Da-Zhi Wang Department of Cardiology Boston Children's Hospital Biography Publications Institution JoVE Articles Da-Zhi Wang has not added a biography. If you are Da-Zhi Wang and would like to personalize this page please email our Author Liaison for assistance. Publications How Cardiomyocytes Sense Pathophysiological Stresses for Cardiac Remodeling Cellular and Molecular Life Sciences : CMLS. Oct, 2016 | Pubmed ID: 27714411 Comparative Transcriptomic Analysis Reveals Novel Insights into the Adaptive Response of Skeletonema Costatum to Changing Ambient Phosphorus Frontiers in Microbiology. 2016 | Pubmed ID: 27703451 (MYO)SLIDing Our Way Into the Vascular Pool of Long Noncoding RNAs Arteriosclerosis, Thrombosis, and Vascular Biology. Oct, 2016 | Pubmed ID: 27655778 Long Non-coding RNAs Link Extracellular Matrix Gene Expression to Ischemic Cardiomyopathy Cardiovascular Research. Aug, 2016 | Pubmed ID: 27557636 Environmental Microbial Community Proteomics: Status, Challenges and Perspectives International Journal of Molecular Sciences. Aug, 2016 | Pubmed ID: 27527164 Regulation of Skeletal Muscle by MicroRNAs Comprehensive Physiology. Jun, 2016 | Pubmed ID: 27347893 Trbp Is Required for Differentiation of Myoblasts and Normal Regeneration of Skeletal Muscle PloS One. 2016 | Pubmed ID: 27159388 Paralytic Shellfish Toxin Biosynthesis in Cyanobacteria and Dinoflagellates: A Molecular Overview Journal of Proteomics. Mar, 2016 | Pubmed ID: 26316331 Mystery of Trbp, Tale of a RBP in the MiRNA Pathway Cell Cycle (Georgetown, Tex.). 2015 | Pubmed ID: 26496166 Cardiomyocyte-enriched Protein CIP Protects Against Pathophysiological Stresses and Regulates Cardiac Homeostasis The Journal of Clinical Investigation. Nov, 2015 | Pubmed ID: 26436652 ITRAQ-based Quantitative Proteomic Analysis of a Toxigenic Dinoflagellate Alexandrium Catenella and Its Non-toxic Mutant Proteomics. Dec, 2015 | Pubmed ID: 26417864 Differential Diagnosis of Malignant Biliary Tract Cancer from Benign Tissues Using Apparent Diffusion Coefficient Measurements with Diffusion Weighted Imaging in Asians Asian Pacific Journal of Cancer Prevention : APJCP. 2015 | Pubmed ID: 26320508 Noncoding RNAs, Emerging Regulators of Skeletal Muscle Development and Diseases BioMed Research International. 2015 | Pubmed ID: 26258142 Trbp Regulates Heart Function Through MicroRNA-mediated Sox6 Repression Nature Genetics. Jul, 2015 | Pubmed ID: 26029872 Novel Roles of GATA4/6 in the Postnatal Heart Identified Through Temporally Controlled, Cardiomyocyte-Specific Gene Inactivation by Adeno-Associated Virus Delivery of Cre Recombinase PloS One. 2015 | Pubmed ID: 26023924 Comparative Proteomics Reveals Highly and Differentially Expressed Proteins in Field-collected and Laboratory-cultured Blooming Cells of the Diatom Skeletonema Costatum Environmental Microbiology. Oct, 2015 | Pubmed ID: 26014042 Proteomic Analysis Provides New Insights into the Adaptive Response of a Dinoflagellate Prorocentrum Donghaiense to Changing Ambient Nitrogen Plant, Cell & Environment. Oct, 2015 | Pubmed ID: 25789726 Pi3kcb Links Hippo-YAP and PI3K-AKT Signaling Pathways to Promote Cardiomyocyte Proliferation and Survival Circulation Research. Jan, 2015 | Pubmed ID: 25249570 Comparative Transcriptome Analysis of a Toxin-producing Dinoflagellate Alexandrium Catenella and Its Non-toxic Mutant Marine Drugs. Nov, 2014 | Pubmed ID: 25421324 The Myriad Essential Roles of MicroRNAs in Cardiovascular Homeostasis and Disease Genes & Diseases. Mar, 2014 | Pubmed ID: 25328909 An Epigenetic "LINK(RNA)" to Pathological Cardiac Hypertrophy Cell Metabolism. Oct, 2014 | Pubmed ID: 25295782 MiR-22 in Cardiac Remodeling and Disease Trends in Cardiovascular Medicine. Oct, 2014 | Pubmed ID: 25218673 Generation of a Cre Knock-in into the Myocardin Locus to Mark Early Cardiac and Smooth Muscle Cell Lineages Genesis (New York, N.Y. : 2000). Oct, 2014 | Pubmed ID: 25174608 LincRNA-p21 Regulates Neointima Formation, Vascular Smooth Muscle Cell Proliferation, Apoptosis, and Atherosclerosis by Enhancing P53 Activity Circulation. Oct, 2014 | Pubmed ID: 25156994 Non-Coding RNAs Including MiRNAs and LncRNAs in Cardiovascular Biology and Disease Cells. Aug, 2014 | Pubmed ID: 25153164 Cardiac-Specific YAP Activation Improves Cardiac Function and Survival in an Experimental Murine MI Model Circulation Research. Jul, 2014 | Pubmed ID: 24833660 Modeling the Mitochondrial Cardiomyopathy of Barth Syndrome with Induced Pluripotent Stem Cell and Heart-on-chip Technologies Nature Medicine. Jun, 2014 | Pubmed ID: 24813252 Crystallin-αB Regulates Skeletal Muscle Homeostasis Via Modulation of Argonaute2 Activity The Journal of Biological Chemistry. Jun, 2014 | Pubmed ID: 24782307 Loss of MicroRNA-155 Protects the Heart from Pathological Cardiac Hypertrophy Circulation Research. May, 2014 | Pubmed ID: 24657879 Marine Dinoflagellate Proteomics: Current Status and Future Perspectives Journal of Proteomics. Jun, 2014 | Pubmed ID: 24503187 Marine Metaproteomics: Current Status and Future Directions Journal of Proteomics. Jan, 2014 | Pubmed ID: 24041543 MicroRNAs in Cardiac Regeneration and Cardiovascular Disease Science China. Life Sciences. Oct, 2013 | Pubmed ID: 23974704 Build a Braveheart: the Missing Linc (RNA) Circulation Research. Jun, 2013 | Pubmed ID: 23743224 Quantitative Proteomic Analysis of Cell Cycle of the Dinoflagellate Prorocentrum Donghaiense (Dinophyceae) PloS One. 2013 | Pubmed ID: 23691081 Quantitative Proteomic Analysis Reveals Evolutionary Divergence and Species-specific Peptides in the Alexandrium Tamarense Complex (Dinophyceae) Journal of Proteomics. Jun, 2013 | Pubmed ID: 23684789 Responses of Nannochloropsis Oceanica IMET1 to Long-Term Nitrogen Starvation and Recovery Plant Physiology. Jun, 2013 | Pubmed ID: 23637339 Mir-17-92 Cluster is Required for and Sufficient to Induce Cardiomyocyte Proliferation in Postnatal and Adult Hearts Circulation Research. Jun, 2013 | Pubmed ID: 23575307 Opposite Roles of Myocardin and Atrogin-1 in L6 Myoblast Differentiation Journal of Cellular Physiology. Oct, 2013 | Pubmed ID: 23526547 MicroRNA-22 Regulates Cardiac Hypertrophy and Remodeling in Response to Stress Circulation Research. Apr, 2013 | Pubmed ID: 23524588 Comparative Proteomic Analysis Reveals Proteins Putatively Involved in Toxin Biosynthesis in the Marine Dinoflagellate Alexandrium Catenella Marine Drugs. Jan, 2013 | Pubmed ID: 23340676 Acetylation of Myocardin is Required for the Activation of Cardiac and Smooth Muscle Genes The Journal of Biological Chemistry. Nov, 2012 | Pubmed ID: 23007391 Quantitative Proteomic Analysis of Differentially Expressed Proteins in the Toxicity-lost Mutant of Alexandrium Catenella (Dinophyceae) in the Exponential Phase Journal of Proteomics. Oct, 2012 | Pubmed ID: 22921724 Xin Proteins and Intercalated Disc Maturation, Signaling and Diseases Frontiers in Bioscience (Landmark Edition). Jun, 2012 | Pubmed ID: 22652799 Cadmium-induced Changes in Trace Element Bioaccumulation and Proteomics Perspective in Four Marine Bivalves Environmental Toxicology and Chemistry. Jun, 2012 | Pubmed ID: 22488592 MicroRNAs in Heart Development Current Topics in Developmental Biology. 2012 | Pubmed ID: 22449848 CIP, a Cardiac Isl1-interacting Protein, Represses Cardiomyocyte Hypertrophy Circulation Research. Mar, 2012 | Pubmed ID: 22343712 MicroRNAs in Cardiovascular Development Journal of Molecular and Cellular Cardiology. May, 2012 | Pubmed ID: 22300733 Quantitative Proteomic Analysis of Okadaic Acid Treated Mouse Small Intestines Reveals Differentially Expressed Proteins Involved in Diarrhetic Shellfish Poisoning Journal of Proteomics. Apr, 2012 | Pubmed ID: 22270013 Determination of MiRNA Targets in Skeletal Muscle Cells Methods in Molecular Biology (Clifton, N.J.). 2012 | Pubmed ID: 22130855 Homology-Driven Proteomics of Dinoflagellates with Unsequenced Genomes Using MALDI-TOF/TOF and Automated De Novo Sequencing Evidence-based Complementary and Alternative Medicine : ECAM. 2011 | Pubmed ID: 21977052 Identification and Characterization of Cell Wall Proteins of a Toxic Dinoflagellate Alexandrium Catenella Using 2-D DIGE and MALDI TOF-TOF Mass Spectrometry Evidence-based Complementary and Alternative Medicine : ECAM. 2011 | Pubmed ID: 21904561 Synergistic Activation of Cardiac Genes by Myocardin and Tbx5 PloS One. 2011 | Pubmed ID: 21897873 MiR-155 Inhibits Expression of the MEF2A Protein to Repress Skeletal Muscle Differentiation The Journal of Biological Chemistry. Oct, 2011 | Pubmed ID: 21868385 The Histone Methyltransferase Set7/9 Promotes Myoblast Differentiation and Myofibril Assembly The Journal of Cell Biology. Aug, 2011 | Pubmed ID: 21859860 Molecular Staging of Marine Medaka: a Model Organism for Marine Ecotoxicity Study Marine Pollution Bulletin. 2011 | Pubmed ID: 21708389 Source and Profile of Paralytic Shellfish Poisoning Toxins in Shellfish in Daya Bay, South China Sea Marine Environmental Research. Jul, 2011 | Pubmed ID: 21658755 'CArG'ing for MicroRNAs Gastroenterology. Jul, 2011 | Pubmed ID: 21620846 Transgenic Overexpression of MiR-133a in Skeletal Muscle BMC Musculoskeletal Disorders. May, 2011 | Pubmed ID: 21615921 [Detection and Application of Allelic Expression Imbalance] Zhonghua Yu Fang Yi Xue Za Zhi [Chinese Journal of Preventive Medicine]. Jan, 2011 | Pubmed ID: 21418811 MicroRNAs in Cardiomyocyte Development Wiley Interdisciplinary Reviews. Systems Biology and Medicine. Mar-Apr, 2011 | Pubmed ID: 21305703 DOT1L Regulates Dystrophin Expression and is Critical for Cardiac Function Genes & Development. Feb, 2011 | Pubmed ID: 21289070 "RISCing" the Heart: In Vivo Identification of Cardiac MicroRNA Targets by RISCome Circulation Research. Jan, 2011 | Pubmed ID: 21212388 Application of MicroRNA in Cardiac and Skeletal Muscle Disease Gene Therapy Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21194029 Induction of MicroRNA-1 by Myocardin in Smooth Muscle Cells Inhibits Cell Proliferation Arteriosclerosis, Thrombosis, and Vascular Biology. Feb, 2011 | Pubmed ID: 21051663 Loss of MicroRNAs in Neural Crest Leads to Cardiovascular Syndromes Resembling Human Congenital Heart Defects Arteriosclerosis, Thrombosis, and Vascular Biology. Dec, 2010 | Pubmed ID: 20884876 MicroRNA-1 and MicroRNA-206 Regulate Skeletal Muscle Satellite Cell Proliferation and Differentiation by Repressing Pax7 The Journal of Cell Biology. Sep, 2010 | Pubmed ID: 20819939 MicroRNAs in Cardiac Remodeling and Disease Journal of Cardiovascular Translational Research. Jun, 2010 | Pubmed ID: 20560042 The Emerging Role of MicroRNAs As a Therapeutic Target for Cardiovascular Disease BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy. Jun, 2010 | Pubmed ID: 20462281 The BMP Pathway Acts to Directly Regulate Tbx20 in the Developing Heart Development (Cambridge, England). Jun, 2010 | Pubmed ID: 20460370 MicroRNAs in Cardiac Development and Remodeling Pediatric Cardiology. Apr, 2010 | Pubmed ID: 20135107 Myocardin-dependent Activation of the CArG Box-rich Smooth Muscle Gamma-actin Gene: Preferential Utilization of a Single CArG Element Through Functional Association with the NKX3.1 Homeodomain Protein The Journal of Biological Chemistry. Nov, 2009 | Pubmed ID: 19797053 MicroRNA-208a is a Regulator of Cardiac Hypertrophy and Conduction in Mice The Journal of Clinical Investigation. Sep, 2009 | Pubmed ID: 19726871 Smooth(ing) Muscle Differentiation by MicroRNAs Cell Stem Cell. Aug, 2009 | Pubmed ID: 19664984 A Myocardium Tropic Adeno-associated Virus (AAV) Evolved by DNA Shuffling and in Vivo Selection Proceedings of the National Academy of Sciences of the United States of America. Mar, 2009 | Pubmed ID: 19234115 Effects of Macronutrient Additions on Nickel Uptake and Distribution in the Dinoflagellate Prorocentrum Donghaiense Lu Environmental Pollution (Barking, Essex : 1987). Jun, 2009 | Pubmed ID: 19217194 MicroRNAs and Muscle Disorders Journal of Cell Science. Jan, 2009 | Pubmed ID: 19092056 Myocardin Marks the Earliest Cardiac Gene Expression and Plays an Important Role in Heart Development Anatomical Record (Hoboken, N.J. : 2007). Oct, 2008 | Pubmed ID: 18780304 Neurotoxins from Marine Dinoflagellates: a Brief Review Marine Drugs. Jun, 2008 | Pubmed ID: 18728731 Taking MicroRNAs to Heart Trends in Molecular Medicine. Jun, 2008 | Pubmed ID: 18457996 Myocardin Inhibits Cellular Proliferation by Inhibiting NF-kappaB(p65)-dependent Cell Cycle Progression Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18296632 切块机心中的目标的删除导致扩张型心肌病和心力衰竭。 Proceedings of the National Academy of Sciences of the United States of America. Feb, 2008 | Pubmed ID: 18256189 Muscling Through the MicroRNA World Experimental Biology and Medicine (Maywood, N.J.). Feb, 2008 | Pubmed ID: 18222968 The MEF2D Transcription Factor Mediates Stress-dependent Cardiac Remodeling in Mice The Journal of Clinical Investigation. Jan, 2008 | Pubmed ID: 18079970 Myocardin is a Bifunctional Switch for Smooth Versus Skeletal Muscle Differentiation Proceedings of the National Academy of Sciences of the United States of America. Oct, 2007 | Pubmed ID: 17940050 Loss of MXinalpha, an Intercalated Disk Protein, Results in Cardiac Hypertrophy and Cardiomyopathy with Conduction Defects American Journal of Physiology. Heart and Circulatory Physiology. Nov, 2007 | Pubmed ID: 17766470 Trophic Transfer of Paralytic Shellfish Toxins from the Cladoceran (Moina Mongolica) to Larvae of the Fish (Sciaenops Ocellatus) Toxicon : Official Journal of the International Society on Toxinology. Oct, 2007 | Pubmed ID: 17619042 Polymorphisms in Interleukin-15 Gene on Chromosome 4q31.2 Are Associated with Psoriasis Vulgaris in Chinese Population The Journal of Investigative Dermatology. Nov, 2007 | Pubmed ID: 17554368 期间心肌细胞肥大动态调节的 Microrna 的表达。 Journal of Molecular and Cellular Cardiology. Jun, 2007 | Pubmed ID: 17498736 MicroRNAs in Skeletal and Cardiac Muscle Development DNA and Cell Biology. Apr, 2007 | Pubmed ID: 17465888 Muscle Ring Finger 1, but Not Muscle Ring Finger 2, Regulates Cardiac Hypertrophy in Vivo Circulation Research. Mar, 2007 | Pubmed ID: 17272810 Influence of N, P Additions on the Transfer of Nickel from Phytoplankton to Copepods Environmental Pollution (Barking, Essex : 1987). Jul, 2007 | Pubmed ID: 17257722 Follow-up Analysis of PSORS9 in 151 Chinese Families Confirmed the Linkage to 4q31-32 and Refined the Evidence to the Families of Early-onset Psoriasis The Journal of Investigative Dermatology. Feb, 2007 | Pubmed ID: 17139270 Wnt2 Coordinates the Commitment of Mesoderm to Hematopoietic, Endothelial, and Cardiac Lineages in Embryoid Bodies The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17098737 Paralytic Shellfish Toxin Profiles and Toxin Variability of the Genus Alexandrium (Dinophyceae) Isolated from the Southeast China Sea Toxicon : Official Journal of the International Society on Toxinology. Aug, 2006 | Pubmed ID: 16859722 Systematic Evaluation of Association Between the Microsomal Glutathione S-transferase 2 Common Variation and Psoriasis Vulgaris in Chinese Population Archives of Dermatological Research. Aug, 2006 | Pubmed ID: 16773312 Micro or Mega: How Important Are MicroRNAs in Muscle? Cell Cycle (Georgetown, Tex.). May, 2006 | Pubmed ID: 16639081 Myocardin Induces Cardiomyocyte Hypertrophy Circulation Research. Apr, 2006 | Pubmed ID: 16556869 The Role of MicroRNA-1 and MicroRNA-133 in Skeletal Muscle Proliferation and Differentiation Nature Genetics. Feb, 2006 | Pubmed ID: 16380711 Identification and Characterization of a "biomarker of Toxicity" from the Proteome of the Paralytic Shellfish Toxin-producing Dinoflagellate Alexandrium Tamarense (Dinophyceae) Proteomics. Jan, 2006 | Pubmed ID: 16342137 Structure, Expression, and Function of a Novel Intercalated Disc Protein, Xin Journal of Medical Sciences (Taipei, Taiwan). Oct, 2005 | Pubmed ID: 16708114 Myocardin Enhances Smad3-mediated Transforming Growth Factor-beta1 Signaling in a CArG Box-independent Manner: Smad-binding Element is an Important Cis Element for SM22alpha Transcription in Vivo Circulation Research. Nov, 2005 | Pubmed ID: 16224064 Bone Morphogenetic Protein Signaling Modulates Myocardin Transactivation of Cardiac Genes Circulation Research. Nov, 2005 | Pubmed ID: 16224060 Myocardin is Sufficient and Necessary for Cardiac Gene Expression in Xenopus Development (Cambridge, England). Mar, 2005 | Pubmed ID: 15673566 Modulation of Smooth Muscle Gene Expression by Association of Histone Acetyltransferases and Deacetylases with Myocardin Molecular and Cellular Biology. Jan, 2005 | Pubmed ID: 15601857 Atrogin-1/muscle Atrophy F-box Inhibits Calcineurin-dependent Cardiac Hypertrophy by Participating in an SCF Ubiquitin Ligase Complex The Journal of Clinical Investigation. Oct, 2004 | Pubmed ID: 15489953 Control of Smooth Muscle Development by the Myocardin Family of Transcriptional Coactivators Current Opinion in Genetics & Development. Oct, 2004 | Pubmed ID: 15380248 Target Gene-specific Modulation of Myocardin Activity by GATA Transcription Factors Molecular and Cellular Biology. Oct, 2004 | Pubmed ID: 15367672 Myocardin and Ternary Complex Factors Compete for SRF to Control Smooth Muscle Gene Expression Nature. Mar, 2004 | Pubmed ID: 15014501 The Serum Response Factor Coactivator Myocardin is Required for Vascular Smooth Muscle Development Proceedings of the National Academy of Sciences of the United States of America. Aug, 2003 | Pubmed ID: 12867591 Myocardin is a Master Regulator of Smooth Muscle Gene Expression Proceedings of the National Academy of Sciences of the United States of America. Jun, 2003 | Pubmed ID: 12756293 Myocardin is a Key Regulator of CArG-dependent Transcription of Multiple Smooth Muscle Marker Genes Circulation Research. May, 2003 | Pubmed ID: 12663482 Effects of Nitrate and Phosphate on Growth and C2 Toxin Productivity of Alexandrium Tamarense CI01 in Culture Marine Pollution Bulletin. 2002 | Pubmed ID: 12398397 Potentiation of Serum Response Factor Activity by a Family of Myocardin-related Transcription Factors Proceedings of the National Academy of Sciences of the United States of America. Nov, 2002 | Pubmed ID: 12397177 Modulation of Cardiac Growth and Development by HOP, an Unusual Homeodomain Protein Cell. Sep, 2002 | Pubmed ID: 12297046 在小鼠心脏rAAV9的制备过表达或敲除基因 Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute Genetics
在小鼠心脏rAAV9的制备过表达或敲除基因 Jian Ding1,2, Zhi-Qiang Lin1,2, Jian-Ming Jiang3,4, Christine E. Seidman3,4, Jonathan G. Seidman3,4, William T. Pu1,2, Da-Zhi Wang1,2 1Department of Cardiology, Boston Children's Hospital, 2Department of Pediatrics, Harvard Medical School, 3Department of Genetics, Harvard Medical School, 4Howard Hughes Medical Institute Genetics