D. Gary Gilliland

Publications

• A Functional Role For The Histone Demethylase Utx In Normal And Malignant Hematopoietic Cells
  Experimental Hematology. Feb, 2012  |   Pubmed ID: 22306297
• KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice
  Blood. Feb, 2012  |   Pubmed ID: 22160378
• AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias
  Cell. Sep, 2011  |   Pubmed ID: 21884932
• Coordinate Loss of a MicroRNA and Protein-coding Gene Cooperate in the Pathogenesis of 5q- Syndrome
  Blood. Oct, 2011  |   Pubmed ID: 21873545
• Differential Niche and Wnt Requirements During Acute Myeloid Leukemia Progression
  Blood. Sep, 2011  |   Pubmed ID: 21765021
• Crosstalk Between NOTCH and AKT Signaling During Murine Megakaryocyte Lineage Specification
  Blood. Aug, 2011  |   Pubmed ID: 21653327
• Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias
  Cancer Research. Jun, 2011  |   Pubmed ID: 21505102
• Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2011  |   Pubmed ID: 21220608
• MTOR Activation Induces Tumor Suppressors That Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells After Pten Deletion
  Cell Stem Cell. Nov, 2010  |   Pubmed ID: 21040901
• Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-like Tyrosine Kinase 3 Receptor (FLT3) and Multi-targeted Kinase Inhibitor, in Patients with Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome with Either Wild-type or Mutated FLT3
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2010  |   Pubmed ID: 20733134
• Musashi-2 Regulates Normal Hematopoiesis and Promotes Aggressive Myeloid Leukemia
  Nature Medicine. Aug, 2010  |   Pubmed ID: 20616797
• Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F
  Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2010  |   Pubmed ID: 20601445
• Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells
  Cancer Cell. Jun, 2010  |   Pubmed ID: 20541703
• Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1
  Stem Cells (Dayton, Ohio). Jul, 2010  |   Pubmed ID: 20506303
• Cdx4 is Dispensable for Murine Adult Hematopoietic Stem Cells but Promotes MLL-AF9-mediated Leukemogenesis
  Haematologica. Oct, 2010  |   Pubmed ID: 20494928
• The Apc(min) Mouse Has Altered Hematopoietic Stem Cell Function and Provides a Model for MPD/MDS
  Blood. Apr, 2010  |   Pubmed ID: 20197553
• Prevalence and Prognostic Impact of Allelic Imbalances Associated with Leukemic Transformation of Philadelphia Chromosome-negative Myeloproliferative Neoplasms
  Blood. Apr, 2010  |   Pubmed ID: 20068225
• Leukemia Stem Cells
  Seminars in Cancer Biology. Apr, 2010  |   Pubmed ID: 20026405
• Constitutively Active AKT Depletes Hematopoietic Stem Cells and Induces Leukemia in Mice
  Blood. Feb, 2010  |   Pubmed ID: 20008787
• Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth
  Science Signaling. 2009  |   Pubmed ID: 19920251
• Direct Inhibition of the NOTCH Transcription Factor Complex
  Nature. Nov, 2009  |   Pubmed ID: 19907488
• Systematic RNA Interference Reveals That Oncogenic KRAS-driven Cancers Require TBK1
  Nature. Nov, 2009  |   Pubmed ID: 19847166
• A Progenitor Cell Origin of Myeloid Malignancies
  Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009  |   Pubmed ID: 19805346
• [The OTT-MAL Fusion Oncogene: Another Notch in Megakaryoblastic Leukemia]
  Médecine Sciences : M/S. Aug-Sep, 2009  |   Pubmed ID: 19765378
• Hedgehog Signaling is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis
  Cell Stem Cell. Jun, 2009  |   Pubmed ID: 19497284
• Synthetic Lethal Interaction Between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells
  Cell. May, 2009  |   Pubmed ID: 19490892
• Genetic Characterization of TET1, TET2, and TET3 Alterations in Myeloid Malignancies
  Blood. Jul, 2009  |   Pubmed ID: 19420352
• The Leukemic Stem Cell Niche: Current Concepts and Therapeutic Opportunities
  Blood. Aug, 2009  |   Pubmed ID: 19401558
• A Germline JAK2 SNP is Associated with Predisposition to the Development of JAK2(V617F)-positive Myeloproliferative Neoplasms
  Nature Genetics. Apr, 2009  |   Pubmed ID: 19287384
• The OTT-MAL Fusion Oncogene Activates RBPJ-mediated Transcription and Induces Acute Megakaryoblastic Leukemia in a Knockin Mouse Model
  The Journal of Clinical Investigation. Apr, 2009  |   Pubmed ID: 19287095
• A Radical Bailout Strategy for Cancer Stem Cells
  Cell Stem Cell. Mar, 2009  |   Pubmed ID: 19265655
• Skewing of X-inactivation Ratios in Blood Cells of Aging Women is Confirmed by Independent Methodologies
  Blood. Apr, 2009  |   Pubmed ID: 19202126
• Constitutive JAK3 Activation Induces Lymphoproliferative Syndromes in Murine Bone Marrow Transplantation Models
  Blood. Mar, 2009  |   Pubmed ID: 19139084
• High-throughput Sequencing Screen Reveals Novel, Transforming RAS Mutations in Myeloid Leukemia Patients
  Blood. Feb, 2009  |   Pubmed ID: 19075190
• Ott1 (Rbm15) is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen
  Molecular and Cellular Biology. Jan, 2009  |   Pubmed ID: 18981216
• Activating Mutations in ALK Provide a Therapeutic Target in Neuroblastoma
  Nature. Oct, 2008  |   Pubmed ID: 18923525
• Going with the Flow: JAK-STAT Signaling in JMML
  Cancer Cell. Oct, 2008  |   Pubmed ID: 18835028
• Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells
  Cell Stem Cell. Sep, 2008  |   Pubmed ID: 18786418
• Myeloproliferative Disorders
  Blood. Sep, 2008  |   Pubmed ID: 18779404
• Genetic Profiling of Myeloproliferative Disorders by Single-nucleotide Polymorphism Oligonucleotide Microarray
  Experimental Hematology. Nov, 2008  |   Pubmed ID: 18723266
• Deregulation of Signaling Pathways in Acute Myeloid Leukemia
  Seminars in Oncology. Aug, 2008  |   Pubmed ID: 18692684
• K-RasG12D-induced T-cell Lymphoblastic Lymphoma/leukemias Harbor Notch1 Mutations and Are Sensitive to Gamma-secretase Inhibitors
  Blood. Oct, 2008  |   Pubmed ID: 18663146
• Kinase Activation and Transformation by NUP214-ABL1 is Dependent on the Context of the Nuclear Pore
  Molecular Cell. Jul, 2008  |   Pubmed ID: 18614052
• Id1 is a Common Downstream Target of Oncogenic Tyrosine Kinases in Leukemic Cells
  Blood. Sep, 2008  |   Pubmed ID: 18559972
• Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-induced Polycythemia Vera
  Cancer Cell. Apr, 2008  |   Pubmed ID: 18394554
• Structural and Numerical Variation of FLT3/ITD in Pediatric AML
  Blood. May, 2008  |   Pubmed ID: 18305215
• High-throughput Sequence Analysis of the Tyrosine Kinome in Acute Myeloid Leukemia
  Blood. May, 2008  |   Pubmed ID: 18252861
• The Jak2V617F Oncogene Associated with Myeloproliferative Diseases Requires a Functional FERM Domain for Transformation and for Expression of the Myc and Pim Proto-oncogenes
  Blood. Apr, 2008  |   Pubmed ID: 18216297
• SOS1 Mutations Are Rare in Human Malignancies: Implications for Noonan Syndrome Patients
  Genes, Chromosomes & Cancer. Mar, 2008  |   Pubmed ID: 18064648
• Host Genetic Variation Contributes to Phenotypic Diversity in Myeloproliferative Disorders
  Blood. Mar, 2008  |   Pubmed ID: 18006699
• PU.1 is a Major Downstream Target of AML1 (RUNX1) in Adult Mouse Hematopoiesis
  Nature Genetics. Jan, 2008  |   Pubmed ID: 17994017
• A Role for JAK2 Mutations in Myeloproliferative Diseases
  Annual Review of Medicine. 2008  |   Pubmed ID: 17919086
• FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System
  Cell Stem Cell. Aug, 2007  |   Pubmed ID: 18371346
• Identification of Driver and Passenger Mutations of FLT3 by High-throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles
  Cancer Cell. Dec, 2007  |   Pubmed ID: 18068628
• FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitors in a Murine Model of Chronic Myelomonocytic Leukemia
  Cancer Cell. Oct, 2007  |   Pubmed ID: 17936561
• Uniform Sensitivity of FLT3 Activation Loop Mutants to the Tyrosine Kinase Inhibitor Midostaurin
  Blood. Dec, 2007  |   Pubmed ID: 17827387
• FGFR3 Activates RSK2 to Mediate Hematopoietic Transformation Through Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway
  Cancer Cell. Sep, 2007  |   Pubmed ID: 17785202
• Role of JAK2 in the Pathogenesis and Therapy of Myeloproliferative Disorders
  Nature Reviews. Cancer. Sep, 2007  |   Pubmed ID: 17721432
• Highly Sensitive Method for Genomewide Detection of Allelic Composition in Nonpaired, Primary Tumor Specimens by Use of Affymetrix Single-nucleotide-polymorphism Genotyping Microarrays
  American Journal of Human Genetics. Jul, 2007  |   Pubmed ID: 17564968
• Proposals and Rationale for Revision of the World Health Organization Diagnostic Criteria for Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis: Recommendations from an Ad Hoc International Expert Panel
  Blood. Aug, 2007  |   Pubmed ID: 17488875
• Ott1(Rbm15) Has Pleiotropic Roles in Hematopoietic Development
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2007  |   Pubmed ID: 17376872
• A Novel Fusion of RBM6 to CSF1R in Acute Megakaryoblastic Leukemia
  Blood. Jul, 2007  |   Pubmed ID: 17360941
• Oncogenes in Myeloproliferative Disorders
  Cell Cycle (Georgetown, Tex.). Mar, 2007  |   Pubmed ID: 17351342
• The Homeobox Gene CDX2 is Aberrantly Expressed in Most Cases of Acute Myeloid Leukemia and Promotes Leukemogenesis
  The Journal of Clinical Investigation. Apr, 2007  |   Pubmed ID: 17347684
• The Retinoblastoma Binding Protein RBP2 is an H3K4 Demethylase
  Cell. Mar, 2007  |   Pubmed ID: 17320163
• JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis
  The New England Journal of Medicine. Feb, 2007  |   Pubmed ID: 17267906
• FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress
  Cell. Jan, 2007  |   Pubmed ID: 17254970
• FoxOs Are Lineage-restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis
  Cell. Jan, 2007  |   Pubmed ID: 17254969
• Jak2: Normal Function and Role in Hematopoietic Disorders
  Current Opinion in Genetics & Development. Feb, 2007  |   Pubmed ID: 17208428
• JAK-2 Mutations and Their Relevance to Myeloproliferative Disease
  Current Opinion in Hematology. Jan, 2007  |   Pubmed ID: 17133099
• The JAK2(V617F) Tyrosine Kinase Mutation in Myeloproliferative Disorders: Summary of Published Literature and a Perspective
  Current Hematologic Malignancy Reports. Jun, 2006  |   Pubmed ID: 20425335
• Concurrent MPL515 and JAK2V617F Mutations in Myelofibrosis: Chronology of Clonal Emergence and Changes in Mutant Allele Burden over Time
  British Journal of Haematology. Dec, 2006  |   Pubmed ID: 17107350
• Cdx4 Dysregulates Hox Gene Expression and Generates Acute Myeloid Leukemia Alone and in Cooperation with Meis1a in a Murine Model
  Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006  |   Pubmed ID: 17068127
• MPL515 Mutations in Myeloproliferative and Other Myeloid Disorders: a Study of 1182 Patients
  Blood. Nov, 2006  |   Pubmed ID: 16868251
• Transformation from Committed Progenitor to Leukaemia Stem Cell Initiated by MLL-AF9
  Nature. Aug, 2006  |   Pubmed ID: 16862118
• Activating Alleles of JAK3 in Acute Megakaryoblastic Leukemia
  Cancer Cell. Jul, 2006  |   Pubmed ID: 16843266
• Cell-autonomous and -nonautonomous Contributions of STAT1 in Murine Models of Tumorigenesis
  Cancer Cell. Jul, 2006  |   Pubmed ID: 16843258
• MPLW515L is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia
  PLoS Medicine. Jul, 2006  |   Pubmed ID: 16834459
• JAK2T875N is a Novel Activating Mutation That Results in Myeloproliferative Disease with Features of Megakaryoblastic Leukemia in a Murine Bone Marrow Transplantation Model
  Blood. Oct, 2006  |   Pubmed ID: 16804112
• Eosinophilic Disorders: Molecular Pathogenesis, New Classification, and Modern Therapy
  Best Practice & Research. Clinical Haematology. 2006  |   Pubmed ID: 16781488
• Activation of FIP1L1-PDGFRalpha Requires Disruption of the Juxtamembrane Domain of PDGFRalpha and is FIP1L1-independent
  Proceedings of the National Academy of Sciences of the United States of America. May, 2006  |   Pubmed ID: 16690743
• International Working Group (IWG) Consensus Criteria for Treatment Response in Myelofibrosis with Myeloid Metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT)
  Blood. Sep, 2006  |   Pubmed ID: 16675707
• Oncogenic K-ras Cooperates with PML-RAR Alpha to Induce an Acute Promyelocytic Leukemia-like Disease
  Blood. Sep, 2006  |   Pubmed ID: 16675706
• Roles of Tyrosine 589 and 591 in STAT5 Activation and Transformation Mediated by FLT3-ITD
  Blood. Aug, 2006  |   Pubmed ID: 16627759
• Absence of the Transcription Factor CCAAT Enhancer Binding Protein Alpha Results in Loss of Myeloid Identity in Bcr/abl-induced Malignancy
  Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006  |   Pubmed ID: 16606850
• Detection of the FIP1L1-PDGFRA Fusion in Idiopathic Hypereosinophilic Syndrome and Chronic Eosinophilic Leukemia
  Methods in Molecular Medicine. 2006  |   Pubmed ID: 16502585
• Prospective Analysis of TEL/AML1-positive Patients Treated on Dana-Farber Cancer Institute Consortium Protocol 95-01
  Blood. Jun, 2006  |   Pubmed ID: 16493009
• Expression of Jak2V617F Causes a Polycythemia Vera-like Disease with Associated Myelofibrosis in a Murine Bone Marrow Transplant Model
  Blood. Jun, 2006  |   Pubmed ID: 16478879
• Block of C/EBP Alpha Function by Phosphorylation in Acute Myeloid Leukemia with FLT3 Activating Mutations
  The Journal of Experimental Medicine. Feb, 2006  |   Pubmed ID: 16446383
• Rare Occurrence of the JAK2 V617F Mutation in AML Subtypes M5, M6, and M7
  Blood. Feb, 2006  |   Pubmed ID: 16434499
• X-inactivation-based Clonality Analysis and Quantitative JAK2V617F Assessment Reveal a Strong Association Between Clonality and JAK2V617F in PV but Not ET/MMM, and Identifies a Subset of JAK2V617F-negative ET and MMM Patients with Clonal Hematopoiesis
  Blood. May, 2006  |   Pubmed ID: 16434490
• The Clinical Phenotype of Wild-type, Heterozygous, and Homozygous JAK2V617F in Polycythemia Vera
  Cancer. Feb, 2006  |   Pubmed ID: 16369984
• Your Health in the 21st Century. Do Stem Cells Cause Cancer?
  Newsweek. 2005  |   Pubmed ID: 16375133
• Expression of a Homodimeric Type I Cytokine Receptor is Required for JAK2V617F-mediated Transformation
  Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005  |   Pubmed ID: 16365288
• JAK2 Mutation in Essential Thrombocythaemia: Clinical Associations and Long-term Prognostic Relevance
  British Journal of Haematology. Oct, 2005  |   Pubmed ID: 16197451
• Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2005  |   Pubmed ID: 16155011
• Mutation Studies in CD3+, CD19+ and CD34+ Cell Fractions in Myeloproliferative Disorders with Homozygous JAK2(V617F) in Granulocytes
  British Journal of Haematology. Sep, 2005  |   Pubmed ID: 16115143
• The JAK2V617F Activating Mutation Occurs in Chronic Myelomonocytic Leukemia and Acute Myeloid Leukemia, but Not in Acute Lymphoblastic Leukemia or Chronic Lymphocytic Leukemia
  Blood. Nov, 2005  |   Pubmed ID: 16081687
• The Small Molecule Tyrosine Kinase Inhibitor AMN107 Inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in Vitro and in Vivo
  Blood. Nov, 2005  |   Pubmed ID: 16030188
• The JAK2V617F Tyrosine Kinase Mutation in Myeloproliferative Disorders: Status Report and Immediate Implications for Disease Classification and Diagnosis
  Mayo Clinic Proceedings. Mayo Clinic. Jul, 2005  |   Pubmed ID: 16007902
• Cancer Biology: Summing Up Cancer Stem Cells
  Nature. Jun, 2005  |   Pubmed ID: 15988505
• Activity of the Tyrosine Kinase Inhibitor PKC412 in a Patient with Mast Cell Leukemia with the D816V KIT Mutation
  Blood. Oct, 2005  |   Pubmed ID: 15972446
• JAK2 in Myeloproliferative Disorders is Not Just Another Kinase
  Cell Cycle (Georgetown, Tex.). Aug, 2005  |   Pubmed ID: 15970705
• Drug Therapy for Acute Myeloid Leukemia
  Blood. Aug, 2005  |   Pubmed ID: 15870183
• The JAK2 V617F Activating Tyrosine Kinase Mutation is an Infrequent Event in Both "atypical" Myeloproliferative Disorders and Myelodysplastic Syndromes
  Blood. Aug, 2005  |   Pubmed ID: 15860661
• Activating Mutation in the Tyrosine Kinase JAK2 in Polycythemia Vera, Essential Thrombocythemia, and Myeloid Metaplasia with Myelofibrosis
  Cancer Cell. Apr, 2005  |   Pubmed ID: 15837627
• Leukaemia Stem Cells and the Evolution of Cancer-stem-cell Research
  Nature Reviews. Cancer. Apr, 2005  |   Pubmed ID: 15803157
• Activation Mutations of Human C-KIT Resistant to Imatinib Mesylate Are Sensitive to the Tyrosine Kinase Inhibitor PKC412
  Blood. Jul, 2005  |   Pubmed ID: 15790786
• Constitutively Activated FGFR3 Mutants Signal Through PLCgamma-dependent and -independent Pathways for Hematopoietic Transformation
  Blood. Jul, 2005  |   Pubmed ID: 15784730
• Loss of Runx1 Perturbs Adult Hematopoiesis and is Associated with a Myeloproliferative Phenotype
  Blood. Jul, 2005  |   Pubmed ID: 15784726
• EGFR Inhibition in Non-small Cell Lung Cancer: Resistance, Once Again, Rears Its Ugly Head
  PLoS Medicine. Mar, 2005  |   Pubmed ID: 15736989
• Prognostic, Therapeutic, and Mechanistic Implications of a Mouse Model of Leukemia Evoked by Shp2 (PTPN11) Mutations
  Cancer Cell. Feb, 2005  |   Pubmed ID: 15710330
• Characterization of AMN107, a Selective Inhibitor of Native and Mutant Bcr-Abl
  Cancer Cell. Feb, 2005  |   Pubmed ID: 15710326
• Global Effects of BCR/ABL and TEL/PDGFRbeta Expression on the Proteome and Phosphoproteome: Identification of the Rho Pathway As a Target of BCR/ABL
  The Journal of Biological Chemistry. Feb, 2005  |   Pubmed ID: 15569670
• KIAA1509 is a Novel PDGFRB Fusion Partner in Imatinib-responsive Myeloproliferative Disease Associated with a T(5;14)(q33;q32)
  Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K. Jan, 2005  |   Pubmed ID: 15496975
• Patients with Acute Myeloid Leukemia and an Activating Mutation in FLT3 Respond to a Small-molecule FLT3 Tyrosine Kinase Inhibitor, PKC412
  Blood. Jan, 2005  |   Pubmed ID: 15345597
• MOZ-TIF2, but Not BCR-ABL, Confers Properties of Leukemic Stem Cells to Committed Murine Hematopoietic Progenitors
  Cancer Cell. Dec, 2004  |   Pubmed ID: 15607963
• The Molecular Basis of Leukemia
  Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2004  |   Pubmed ID: 15561678
• PKC412 Inhibits the Zinc Finger 198-fibroblast Growth Factor Receptor 1 Fusion Tyrosine Kinase and is Active in Treatment of Stem Cell Myeloproliferative Disorder
  Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004  |   Pubmed ID: 15448205
• Blasts from the Past: New Lessons in Stem Cell Biology from Chronic Myelogenous Leukemia
  Cancer Cell. Sep, 2004  |   Pubmed ID: 15380509
• Prediction of Resistance to Small Molecule FLT3 Inhibitors: Implications for Molecularly Targeted Therapy of Acute Leukemia
  Cancer Research. Sep, 2004  |   Pubmed ID: 15374944
• Mouse Model of Noonan Syndrome Reveals Cell Type- and Gene Dosage-dependent Effects of Ptpn11 Mutation
  Nature Medicine. Aug, 2004  |   Pubmed ID: 15273746
• Variable Sensitivity of FLT3 Activation Loop Mutations to the Small Molecule Tyrosine Kinase Inhibitor MLN518
  Blood. Nov, 2004  |   Pubmed ID: 15256420
• Stable Expression of Small Interfering RNA Sensitizes TEL-PDGFbetaR to Inhibition with Imatinib or Rapamycin
  The Journal of Clinical Investigation. Jun, 2004  |   Pubmed ID: 15199413
• Identifying and Characterizing a Novel Activating Mutation of the FLT3 Tyrosine Kinase in AML
  Blood. Sep, 2004  |   Pubmed ID: 15178581
• Platelet-derived Growth Factor Receptor Inhibition to Treat Idiopathic Hypereosinophilic Syndrome
  Seminars in Oncology. Apr, 2004  |   Pubmed ID: 15175999
• The FIP1L1-PDGFRalpha Fusion Tyrosine Kinase in Hypereosinophilic Syndrome and Chronic Eosinophilic Leukemia: Implications for Diagnosis, Classification, and Management
  Blood. Apr, 2004  |   Pubmed ID: 15070659
• Positive and Negative Regulatory Roles of the WW-like Domain in TEL-PDGFbetaR Transformation
  Blood. Jul, 2004  |   Pubmed ID: 15054045
• Oncogenic K-ras in Mouse Models of Myeloproliferative Disease and Acute Myeloid Leukemia
  Cell Cycle (Georgetown, Tex.). May, 2004  |   Pubmed ID: 15020845
• Combination of Rapamycin and Protein Tyrosine Kinase (PTK) Inhibitors for the Treatment of Leukemias Caused by Oncogenic PTKs
  Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004  |   Pubmed ID: 14976243
• Conditional Expression of Oncogenic K-ras from Its Endogenous Promoter Induces a Myeloproliferative Disease
  The Journal of Clinical Investigation. Feb, 2004  |   Pubmed ID: 14966562
• NPM-ALK Fusion Kinase of Anaplastic Large-cell Lymphoma Regulates Survival and Proliferative Signaling Through Modulation of FOXO3a
  Blood. Jun, 2004  |   Pubmed ID: 14962911
• The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis
  Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2004  |   Pubmed ID: 14722044
• The FIP1L1-PDGFRalpha Kinase in Hypereosinophilic Syndrome and Chronic Eosinophilic Leukemia
  Current Opinion in Hematology. Jan, 2004  |   Pubmed ID: 14676627
• The EOL-1 Cell Line As an in Vitro Model for the Study of FIP1L1-PDGFRA-positive Chronic Eosinophilic Leukemia
  Blood. Apr, 2004  |   Pubmed ID: 14630792
• Proteolytic Processing in Development and Leukemogenesis
  Cell. Oct, 2003  |   Pubmed ID: 14636551
• FLT3-activating Mutations in Acute Promyelocytic Leukaemia: a Rationale for Risk-adapted Therapy with FLT3 Inhibitors
  Best Practice & Research. Clinical Haematology. Sep, 2003  |   Pubmed ID: 12935959
• CHIC2 Deletion, a Surrogate for FIP1L1-PDGFRA Fusion, Occurs in Systemic Mastocytosis Associated with Eosinophilia and Predicts Response to Imatinib Mesylate Therapy
  Blood. Nov, 2003  |   Pubmed ID: 12842979
• PKC412 Overcomes Resistance to Imatinib in a Murine Model of FIP1L1-PDGFRα-induced Myeloproliferative Disease
  Cancer Cell. May, 2003  |   Pubmed ID: 12781364
• Elevated Serum Tryptase Levels Identify a Subset of Patients with a Myeloproliferative Variant of Idiopathic Hypereosinophilic Syndrome Associated with Tissue Fibrosis, Poor Prognosis, and Imatinib Responsiveness
  Blood. Jun, 2003  |   Pubmed ID: 12676775
• MOZ-TIF2-induced Acute Myeloid Leukemia Requires the MOZ Nucleosome Binding Motif and TIF2-mediated Recruitment of CBP
  Cancer Cell. Mar, 2003  |   Pubmed ID: 12676584
• A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes As a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome
  The New England Journal of Medicine. Mar, 2003  |   Pubmed ID: 12660384
• A Model of APL with FLT3 Mutation is Responsive to Retinoic Acid and a Receptor Tyrosine Kinase Inhibitor, SU11657
  Blood. Apr, 2003  |   Pubmed ID: 12515727
• The Protein Tyrosine Kinase Inhibitor SU5614 Inhibits FLT3 and Induces Growth Arrest and Apoptosis in AML-derived Cell Lines Expressing a Constitutively Activated FLT3
  Blood. Feb, 2003  |   Pubmed ID: 12406902
• Molecular Genetics of Human Leukemias: New Insights into Therapy
  Seminars in Hematology. Oct, 2002  |   Pubmed ID: 12447846
• Genetics of Myeloid Leukemias
  Annual Review of Genomics and Human Genetics. 2002  |   Pubmed ID: 12194988
• The Roles of FLT3 in Hematopoiesis and Leukemia
  Blood. Sep, 2002  |   Pubmed ID: 12176867
• Inhibition of Mutant FLT3 Receptors in Leukemia Cells by the Small Molecule Tyrosine Kinase Inhibitor PKC412
  Cancer Cell. Jun, 2002  |   Pubmed ID: 12124173
• CT53518, a Novel Selective FLT3 Antagonist for the Treatment of Acute Myelogenous Leukemia (AML)
  Cancer Cell. Jun, 2002  |   Pubmed ID: 12124172
• Focus on Acute Leukemias
  Cancer Cell. Jun, 2002  |   Pubmed ID: 12124171
• Core-binding Factors in Haematopoiesis and Leukaemia
  Nature Reviews. Cancer. Jul, 2002  |   Pubmed ID: 12094236
• Gene Expression Signatures Define Novel Oncogenic Pathways in T Cell Acute Lymphoblastic Leukemia
  Cancer Cell. Feb, 2002  |   Pubmed ID: 12086890
• PML/RARalpha and FLT3-ITD Induce an APL-like Disease in a Mouse Model
  Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002  |   Pubmed ID: 12060771
• Role of FLT3 in Leukemia
  Current Opinion in Hematology. Jul, 2002  |   Pubmed ID: 12042700
• The Tel-Abl (ETV6-Abl) Tyrosine Kinase, Product of Complex (9;12) Translocations in Human Leukemia, Induces Distinct Myeloproliferative Disease in Mice
  Blood. Jun, 2002  |   Pubmed ID: 12036890
• A Murine Model of CML Blast Crisis Induced by Cooperation Between BCR/ABL and NUP98/HOXA9
  Proceedings of the National Academy of Sciences of the United States of America. May, 2002  |   Pubmed ID: 12032333
• Evaluation of the Risk of Therapy-related MDS/AML After Autologous Stem Cell Transplantation
  Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 2002  |   Pubmed ID: 11846355
• Comprehensive Genotypic Analysis of Leukemia: Clinical and Therapeutic Implications
  Current Opinion in Oncology. Jan, 2002  |   Pubmed ID: 11790974
• FLT3 Internal Tandem Duplication Mutations Associated with Human Acute Myeloid Leukemias Induce Myeloproliferative Disease in a Murine Bone Marrow Transplant Model
  Blood. Jan, 2002  |   Pubmed ID: 11756186