Da-Zhi Wang Department of Cardiology Boston Children's Hospital Biography Publications Institution JoVE Articles Da-Zhi Wang has not added a biography. If you are Da-Zhi Wang and would like to personalize this page please email our Author Liaison for assistance. Publications How Cardiomyocytes Sense Pathophysiological Stresses for Cardiac Remodeling Cellular and Molecular Life Sciences : CMLS. Oct, 2016 | Pubmed ID: 27714411 Comparative Transcriptomic Analysis Reveals Novel Insights into the Adaptive Response of Skeletonema Costatum to Changing Ambient Phosphorus Frontiers in Microbiology. 2016 | Pubmed ID: 27703451 (MYO)SLIDing Our Way Into the Vascular Pool of Long Noncoding RNAs Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2016 | Pubmed ID: 27655778 Long Non-coding RNAs Link Extracellular Matrix Gene Expression to Ischemic Cardiomyopathy Cardiovascular Research. Aug, 2016 | Pubmed ID: 27557636 Environmental Microbial Community Proteomics: Status, Challenges and Perspectives International Journal of Molecular Sciences. Aug, 2016 | Pubmed ID: 27527164 Regulation of Skeletal Muscle by MicroRNAs Comprehensive Physiology. Jun, 2016 | Pubmed ID: 27347893 Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle PloS One. 2016 | Pubmed ID: 27159388 Paralytic Shellfish Toxin Biosynthesis in Cyanobacteria and Dinoflagellates: A Molecular Overview Journal of Proteomics. Mar, 2016 | Pubmed ID: 26316331 Mystery of Trbp, Tale of a RBP in the MiRNA Pathway Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 26496166 Cardiomyocyte-enriched Protein CIP Protects Against Pathophysiological Stresses and Regulates Cardiac Homeostasis The Journal of Clinical Investigation. Nov, 2015 | Pubmed ID: 26436652 ITRAQ-based Quantitative Proteomic Analysis of a Toxigenic Dinoflagellate Alexandrium Catenella and Its Non-toxic Mutant Proteomics. Dec, 2015 | Pubmed ID: 26417864 Differential Diagnosis of Malignant Biliary Tract Cancer from Benign Tissues Using Apparent Diffusion Coefficient Measurements with Diffusion Weighted Imaging in Asians Asian Pacific Journal of Cancer Prevention : APJCP. 2015 | Pubmed ID: 26320508 Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases BioMed Research International. 2015 | Pubmed ID: 26258142 Trbp Regulates Heart Function Through MicroRNA-mediated Sox6 Repression Nature Genetics. Jul, 2015 | Pubmed ID: 26029872 Novel Roles of GATA4/6 in the Postnatal Heart Identified Through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase PloS One. 2015 | Pubmed ID: 26023924 Comparative Proteomics Reveals Highly and Differentially Expressed Proteins in Field-collected and Laboratory-cultured Blooming Cells of the Diatom Skeletonema Costatum Environmental Microbiology. Oct, 2015 | Pubmed ID: 26014042 Proteomic Analysis Provides New Insights into the Adaptive Response of a Dinoflagellate Prorocentrum Donghaiense to Changing Ambient Nitrogen Plant, Cell & Environment. Oct, 2015 | Pubmed ID: 25789726 Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival Circulation Research. Jan, 2015 | Pubmed ID: 25249570 Comparative Transcriptome Analysis of a Toxin-producing Dinoflagellate Alexandrium Catenella and Its Non-toxic Mutant Marine Drugs. Nov, 2014 | Pubmed ID: 25421324 The Myriad Essential Roles of MicroRNAs in Cardiovascular Homeostasis and Disease Genes & Diseases. Mar, 2014 | Pubmed ID: 25328909 An Epigenetic "LINK(RNA)" to Pathological Cardiac Hypertrophy Cell Metabolism. Oct, 2014 | Pubmed ID: 25295782 MiR-22 in Cardiac Remodeling and Disease Trends in Cardiovascular Medicine. Oct, 2014 | Pubmed ID: 25218673 Generation of a Cre Knock-in into the Myocardin Locus to Mark Early Cardiac and Smooth Muscle Cell Lineages Genesis (New York, N.Y. : 2000). Oct, 2014 | Pubmed ID: 25174608 LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing P53 Activity Circulation. Oct, 2014 | Pubmed ID: 25156994 Non-Coding RNAs Including MiRNAs and LncRNAs in Cardiovascular Biology and Disease Cells. Aug, 2014 | Pubmed ID: 25153164 Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model Circulation Research. Jul, 2014 | Pubmed ID: 24833660 Modeling the Mitochondrial Cardiomyopathy of Barth Syndrome with Induced Pluripotent Stem Cell and Heart-on-chip Technologies Nature Medicine. Jun, 2014 | Pubmed ID: 24813252 Crystallin-αB Regulates Skeletal Muscle Homeostasis Via Modulation of Argonaute2 Activity The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24782307 Loss of MicroRNA-155 Protects the Heart from Pathological Cardiac Hypertrophy Circulation Research. May, 2014 | Pubmed ID: 24657879 Marine Dinoflagellate Proteomics: Current Status and Future Perspectives Journal of Proteomics. Jun, 2014 | Pubmed ID: 24503187 Marine Metaproteomics: Current Status and Future Directions Journal of Proteomics. Jan, 2014 | Pubmed ID: 24041543 MicroRNAs in Cardiac Regeneration and Cardiovascular Disease Science China. Life Sciences. Oct, 2013 | Pubmed ID: 23974704 Build a Braveheart: the Missing Linc (RNA) Circulation Research. Jun, 2013 | Pubmed ID: 23743224 Quantitative Proteomic Analysis of Cell Cycle of the Dinoflagellate Prorocentrum Donghaiense (Dinophyceae) PloS One. 2013 | Pubmed ID: 23691081 Quantitative Proteomic Analysis Reveals Evolutionary Divergence and Species-specific Peptides in the Alexandrium Tamarense Complex (Dinophyceae) Journal of Proteomics. Jun, 2013 | Pubmed ID: 23684789 Responses of Nannochloropsis Oceanica IMET1 to Long-Term Nitrogen Starvation and Recovery Plant Physiology. Jun, 2013 | Pubmed ID: 23637339 Mir-17-92 Cluster is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts Circulation Research. Jun, 2013 | Pubmed ID: 23575307 Opposite Roles of Myocardin and Atrogin-1 in L6 Myoblast Differentiation Journal of Cellular Physiology. Oct, 2013 | Pubmed ID: 23526547 MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress Circulation Research. Apr, 2013 | Pubmed ID: 23524588 Comparative Proteomic Analysis Reveals Proteins Putatively Involved in Toxin Biosynthesis in the Marine Dinoflagellate Alexandrium Catenella Marine Drugs. Jan, 2013 | Pubmed ID: 23340676 Acetylation of Myocardin is Required for the Activation of Cardiac and Smooth Muscle Genes The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23007391 Quantitative Proteomic Analysis of Differentially Expressed Proteins in the Toxicity-lost Mutant of Alexandrium Catenella (Dinophyceae) in the Exponential Phase Journal of Proteomics. Oct, 2012 | Pubmed ID: 22921724 Xin Proteins and Intercalated Disc Maturation, Signaling and Diseases Frontiers in Bioscience (Landmark Edition). Jun, 2012 | Pubmed ID: 22652799 Cadmium-induced Changes in Trace Element Bioaccumulation and Proteomics Perspective in Four Marine Bivalves Environmental Toxicology and Chemistry. Jun, 2012 | Pubmed ID: 22488592 MicroRNAs in Heart Development Current Topics in Developmental Biology. 2012 | Pubmed ID: 22449848 CIP, a Cardiac Isl1-interacting Protein, Represses Cardiomyocyte Hypertrophy Circulation Research. Mar, 2012 | Pubmed ID: 22343712 MicroRNAs in Cardiovascular Development Journal of Molecular and Cellular Cardiology. May, 2012 | Pubmed ID: 22300733 Quantitative Proteomic Analysis of Okadaic Acid Treated Mouse Small Intestines Reveals Differentially Expressed Proteins Involved in Diarrhetic Shellfish Poisoning Journal of Proteomics. Apr, 2012 | Pubmed ID: 22270013 Determination of MiRNA Targets in Skeletal Muscle Cells Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130855 Homology-Driven Proteomics of Dinoflagellates with Unsequenced Genomes Using MALDI-TOF/TOF and Automated De Novo Sequencing Evidence-based Complementary and Alternative Medicine : ECAM. 2011 | Pubmed ID: 21977052 Identification and Characterization of Cell Wall Proteins of a Toxic Dinoflagellate Alexandrium Catenella Using 2-D DIGE and MALDI TOF-TOF Mass Spectrometry Evidence-based Complementary and Alternative Medicine : ECAM. 2011 | Pubmed ID: 21904561 Synergistic Activation of Cardiac Genes by Myocardin and Tbx5 PloS One. 2011 | Pubmed ID: 21897873 MiR-155 Inhibits Expression of the MEF2A Protein to Repress Skeletal Muscle Differentiation The Journal of Biological Chemistry. Oct, 2011 | Pubmed ID: 21868385 The Histone Methyltransferase Set7/9 Promotes Myoblast Differentiation and Myofibril Assembly The Journal of Cell Biology. Aug, 2011 | Pubmed ID: 21859860 Molecular Staging of Marine Medaka: a Model Organism for Marine Ecotoxicity Study Marine Pollution Bulletin. 2011 | Pubmed ID: 21708389 Source and Profile of Paralytic Shellfish Poisoning Toxins in Shellfish in Daya Bay, South China Sea Marine Environmental Research. Jul, 2011 | Pubmed ID: 21658755 'CArG'ing for MicroRNAs Gastroenterology. Jul, 2011 | Pubmed ID: 21620846 Transgenic Overexpression of MiR-133a in Skeletal Muscle BMC Musculoskeletal Disorders. May, 2011 | Pubmed ID: 21615921 [Detection and Application of Allelic Expression Imbalance] Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]. Jan, 2011 | Pubmed ID: 21418811 MicroRNAs in Cardiomyocyte Development Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Mar-Apr, 2011 | Pubmed ID: 21305703 DOT1L Regulates Dystrophin Expression and is Critical for Cardiac Function Genes & Development. Feb, 2011 | Pubmed ID: 21289070 "RISCing" the Heart: In Vivo Identification of Cardiac MicroRNA Targets by RISCome Circulation Research. Jan, 2011 | Pubmed ID: 21212388 Application of MicroRNA in Cardiac and Skeletal Muscle Disease Gene Therapy Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21194029 Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2011 | Pubmed ID: 21051663 Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2010 | Pubmed ID: 20884876 MicroRNA-1 and MicroRNA-206 Regulate Skeletal Muscle Satellite Cell Proliferation and Differentiation by Repressing Pax7 The Journal of Cell Biology. Sep, 2010 | Pubmed ID: 20819939 MicroRNAs in Cardiac Remodeling and Disease Journal of Cardiovascular Translational Research. Jun, 2010 | Pubmed ID: 20560042 The Emerging Role of MicroRNAs As a Therapeutic Target for Cardiovascular Disease BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. Jun, 2010 | Pubmed ID: 20462281 The BMP Pathway Acts to Directly Regulate Tbx20 in the Developing Heart Development (Cambridge, England). Jun, 2010 | Pubmed ID: 20460370 MicroRNAs in Cardiac Development and Remodeling Pediatric Cardiology. Apr, 2010 | Pubmed ID: 20135107 Myocardin-dependent Activation of the CArG Box-rich Smooth Muscle Gamma-actin Gene: Preferential Utilization of a Single CArG Element Through Functional Association with the NKX3.1 Homeodomain Protein The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19797053 MicroRNA-208a is a Regulator of Cardiac Hypertrophy and Conduction in Mice The Journal of Clinical Investigation. Sep, 2009 | Pubmed ID: 19726871 Smooth(ing) Muscle Differentiation by MicroRNAs Cell Stem Cell. Aug, 2009 | Pubmed ID: 19664984 A Myocardium Tropic Adeno-associated Virus (AAV) Evolved by DNA Shuffling and in Vivo Selection Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19234115 Effects of Macronutrient Additions on Nickel Uptake and Distribution in the Dinoflagellate Prorocentrum Donghaiense Lu Environmental Pollution (Barking, Essex : 1987). Jun, 2009 | Pubmed ID: 19217194 MicroRNAs and Muscle Disorders Journal of Cell Science. Jan, 2009 | Pubmed ID: 19092056 Myocardin Marks the Earliest Cardiac Gene Expression and Plays an Important Role in Heart Development Anatomical Record (Hoboken, N.J. : 2007). Oct, 2008 | Pubmed ID: 18780304 Neurotoxins from Marine Dinoflagellates: a Brief Review Marine Drugs. Jun, 2008 | Pubmed ID: 18728731 Taking MicroRNAs to Heart Trends in Molecular Medicine. Jun, 2008 | Pubmed ID: 18457996 Myocardin Inhibits Cellular Proliferation by Inhibiting NF-kappaB(p65)-dependent Cell Cycle Progression Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18296632 Targeted Deletion of Dicer in the Heart Leads to Dilated Cardiomyopathy and Heart Failure Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18256189 Muscling Through the MicroRNA World Experimental Biology and Medicine (Maywood, N.J.). Feb, 2008 | Pubmed ID: 18222968 The MEF2D Transcription Factor Mediates Stress-dependent Cardiac Remodeling in Mice The Journal of Clinical Investigation. Jan, 2008 | Pubmed ID: 18079970 Myocardin is a Bifunctional Switch for Smooth Versus Skeletal Muscle Differentiation Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17940050 Loss of MXinalpha, an Intercalated Disk Protein, Results in Cardiac Hypertrophy and Cardiomyopathy with Conduction Defects American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2007 | Pubmed ID: 17766470 Trophic Transfer of Paralytic Shellfish Toxins from the Cladoceran (Moina Mongolica) to Larvae of the Fish (Sciaenops Ocellatus) Toxicon : Official Journal of the International Society on Toxinology. Oct, 2007 | Pubmed ID: 17619042 Polymorphisms in Interleukin-15 Gene on Chromosome 4q31.2 Are Associated with Psoriasis Vulgaris in Chinese Population The Journal of Investigative Dermatology. Nov, 2007 | Pubmed ID: 17554368 Expression of MicroRNAs is Dynamically Regulated During Cardiomyocyte Hypertrophy Journal of Molecular and Cellular Cardiology. Jun, 2007 | Pubmed ID: 17498736 MicroRNAs in Skeletal and Cardiac Muscle Development DNA and Cell Biology. Apr, 2007 | Pubmed ID: 17465888 Muscle Ring Finger 1, but Not Muscle Ring Finger 2, Regulates Cardiac Hypertrophy in Vivo Circulation Research. Mar, 2007 | Pubmed ID: 17272810 Influence of N, P Additions on the Transfer of Nickel from Phytoplankton to Copepods Environmental Pollution (Barking, Essex : 1987). Jul, 2007 | Pubmed ID: 17257722 Follow-up Analysis of PSORS9 in 151 Chinese Families Confirmed the Linkage to 4q31-32 and Refined the Evidence to the Families of Early-onset Psoriasis The Journal of Investigative Dermatology. Feb, 2007 | Pubmed ID: 17139270 Wnt2 Coordinates the Commitment of Mesoderm to Hematopoietic, Endothelial, and Cardiac Lineages in Embryoid Bodies The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17098737 Paralytic Shellfish Toxin Profiles and Toxin Variability of the Genus Alexandrium (Dinophyceae) Isolated from the Southeast China Sea Toxicon : Official Journal of the International Society on Toxinology. Aug, 2006 | Pubmed ID: 16859722 Systematic Evaluation of Association Between the Microsomal Glutathione S-transferase 2 Common Variation and Psoriasis Vulgaris in Chinese Population Archives of Dermatological Research. Aug, 2006 | Pubmed ID: 16773312 Micro or Mega: How Important Are MicroRNAs in Muscle? Cell Cycle (Georgetown, Tex.). May, 2006 | Pubmed ID: 16639081 Myocardin Induces Cardiomyocyte Hypertrophy Circulation Research. Apr, 2006 | Pubmed ID: 16556869 The Role of MicroRNA-1 and MicroRNA-133 in Skeletal Muscle Proliferation and Differentiation Nature Genetics. Feb, 2006 | Pubmed ID: 16380711 Identification and Characterization of a "biomarker of Toxicity" from the Proteome of the Paralytic Shellfish Toxin-producing Dinoflagellate Alexandrium Tamarense (Dinophyceae) Proteomics. Jan, 2006 | Pubmed ID: 16342137 Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin Journal of Medical Sciences (Taipei, Taiwan). Oct, 2005 | Pubmed ID: 16708114 Myocardin Enhances Smad3-mediated Transforming Growth Factor-beta1 Signaling in a CArG Box-independent Manner: Smad-binding Element is an Important Cis Element for SM22alpha Transcription in Vivo Circulation Research. Nov, 2005 | Pubmed ID: 16224064 Bone Morphogenetic Protein Signaling Modulates Myocardin Transactivation of Cardiac Genes Circulation Research. Nov, 2005 | Pubmed ID: 16224060 Myocardin is Sufficient and Necessary for Cardiac Gene Expression in Xenopus Development (Cambridge, England). Mar, 2005 | Pubmed ID: 15673566 Modulation of Smooth Muscle Gene Expression by Association of Histone Acetyltransferases and Deacetylases with Myocardin Molecular and Cellular Biology. Jan, 2005 | Pubmed ID: 15601857 Atrogin-1/muscle Atrophy F-box Inhibits Calcineurin-dependent Cardiac Hypertrophy by Participating in an SCF Ubiquitin Ligase Complex The Journal of Clinical Investigation. Oct, 2004 | Pubmed ID: 15489953 Control of Smooth Muscle Development by the Myocardin Family of Transcriptional Coactivators Current Opinion in Genetics & Development. Oct, 2004 | Pubmed ID: 15380248 Target Gene-specific Modulation of Myocardin Activity by GATA Transcription Factors Molecular and Cellular Biology. Oct, 2004 | Pubmed ID: 15367672 Myocardin and Ternary Complex Factors Compete for SRF to Control Smooth Muscle Gene Expression Nature. Mar, 2004 | Pubmed ID: 15014501 The Serum Response Factor Coactivator Myocardin is Required for Vascular Smooth Muscle Development Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12867591 Myocardin is a Master Regulator of Smooth Muscle Gene Expression Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12756293 Myocardin is a Key Regulator of CArG-dependent Transcription of Multiple Smooth Muscle Marker Genes Circulation Research. May, 2003 | Pubmed ID: 12663482 Effects of Nitrate and Phosphate on Growth and C2 Toxin Productivity of Alexandrium Tamarense CI01 in Culture Marine Pollution Bulletin. 2002 | Pubmed ID: 12398397 Potentiation of Serum Response Factor Activity by a Family of Myocardin-related Transcription Factors Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12397177 Modulation of Cardiac Growth and Development by HOP, an Unusual Homeodomain Protein Cell. Sep, 2002 | Pubmed ID: 12297046 Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute JoVE 54787 Genetics
Preparation of rAAV9 to Overexpress or Knockdown Genes in Mouse Hearts Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute JoVE 54787 Genetics