Dale W. Laird Biography Publications JoVE Articles Dale W. Laird has not added a biography. If you are Dale W. Laird and would like to personalize this page please email our Author Liaison for assistance. Publications The Biochemistry and Function of Pannexin Channels Biochimica Et Biophysica Acta. Jan, 2012 | Pubmed ID: 22305965 The Effect of Connexin43 on the Level of Vascular Endothelial Growth Factor in Human Retinal Pigment Epithelial Cells Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. Dec, 2011 | Pubmed ID: 22138732 Pannexin 3 is a Novel Target for Runx2, Expressed by Osteoblasts and Mature Growth Plate Chondrocytes Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Dec, 2011 | Pubmed ID: 21915903 The G60S Connexin43 Mutant Regulates Hair Growth and Hair Fiber Morphology in a Mouse Model of Human Oculodentodigital Dysplasia The Journal of Investigative Dermatology. Nov, 2011 | Pubmed ID: 21716323 Pathways Regulating the Trafficking and Turnover of Pannexin1 Protein and the Role of the C-terminal Domain The Journal of Biological Chemistry. Aug, 2011 | Pubmed ID: 21659516 Rho Signaling Regulates Pannexin 1-mediated ATP Release from Airway Epithelia The Journal of Biological Chemistry. Jul, 2011 | Pubmed ID: 21606493 Pannexin1 Regulates α1-adrenergic Receptor- Mediated Vasoconstriction Circulation Research. Jun, 2011 | Pubmed ID: 21546608 Pannexin Channels Are Not Gap Junction Hemichannels Channels (Austin, Tex.). May-Jun, 2011 | Pubmed ID: 21532340 Characterization of Pannexin1 and Pannexin3 and Their Regulation by Androgens in the Male Reproductive Tract of the Adult Rat Molecular Reproduction and Development. Feb, 2011 | Pubmed ID: 21337450 Human Dermal Fibroblasts Derived from Oculodentodigital Dysplasia Patients Suggest That Patients May Have Wound-healing Defects Human Mutation. Apr, 2011 | Pubmed ID: 21305658 Ocular Pathology Relevant to Glaucoma in a Gja1(Jrt/+) Mouse Model of Human Oculodentodigital Dysplasia Investigative Ophthalmology & Visual Science. May, 2011 | Pubmed ID: 21273537 Pannexin 1 Channels Mediate 'find-me' Signal Release and Membrane Permeability During Apoptosis Nature. Oct, 2010 | Pubmed ID: 20944749 Hypoxia and Reoxygenation-induced Oxidant Production Increase in Microvascular Endothelial Cells Depends on Connexin40 Free Radical Biology & Medicine. Sep, 2010 | Pubmed ID: 20541007 The Potency of the Fs260 Connexin43 Mutant to Impair Keratinocyte Differentiation is Distinct from Other Disease-linked Connexin43 Mutants The Biochemical Journal. Aug, 2010 | Pubmed ID: 20515445 Implications and Challenges of Connexin Connections to Cancer Nature Reviews. Cancer. Jun, 2010 | Pubmed ID: 20495577 The Tumor-suppressive Function of Connexin43 in Keratinocytes is Mediated in Part Via Interaction with Caveolin-1 Cancer Research. May, 2010 | Pubmed ID: 20406988 Implications of Pannexin 1 and Pannexin 3 for Keratinocyte Differentiation Journal of Cell Science. Apr, 2010 | Pubmed ID: 20332104 Milk Secretion and Ejection Are Impaired in the Mammary Gland of Mice Harboring a Cx43 Mutant While Expression and Localization of Tight and Adherens Junction Proteins Remain Unchanged Biology of Reproduction. May, 2010 | Pubmed ID: 20089884 Pannexin1 and Pannexin3 Delivery, Cell Surface Dynamics, and Cytoskeletal Interactions The Journal of Biological Chemistry. Mar, 2010 | Pubmed ID: 20086016 The Gap Junction Proteome and Its Relationship to Disease Trends in Cell Biology. Feb, 2010 | Pubmed ID: 19944606 Methods in Molecular Biology (Clifton, N.J.). 2010 | Pubmed ID: 19908013 Glycosylation Regulates Pannexin Intermixing and Cellular Localization Molecular Biology of the Cell. Oct, 2009 | Pubmed ID: 19692571 Oogenesis Defects in a Mutant Mouse Model of Oculodentodigital Dysplasia Disease Models & Mechanisms. Mar-Apr, 2009 | Pubmed ID: 19259389 A Dominant Loss-of-function GJA1 (Cx43) Mutant Impairs Parturition in the Mouse Biology of Reproduction. Jun, 2009 | Pubmed ID: 19176884 Cx43 Has Distinct Mobility Within Plasma-membrane Domains, Indicative of Progressive Formation of Gap-junction Plaques Journal of Cell Science. Feb, 2009 | Pubmed ID: 19174466 Fate of Connexin43 in Cardiac Tissue Harbouring a Disease-linked Connexin43 Mutant Cardiovascular Research. Dec, 2008 | Pubmed ID: 18678643 Diverse Subcellular Distribution Profiles of Pannexin 1 and Pannexin 3 Cell Communication & Adhesion. May, 2008 | Pubmed ID: 18649185 Decreased Levels of Connexin43 Result in Impaired Development of the Mammary Gland in a Mouse Model of Oculodentodigital Dysplasia Developmental Biology. Jun, 2008 | Pubmed ID: 18455714 Zebrafish Early Cardiac Connexin, Cx36.7/Ecx, Regulates Myofibril Orientation and Heart Morphogenesis by Establishing Nkx2.5 Expression Proceedings of the National Academy of Sciences of the United States of America. Mar, 2008 | Pubmed ID: 18337497 ODDD-linked Cx43 Mutants Reduce Endogenous Cx43 Expression and Function in Osteoblasts and Inhibit Late Stage Differentiation Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research. Jun, 2008 | Pubmed ID: 18269311 The Protective Effect of Functional Connexin43 Channels on a Human Epithelial Cell Line Exposed to Oxidative Stress Investigative Ophthalmology & Visual Science. Feb, 2008 | Pubmed ID: 18235030 Caveolin-1 and -2 Interact with Connexin43 and Regulate Gap Junctional Intercellular Communication in Keratinocytes Molecular Biology of the Cell. Mar, 2008 | Pubmed ID: 18162583 Closing the Gap on Autosomal Dominant Connexin-26 and Connexin-43 Mutants Linked to Human Disease The Journal of Biological Chemistry. Feb, 2008 | Pubmed ID: 18089569 Pannexin 1 and Pannexin 3 Are Glycoproteins That Exhibit Many Distinct Characteristics from the Connexin Family of Gap Junction Proteins Journal of Cell Science. Nov, 2007 | Pubmed ID: 17925379 Connexin Levels Regulate Keratinocyte Differentiation in the Epidermis The Journal of Biological Chemistry. Oct, 2007 | Pubmed ID: 17693411 Connexins and Gap Junctions in Mammary Gland Development and Breast Cancer Progression The Journal of Membrane Biology. Aug, 2007 | Pubmed ID: 17661126 Differentiation of Organotypic Epidermis in the Presence of Skin Disease-linked Dominant-negative Cx26 Mutants and Knockdown Cx26 The Journal of Membrane Biology. Jun, 2007 | Pubmed ID: 17638039 Differential Potency of Dominant Negative Connexin43 Mutants in Oculodentodigital Dysplasia The Journal of Biological Chemistry. Jun, 2007 | Pubmed ID: 17420259 Connexins Act As Tumor Suppressors in Three-dimensional Mammary Cell Organoids by Regulating Differentiation and Angiogenesis Cancer Research. Oct, 2006 | Pubmed ID: 17047050 Functional Characterization of a GJA1 Frameshift Mutation Causing Oculodentodigital Dysplasia and Palmoplantar Keratoderma The Journal of Biological Chemistry. Oct, 2006 | Pubmed ID: 16891658 Cx26 Inhibits Breast MDA-MB-435 Cell Tumorigenic Properties by a Gap Junctional Intercellular Communication-independent Mechanism Carcinogenesis. Dec, 2006 | Pubmed ID: 16777986 A Histone Deacetylation-dependent Mechanism for Transcriptional Repression of the Gap Junction Gene Cx43 in Prostate Cancer Cells The Prostate. Aug, 2006 | Pubmed ID: 16652385 Life Cycle of Connexins in Health and Disease The Biochemical Journal. Mar, 2006 | Pubmed ID: 16492141 Functional Characterization of Oculodentodigital Dysplasia-associated Cx43 Mutants Cell Communication & Adhesion. Jul-Dec, 2005 | Pubmed ID: 16531323 Rat Epidermal Keratinocytes As an Organotypic Model for Examining the Role of Cx43 and Cx26 in Skin Differentiation Cell Communication & Adhesion. Jul-Dec, 2005 | Pubmed ID: 16531317 Mechanisms of Cx43 and Cx26 Transport to the Plasma Membrane and Gap Junction Regeneration Journal of Cell Science. Oct, 2005 | Pubmed ID: 16159960 A Gja1 Missense Mutation in a Mouse Model of Oculodentodigital Dysplasia Development (Cambridge, England). Oct, 2005 | Pubmed ID: 16155213 Connexin 43 Mediated Gap Junctional Communication Enhances Breast Tumor Cell Diapedesis in Culture Breast Cancer Research : BCR. 2005 | Pubmed ID: 15987459 Connexin Phosphorylation As a Regulatory Event Linked to Gap Junction Internalization and Degradation Biochimica Et Biophysica Acta. Jun, 2005 | Pubmed ID: 15955302 Down-regulation of Cx43 by Retroviral Delivery of Small Interfering RNA Promotes an Aggressive Breast Cancer Cell Phenotype Cancer Research. Apr, 2005 | Pubmed ID: 15805269 Oculodentodigital Dysplasia-causing Connexin43 Mutants Are Non-functional and Exhibit Dominant Effects on Wild-type Connexin43 The Journal of Biological Chemistry. Mar, 2005 | Pubmed ID: 15644317 Beta3 Integrins Facilitate Matrix Interactions During Transendothelial Migration of PC3 Prostate Tumor Cells The Prostate. Apr, 2005 | Pubmed ID: 15468167 Selective Assembly of Connexin37 into Heterocellular Gap Junctions at the Oocyte/granulosa Cell Interface Journal of Cell Science. Jun, 2004 | Pubmed ID: 15138288 Functional Domain Mapping and Selective Trans-dominant Effects Exhibited by Cx26 Disease-causing Mutations The Journal of Biological Chemistry. Apr, 2004 | Pubmed ID: 14978038 Connexin26 Regulates the Expression of Angiogenesis-related Genes in Human Breast Tumor Cells by Both GJIC-dependent and -independent Mechanisms Cell Communication & Adhesion. Jul-Dec, 2003 | Pubmed ID: 14681046 Transport and Function of Cx26 Mutants Involved in Skin and Deafness Disorders Cell Communication & Adhesion. Jul-Dec, 2003 | Pubmed ID: 14681041 Lysosomal and Proteasomal Degradation Play Distinct Roles in the Life Cycle of Cx43 in Gap Junctional Intercellular Communication-deficient and -competent Breast Tumor Cells The Journal of Biological Chemistry. Aug, 2003 | Pubmed ID: 12767974 Retroviral Delivery of Connexin Genes to Human Breast Tumor Cells Inhibits in Vivo Tumor Growth by a Mechanism That is Independent of Significant Gap Junctional Intercellular Communication The Journal of Biological Chemistry. Aug, 2002 | Pubmed ID: 12042301 Multicolor and Electron Microscopic Imaging of Connexin Trafficking Science (New York, N.Y.). Apr, 2002 | Pubmed ID: 11964472 Gap Junctions Assemble in the Presence of Cytoskeletal Inhibitors, but Enhanced Assembly Requires Microtubules Experimental Cell Research. Apr, 2002 | Pubmed ID: 11925106 Evaluation of Mammary Gland Development and Function in Mouse Models JoVE 2828 Biology