Pharmaceutics. Nov, 2012  |   Pubmed ID: 23030411
• Colloidal Characteristics and Formulation of Pure Protein Particulate Vaccines
  The Journal of Pharmacy and Pharmacology. Oct, 2012  |   Pubmed ID: 22943169
• Synthesis and Biological Evaluation of Adenosines with Heterobicyclic and Polycyclic N(6)-substituents As Adenosine A(1) Receptor Agonists
  ChemMedChem. Jul, 2012  |   Pubmed ID: 22684887
• Lipid Digestion As a Trigger for Supersaturation: Evaluation of the Impact of Supersaturation Stabilization on the in Vitro and in Vivo Performance of Self-emulsifying Drug Delivery Systems
  Molecular Pharmaceutics. Jul, 2012  |   Pubmed ID: 22656917
• Toward the Establishment of Standardized in Vitro Tests for Lipid-based Formulations, Part 1: Method Parameterization and Comparison of in Vitro Digestion Profiles Across a Range of Representative Formulations
  Journal of Pharmaceutical Sciences. Sep, 2012  |   Pubmed ID: 22644939
• Lmx1a Allows Context-specific Isolation of Progenitors of GABAergic or Dopaminergic Neurons During Neural Differentiation of Embryonic Stem Cells
  Stem Cells (Dayton, Ohio). Jul, 2012  |   Pubmed ID: 22495882
• Synthesis and Pharmacological Evaluation of Dual Acting Antioxidant A(2A) Adenosine Receptor Agonists
  Journal of Medicinal Chemistry. Apr, 2012  |   Pubmed ID: 22432713
• In Vitro Maturation of Dopaminergic Neurons Derived from Mouse Embryonic Stem Cells: Implications for Transplantation
  PloS One. 2012  |   Pubmed ID: 22384125
• Enhanced Extravasation, Stability and in Vivo Cardiac Gene Silencing Via in Situ SiRNA-albumin Conjugation
  Molecular Pharmaceutics. Jan, 2012  |   Pubmed ID: 22141328
• NKX2-5(eGFP/w) HESCs for Isolation of Human Cardiac Progenitors and Cardiomyocytes
  Nature Methods. Dec, 2011  |   Pubmed ID: 22020065
• Using Molecular Dynamics to Study Liquid Phase Behavior: Simulations of the Ternary Sodium Laurate/sodium Oleate/water System
  Langmuir : the ACS Journal of Surfaces and Colloids. Sep, 2011  |   Pubmed ID: 21838286
• Commercially Supplied Amine-Modified SiRNAs May Require Ultrafiltration Prior to Conjugation with Amine-Reactive Compounds
  Journal of Nucleic Acids. 2011  |   Pubmed ID: 21772990
• Extended Periods of Neural Induction and Propagation of Embryonic Stem Cell-derived Neural Progenitors with EGF and FGF2 Enhances Lmx1a Expression and Neurogenic Potential
  Neurochemistry International. Sep, 2011  |   Pubmed ID: 21624410
• Directed Expression of Gata2, Mash1, and Foxa2 Synergize to Induce the Serotonergic Neuron Phenotype During in Vitro Differentiation of Embryonic Stem Cells
  Stem Cells (Dayton, Ohio). Jun, 2011  |   Pubmed ID: 21472823
• A Targeted NKX2.1 Human Embryonic Stem Cell Reporter Line Enables Identification of Human Basal Forebrain Derivatives
  Stem Cells (Dayton, Ohio). Mar, 2011  |   Pubmed ID: 21425409
• Mechanism of Microtubule-facilitated "fast Track" Nuclear Import
  The Journal of Biological Chemistry. Apr, 2011  |   Pubmed ID: 21339293
• Using Polymeric Precipitation Inhibitors to Improve the Absorption of Poorly Water-soluble Drugs: A Mechanistic Basis for Utility
  Journal of Drug Targeting. Dec, 2010  |   Pubmed ID: 20973755
• Cooperative Cardioprotection Through Adenosine A1 and A2A Receptor Agonism in Ischemia-reperfused Isolated Mouse Heart
  Journal of Cardiovascular Pharmacology. Oct, 2010  |   Pubmed ID: 20930592
• Interaction of Viruses with Host Cell Molecular Motors
  Current Opinion in Biotechnology. Oct, 2010  |   Pubmed ID: 20638267
• Adenovirus: a Blueprint for Non-viral Gene Delivery
  Current Opinion in Biotechnology. Oct, 2010  |   Pubmed ID: 20638266
• A Novel Highly Selective Adenosine A1 Receptor Agonist VCP28 Reduces Ischemia Injury in a Cardiac Cell Line and Ischemia-reperfusion Injury in Isolated Rat Hearts at Concentrations That Do Not Affect Heart Rate
  Journal of Cardiovascular Pharmacology. Sep, 2010  |   Pubmed ID: 20571427
• Synthesis and Evaluation of New N6-substituted Adenosine-5'-N-methylcarboxamides As A3 Adenosine Receptor Agonists
  Bioorganic & Medicinal Chemistry. May, 2010  |   Pubmed ID: 20385496
• Investigations into the Binding Affinities of Different Human 5-HT4 Receptor Splice Variants
  Pharmacology. 2010  |   Pubmed ID: 20299822
• Troubleshooting Immunohistochemical Labelling of Proliferating Cell Nuclear Antigen (PCNA) in Cryocut Tissue Sections of Mouse Prostate
  Journal of Pharmacological and Toxicological Methods. Mar-Apr, 2010  |   Pubmed ID: 19945538
• Modulation of Nucleocytoplasmic Trafficking by Retention in Cytoplasm or Nucleus
  Journal of Cellular Biochemistry. Aug, 2009  |   Pubmed ID: 19507231
• Cardioprotection Induced by Adenosine A1 Receptor Agonists in a Cardiac Cell Ischemia Model Involves Cooperative Activation of Adenosine A2A and A2B Receptors by Endogenous Adenosine
  Journal of Cardiovascular Pharmacology. May, 2009  |   Pubmed ID: 19333129
• A Stably Engineered, Suicidal Strain of Listeria Monocytogenes Delivers Protein And/or DNA to Fully Differentiated Intestinal Epithelial Monolayers
  Molecular Pharmaceutics. Jul-Aug, 2009  |   Pubmed ID: 19317435
• Overcoming Biological Barriers to in Vivo Efficacy of Antisense Oligonucleotides
  Expert Reviews in Molecular Medicine. 2009  |   Pubmed ID: 19302730
• Structure and Dynamics of Glyceride Lipid Formulations, with Propylene Glycol and Water
  Molecular Pharmaceutics. Mar-Apr, 2009  |   Pubmed ID: 19260675
• Design of Lipid-based Formulations for Oral Administration of Poorly Water-soluble Drugs: Precipitation of Drug After Dispersion of Formulations in Aqueous Solution
  Journal of Pharmaceutical Sciences. Oct, 2009  |   Pubmed ID: 19130605
• Preparation and in Vitro Evaluation of Novel Lipopeptide Transfection Agents for Efficient Gene Delivery
  Bioconjugate Chemistry. Apr, 2008  |   Pubmed ID: 18333604
• Enhancing Intestinal Drug Solubilisation Using Lipid-based Delivery Systems
  Advanced Drug Delivery Reviews. Mar, 2008  |   Pubmed ID: 18155801
• Formulation of Lipid-based Delivery Systems for Oral Administration: Materials, Methods and Strategies
  Advanced Drug Delivery Reviews. Mar, 2008  |   Pubmed ID: 18068260
• Evaluation of the Impact of Surfactant Digestion on the Bioavailability of Danazol After Oral Administration of Lipidic Self-emulsifying Formulations to Dogs
  Journal of Pharmaceutical Sciences. Feb, 2008  |   Pubmed ID: 18064698
• Dual Acting Antioxidant A1 Adenosine Receptor Agonists
  Bioorganic & Medicinal Chemistry Letters. Oct, 2007  |   Pubmed ID: 17689079
• Targeted Delivery to the Nucleus
  Advanced Drug Delivery Reviews. Aug, 2007  |   Pubmed ID: 17681634
• Embryonic Stem Cells As a Source of Models for Drug Discovery
  Nature Reviews. Drug Discovery. Aug, 2007  |   Pubmed ID: 17667955
• Dynein Light Chain Association Sequences Can Facilitate Nuclear Protein Import
  Molecular Biology of the Cell. Aug, 2007  |   Pubmed ID: 17567954
• A Microtubule-facilitated Nuclear Import Pathway for Cancer Regulatory Proteins
  Traffic (Copenhagen, Denmark). Jun, 2007  |   Pubmed ID: 17511743
• Heterogeneous Population of Dopaminergic Neurons Derived from Mouse Embryonic Stem Cells: Preliminary Phenotyping Based on Receptor Expression and Function
  The European Journal of Neuroscience. Apr, 2007  |   Pubmed ID: 17419751
• Increasing the Proportional Content of Surfactant (Cremophor EL) Relative to Lipid in Self-emulsifying Lipid-based Formulations of Danazol Reduces Oral Bioavailability in Beagle Dogs
  Pharmaceutical Research. Apr, 2007  |   Pubmed ID: 17372700
• Comparison of 5-HT4 and 5-HT7 Receptor Expression and Function in the Circular Muscle of the Human Colon
  Life Sciences. Mar, 2007  |   Pubmed ID: 17258778
• Formulation of Poorly Water-soluble Drugs for Oral Administration: Physicochemical and Physiological Issues and the Lipid Formulation Classification System
  European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences. Nov, 2006  |   Pubmed ID: 16815001
• Pharmaceutical Applications of Embryonic Stem Cells
  Advanced Drug Delivery Reviews. Dec, 2005  |   Pubmed ID: 16290153