Dalia Barsyte-Lovejoy Pharmacology and Toxicology and Structural Genomics Consortium University of Toronto Biography Publications Institution JoVE Articles Dalia Barsyte-Lovejoy has not added a biography. If you are Dalia Barsyte-Lovejoy and would like to personalize this page please email our Author Liaison for assistance. Publications Skeletal Muscle Metabolism and Contraction Performance Regulation by Teneurin C-terminal-associated Peptide-1 Frontiers in Physiology. 2022 | Pubmed ID: 36523555 Distal Extracellular Teneurin Region (teneurin C-terminal Associated Peptide; TCAP) Possesses Independent Intracellular Calcium Regulating Actions, : A Potential Antagonist of Corticotropin-releasing Factor (CRF) Biochemistry and Biophysics Reports. Dec, 2022 | Pubmed ID: 36467544 Combinatorial Anticancer Drug Screen Identifies Off-Target Effects of Epigenetic Chemical Probes ACS Chemical Biology. Oct, 2022 | Pubmed ID: 36084291 Enzymatic Nucleosome Acetylation Selectively Affects Activity of Histone Methyltransferases in Vitro Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Jul, 2022 | Pubmed ID: 35907431 Chemical Biology and Pharmacology of Histone Lysine Methylation Inhibitors Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. Aug, 2022 | Pubmed ID: 35753676 PRMT Inhibition Induces a Viral Mimicry Response in Triple-negative Breast Cancer Nature Chemical Biology. Aug, 2022 | Pubmed ID: 35578032 Validating Small Molecule Chemical Probes for Biological Discovery Annual Review of Biochemistry. Jun, 2022 | Pubmed ID: 35363509 PRMT7 Ablation Stimulates Anti-tumor Immunity and Sensitizes Melanoma to Immune Checkpoint Blockade Cell Reports. Mar, 2022 | Pubmed ID: 35354055 PRMT5 Regulates ATF4 Transcript Splicing and Oxidative Stress Response Redox Biology. May, 2022 | Pubmed ID: 35305370 A Chemical Probe Targeting the PWWP Domain Alters NSD2 Nucleolar Localization Nature Chemical Biology. Jan, 2022 | Pubmed ID: 34782742 Structure and Function of Protein Arginine Methyltransferase PRMT7 Life (Basel, Switzerland). Jul, 2021 | Pubmed ID: 34440512 Development of LM98, a Small-Molecule TEAD Inhibitor Derived from Flufenamic Acid ChemMedChem. Jun, 2021 | Pubmed ID: 34164919 Discovery of the SMYD3 Inhibitor BAY-6035 Using Thermal Shift Assay (TSA)-Based High-Throughput Screening SLAS Discovery : Advancing Life Sciences R & D. Jun, 2021 | Pubmed ID: 34154424 Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders Journal of Medicinal Chemistry. May, 2021 | Pubmed ID: 33980013 Protein Arginine Methylation: from Enigmatic Functions to Therapeutic Targeting Nature Reviews. Drug Discovery. 07, 2021 | Pubmed ID: 33742187 A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6 Journal of Medicinal Chemistry. 04, 2021 | Pubmed ID: 33591753 PRMT5 Inhibition Disrupts Splicing and Stemness in Glioblastoma Nature Communications. 02, 2021 | Pubmed ID: 33579912 Discovery of Small-Molecule Antagonists of the PWWP Domain of NSD2 Journal of Medicinal Chemistry. 02, 2021 | Pubmed ID: 33522809 Discovery of Potent and Selective Allosteric Inhibitors of Protein Arginine Methyltransferase 3 (PRMT3) Journal of Medicinal Chemistry. Feb, 2018 | Pubmed ID: 29244490 Discovery of a Potent, Selective, and Cell-Active Dual Inhibitor of Protein Arginine Methyltransferase 4 and Protein Arginine Methyltransferase 6 Journal of Medicinal Chemistry. 10, 2016 | Pubmed ID: 27584694 A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases ACS Chemical Biology. Mar, 2016 | Pubmed ID: 26598975 LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2 The Journal of Biological Chemistry. May, 2015 | Pubmed ID: 25825497 A Potent, Selective and Cell-active Allosteric Inhibitor of Protein Arginine Methyltransferase 3 (PRMT3) Angewandte Chemie (International Ed. in English). Apr, 2015 | Pubmed ID: 25728001 (R)-PFI-2 is a Potent and Selective Inhibitor of SETD7 Methyltransferase Activity in Cells Proceedings of the National Academy of Sciences of the United States of America. Sep, 2014 | Pubmed ID: 25136132 Discovery of an in Vivo Chemical Probe of the Lysine Methyltransferases G9a and GLP Journal of Medicinal Chemistry. Nov, 2013 | Pubmed ID: 24102134 An Orally Bioavailable Chemical Probe of the Lysine Methyltransferases EZH2 and EZH1 ACS Chemical Biology. 2013 | Pubmed ID: 23614352 Discovery of a Chemical Probe for the L3MBTL3 Methyllysine Reader Domain Nature Chemical Biology. Jan, 2013 | Pubmed ID: 23292653 Small-molecule Inhibition of MLL Activity by Disruption of Its Interaction with WDR5 The Biochemical Journal. Jan, 2013 | Pubmed ID: 22989411 Catalytic Site Remodelling of the DOT1L Methyltransferase by Selective Inhibitors Nature Communications. 2012 | Pubmed ID: 23250418 Association of UHRF1 with Methylated H3K9 Directs the Maintenance of DNA Methylation Nature Structural & Molecular Biology. Nov, 2012 | Pubmed ID: 23022729 Optimization of Cellular Activity of G9a Inhibitors 7-aminoalkoxy-quinazolines Journal of Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21780790 A Chemical Probe Selectively Inhibits G9a and GLP Methyltransferase Activity in Cells Nature Chemical Biology. Aug, 2011 | Pubmed ID: 21743462 CUL7 is a Novel Antiapoptotic Oncogene Cancer Research. Oct, 2007 | Pubmed ID: 17942889 Analysis of Myc Bound Loci Identified by CpG Island Arrays Shows That Max is Essential for Myc-dependent Repression Current Biology : CB. May, 2003 | Pubmed ID: 12747840 Author Correction: Pharmacological Inhibition of PRMT7 Links Arginine Monomethylation to the Cellular Stress Response Nature Communications. | Pubmed ID: 32457299 Pharmacological Inhibition of PRMT7 Links Arginine Monomethylation to the Cellular Stress Response Nature Communications. | Pubmed ID: 32409666 Discovery of a First-in-Class Protein Arginine Methyltransferase 6 (PRMT6) Covalent Inhibitor Journal of Medicinal Chemistry. | Pubmed ID: 32367723 Telomere Dysfunction Cooperates with Epigenetic Alterations to Impair Murine Embryonic Stem Cell Fate Commitment ELife. | Pubmed ID: 32297856 Discovery of a Chemical Probe for PRDM9 Nature Communications. | Pubmed ID: 31848333 Synthetic Peptides As Therapeutic Agents: Lessons Learned From Evolutionary Ancient Peptides and Their Transit Across Blood-Brain Barriers Frontiers in Endocrinology. | Pubmed ID: 31781029 SETD7 at the Heart of Chromatin Factor Interplay Stem Cell Investigation. | Pubmed ID: 31559307 Selective, Small-Molecule Co-Factor Binding Site Inhibition of a Su(var)3-9, Enhancer of Zeste, Trithorax Domain Containing Lysine Methyltransferase Journal of Medicinal Chemistry. | Pubmed ID: 31415173 Therapeutic Targeting of RNA Splicing Catalysis Through Inhibition of Protein Arginine Methylation Cancer Cell. | Pubmed ID: 31408619 A C19MC-LIN28A-MYCN Oncogenic Circuit Driven by Hijacked Super-enhancers Is a Distinct Therapeutic Vulnerability in ETMRs: A Lethal Brain Tumor Cancer Cell. | Pubmed ID: 31287992 Fragment-based Discovery of a Chemical Probe for the PWWP1 Domain of NSD3 Nature Chemical Biology. | Pubmed ID: 31285596 Discovery of a Potent and Selective Fragment-like Inhibitor of Methyllysine Reader Protein Spindlin 1 (SPIN1) Journal of Medicinal Chemistry. | Pubmed ID: 31260300 Targeting Protein Methylation: from Chemical Tools to Precision Medicines Cellular and Molecular Life Sciences : CMLS. | Pubmed ID: 31104094 Targeting Bivalency De-represses Indian Hedgehog and Inhibits Self-renewal of Colorectal Cancer-initiating Cells Nature Communications. | Pubmed ID: 30926792 Teneurin C-Terminal Associated Peptide (TCAP)-1 and Latrophilin Interaction in HEK293 Cells: Evidence for Modulation of Intercellular Adhesion Frontiers in Endocrinology. | Pubmed ID: 30774623 A Chemical Biology Toolbox to Study Protein Methyltransferases and Epigenetic Signaling Nature Communications. | Pubmed ID: 30604761 Direct Interaction Between the PRDM3 and PRDM16 Tumor Suppressors and the NuRD Chromatin Remodeling Complex Nucleic Acids Research. | Pubmed ID: 30462309 Characterization of Inv(3) Cell Line OCI-AML-20 with Stroma-dependent CD34 Expression Experimental Hematology. | Pubmed ID: 30352278 LLY-283, a Potent and Selective Inhibitor of Arginine Methyltransferase 5, PRMT5, with Antitumor Activity ACS Medicinal Chemistry Letters. | Pubmed ID: 30034588 Mammary Molecular Portraits Reveal Lineage-specific Features and Progenitor Cell Vulnerabilities The Journal of Cell Biology. | Pubmed ID: 29921600 TP-064, a Potent and Selective Small Molecule Inhibitor of PRMT4 for Multiple Myeloma Oncotarget. | Pubmed ID: 29719619 Assay Interference and Off-target Liabilities of Reported Histone Acetyltransferase Inhibitors Nature Communications. | Pubmed ID: 29142305 Targeting Human SET1/MLL Family of Proteins Protein Science : a Publication of the Protein Society. | Pubmed ID: 28160335 The EED Protein-protein Interaction Inhibitor A-395 Inactivates the PRC2 Complex Nature Chemical Biology. | Pubmed ID: 28135237 The SUV4-20 Inhibitor A-196 Verifies a Role for Epigenetics in Genomic Integrity Nature Chemical Biology. | Pubmed ID: 28114273 Integrated (epi)-Genomic Analyses Identify Subgroup-Specific Therapeutic Targets in CNS Rhabdoid Tumors Cancer Cell. | Pubmed ID: 27960086 Discovery of a Potent and Selective Coactivator Associated Arginine Methyltransferase 1 (CARM1) Inhibitor by Virtual Screening Journal of Medicinal Chemistry. | Pubmed ID: 27390919 An Integrative Proteomic Approach Identifies Novel Cellular SMYD2 Substrates Journal of Proteome Research. | Pubmed ID: 27163177 Discovery and Characterization of a Highly Potent and Selective Aminopyrazoline-Based in Vivo Probe (BAY-598) for the Protein Lysine Methyltransferase SMYD2 Journal of Medicinal Chemistry. | Pubmed ID: 27075367 Discovery of a Potent Class I Protein Arginine Methyltransferase Fragment Inhibitor Journal of Medicinal Chemistry. | Pubmed ID: 26824386 MLL5 Orchestrates a Cancer Self-Renewal State by Repressing the Histone Variant H3.3 and Globally Reorganizing Chromatin Cancer Cell. | Pubmed ID: 26626085 Gain-of-function P53 Mutants Co-opt Chromatin Pathways to Drive Cancer Growth Nature. | Pubmed ID: 26331536 Pharmacological Targeting of the Wdr5-MLL Interaction in C/EBPα N-terminal Leukemia Nature Chemical Biology. | Pubmed ID: 26167872 Discovery of a Dual PRMT5-PRMT7 Inhibitor ACS Medicinal Chemistry Letters. | Pubmed ID: 25893041 A Chemical Tool for in Vitro and in Vivo Precipitation of Lysine Methyltransferase G9a ChemMedChem. | Pubmed ID: 24443078 Systems Approaches to Genomic and Epigenetic Inter-regulation of Peptide Hormones in Stress and Reproduction Progress in Biophysics and Molecular Biology. | Pubmed ID: 23500148 C-terminal Processing of the Teneurin Proteins: Independent Actions of a Teneurin C-terminal Associated Peptide in Hippocampal Cells Molecular and Cellular Neurosciences. | Pubmed ID: 23026563 Histone Recognition and Large-scale Structural Analysis of the Human Bromodomain Family Cell. | Pubmed ID: 22464331 Characterization of a Corticotropin-releasing Factor (CRF)/diuretic Hormone-like Peptide from Tunicates: Insight into the Origins of the Vertebrate CRF Family General and Comparative Endocrinology. | Pubmed ID: 19646444 Evolution of Complementary Peptide Systems: Teneurin C-terminal-associated Peptides and Corticotropin-releasing Factor Superfamilies Annals of the New York Academy of Sciences. | Pubmed ID: 19456342 Teneurin Carboxy (C)-terminal Associated Peptide-1 Inhibits Alkalosis-associated Necrotic Neuronal Death by Stimulating Superoxide Dismutase and Catalase Activity in Immortalized Mouse Hypothalamic Cells Brain Research. | Pubmed ID: 17900539 Integrin Alpha 11 Regulates IGF2 Expression in Fibroblasts to Enhance Tumorigenicity of Human Non-small-cell Lung Cancer Cells Proceedings of the National Academy of Sciences of the United States of America. | Pubmed ID: 17600088 The C-Myc Oncogene Directly Induces the H19 Noncoding RNA by Allele-specific Binding to Potentiate Tumorigenesis Cancer Research. | Pubmed ID: 16707459 Cancer Therapeutics: Targeting the Dark Side of Myc European Journal of Cancer (Oxford, England : 1990). | Pubmed ID: 16243519 Teneurin Proteins Possess a Carboxy Terminal Sequence with Neuromodulatory Activity Brain Research. Molecular Brain Research. | Pubmed ID: 15710242 Promoter-binding and Repression of PDGFRB by C-Myc Are Separable Activities Nucleic Acids Research. | Pubmed ID: 15226411 Cloning and Characterization of Teneurin C-terminus Associated Peptide (TCAP)-3 from the Hypothalamus of an Adult Rainbow Trout (Oncorhynchus Mykiss) General and Comparative Endocrinology. | Pubmed ID: 15158132 C-Myc Represses the Proximal Promoters of GADD45a and GADD153 by a Post-RNA Polymerase II Recruitment Mechanism Oncogene. | Pubmed ID: 15021909 Studying Protein Arginine Methylation: Approaches and Methods Dalia Barsyte-Lovejoy1 1Pharmacology and Toxicology and Structural Genomics Consortium, University of Toronto JoVE 64821 Editorial Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells Magdalena M. Szewczyk1, Victoria Vu1, Dalia Barsyte-Lovejoy1,2 1Structural Genomics Consortium, University of Toronto, 2Department of Pharmacology and Toxicology, University of Toronto JoVE 62418 Biology
Studying Protein Arginine Methylation: Approaches and Methods Dalia Barsyte-Lovejoy1 1Pharmacology and Toxicology and Structural Genomics Consortium, University of Toronto JoVE 64821 Editorial
Quantitative Methods to Study Protein Arginine Methyltransferase 1-9 Activity in Cells Magdalena M. Szewczyk1, Victoria Vu1, Dalia Barsyte-Lovejoy1,2 1Structural Genomics Consortium, University of Toronto, 2Department of Pharmacology and Toxicology, University of Toronto JoVE 62418 Biology
