D. Gary Gilliland Department of Hematology and Oncology Brigham and Women's Hospital and Harvard Medical School Biography Publications Institution JoVE Articles D. Gary Gilliland has not added a biography. If you are D. Gary Gilliland and would like to personalize this page please email our Author Liaison for assistance. Publications A Functional Role For The Histone Demethylase Utx In Normal And Malignant Hematopoietic Cells Experimental Hematology. Feb, 2012 | Pubmed ID: 22306297 KIT with D816 Mutations Cooperates with CBFB-MYH11 for Leukemogenesis in Mice Blood. Feb, 2012 | Pubmed ID: 22160378 AKT/FOXO Signaling Enforces Reversible Differentiation Blockade in Myeloid Leukemias Cell. Sep, 2011 | Pubmed ID: 21884932 Coordinate Loss of a MicroRNA and Protein-coding Gene Cooperate in the Pathogenesis of 5q- Syndrome Blood. Oct, 2011 | Pubmed ID: 21873545 Differential Niche and Wnt Requirements During Acute Myeloid Leukemia Progression Blood. Sep, 2011 | Pubmed ID: 21765021 Crosstalk Between NOTCH and AKT Signaling During Murine Megakaryocyte Lineage Specification Blood. Aug, 2011 | Pubmed ID: 21653327 Common and Overlapping Oncogenic Pathways Contribute to the Evolution of Acute Myeloid Leukemias Cancer Research. Jun, 2011 | Pubmed ID: 21505102 Safety and Efficacy of TG101348, a Selective JAK2 Inhibitor, in Myelofibrosis Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Mar, 2011 | Pubmed ID: 21220608 MTOR Activation Induces Tumor Suppressors That Inhibit Leukemogenesis and Deplete Hematopoietic Stem Cells After Pten Deletion Cell Stem Cell. Nov, 2010 | Pubmed ID: 21040901 Phase IIB Trial of Oral Midostaurin (PKC412), the FMS-like Tyrosine Kinase 3 Receptor (FLT3) and Multi-targeted Kinase Inhibitor, in Patients with Acute Myeloid Leukemia and High-risk Myelodysplastic Syndrome with Either Wild-type or Mutated FLT3 Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Oct, 2010 | Pubmed ID: 20733134 Musashi-2 Regulates Normal Hematopoiesis and Promotes Aggressive Myeloid Leukemia Nature Medicine. Aug, 2010 | Pubmed ID: 20616797 Transcriptional Profiling of Polycythemia Vera Identifies Gene Expression Patterns Both Dependent and Independent from the Action of JAK2V617F Clinical Cancer Research : an Official Journal of the American Association for Cancer Research. Sep, 2010 | Pubmed ID: 20601445 Physiological Jak2V617F Expression Causes a Lethal Myeloproliferative Neoplasm with Differential Effects on Hematopoietic Stem and Progenitor Cells Cancer Cell. Jun, 2010 | Pubmed ID: 20541703 Hematopoietic Stem Cell Defects in Mice with Deficiency of Fancd2 or Usp1 Stem Cells (Dayton, Ohio). Jul, 2010 | Pubmed ID: 20506303 Cdx4 is Dispensable for Murine Adult Hematopoietic Stem Cells but Promotes MLL-AF9-mediated Leukemogenesis Haematologica. Oct, 2010 | Pubmed ID: 20494928 The Apc(min) Mouse Has Altered Hematopoietic Stem Cell Function and Provides a Model for MPD/MDS Blood. Apr, 2010 | Pubmed ID: 20197553 Prevalence and Prognostic Impact of Allelic Imbalances Associated with Leukemic Transformation of Philadelphia Chromosome-negative Myeloproliferative Neoplasms Blood. Apr, 2010 | Pubmed ID: 20068225 Leukemia Stem Cells Seminars in Cancer Biology. Apr, 2010 | Pubmed ID: 20026405 Constitutively Active AKT Depletes Hematopoietic Stem Cells and Induces Leukemia in Mice Blood. Feb, 2010 | Pubmed ID: 20008787 Tyrosine Phosphorylation Inhibits PKM2 to Promote the Warburg Effect and Tumor Growth Science Signaling. 2009 | Pubmed ID: 19920251 Direct Inhibition of the NOTCH Transcription Factor Complex Nature. Nov, 2009 | Pubmed ID: 19907488 Systematic RNA Interference Reveals That Oncogenic KRAS-driven Cancers Require TBK1 Nature. Nov, 2009 | Pubmed ID: 19847166 A Progenitor Cell Origin of Myeloid Malignancies Proceedings of the National Academy of Sciences of the United States of America. Sep, 2009 | Pubmed ID: 19805346 [The OTT-MAL Fusion Oncogene: Another Notch in Megakaryoblastic Leukemia] Médecine Sciences : M/S. Aug-Sep, 2009 | Pubmed ID: 19765378 Hedgehog Signaling is Dispensable for Adult Murine Hematopoietic Stem Cell Function and Hematopoiesis Cell Stem Cell. Jun, 2009 | Pubmed ID: 19497284 Synthetic Lethal Interaction Between Oncogenic KRAS Dependency and STK33 Suppression in Human Cancer Cells Cell. May, 2009 | Pubmed ID: 19490892 Genetic Characterization of TET1, TET2, and TET3 Alterations in Myeloid Malignancies Blood. Jul, 2009 | Pubmed ID: 19420352 The Leukemic Stem Cell Niche: Current Concepts and Therapeutic Opportunities Blood. Aug, 2009 | Pubmed ID: 19401558 A Germline JAK2 SNP is Associated with Predisposition to the Development of JAK2(V617F)-positive Myeloproliferative Neoplasms Nature Genetics. Apr, 2009 | Pubmed ID: 19287384 The OTT-MAL Fusion Oncogene Activates RBPJ-mediated Transcription and Induces Acute Megakaryoblastic Leukemia in a Knockin Mouse Model The Journal of Clinical Investigation. Apr, 2009 | Pubmed ID: 19287095 A Radical Bailout Strategy for Cancer Stem Cells Cell Stem Cell. Mar, 2009 | Pubmed ID: 19265655 Skewing of X-inactivation Ratios in Blood Cells of Aging Women is Confirmed by Independent Methodologies Blood. Apr, 2009 | Pubmed ID: 19202126 Constitutive JAK3 Activation Induces Lymphoproliferative Syndromes in Murine Bone Marrow Transplantation Models Blood. Mar, 2009 | Pubmed ID: 19139084 High-throughput Sequencing Screen Reveals Novel, Transforming RAS Mutations in Myeloid Leukemia Patients Blood. Feb, 2009 | Pubmed ID: 19075190 Ott1 (Rbm15) is Essential for Placental Vascular Branching Morphogenesis and Embryonic Development of the Heart and Spleen Molecular and Cellular Biology. Jan, 2009 | Pubmed ID: 18981216 Activating Mutations in ALK Provide a Therapeutic Target in Neuroblastoma Nature. Oct, 2008 | Pubmed ID: 18923525 Going with the Flow: JAK-STAT Signaling in JMML Cancer Cell. Oct, 2008 | Pubmed ID: 18835028 Notch Signaling Specifies Megakaryocyte Development from Hematopoietic Stem Cells Cell Stem Cell. Sep, 2008 | Pubmed ID: 18786418 Myeloproliferative Disorders Blood. Sep, 2008 | Pubmed ID: 18779404 Genetic Profiling of Myeloproliferative Disorders by Single-nucleotide Polymorphism Oligonucleotide Microarray Experimental Hematology. Nov, 2008 | Pubmed ID: 18723266 Deregulation of Signaling Pathways in Acute Myeloid Leukemia Seminars in Oncology. Aug, 2008 | Pubmed ID: 18692684 K-RasG12D-induced T-cell Lymphoblastic Lymphoma/leukemias Harbor Notch1 Mutations and Are Sensitive to Gamma-secretase Inhibitors Blood. Oct, 2008 | Pubmed ID: 18663146 Kinase Activation and Transformation by NUP214-ABL1 is Dependent on the Context of the Nuclear Pore Molecular Cell. Jul, 2008 | Pubmed ID: 18614052 Id1 is a Common Downstream Target of Oncogenic Tyrosine Kinases in Leukemic Cells Blood. Sep, 2008 | Pubmed ID: 18559972 Efficacy of TG101348, a Selective JAK2 Inhibitor, in Treatment of a Murine Model of JAK2V617F-induced Polycythemia Vera Cancer Cell. Apr, 2008 | Pubmed ID: 18394554 Structural and Numerical Variation of FLT3/ITD in Pediatric AML Blood. May, 2008 | Pubmed ID: 18305215 High-throughput Sequence Analysis of the Tyrosine Kinome in Acute Myeloid Leukemia Blood. May, 2008 | Pubmed ID: 18252861 The Jak2V617F Oncogene Associated with Myeloproliferative Diseases Requires a Functional FERM Domain for Transformation and for Expression of the Myc and Pim Proto-oncogenes Blood. Apr, 2008 | Pubmed ID: 18216297 SOS1 Mutations Are Rare in Human Malignancies: Implications for Noonan Syndrome Patients Genes, Chromosomes & Cancer. Mar, 2008 | Pubmed ID: 18064648 Host Genetic Variation Contributes to Phenotypic Diversity in Myeloproliferative Disorders Blood. Mar, 2008 | Pubmed ID: 18006699 PU.1 is a Major Downstream Target of AML1 (RUNX1) in Adult Mouse Hematopoiesis Nature Genetics. Jan, 2008 | Pubmed ID: 17994017 A Role for JAK2 Mutations in Myeloproliferative Diseases Annual Review of Medicine. 2008 | Pubmed ID: 17919086 FoxO Transcription Factors and Stem Cell Homeostasis: Insights from the Hematopoietic System Cell Stem Cell. Aug, 2007 | Pubmed ID: 18371346 Identification of Driver and Passenger Mutations of FLT3 by High-throughput DNA Sequence Analysis and Functional Assessment of Candidate Alleles Cancer Cell. Dec, 2007 | Pubmed ID: 18068628 FLT3 Mutations Confer Enhanced Proliferation and Survival Properties to Multipotent Progenitors in a Murine Model of Chronic Myelomonocytic Leukemia Cancer Cell. Oct, 2007 | Pubmed ID: 17936561 Uniform Sensitivity of FLT3 Activation Loop Mutants to the Tyrosine Kinase Inhibitor Midostaurin Blood. Dec, 2007 | Pubmed ID: 17827387 FGFR3 Activates RSK2 to Mediate Hematopoietic Transformation Through Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway Cancer Cell. Sep, 2007 | Pubmed ID: 17785202 Role of JAK2 in the Pathogenesis and Therapy of Myeloproliferative Disorders Nature Reviews. Cancer. Sep, 2007 | Pubmed ID: 17721432 Highly Sensitive Method for Genomewide Detection of Allelic Composition in Nonpaired, Primary Tumor Specimens by Use of Affymetrix Single-nucleotide-polymorphism Genotyping Microarrays American Journal of Human Genetics. Jul, 2007 | Pubmed ID: 17564968 Proposals and Rationale for Revision of the World Health Organization Diagnostic Criteria for Polycythemia Vera, Essential Thrombocythemia, and Primary Myelofibrosis: Recommendations from an Ad Hoc International Expert Panel Blood. Aug, 2007 | Pubmed ID: 17488875 Ott1(Rbm15) Has Pleiotropic Roles in Hematopoietic Development Proceedings of the National Academy of Sciences of the United States of America. Apr, 2007 | Pubmed ID: 17376872 A Novel Fusion of RBM6 to CSF1R in Acute Megakaryoblastic Leukemia Blood. Jul, 2007 | Pubmed ID: 17360941 Oncogenes in Myeloproliferative Disorders Cell Cycle (Georgetown, Tex.). Mar, 2007 | Pubmed ID: 17351342 The Homeobox Gene CDX2 is Aberrantly Expressed in Most Cases of Acute Myeloid Leukemia and Promotes Leukemogenesis The Journal of Clinical Investigation. Apr, 2007 | Pubmed ID: 17347684 The Retinoblastoma Binding Protein RBP2 is an H3K4 Demethylase Cell. Mar, 2007 | Pubmed ID: 17320163 JAK2 Exon 12 Mutations in Polycythemia Vera and Idiopathic Erythrocytosis The New England Journal of Medicine. Feb, 2007 | Pubmed ID: 17267906 FoxOs Are Critical Mediators of Hematopoietic Stem Cell Resistance to Physiologic Oxidative Stress Cell. Jan, 2007 | Pubmed ID: 17254970 FoxOs Are Lineage-restricted Redundant Tumor Suppressors and Regulate Endothelial Cell Homeostasis Cell. Jan, 2007 | Pubmed ID: 17254969 Jak2: Normal Function and Role in Hematopoietic Disorders Current Opinion in Genetics & Development. Feb, 2007 | Pubmed ID: 17208428 JAK-2 Mutations and Their Relevance to Myeloproliferative Disease Current Opinion in Hematology. Jan, 2007 | Pubmed ID: 17133099 The JAK2(V617F) Tyrosine Kinase Mutation in Myeloproliferative Disorders: Summary of Published Literature and a Perspective Current Hematologic Malignancy Reports. Jun, 2006 | Pubmed ID: 20425335 Concurrent MPL515 and JAK2V617F Mutations in Myelofibrosis: Chronology of Clonal Emergence and Changes in Mutant Allele Burden over Time British Journal of Haematology. Dec, 2006 | Pubmed ID: 17107350 Cdx4 Dysregulates Hox Gene Expression and Generates Acute Myeloid Leukemia Alone and in Cooperation with Meis1a in a Murine Model Proceedings of the National Academy of Sciences of the United States of America. Nov, 2006 | Pubmed ID: 17068127 MPL515 Mutations in Myeloproliferative and Other Myeloid Disorders: a Study of 1182 Patients Blood. Nov, 2006 | Pubmed ID: 16868251 Transformation from Committed Progenitor to Leukaemia Stem Cell Initiated by MLL-AF9 Nature. Aug, 2006 | Pubmed ID: 16862118 Activating Alleles of JAK3 in Acute Megakaryoblastic Leukemia Cancer Cell. Jul, 2006 | Pubmed ID: 16843266 Cell-autonomous and -nonautonomous Contributions of STAT1 in Murine Models of Tumorigenesis Cancer Cell. Jul, 2006 | Pubmed ID: 16843258 MPLW515L is a Novel Somatic Activating Mutation in Myelofibrosis with Myeloid Metaplasia PLoS Medicine. Jul, 2006 | Pubmed ID: 16834459 JAK2T875N is a Novel Activating Mutation That Results in Myeloproliferative Disease with Features of Megakaryoblastic Leukemia in a Murine Bone Marrow Transplantation Model Blood. Oct, 2006 | Pubmed ID: 16804112 Eosinophilic Disorders: Molecular Pathogenesis, New Classification, and Modern Therapy Best Practice & Research. Clinical Haematology. 2006 | Pubmed ID: 16781488 Activation of FIP1L1-PDGFRalpha Requires Disruption of the Juxtamembrane Domain of PDGFRalpha and is FIP1L1-independent Proceedings of the National Academy of Sciences of the United States of America. May, 2006 | Pubmed ID: 16690743 International Working Group (IWG) Consensus Criteria for Treatment Response in Myelofibrosis with Myeloid Metaplasia, for the IWG for Myelofibrosis Research and Treatment (IWG-MRT) Blood. Sep, 2006 | Pubmed ID: 16675707 Oncogenic K-ras Cooperates with PML-RAR Alpha to Induce an Acute Promyelocytic Leukemia-like Disease Blood. Sep, 2006 | Pubmed ID: 16675706 Roles of Tyrosine 589 and 591 in STAT5 Activation and Transformation Mediated by FLT3-ITD Blood. Aug, 2006 | Pubmed ID: 16627759 Absence of the Transcription Factor CCAAT Enhancer Binding Protein Alpha Results in Loss of Myeloid Identity in Bcr/abl-induced Malignancy Proceedings of the National Academy of Sciences of the United States of America. Apr, 2006 | Pubmed ID: 16606850 Detection of the FIP1L1-PDGFRA Fusion in Idiopathic Hypereosinophilic Syndrome and Chronic Eosinophilic Leukemia Methods in Molecular Medicine. 2006 | Pubmed ID: 16502585 Prospective Analysis of TEL/AML1-positive Patients Treated on Dana-Farber Cancer Institute Consortium Protocol 95-01 Blood. Jun, 2006 | Pubmed ID: 16493009 Expression of Jak2V617F Causes a Polycythemia Vera-like Disease with Associated Myelofibrosis in a Murine Bone Marrow Transplant Model Blood. Jun, 2006 | Pubmed ID: 16478879 Block of C/EBP Alpha Function by Phosphorylation in Acute Myeloid Leukemia with FLT3 Activating Mutations The Journal of Experimental Medicine. Feb, 2006 | Pubmed ID: 16446383 Rare Occurrence of the JAK2 V617F Mutation in AML Subtypes M5, M6, and M7 Blood. Feb, 2006 | Pubmed ID: 16434499 X-inactivation-based Clonality Analysis and Quantitative JAK2V617F Assessment Reveal a Strong Association Between Clonality and JAK2V617F in PV but Not ET/MMM, and Identifies a Subset of JAK2V617F-negative ET and MMM Patients with Clonal Hematopoiesis Blood. May, 2006 | Pubmed ID: 16434490 The Clinical Phenotype of Wild-type, Heterozygous, and Homozygous JAK2V617F in Polycythemia Vera Cancer. Feb, 2006 | Pubmed ID: 16369984 Your Health in the 21st Century. Do Stem Cells Cause Cancer? Newsweek. 2005 | Pubmed ID: 16375133 Expression of a Homodimeric Type I Cytokine Receptor is Required for JAK2V617F-mediated Transformation Proceedings of the National Academy of Sciences of the United States of America. Dec, 2005 | Pubmed ID: 16365288 JAK2 Mutation in Essential Thrombocythaemia: Clinical Associations and Long-term Prognostic Relevance British Journal of Haematology. Oct, 2005 | Pubmed ID: 16197451 Genetics of Myeloid Malignancies: Pathogenetic and Clinical Implications Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Sep, 2005 | Pubmed ID: 16155011 Mutation Studies in CD3+, CD19+ and CD34+ Cell Fractions in Myeloproliferative Disorders with Homozygous JAK2(V617F) in Granulocytes British Journal of Haematology. Sep, 2005 | Pubmed ID: 16115143 The JAK2V617F Activating Mutation Occurs in Chronic Myelomonocytic Leukemia and Acute Myeloid Leukemia, but Not in Acute Lymphoblastic Leukemia or Chronic Lymphocytic Leukemia Blood. Nov, 2005 | Pubmed ID: 16081687 The Small Molecule Tyrosine Kinase Inhibitor AMN107 Inhibits TEL-PDGFRbeta and FIP1L1-PDGFRalpha in Vitro and in Vivo Blood. Nov, 2005 | Pubmed ID: 16030188 The JAK2V617F Tyrosine Kinase Mutation in Myeloproliferative Disorders: Status Report and Immediate Implications for Disease Classification and Diagnosis Mayo Clinic Proceedings. Mayo Clinic. Jul, 2005 | Pubmed ID: 16007902 Cancer Biology: Summing Up Cancer Stem Cells Nature. Jun, 2005 | Pubmed ID: 15988505 Activity of the Tyrosine Kinase Inhibitor PKC412 in a Patient with Mast Cell Leukemia with the D816V KIT Mutation Blood. Oct, 2005 | Pubmed ID: 15972446 JAK2 in Myeloproliferative Disorders is Not Just Another Kinase Cell Cycle (Georgetown, Tex.). Aug, 2005 | Pubmed ID: 15970705 Drug Therapy for Acute Myeloid Leukemia Blood. Aug, 2005 | Pubmed ID: 15870183 The JAK2 V617F Activating Tyrosine Kinase Mutation is an Infrequent Event in Both "atypical" Myeloproliferative Disorders and Myelodysplastic Syndromes Blood. Aug, 2005 | Pubmed ID: 15860661 Activating Mutation in the Tyrosine Kinase JAK2 in Polycythemia Vera, Essential Thrombocythemia, and Myeloid Metaplasia with Myelofibrosis Cancer Cell. Apr, 2005 | Pubmed ID: 15837627 Leukaemia Stem Cells and the Evolution of Cancer-stem-cell Research Nature Reviews. Cancer. Apr, 2005 | Pubmed ID: 15803157 Activation Mutations of Human C-KIT Resistant to Imatinib Mesylate Are Sensitive to the Tyrosine Kinase Inhibitor PKC412 Blood. Jul, 2005 | Pubmed ID: 15790786 Constitutively Activated FGFR3 Mutants Signal Through PLCgamma-dependent and -independent Pathways for Hematopoietic Transformation Blood. Jul, 2005 | Pubmed ID: 15784730 Loss of Runx1 Perturbs Adult Hematopoiesis and is Associated with a Myeloproliferative Phenotype Blood. Jul, 2005 | Pubmed ID: 15784726 EGFR Inhibition in Non-small Cell Lung Cancer: Resistance, Once Again, Rears Its Ugly Head PLoS Medicine. Mar, 2005 | Pubmed ID: 15736989 Prognostic, Therapeutic, and Mechanistic Implications of a Mouse Model of Leukemia Evoked by Shp2 (PTPN11) Mutations Cancer Cell. Feb, 2005 | Pubmed ID: 15710330 Characterization of AMN107, a Selective Inhibitor of Native and Mutant Bcr-Abl Cancer Cell. Feb, 2005 | Pubmed ID: 15710326 Global Effects of BCR/ABL and TEL/PDGFRbeta Expression on the Proteome and Phosphoproteome: Identification of the Rho Pathway As a Target of BCR/ABL The Journal of Biological Chemistry. Feb, 2005 | Pubmed ID: 15569670 KIAA1509 is a Novel PDGFRB Fusion Partner in Imatinib-responsive Myeloproliferative Disease Associated with a T(5;14)(q33;q32) Leukemia : Official Journal of the Leukemia Society of America, Leukemia Research Fund, U.K. Jan, 2005 | Pubmed ID: 15496975 Patients with Acute Myeloid Leukemia and an Activating Mutation in FLT3 Respond to a Small-molecule FLT3 Tyrosine Kinase Inhibitor, PKC412 Blood. Jan, 2005 | Pubmed ID: 15345597 MOZ-TIF2, but Not BCR-ABL, Confers Properties of Leukemic Stem Cells to Committed Murine Hematopoietic Progenitors Cancer Cell. Dec, 2004 | Pubmed ID: 15607963 The Molecular Basis of Leukemia Hematology / the Education Program of the American Society of Hematology. American Society of Hematology. Education Program. 2004 | Pubmed ID: 15561678 PKC412 Inhibits the Zinc Finger 198-fibroblast Growth Factor Receptor 1 Fusion Tyrosine Kinase and is Active in Treatment of Stem Cell Myeloproliferative Disorder Proceedings of the National Academy of Sciences of the United States of America. Oct, 2004 | Pubmed ID: 15448205 Blasts from the Past: New Lessons in Stem Cell Biology from Chronic Myelogenous Leukemia Cancer Cell. Sep, 2004 | Pubmed ID: 15380509 Prediction of Resistance to Small Molecule FLT3 Inhibitors: Implications for Molecularly Targeted Therapy of Acute Leukemia Cancer Research. Sep, 2004 | Pubmed ID: 15374944 Mouse Model of Noonan Syndrome Reveals Cell Type- and Gene Dosage-dependent Effects of Ptpn11 Mutation Nature Medicine. Aug, 2004 | Pubmed ID: 15273746 Variable Sensitivity of FLT3 Activation Loop Mutations to the Small Molecule Tyrosine Kinase Inhibitor MLN518 Blood. Nov, 2004 | Pubmed ID: 15256420 Stable Expression of Small Interfering RNA Sensitizes TEL-PDGFbetaR to Inhibition with Imatinib or Rapamycin The Journal of Clinical Investigation. Jun, 2004 | Pubmed ID: 15199413 Identifying and Characterizing a Novel Activating Mutation of the FLT3 Tyrosine Kinase in AML Blood. Sep, 2004 | Pubmed ID: 15178581 Platelet-derived Growth Factor Receptor Inhibition to Treat Idiopathic Hypereosinophilic Syndrome Seminars in Oncology. Apr, 2004 | Pubmed ID: 15175999 The FIP1L1-PDGFRalpha Fusion Tyrosine Kinase in Hypereosinophilic Syndrome and Chronic Eosinophilic Leukemia: Implications for Diagnosis, Classification, and Management Blood. Apr, 2004 | Pubmed ID: 15070659 Positive and Negative Regulatory Roles of the WW-like Domain in TEL-PDGFbetaR Transformation Blood. Jul, 2004 | Pubmed ID: 15054045 Oncogenic K-ras in Mouse Models of Myeloproliferative Disease and Acute Myeloid Leukemia Cell Cycle (Georgetown, Tex.). May, 2004 | Pubmed ID: 15020845 Combination of Rapamycin and Protein Tyrosine Kinase (PTK) Inhibitors for the Treatment of Leukemias Caused by Oncogenic PTKs Proceedings of the National Academy of Sciences of the United States of America. Mar, 2004 | Pubmed ID: 14976243 Conditional Expression of Oncogenic K-ras from Its Endogenous Promoter Induces a Myeloproliferative Disease The Journal of Clinical Investigation. Feb, 2004 | Pubmed ID: 14966562 NPM-ALK Fusion Kinase of Anaplastic Large-cell Lymphoma Regulates Survival and Proliferative Signaling Through Modulation of FOXO3a Blood. Jun, 2004 | Pubmed ID: 14962911 The Role of Signal Transducer and Activator of Transcription Factors in Leukemogenesis Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology. Jan, 2004 | Pubmed ID: 14722044 The FIP1L1-PDGFRalpha Kinase in Hypereosinophilic Syndrome and Chronic Eosinophilic Leukemia Current Opinion in Hematology. Jan, 2004 | Pubmed ID: 14676627 The EOL-1 Cell Line As an in Vitro Model for the Study of FIP1L1-PDGFRA-positive Chronic Eosinophilic Leukemia Blood. Apr, 2004 | Pubmed ID: 14630792 Proteolytic Processing in Development and Leukemogenesis Cell. Oct, 2003 | Pubmed ID: 14636551 FLT3-activating Mutations in Acute Promyelocytic Leukaemia: a Rationale for Risk-adapted Therapy with FLT3 Inhibitors Best Practice & Research. Clinical Haematology. Sep, 2003 | Pubmed ID: 12935959 CHIC2 Deletion, a Surrogate for FIP1L1-PDGFRA Fusion, Occurs in Systemic Mastocytosis Associated with Eosinophilia and Predicts Response to Imatinib Mesylate Therapy Blood. Nov, 2003 | Pubmed ID: 12842979 PKC412 Overcomes Resistance to Imatinib in a Murine Model of FIP1L1-PDGFRα-induced Myeloproliferative Disease Cancer Cell. May, 2003 | Pubmed ID: 12781364 Elevated Serum Tryptase Levels Identify a Subset of Patients with a Myeloproliferative Variant of Idiopathic Hypereosinophilic Syndrome Associated with Tissue Fibrosis, Poor Prognosis, and Imatinib Responsiveness Blood. Jun, 2003 | Pubmed ID: 12676775 MOZ-TIF2-induced Acute Myeloid Leukemia Requires the MOZ Nucleosome Binding Motif and TIF2-mediated Recruitment of CBP Cancer Cell. Mar, 2003 | Pubmed ID: 12676584 A Tyrosine Kinase Created by Fusion of the PDGFRA and FIP1L1 Genes As a Therapeutic Target of Imatinib in Idiopathic Hypereosinophilic Syndrome The New England Journal of Medicine. Mar, 2003 | Pubmed ID: 12660384 A Model of APL with FLT3 Mutation is Responsive to Retinoic Acid and a Receptor Tyrosine Kinase Inhibitor, SU11657 Blood. Apr, 2003 | Pubmed ID: 12515727 The Protein Tyrosine Kinase Inhibitor SU5614 Inhibits FLT3 and Induces Growth Arrest and Apoptosis in AML-derived Cell Lines Expressing a Constitutively Activated FLT3 Blood. Feb, 2003 | Pubmed ID: 12406902 Molecular Genetics of Human Leukemias: New Insights into Therapy Seminars in Hematology. Oct, 2002 | Pubmed ID: 12447846 Genetics of Myeloid Leukemias Annual Review of Genomics and Human Genetics. 2002 | Pubmed ID: 12194988 The Roles of FLT3 in Hematopoiesis and Leukemia Blood. Sep, 2002 | Pubmed ID: 12176867 Inhibition of Mutant FLT3 Receptors in Leukemia Cells by the Small Molecule Tyrosine Kinase Inhibitor PKC412 Cancer Cell. Jun, 2002 | Pubmed ID: 12124173 CT53518, a Novel Selective FLT3 Antagonist for the Treatment of Acute Myelogenous Leukemia (AML) Cancer Cell. Jun, 2002 | Pubmed ID: 12124172 Focus on Acute Leukemias Cancer Cell. Jun, 2002 | Pubmed ID: 12124171 Core-binding Factors in Haematopoiesis and Leukaemia Nature Reviews. Cancer. Jul, 2002 | Pubmed ID: 12094236 Gene Expression Signatures Define Novel Oncogenic Pathways in T Cell Acute Lymphoblastic Leukemia Cancer Cell. Feb, 2002 | Pubmed ID: 12086890 PML/RARalpha and FLT3-ITD Induce an APL-like Disease in a Mouse Model Proceedings of the National Academy of Sciences of the United States of America. Jun, 2002 | Pubmed ID: 12060771 Role of FLT3 in Leukemia Current Opinion in Hematology. Jul, 2002 | Pubmed ID: 12042700 The Tel-Abl (ETV6-Abl) Tyrosine Kinase, Product of Complex (9;12) Translocations in Human Leukemia, Induces Distinct Myeloproliferative Disease in Mice Blood. Jun, 2002 | Pubmed ID: 12036890 A Murine Model of CML Blast Crisis Induced by Cooperation Between BCR/ABL and NUP98/HOXA9 Proceedings of the National Academy of Sciences of the United States of America. May, 2002 | Pubmed ID: 12032333 Evaluation of the Risk of Therapy-related MDS/AML After Autologous Stem Cell Transplantation Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation. 2002 | Pubmed ID: 11846355 Comprehensive Genotypic Analysis of Leukemia: Clinical and Therapeutic Implications Current Opinion in Oncology. Jan, 2002 | Pubmed ID: 11790974 FLT3 Internal Tandem Duplication Mutations Associated with Human Acute Myeloid Leukemias Induce Myeloproliferative Disease in a Murine Bone Marrow Transplant Model Blood. Jan, 2002 | Pubmed ID: 11756186 Isolamento de Células-Tronco Hematopoéticas início de murino saco vitelino e AGM Kelly Morgan1, Michael Kharas1, Elaine Dzierzak2, D. Gary Gilliland1,3 1Department of Hematology and Oncology, Brigham and Women's Hospital and Harvard Medical School, 2Department of Cell Biology and Genetics, Erasmus University Medical Center, 3Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital and Harvard Medical School JoVE 789 Biology
Isolamento de Células-Tronco Hematopoéticas início de murino saco vitelino e AGM Kelly Morgan1, Michael Kharas1, Elaine Dzierzak2, D. Gary Gilliland1,3 1Department of Hematology and Oncology, Brigham and Women's Hospital and Harvard Medical School, 2Department of Cell Biology and Genetics, Erasmus University Medical Center, 3Department of Medicine, Howard Hughes Medical Institute, Brigham and Women's Hospital and Harvard Medical School JoVE 789 Biology