Cynthia E. Dunbar

Publications

• Path to the Clinic: Assessment of IPSC-based Cell Therapies in Vivo in a Nonhuman Primate Model
  Cell Reports. May, 2014  |   Pubmed ID: 24835994
• IFN-γ Regulates Survival and Function of Tumor-induced CD11b(+) Gr-1(high) Myeloid Derived Suppressor Cells by Modulating the Anti-apoptotic Molecule Bcl2a1
  European Journal of Immunology. May, 2014  |   Pubmed ID: 24810636
• Clonal Tracking of Rhesus Macaque Hematopoiesis Highlights a Distinct Lineage Origin for Natural Killer Cells
  Cell Stem Cell. Apr, 2014  |   Pubmed ID: 24702997
• Dynamics of HSPC Repopulation in Nonhuman Primates Revealed by a Decade-long Clonal-tracking Study
  Cell Stem Cell. Apr, 2014  |   Pubmed ID: 24702996
• Patients with Myeloid Malignancies Bearing PDGFRB Fusion Genes Achieve Durable Long-term Remissions with Imatinib
  Blood. Jun, 2014  |   Pubmed ID: 24687085
• Eltrombopag Restores Trilineage Hematopoiesis in Refractory Severe Aplastic Anemia That Can Be Sustained on Discontinuation of Drug
  Blood. Mar, 2014  |   Pubmed ID: 24345753
• No Impact of Lentiviral Transduction on Hematopoietic Stem/progenitor Cell Telomere Length or Gene Expression in the Rhesus Macaque Model
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jan, 2014  |   Pubmed ID: 23863881
• Integration-specific In Vitro Evaluation of Lentivirally Transduced Rhesus CD34(+) Cells Correlates With In Vivo Vector Copy Number
  Molecular Therapy. Nucleic Acids. 2013  |   Pubmed ID: 24045711
• Hematopoietic Stem Cell Gene Therapy:assessing the Relevance of Preclinical Models
  Seminars in Hematology. Apr, 2013  |   Pubmed ID: 24014892
• Pathophysiology and Management of Thrombocytopenia in Bone Marrow Failure: Possible Clinical Applications of TPO Receptor Agonists in Aplastic Anemia and Myelodysplastic Syndromes
  International Journal of Hematology. Jul, 2013  |   Pubmed ID: 23690288
• Defective Telomere Elongation and Hematopoiesis from Telomerase-mutant Aplastic Anemia IPSCs
  The Journal of Clinical Investigation. May, 2013  |   Pubmed ID: 23585473
• Assessing the Risks of Genotoxicity in the Therapeutic Development of Induced Pluripotent Stem Cells
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Feb, 2013  |   Pubmed ID: 23207694
• Measurement of the Absolute Immature Platelet Number Reflects Marrow Production and is Not Impacted by Platelet Transfusion
  Transfusion. Jun, 2013  |   Pubmed ID: 23043309
• High Efficiency Restriction Enzyme-free Linear Amplification-mediated Polymerase Chain Reaction Approach for Tracking Lentiviral Integration Sites Does Not Abrogate Retrieval Bias
  Human Gene Therapy. Jan, 2013  |   Pubmed ID: 22992116
• An Educational Infusion: More Synergy Between Blood and the American Society of Hematology
  Blood. Nov, 2012  |   Pubmed ID: 23197578
• BCL2A1a Over-expression in Murine Hematopoietic Stem and Progenitor Cells Decreases Apoptosis and Results in Hematopoietic Transformation
  PloS One. 2012  |   Pubmed ID: 23118966
• Dynamic Clonal Analysis of Murine Hematopoietic Stem and Progenitor Cells Marked by 5 Fluorescent Proteins Using Confocal and Multiphoton Microscopy
  Blood. Dec, 2012  |   Pubmed ID: 22995900
• Thymidine Kinase Suicide Gene-mediated Ganciclovir Ablation of Autologous Gene-modified Rhesus Hematopoiesis
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2012  |   Pubmed ID: 22910293
• Eltrombopag and Improved Hematopoiesis in Refractory Aplastic Anemia
  The New England Journal of Medicine. Jul, 2012  |   Pubmed ID: 22762314
• Pharmacological Modulation of Humoral Immunity in a Nonhuman Primate Model of AAV Gene Transfer for Hemophilia B
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jul, 2012  |   Pubmed ID: 22565846
• Bone Marrow Homing and Engraftment of Human Hematopoietic Stem and Progenitor Cells is Mediated by a Polarized Membrane Domain
  Blood. Feb, 2012  |   Pubmed ID: 22228628
• Hematopoietic Stem Cell Engineering at a Crossroads
  Blood. Feb, 2012  |   Pubmed ID: 22096239
• Transient Silencing of PTEN in Human CD34(+) Cells Enhances Their Proliferative Potential and Ability to Engraft Immunodeficient Mice
  Experimental Hematology. Jan, 2012  |   Pubmed ID: 22019626
• Stem Cell Gene Therapy: the Risks of Insertional Mutagenesis and Approaches to Minimize Genotoxicity
  Frontiers of Medicine. Dec, 2011  |   Pubmed ID: 22198747
• Sox4 Cooperates with PU.1 Haploinsufficiency in Murine Myeloid Leukemia
  Blood. Oct, 2011  |   Pubmed ID: 21878674
• Insertion Sites in Engrafted Cells Cluster Within a Limited Repertoire of Genomic Areas After Gammaretroviral Vector Gene Therapy
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Nov, 2011  |   Pubmed ID: 21862999
• CD9 Up-regulation on CD34+ Cells with Ingenol 3,20-dibenzoate Does Not Improve Homing in NSG Mice
  Blood. May, 2011  |   Pubmed ID: 21617010
• Patients, Hematologists, and Time
  Blood. Mar, 2011  |   Pubmed ID: 21393501
• Contributions of Gene Marking to Cell and Gene Therapies
  Human Gene Therapy. Jun, 2011  |   Pubmed ID: 21261461
• Human and Rhesus Macaque Hematopoietic Stem Cells Cannot Be Purified Based Only on SLAM Family Markers
  Blood. Feb, 2011  |   Pubmed ID: 21163926
• Ex Vivo Expansion of Retrovirally Transduced Primate CD34+ Cells Results in Overrepresentation of Clones with MDS1/EVI1 Insertion Sites in the Myeloid Lineage After Transplantation
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2010  |   Pubmed ID: 20571542
• No Evidence for Clonal Selection Due to Lentiviral Integration Sites in Human Induced Pluripotent Stem Cells
  Stem Cells (Dayton, Ohio). Apr, 2010  |   Pubmed ID: 20166152
• Gene Therapy Activates EVI1, Destabilizes Chromosomes
  Nature Medicine. Feb, 2010  |   Pubmed ID: 20134468
• Keeping Up with Blood: Introducing Our CME Program
  Blood. Jan, 2010  |   Pubmed ID: 20110432
• Repetitive Busulfan Administration After Hematopoietic Stem Cell Gene Therapy Associated with a Dominant HDAC7 Clone in a Nonhuman Primate
  Human Gene Therapy. Jun, 2010  |   Pubmed ID: 20102258
• In Vivo Selection of Hematopoietic Progenitor Cells and Temozolomide Dose Intensification in Rhesus Macaques Through Lentiviral Transduction with a Drug Resistance Gene
  The Journal of Clinical Investigation. Jul, 2009  |   Pubmed ID: 19509470
• Introducing "e-Blood"
  Blood. May, 2009  |   Pubmed ID: 19423743
• Genetically Modified CD34+ Hematopoietic Stem Cells Contribute to Turnover of Brain Perivascular Macrophages in Long-term Repopulated Primates
  The American Journal of Pathology. May, 2009  |   Pubmed ID: 19349370
• Sustained High-level Polyclonal Hematopoietic Marking and Transgene Expression 4 Years After Autologous Transplantation of Rhesus Macaques with SIV Lentiviral Vector-transduced CD34+ Cells
  Blood. May, 2009  |   Pubmed ID: 19339698
• Intercellular Transfer to Signalling Endosomes Regulates an Ex Vivo Bone Marrow Niche
  Nature Cell Biology. Mar, 2009  |   Pubmed ID: 19198600
• 'Ghostbusting' at Blood
  Blood. Jan, 2009  |   Pubmed ID: 19147793
• More Frequent Blood Transfusions
  Blood. Jan, 2009  |   Pubmed ID: 19122117
• Sorting of Transgenic Secretory Proteins in Rhesus Macaque Parotid Glands After Adenovirus-mediated Gene Transfer
  Human Gene Therapy. Dec, 2008  |   Pubmed ID: 18764738
• Reduced Genotoxicity of Avian Sarcoma Leukosis Virus Vectors in Rhesus Long-term Repopulating Cells Compared to Standard Murine Retrovirus Vectors
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Sep, 2008  |   Pubmed ID: 18578011
• Donor Demographic and Laboratory Predictors of Allogeneic Peripheral Blood Stem Cell Mobilization in an Ethnically Diverse Population
  Blood. Sep, 2008  |   Pubmed ID: 18523146
• HOXB4 and Retroviral Vectors: Adding Fuel to the Fire
  The Journal of Clinical Investigation. Apr, 2008  |   Pubmed ID: 18357348
• The MDS1-EVI1 Gene Complex As a Retrovirus Integration Site: Impact on Behavior of Hematopoietic Cells and Implications for Gene Therapy
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2008  |   Pubmed ID: 18227842
• The Yin and Yang of Stem Cell Gene Therapy: Insights into Hematopoiesis, Leukemogenesis, and Gene Therapy Safety
  Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2007  |   Pubmed ID: 18024665
• Relapse Following Discontinuation of Imatinib Mesylate Therapy for FIP1L1/PDGFRA-positive Chronic Eosinophilic Leukemia: Implications for Optimal Dosing
  Blood. Nov, 2007  |   Pubmed ID: 17709602
• Transduction of Rhesus Macaque Hematopoietic Stem and Progenitor Cells with Avian Sarcoma and Leukosis Virus Vectors
  Human Gene Therapy. Aug, 2007  |   Pubmed ID: 17655493
• No Evidence of Clonal Dominance in Primates Up to 4 Years Following Transplantation of Multidrug Resistance 1 Retrovirally Transduced Long-term Repopulating Cells
  Stem Cells (Dayton, Ohio). Oct, 2007  |   Pubmed ID: 17615269
• Antibody-mediated Cell Labeling of Peripheral T Cells with Micron-sized Iron Oxide Particles (MPIOs) Allows Single Cell Detection by MRI
  Contrast Media & Molecular Imaging. May-Jun, 2007  |   Pubmed ID: 17541955
• Hematopoietic Stem-cell Behavior in Nonhuman Primates
  Blood. Sep, 2007  |   Pubmed ID: 17526860
• Keratinocyte Growth Factor Augments Immune Reconstitution After Autologous Hematopoietic Progenitor Cell Transplantation in Rhesus Macaques
  Blood. Jul, 2007  |   Pubmed ID: 17374737
• Cytokine-independent Growth and Clonal Expansion of a Primary Human CD8+ T-cell Clone Following Retroviral Transduction with the IL-15 Gene
  Blood. Jun, 2007  |   Pubmed ID: 17353346
• Adeno-associated Virus Serotype 2-mediated Gene Transfer to the Parotid Glands of Nonhuman Primates
  Human Gene Therapy. Feb, 2007  |   Pubmed ID: 17328682
• Correction of the Disease Phenotype in Canine Leukocyte Adhesion Deficiency Using Ex Vivo Hematopoietic Stem Cell Gene Therapy
  Blood. Nov, 2006  |   Pubmed ID: 16868255
• Genotoxicity of Retroviral Integration in Hematopoietic Cells
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Jun, 2006  |   Pubmed ID: 16624621
• In Vitro Culture During Retroviral Transduction Improves Thymic Repopulation and Output After Total Body Irradiation and Autologous Peripheral Blood Progenitor Cell Transplantation in Rhesus Macaques
  Stem Cells (Dayton, Ohio). Jun, 2006  |   Pubmed ID: 16497945
• Combination Therapy with RFVIIa and Platelets for Hemorrhage in Patients with Severe Thrombocytopenia and Alloimmunization
  American Journal of Hematology. Mar, 2006  |   Pubmed ID: 16493611
• Anti-interleukin-2 Receptor Antibody (daclizumab) Treatment of Corticosteroid-refractory Autoimmune Thrombocytopenic Purpura
  Haematologica. Feb, 2006  |   Pubmed ID: 16461323
• AMD3100 Mobilizes Hematopoietic Stem Cells with Long-term Repopulating Capacity in Nonhuman Primates
  Blood. May, 2006  |   Pubmed ID: 16439684
• Mobilization As a Preparative Regimen for Hematopoietic Stem Cell Transplantation
  Blood. May, 2006  |   Pubmed ID: 16439683
• Acute Myeloid Leukemia is Associated with Retroviral Gene Transfer to Hematopoietic Progenitor Cells in a Rhesus Macaque
  Blood. May, 2006  |   Pubmed ID: 16439674
• Large Animal Models for Stem and Progenitor Cell Analysis
  Current Protocols in Immunology / Edited by John E. Coligan ... [et Al.]. Nov, 2005  |   Pubmed ID: 18432946
• Outcomes and Risks of Granulocyte Colony-stimulating Factor in Patients with Coronary Artery Disease
  Journal of the American College of Cardiology. Nov, 2005  |   Pubmed ID: 16256862
• Hematopoietic Stem Cell Gene Therapy: Dead or Alive?
  Trends in Biotechnology. Dec, 2005  |   Pubmed ID: 16216357
• A New Direction for Gene Therapy: Intrathymic T Cell-specific Lentiviral Gene Transfer
  The Journal of Clinical Investigation. Aug, 2005  |   Pubmed ID: 16075048
• Large Granular Lymphocytic Proliferation-associated Cyclic Thrombocytopenia
  American Journal of Hematology. Aug, 2005  |   Pubmed ID: 16044437
• Stem Cell Gene Transfer: Insights into Integration and Hematopoiesis from Primate Genetic Marking Studies
  Annals of the New York Academy of Sciences. Jun, 2005  |   Pubmed ID: 15958711
• Recurrent Retroviral Vector Integration at the Mds1/Evi1 Locus in Nonhuman Primate Hematopoietic Cells
  Blood. Oct, 2005  |   Pubmed ID: 15933056
• Imatinib Inhibits T-cell Receptor-mediated T-cell Proliferation and Activation in a Dose-dependent Manner
  Blood. Mar, 2005  |   Pubmed ID: 15572591
• Low-dose Total Body Irradiation Causes Clonal Fluctuation of Primate Hematopoietic Stem and Progenitor Cells
  Blood. Feb, 2005  |   Pubmed ID: 15383461
• Distinct Genomic Integration of MLV and SIV Vectors in Primate Hematopoietic Stem and Progenitor Cells
  PLoS Biology. Dec, 2004  |   Pubmed ID: 15550989
• Genetic Manipulation of Hematopoietic Stem Cells
  Seminars in Hematology. Oct, 2004  |   Pubmed ID: 15508111
• Gene Therapy for Hematologic Disease: Don't Throw the Baby out with the Bathwater!
  Seminars in Hematology. Oct, 2004  |   Pubmed ID: 15508110
• MRI Detection of Single Particles for Cellular Imaging
  Proceedings of the National Academy of Sciences of the United States of America. Jul, 2004  |   Pubmed ID: 15256592
• The Impact of Low-dose Busulfan on Clonal Dynamics in Nonhuman Primates
  Blood. Sep, 2004  |   Pubmed ID: 15126320
• The Presence of the Carboxy-terminal Fragment of Fibronectin Allows Maintenance of Non-human Primate Long-term Hematopoietic Repopulating Cells During Extended Ex Vivo Culture and Transduction
  Experimental Hematology. Feb, 2004  |   Pubmed ID: 15102477
• In Vivo Gene Marking of Rhesus Macaque Long-term Repopulating Hematopoietic Cells Using a VSV-G Pseudotyped Versus Amphotropic Oncoretroviral Vector
  The Journal of Gene Medicine. Apr, 2004  |   Pubmed ID: 15079811
• Long-term Clinical and Molecular Follow-up of Large Animals Receiving Retrovirally Transduced Stem and Progenitor Cells: No Progression to Clonal Hematopoiesis or Leukemia
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2004  |   Pubmed ID: 15006605
• Efficient Gene Transfer into Rhesus Repopulating Hematopoietic Stem Cells Using a Simian Immunodeficiency Virus-based Lentiviral Vector System
  Blood. Jun, 2004  |   Pubmed ID: 14976042
• Effect of Chronic Cytokine Therapy on Clonal Dynamics in Nonhuman Primates
  Blood. Jun, 2004  |   Pubmed ID: 14962906
• Transient in Vivo Selection of Transduced Peripheral Blood Cells Using Antifolate Drug Selection in Rhesus Macaques That Received Transplants with Hematopoietic Stem Cells Expressing Dihydrofolate Reductase Vectors
  Blood. Feb, 2004  |   Pubmed ID: 12920024
• Resetting the Immune System in Immune Thrombocytopenic Purpura: Immunoablative Strategies
  Clinical Advances in Hematology & Oncology : H&O. Jun, 2003  |   Pubmed ID: 16235418
• Direct Comparison of RD114-pseudotyped Versus Amphotropic-pseudotyped Retroviral Vectors for Transduction of Rhesus Macaque Long-term Repopulating Cells
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Oct, 2003  |   Pubmed ID: 14529834
• Serial Cardiac Magnetic Resonance Imaging of Injected Mesenchymal Stem Cells
  Circulation. Aug, 2003  |   Pubmed ID: 12912822
• Efficient Characterization of Retro-, Lenti-, and Foamyvector-transduced Cell Populations by High-accuracy Insertion Site Sequencing
  Annals of the New York Academy of Sciences. May, 2003  |   Pubmed ID: 12799289
• Highly Efficient Endosomal Labeling of Progenitor and Stem Cells with Large Magnetic Particles Allows Magnetic Resonance Imaging of Single Cells
  Blood. Aug, 2003  |   Pubmed ID: 12676779
• Prolonged Multilineage Clonal Hematopoiesis in a Rhesus Recipient of CD34 Positive Cells Marked with a RD114 Pseudotyped Oncoretroviral Vector
  Blood Cells, Molecules & Diseases. Jan-Feb, 2003  |   Pubmed ID: 12667996
• Persistence and Expression of the Adenosine Deaminase Gene for 12 Years and Immune Reaction to Gene Transfer Components: Long-term Results of the First Clinical Gene Therapy Trial
  Blood. Apr, 2003  |   Pubmed ID: 12456496
• Retroviral Transduction Efficiency of G-CSF+SCF-mobilized Peripheral Blood CD34+ Cells is Superior to G-CSF or G-CSF+Flt3-L-mobilized Cells in Nonhuman Primates
  Blood. Mar, 2003  |   Pubmed ID: 12424191
• High-dose Cyclophosphamide with Autologous Lymphocyte-depleted Peripheral Blood Stem Cell (PBSC) Support for Treatment of Refractory Chronic Autoimmune Thrombocytopenia
  Blood. Jan, 2003  |   Pubmed ID: 12393623
• Update on Hematopoietic Stem Cell Gene Transfer Using Non-human Primate Models
  Current Opinion in Molecular Therapeutics. Oct, 2002  |   Pubmed ID: 12435050
• Polyclonal Long-term Repopulating Stem Cell Clones in a Primate Model
  Blood. Oct, 2002  |   Pubmed ID: 12351380
• Absence of Donor-derived Keratinocyte Stem Cells in Skin Tissues Cultured from Patients After Mobilized Peripheral Blood Hematopoietic Stem Cell Transplantation
  Experimental Hematology. Aug, 2002  |   Pubmed ID: 12160846
• Activity of STI571 in Chronic Myelomonocytic Leukemia with a Platelet-derived Growth Factor Beta Receptor Fusion Oncogene
  Blood. Aug, 2002  |   Pubmed ID: 12130532
• Plasticity and Hematopoiesis: Circe's Transforming Potion?
  Current Opinion in Hematology. Jul, 2002  |   Pubmed ID: 12042699
• Genetic Marking As an Approach to Studying in Vivo Hematopoiesis: Progress in the Non-human Primate Model
  Oncogene. May, 2002  |   Pubmed ID: 12032769
• Retroviral Transduction and Engraftment Ability of Primate Hematopoietic Progenitor and Stem Cells Transduced Under Serum-free Versus Serum-containing Conditions
  Molecular Therapy : the Journal of the American Society of Gene Therapy. Mar, 2002  |   Pubmed ID: 11863422