Daniel Alcolea Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau Universitat Autònoma de Barcelona Biography Publications Institution JoVE Articles Daniel Alcolea has not added a biography. If you are Daniel Alcolea and would like to personalize this page please email our Author Liaison for assistance. Publications Intermediate and Expanded HTT Alleles and the Risk for α-Synucleinopathies Movement Disorders : Official Journal of the Movement Disorder Society. Jul, 2022 | Pubmed ID: 35852957 Establishing In-House Cutoffs of CSF Alzheimer's Disease Biomarkers for the AT(N) Stratification of the Alzheimer Center Barcelona Cohort International Journal of Molecular Sciences. Jun, 2022 | Pubmed ID: 35805894 Association of Alzheimer Disease With Life Expectancy in People With Down Syndrome JAMA Network Open. 05, 2022 | Pubmed ID: 35604690 Importance of Cerebrospinal Fluid Storage Conditions for the Alzheimer's Disease Diagnostics on an Automated Platform Clinical Chemistry and Laboratory Medicine. Jun, 2022 | Pubmed ID: 35405043 Multimarker Synaptic Protein Cerebrospinal Fluid Panels Reflect TDP-43 Pathology and Cognitive Performance in a Pathological Cohort of Frontotemporal Lobar Degeneration Molecular Neurodegeneration. 04, 2022 | Pubmed ID: 35395770 New Insights into the Genetic Etiology of Alzheimer's Disease and Related Dementias Nature Genetics. 04, 2022 | Pubmed ID: 35379992 Blood Amyloid and Tau Biomarkers As Predictors of Cerebrospinal Fluid Profiles Journal of Neural Transmission (Vienna, Austria : 1996). 02, 2022 | Pubmed ID: 35169889 Hypothalamic Pregnenolone Mediates Recognition Memory in the Context of Metabolic Disorders Cell Metabolism. 02, 2022 | Pubmed ID: 35108514 The Aβ1-42/Aβ1-40 Ratio in CSF is More Strongly Associated to Tau Markers and Clinical Progression Than Aβ1-42 Alone Alzheimer's Research & Therapy. 02, 2022 | Pubmed ID: 35105351 Pathophysiological Underpinnings of Extra-Motor Neurodegeneration in Amyotrophic Lateral Sclerosis: New Insights From Biomarker Studies Frontiers in Neurology. 2021 | Pubmed ID: 35115992 Plasma Glial Fibrillary Acidic Protein and Neurofilament Light Chain for the Diagnostic and Prognostic Evaluation of Frontotemporal Dementia Translational Neurodegeneration. 12, 2021 | Pubmed ID: 34893073 Correction To: Cerebrospinal Fluid Levels of the Neurotrophic Factor Neuroleukin Are Increased in Early Alzheimer's Disease, but Not in Cerebral Amyloid Angiopathy Alzheimer's Research & Therapy. Nov, 2021 | Pubmed ID: 34784952 Cerebrospinal Fluid Levels of the Neurotrophic Factor Neuroleukin Are Increased in Early Alzheimer's Disease, but Not in Cerebral Amyloid Angiopathy Alzheimer's Research & Therapy. 09, 2021 | Pubmed ID: 34560885 Metabolite Signature of Alzheimer's Disease in Adults with Down Syndrome Annals of Neurology. 09, 2021 | Pubmed ID: 34309066 Diagnostic and Prognostic Performance and Longitudinal Changes in Plasma Neurofilament Light Chain Concentrations in Adults with Down Syndrome: a Cohort Study The Lancet. Neurology. 08, 2021 | Pubmed ID: 34302785 Phosphorylated Tau181 in Plasma As a Potential Biomarker for Alzheimer's Disease in Adults with Down Syndrome Nature Communications. 07, 2021 | Pubmed ID: 34262030 Association of Apolipoprotein E ɛ4 Allele With Clinical and Multimodal Biomarker Changes of Alzheimer Disease in Adults With Down Syndrome JAMA Neurology. 08, 2021 | Pubmed ID: 34228042 Use of Plasma Biomarkers for AT(N) Classification of Neurodegenerative Dementias Journal of Neurology, Neurosurgery, and Psychiatry. 11, 2021 | Pubmed ID: 34103344 Common Variants in Alzheimer's Disease and Risk Stratification by Polygenic Risk Scores Nature Communications. 06, 2021 | Pubmed ID: 34099642 AMYQ: An Index to Standardize Quantitative Amyloid Load Across PET Tracers Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 09, 2021 | Pubmed ID: 33797846 Diagnostic Utility of Measuring Cerebral Atrophy in the Behavioral Variant of Frontotemporal Dementia and Association With Clinical Deterioration JAMA Network Open. 03, 2021 | Pubmed ID: 33704477 Sex Differences in the Behavioral Variant of Frontotemporal Dementia: A New Window to Executive and Behavioral Reserve Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 08, 2021 | Pubmed ID: 33590953 Genome Sequencing Analysis Identifies New Loci Associated with Lewy Body Dementia and Provides Insights into Its Genetic Architecture Nature Genetics. 03, 2021 | Pubmed ID: 33589841 Biphasic Cortical Macro- and Microstructural Changes in Autosomal Dominant Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 04, 2021 | Pubmed ID: 33196147 Heterozygous APOE Christchurch in Familial Alzheimer's Disease Without Mutations in Other Mendelian Genes Neuropathology and Applied Neurobiology. 06, 2021 | Pubmed ID: 33095930 Serum Neurofilament Light Chain Predicts Long-term Prognosis in Guillain-Barré Syndrome Patients Journal of Neurology, Neurosurgery, and Psychiatry. Nov, 2020 | Pubmed ID: 33154183 Cerebrospinal Fluid A Beta 1-40 Peptides Increase in Alzheimer's Disease and Are Highly Correlated with Phospho-tau in Control Individuals Alzheimer's Research & Therapy. 10, 2020 | Pubmed ID: 33008460 Cortical Microstructure in the Amyotrophic Lateral Sclerosis-frontotemporal Dementia Continuum Neurology. 11, 2020 | Pubmed ID: 32913016 Obesity Impacts Brain Metabolism and Structure Independently of Amyloid and Tau Pathology in Healthy Elderly Alzheimer's & Dementia (Amsterdam, Netherlands). 2020 | Pubmed ID: 32743041 Motor Cortex Transcriptome Reveals Microglial Key Events in Amyotrophic Lateral Sclerosis Neurology(R) Neuroimmunology & Neuroinflammation. 09, 2020 | Pubmed ID: 32669313 Clinical and Biomarker Changes of Alzheimer's Disease in Adults with Down Syndrome: a Cross-sectional Study Lancet (London, England). 06, 2020 | Pubmed ID: 32593336 Disease-Specific Changes in Reelin Protein and MRNA in Neurodegenerative Diseases Cells. 05, 2020 | Pubmed ID: 32438605 Assessing Circular RNAs in Alzheimer's Disease and Frontotemporal Lobar Degeneration Neurobiology of Aging. 08, 2020 | Pubmed ID: 32335360 Correction To: A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity Acta Neuropathologica. 05, 2020 | Pubmed ID: 31955222 Atrophy of Basal Forebrain Initiates with Tau Pathology in Individuals at Risk for Alzheimer's Disease Cerebral Cortex (New York, N.Y. : 1991). 04, 2020 | Pubmed ID: 31799623 Detection of Amyloid Beta Peptides in Body Fluids for the Diagnosis of Alzheimer's Disease: Where Do We Stand? Critical Reviews in Clinical Laboratory Sciences. 03, 2020 | Pubmed ID: 31661652 APP-derived Peptides Reflect Neurodegeneration in Frontotemporal Dementia Annals of Clinical and Translational Neurology. 12, 2019 | Pubmed ID: 31789459 The Sant Pau Initiative on Neurodegeneration (SPIN) Cohort: A Data Set for Biomarker Discovery and Validation in Neurodegenerative Disorders Alzheimer's & Dementia (New York, N. Y.). 2019 | Pubmed ID: 31650016 Agreement of Amyloid PET and CSF Biomarkers for Alzheimer's Disease on Lumipulse Annals of Clinical and Translational Neurology. 09, 2019 | Pubmed ID: 31464088 The Gene Cluster is a Key Modulator of Soluble TREM2 and Alzheimer's Disease Risk Science Translational Medicine. 08, 2019 | Pubmed ID: 31413141 A Nonsynonymous Mutation in PLCG2 Reduces the Risk of Alzheimer's Disease, Dementia with Lewy Bodies and Frontotemporal Dementia, and Increases the Likelihood of Longevity Acta Neuropathologica. 08, 2019 | Pubmed ID: 31131421 Cortical Microstructure in the Behavioural Variant of Frontotemporal Dementia: Looking Beyond Atrophy Brain : a Journal of Neurology. 04, 2019 | Pubmed ID: 30906945 Impact of CSF Storage Volume on the Analysis of Alzheimer's Disease Biomarkers on an Automated Platform Clinica Chimica Acta; International Journal of Clinical Chemistry. Mar, 2019 | Pubmed ID: 30579960 Elevated YKL-40 and Low SAPPβ:YKL-40 Ratio in Antemortem Cerebrospinal Fluid of Patients with Pathologically Confirmed FTLD Journal of Neurology, Neurosurgery, and Psychiatry. 02, 2019 | Pubmed ID: 30297518 CSF SAPPβ, YKL-40, and NfL Along the ALS-FTD Spectrum Neurology. 10, 2018 | Pubmed ID: 30291183 Decreased CX3CL1 Levels in the Cerebrospinal Fluid of Patients With Alzheimer's Disease Frontiers in Neuroscience. 2018 | Pubmed ID: 30245615 Challenges Associated with Biomarker-based Classification Systems for Alzheimer's Disease Alzheimer's & Dementia (Amsterdam, Netherlands). 2018 | Pubmed ID: 30175226 Cerebral Changes and Disrupted Gray Matter Cortical Networks in Asymptomatic Older Adults at Risk for Alzheimer's Disease Neurobiology of Aging. 04, 2018 | Pubmed ID: 29331877 Cortical Microstructural Changes Along the Alzheimer's Disease Continuum Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 03, 2018 | Pubmed ID: 29080407 Cerebrospinal Fluid and Blood Biomarkers for Neurodegenerative Dementias: An Update of the Consensus of the Task Force on Biological Markers in Psychiatry of the World Federation of Societies of Biological Psychiatry The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry. 06, 2018 | Pubmed ID: 29076399 Weight Loss in the Healthy Elderly Might Be a Non-cognitive Sign of Preclinical Alzheimer's Disease Oncotarget. Dec, 2017 | Pubmed ID: 29285207 The Pitfalls of Biomarker-based Classification Schemes Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 09, 2017 | Pubmed ID: 28704640 CSF SAPPβ, YKL-40, and Neurofilament Light in Frontotemporal Lobar Degeneration Neurology. Jul, 2017 | Pubmed ID: 28592456 Diagnostic and Prognostic Value Of the Combination of Two Measures Of Verbal Memory in Mild Cognitive Impairment Due to Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28527215 Cerebral Amyloid Angiopathy in Down Syndrome and Sporadic and Autosomal-dominant Alzheimer's Disease Alzheimer's & Dementia : the Journal of the Alzheimer's Association. Nov, 2017 | Pubmed ID: 28463681 Cerebrospinal Fluid Mitochondrial DNA in the Alzheimer's Disease Continuum Neurobiology of Aging. 05, 2017 | Pubmed ID: 28089353 A Common Variant in the MC1R Gene (p.V92M) is Associated with Alzheimer's Disease Risk Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 28059796 Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease in Subjects with Down Syndrome Journal of Alzheimer's Disease : JAD. 2017 | Pubmed ID: 27858714 CSF MicroRNA Profiling in Alzheimer's Disease: a Screening and Validation Study Molecular Neurobiology. 11, 2017 | Pubmed ID: 27738874 Progranulin Protein Levels in Cerebrospinal Fluid in Primary Neurodegenerative Dementias Journal of Alzheimer's Disease : JAD. 2016 | Pubmed ID: 26682689 Cerebrospinal Fluid Anti-Amyloid-β Autoantibodies and Amyloid PET in Cerebral Amyloid Angiopathy-Related Inflammation Journal of Alzheimer's Disease : JAD. 2016 | Pubmed ID: 26639966 Amyloid Precursor Protein Metabolism and Inflammation Markers in Preclinical Alzheimer Disease Neurology. Aug, 2015 | Pubmed ID: 26180139 Analysis of the CHCHD10 Gene in Patients with Frontotemporal Dementia and Amyotrophic Lateral Sclerosis from Spain Brain : a Journal of Neurology. Dec, 2015 | Pubmed ID: 26152333 Relationship Between Cortical Thickness and Cerebrospinal Fluid YKL-40 in Predementia Stages of Alzheimer's Disease Neurobiology of Aging. Jun, 2015 | Pubmed ID: 25865441 Cerebral Amyloid Angiopathy-related Atraumatic Convexal Subarachnoid Hemorrhage: an ARIA Before the Tsunami Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. May, 2015 | Pubmed ID: 25735919 Early Cerebellar Hypometabolism in Patients With Frontotemporal Dementia Carrying the C9orf72 Expansion Alzheimer Disease and Associated Disorders. Oct-Dec, 2015 | Pubmed ID: 25203513 TREM2 Mutations Implicated in Neurodegeneration Impair Cell Surface Transport and Phagocytosis Science Translational Medicine. Jul, 2014 | Pubmed ID: 24990881 Relationship Between β-Secretase, Inflammation and Core Cerebrospinal Fluid Biomarkers for Alzheimer's Disease Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24820015 Posttranslational Nitro-glycative Modifications of Albumin in Alzheimer's Disease: Implications in Cytotoxicity and Amyloid-β Peptide Aggregation Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24503620 Plasma Phosphorylated TDP-43 Levels Are Elevated in Patients with Frontotemporal Dementia Carrying a C9orf72 Repeat Expansion or a GRN Mutation Journal of Neurology, Neurosurgery, and Psychiatry. Jun, 2014 | Pubmed ID: 24309270 Feasibility of Lumbar Puncture in the Study of Cerebrospinal Fluid Biomarkers for Alzheimer's Disease: a Multicenter Study in Spain Journal of Alzheimer's Disease : JAD. 2014 | Pubmed ID: 24254700 Characterization of the Repeat Expansion Size in C9orf72 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Human Molecular Genetics. Feb, 2014 | Pubmed ID: 24057670 Distinct Patterns of APP Processing in the CNS in Autosomal-dominant and Sporadic Alzheimer Disease Acta Neuropathologica. Feb, 2013 | Pubmed ID: 23224319 Expansion Mutation in C9ORF72 Does Not Influence Plasma Progranulin Levels in Frontotemporal Dementia Neurobiology of Aging. Aug, 2012 | Pubmed ID: 22502998 Dementia Risk in Parkinson Disease: Disentangling the Role of MAPT Haplotypes Archives of Neurology. Mar, 2011 | Pubmed ID: 21403021 Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma Natalia Valle-Tamayo1,2, Rocío Pérez-González2,3, Gemma Chiva-Blanch4,5, Olivia Belbin1,2, Sara Serrano-Requena1,2, Sònia Sirisi1,2, Alba Cervantes González1,2, Oriol Giró4,5, Érika Sánchez-Aced1,2, Oriol Dols-Icardo1,2, Daniel Alcolea1,2, María Carmona-Iragui1,2, Amanda Jimenez4,5, Alberto Lleó1,2, Juan Fortea1,2, M. Florencia Iulita1,2 1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, 2Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 3Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 4Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, 5Spanish Biomedical Research Network in Physiopathology of Obesity and Nutrition (CIBEROBN) JoVE 64107 Neuroscience
Enrichment of Astrocyte-Derived Extracellular Vesicles from Human Plasma Natalia Valle-Tamayo1,2, Rocío Pérez-González2,3, Gemma Chiva-Blanch4,5, Olivia Belbin1,2, Sara Serrano-Requena1,2, Sònia Sirisi1,2, Alba Cervantes González1,2, Oriol Giró4,5, Érika Sánchez-Aced1,2, Oriol Dols-Icardo1,2, Daniel Alcolea1,2, María Carmona-Iragui1,2, Amanda Jimenez4,5, Alberto Lleó1,2, Juan Fortea1,2, M. Florencia Iulita1,2 1Sant Pau Memory Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, Biomedical Research Institute Sant Pau, Universitat Autònoma de Barcelona, 2Center of Biomedical Investigation Network for Neurodegenerative Diseases (CIBERNED), 3Movement Disorders Unit, Department of Neurology, Hospital de la Santa Creu i Sant Pau, 4Department of Endocrinology and Nutrition, Hospital Clínic de Barcelona, August Pi i Sunyer Biomedical Research Institute - IDIBAPS, 5Spanish Biomedical Research Network in Physiopathology of Obesity and Nutrition (CIBEROBN) JoVE 64107 Neuroscience