Daniele Piomelli Drug Discovery and Development Istituto Italiano di Tecnologia Biography Publications Institution JoVE Articles Daniele Piomelli has not added a biography. If you are Daniele Piomelli and would like to personalize this page please email our Author Liaison for assistance. Publications Bile Acid Recognition by NAPE-PLD ACS Chemical Biology. Oct, 2016 | Pubmed ID: 27571266 A Primary Cortical Input to Hippocampus Expresses a Pathway-Specific and Endocannabinoid-Dependent Form of Long-Term Potentiation ENeuro. Jul-Aug, 2016 | Pubmed ID: 27517090 Free-energy Studies Reveal a Possible Mechanism for Oxidation-dependent Inhibition of MGL Scientific Reports. Aug, 2016 | Pubmed ID: 27499063 Endogenous N-acyl Taurines Regulate Skin Wound Healing Proceedings of the National Academy of Sciences of the United States of America. Jul, 2016 | Pubmed ID: 27412859 Second-Generation Non-Covalent NAAA Inhibitors Are Protective in a Model of Multiple Sclerosis Angewandte Chemie (International Ed. in English). Sep, 2016 | Pubmed ID: 27404798 Absolute Nutrient Concentration Measurements in Cell Culture Media: (1)H Q-NMR Spectra and Data to Compare the Efficiency of PH-controlled Protein Precipitation Versus CPMG or Post-processing Filtering Approaches Data in Brief. Sep, 2016 | Pubmed ID: 27331118 Obesity Development in Neuron-specific Lipoprotein Lipase Deficient Mice is Not Responsive to Increased Dietary Fat Content or Change in Fat Composition Metabolism: Clinical and Experimental. Jul, 2016 | Pubmed ID: 27282869 Assay of Monoacylglycerol Lipase Activity Methods in Molecular Biology (Clifton, N.J.). 2016 | Pubmed ID: 27245902 Ion Mobility Mass Spectrometry Enhances Low-abundance Species Detection in Untargeted Lipidomics Metabolomics : Official Journal of the Metabolomic Society. 2016 | Pubmed ID: 26900387 A Simple and Accurate Protocol for Absolute Polar Metabolite Quantification in Cell Cultures Using Quantitative Nuclear Magnetic Resonance Analytical Biochemistry. May, 2016 | Pubmed ID: 26898303 Vaccenic Acid Suppresses Intestinal Inflammation by Increasing the Endocannabinoid Anandamide and Non-cannabinoid Signaling Molecules in a Rat Model of the Metabolic Syndrome Journal of Lipid Research. Feb, 2016 | Pubmed ID: 26891736 Development and Pharmacological Characterization of Selective Blockers of 2-Arachidonoyl Glycerol Degradation with Efficacy in Rodent Models of Multiple Sclerosis and Pain Journal of Medicinal Chemistry. Mar, 2016 | Pubmed ID: 26888301 A Role for the Endocannabinoid 2-arachidonoyl-sn-glycerol for Social and High-fat Food Reward in Male Mice Psychopharmacology. May, 2016 | Pubmed ID: 26873082 Potent α-amino-β-lactam Carbamic Acid Ester As NAAA Inhibitors. Synthesis and Structure-activity Relationship (SAR) Studies European Journal of Medicinal Chemistry. Mar, 2016 | Pubmed ID: 26866968 Potent Multitarget FAAH-COX Inhibitors: Design and Structure-activity Relationship Studies European Journal of Medicinal Chemistry. Feb, 2016 | Pubmed ID: 26774927 Fluorine Nuclear Magnetic Resonance-based Assay in Living Mammalian Cells Analytical Biochemistry. Feb, 2016 | Pubmed ID: 26686030 Macrophage-derived Lipid Agonists of PPAR-α As Intrinsic Controllers of Inflammation Critical Reviews in Biochemistry and Molecular Biology. 2016 | Pubmed ID: 26585314 Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors on Working Memory in Rats Psychopharmacology. May, 2016 | Pubmed ID: 26558620 Acid Ceramidase in Melanoma: EXPRESSION, LOCALIZATION, AND EFFECTS OF PHARMACOLOGICAL INHIBITION The Journal of Biological Chemistry. Jan, 2016 | Pubmed ID: 26553872 A Double Whammy: Targeting Both Fatty Acid Amide Hydrolase (FAAH) and Cyclooxygenase (COX) To Treat Pain and Inflammation ChemMedChem. Jun, 2016 | Pubmed ID: 26486424 Endocannabinoid Modulation of Predator Stress-Induced Long-Term Anxiety in Rats Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Apr, 2016 | Pubmed ID: 26361059 Monoglyceride Lipase: Structure and Inhibitors Chemistry and Physics of Lipids. May, 2016 | Pubmed ID: 26216043 Role of the Satiety Factor Oleoylethanolamide in Alcoholism Addiction Biology. Jul, 2016 | Pubmed ID: 26037332 Benzoxazolone Carboxamides As Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies Journal of Medicinal Chemistry. Dec, 2015 | Pubmed ID: 26560855 Endocannabinoid Signaling Mediates Oxytocin-driven Social Reward Proceedings of the National Academy of Sciences of the United States of America. Nov, 2015 | Pubmed ID: 26504214 Fasting Stimulates 2-AG Biosynthesis in the Small Intestine: Role of Cholinergic Pathways American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Oct, 2015 | Pubmed ID: 26290104 Deficiency of Lipoprotein Lipase in Neurons Decreases AMPA Receptor Phosphorylation and Leads to Neurobehavioral Abnormalities in Mice PloS One. 2015 | Pubmed ID: 26263173 Activity-Based Probe for N-Acylethanolamine Acid Amidase ACS Chemical Biology. Sep, 2015 | Pubmed ID: 26102511 Feeding-induced Oleoylethanolamide Mobilization is Disrupted in the Gut of Diet-induced Obese Rodents Biochimica Et Biophysica Acta. Sep, 2015 | Pubmed ID: 26024927 Peroxide-Dependent MGL Sulfenylation Regulates 2-AG-Mediated Endocannabinoid Signaling in Brain Neurons Chemistry & Biology. May, 2015 | Pubmed ID: 26000748 Peripheral FAAH and Soluble Epoxide Hydrolase Inhibitors Are Synergistically Antinociceptive Pharmacological Research. Jul, 2015 | Pubmed ID: 25882247 A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor That Suppresses Inflammation and Human Macrophage Activation ACS Chemical Biology. Aug, 2015 | Pubmed ID: 25874594 Multitarget Fatty Acid Amide Hydrolase/cyclooxygenase Blockade Suppresses Intestinal Inflammation and Protects Against Nonsteroidal Anti-inflammatory Drug-dependent Gastrointestinal Damage FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2015 | Pubmed ID: 25757568 Effects of Fatty Acid Amide Hydrolase (FAAH) Inhibitors in Non-Human Primate Models of Nicotine Reward and Relapse Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Aug, 2015 | Pubmed ID: 25754762 Rapid Evaluation of 25 Key Sphingolipids and Phosphosphingolipids in Human Plasma by LC-MS/MS Analytical and Bioanalytical Chemistry. Jul, 2015 | Pubmed ID: 25749796 Modulation of Sweet Taste Sensitivities by Endogenous Leptin and Endocannabinoids in Mice The Journal of Physiology. Jun, 2015 | Pubmed ID: 25728242 Structure of Human N-acylphosphatidylethanolamine-hydrolyzing Phospholipase D: Regulation of Fatty Acid Ethanolamide Biosynthesis by Bile Acids Structure (London, England : 1993). Mar, 2015 | Pubmed ID: 25684574 Methamphetamine Accelerates Cellular Senescence Through Stimulation of De Novo Ceramide Biosynthesis PloS One. 2015 | Pubmed ID: 25671639 Intestinal Lipid-derived Signals That Sense Dietary Fat The Journal of Clinical Investigation. Mar, 2015 | Pubmed ID: 25642767 Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid Ceramidase Angewandte Chemie (International Ed. in English). Jan, 2015 | Pubmed ID: 25395373 O-(triazolyl)methyl Carbamates As a Novel and Potent Class of Fatty Acid Amide Hydrolase (FAAH) Inhibitors ChemMedChem. Feb, 2015 | Pubmed ID: 25338703 A Lipid Gate for the Peripheral Control of Pain The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Nov, 2014 | Pubmed ID: 25392487 Synthesis, Biological Evaluation, and 3D QSAR Study of 2-methyl-4-oxo-3-oxetanylcarbamic Acid Esters As N-acylethanolamine Acid Amidase (NAAA) Inhibitors Journal of Medicinal Chemistry. Dec, 2014 | Pubmed ID: 25380517 Structural Determinants of Peripheral O-arylcarbamate FAAH Inhibitors Render Them Dual Substrates for Abcb1 and Abcg2 and Restrict Their Access to the Brain Pharmacological Research. Sep, 2014 | Pubmed ID: 24993496 A Mighty (ochondrial) Fight? Molecular Metabolism. Jul, 2014 | Pubmed ID: 24944892 Role of Oleoylethanolamide As a Feeding Regulator in Goldfish The Journal of Experimental Biology. Aug, 2014 | Pubmed ID: 24855680 3-Aminoazetidin-2-one Derivatives As N-acylethanolamine Acid Amidase (NAAA) Inhibitors Suitable for Systemic Administration ChemMedChem. Jul, 2014 | Pubmed ID: 24828120 Cannabinoid Type 1 Receptor Availability in the Amygdala Mediates Threat Processing in Trauma Survivors Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Oct, 2014 | Pubmed ID: 24820537 Advances in the Discovery of N-acylethanolamine Acid Amidase Inhibitors Pharmacological Research. Aug, 2014 | Pubmed ID: 24798679 Sample Preparation and Orthogonal Chromatography for Broad Polarity Range Plasma Metabolomics: Application to Human Subjects with Neurodegenerative Dementia Analytical Biochemistry. Jun, 2014 | Pubmed ID: 24708938 Applying a Multitarget Rational Drug Design Strategy: the First Set of Modulators with Potent and Balanced Activity Toward Dopamine D3 Receptor and Fatty Acid Amide Hydrolase Chemical Communications (Cambridge, England). May, 2014 | Pubmed ID: 24691497 A Discount on Cannabinoids Biological Psychiatry. Mar, 2014 | Pubmed ID: 24560432 Peripheral Gating of Pain Signals by Endogenous Lipid Mediators Nature Neuroscience. Feb, 2014 | Pubmed ID: 24473264 Circadian Control of Fatty Acid Elongation by SIRT1 Protein-mediated Deacetylation of Acetyl-coenzyme A Synthetase 1 The Journal of Biological Chemistry. Feb, 2014 | Pubmed ID: 24425865 Synthesis, Structure-activity, and Structure-stability Relationships of 2-substituted-N-(4-oxo-3-oxetanyl) N-acylethanolamine Acid Amidase (NAAA) Inhibitors ChemMedChem. Feb, 2014 | Pubmed ID: 24403170 Effects of Acute Stress on Cardiac Endocannabinoids, Lipogenesis, and Inflammation in Rats Psychosomatic Medicine. Jan, 2014 | Pubmed ID: 24367128 Fluorine NMR-based Screening on Cell Membrane Extracts ChemMedChem. Feb, 2014 | Pubmed ID: 24339446 A Glycosylated, Labionin-containing Lanthipeptide with Marked Antinociceptive Activity ACS Chemical Biology. Feb, 2014 | Pubmed ID: 24191663 Lipid-enriched Diet Rescues Lethality and Slows Down Progression in a Murine Model of VCP-associated Disease Human Molecular Genetics. Mar, 2014 | Pubmed ID: 24158850 More Surprises Lying Ahead. The Endocannabinoids Keep Us Guessing Neuropharmacology. Jan, 2014 | Pubmed ID: 23954677 Wagging the Tail: Essential Role of Substrate Flexibility in FAAH Catalysis Journal of Chemical Theory and Computation. Feb, 2013 | Pubmed ID: 26588763 Brown Adipose Tissue Quantification in Human Neonates Using Water-fat Separated MRI PloS One. 2013 | Pubmed ID: 24205024 Synthesis and Structure-activity Relationship (SAR) of 2-methyl-4-oxo-3-oxetanylcarbamic Acid Esters, a Class of Potent N-acylethanolamine Acid Amidase (NAAA) Inhibitors Journal of Medicinal Chemistry. Sep, 2013 | Pubmed ID: 23991897 Development of Fragment-based N-FABS NMR Screening Applied to the Membrane Enzyme FAAH Chembiochem : a European Journal of Chemical Biology. Sep, 2013 | Pubmed ID: 23918626 Synthesis and Structure-activity Relationship Studies of O-biphenyl-3-yl Carbamates As Peripherally Restricted Fatty Acid Amide Hydrolase Inhibitors Journal of Medicinal Chemistry. Jul, 2013 | Pubmed ID: 23822179 Discovery of a New Class of Highly Potent Inhibitors of Acid Ceramidase: Synthesis and Structure-activity Relationship (SAR) Journal of Medicinal Chemistry. May, 2013 | Pubmed ID: 23614460 A Fatty Gut Feeling Trends in Endocrinology and Metabolism: TEM. Jul, 2013 | Pubmed ID: 23567058 Galantamine Potentiates the Neuroprotective Effect of Memantine Against NMDA-induced Excitotoxicity Brain and Behavior. Mar, 2013 | Pubmed ID: 23532860 Endocannabinoid Signaling in the Gut Mediates Preference for Dietary Unsaturated Fats FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology. Jun, 2013 | Pubmed ID: 23463697 Pharmacological Characterization of Memoquin, a Multi-target Compound for the Treatment of Alzheimer's Disease PloS One. 2013 | Pubmed ID: 23441223 Quantum Mechanics/molecular Mechanics Modeling of Fatty Acid Amide Hydrolase Reactivation Distinguishes Substrate from Irreversible Covalent Inhibitors Journal of Medicinal Chemistry. Mar, 2013 | Pubmed ID: 23425199 Discovery of Highly Potent Acid Ceramidase Inhibitors with in Vitro Tumor Chemosensitizing Activity Scientific Reports. 2013 | Pubmed ID: 23301156 A Binding Site for Nonsteroidal Anti-inflammatory Drugs in Fatty Acid Amide Hydrolase Journal of the American Chemical Society. Jan, 2013 | Pubmed ID: 23240907 Antinociceptive Effects of the N-acylethanolamine Acid Amidase Inhibitor ARN077 in Rodent Pain Models Pain. Mar, 2013 | Pubmed ID: 23218523 β-Lactones Inhibit N-acylethanolamine Acid Amidase by S-Acylation of the Catalytic N-Terminal Cysteine ACS Medicinal Chemistry Letters. May, 2012 | Pubmed ID: 24900487 Synergistic Effects of Galantamine and Memantine in Attenuating Scopolamine-induced Amnesia in Mice Journal of Pharmacological Sciences. 2012 | Pubmed ID: 23149577 Identification and Characterization of Carprofen As a Multitarget Fatty Acid Amide Hydrolase/cyclooxygenase Inhibitor Journal of Medicinal Chemistry. Oct, 2012 | Pubmed ID: 23043222 Combining Galantamine and Memantine in Multitargeted, New Chemical Entities Potentially Useful in Alzheimer's Disease Journal of Medicinal Chemistry. Nov, 2012 | Pubmed ID: 23033965 Uncoupling of the Endocannabinoid Signalling Complex in a Mouse Model of Fragile X Syndrome Nature Communications. 2012 | Pubmed ID: 23011134 Peroxisome Proliferator-activated Receptor α Mediates Acute Effects of Palmitoylethanolamide on Sensory Neurons The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Sep, 2012 | Pubmed ID: 22972997 Associations of Fatty Acids in Cerebrospinal Fluid with Peripheral Glucose Concentrations and Energy Metabolism PloS One. 2012 | Pubmed ID: 22911803 Pretreatment with the Monoacylglycerol Lipase Inhibitor URB602 Protects from the Long-term Consequences of Neonatal Hypoxic-ischemic Brain Injury in Rats Pediatric Research. Oct, 2012 | Pubmed ID: 22821058 Activation of Type 5 Metabotropic Glutamate Receptors and Diacylglycerol Lipase-α Initiates 2-arachidonoylglycerol Formation and Endocannabinoid-mediated Analgesia The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jul, 2012 | Pubmed ID: 22787031 Selective Cannabinoid-1 Receptor Blockade Benefits Fatty Acid and Triglyceride Metabolism Significantly in Weight-stable Nonhuman Primates American Journal of Physiology. Endocrinology and Metabolism. Sep, 2012 | Pubmed ID: 22761159 The Thrifty Lipids: Endocannabinoids and the Neural Control of Energy Conservation Trends in Neurosciences. Jul, 2012 | Pubmed ID: 22622030 N-(2-oxo-3-oxetanyl)carbamic Acid Esters As N-acylethanolamine Acid Amidase Inhibitors: Synthesis and Structure-activity and Structure-property Relationships Journal of Medicinal Chemistry. May, 2012 | Pubmed ID: 22515328 Peripheral FAAH Inhibition Causes Profound Antinociception and Protects Against Indomethacin-induced Gastric Lesions Pharmacological Research. May, 2012 | Pubmed ID: 22420940 2-arachidonoylglycerol Signaling in Forebrain Regulates Systemic Energy Metabolism Cell Metabolism. Mar, 2012 | Pubmed ID: 22405068 A Catalytic Mechanism for Cysteine N-terminal Nucleophile Hydrolases, As Revealed by Free Energy Simulations PloS One. 2012 | Pubmed ID: 22389698 Moving Beyond "good Fat, Bad Fat": the Complex Roles of Dietary Lipids in Cellular Function and Health: Session Abstracts Advances in Nutrition (Bethesda, Md.). Jan, 2012 | Pubmed ID: 22332103 Decreased Body Weight and Hepatic Steatosis with Altered Fatty Acid Ethanolamide Metabolism in Aged L-Fabp -/- Mice Journal of Lipid Research. Apr, 2012 | Pubmed ID: 22327204 A Thickening Network of Lipids Pain. Jan, 2012 | Pubmed ID: 22019134 Endocannabinoid Regulation of Acute and Protracted Nicotine Withdrawal: Effect of FAAH Inhibition PloS One. 2011 | Pubmed ID: 22140525 A Catalytically Silent FAAH-1 Variant Drives Anandamide Transport in Neurons Nature Neuroscience. Nov, 2011 | Pubmed ID: 22101642 Elevated Stearoyl-CoA Desaturase in Brains of Patients with Alzheimer's Disease PloS One. 2011 | Pubmed ID: 22046234 Dietary and Behavioral Interventions Protect Against Age Related Activation of Caspase Cascades in the Canine Brain PloS One. 2011 | Pubmed ID: 21931796 Covalent Inhibitors of Fatty Acid Amide Hydrolase: a Rationale for the Activity of Piperidine and Piperazine Aryl Ureas Journal of Medicinal Chemistry. Oct, 2011 | Pubmed ID: 21830831 Biphenyl-3-yl Alkylcarbamates As Fatty Acid Amide Hydrolase (FAAH) Inhibitors: Steric Effects of N-alkyl Chain on Rat Plasma and Liver Stability European Journal of Medicinal Chemistry. Sep, 2011 | Pubmed ID: 21820769 The ABC Membrane Transporter ABCG2 Prevents Access of FAAH Inhibitor URB937 to the Central Nervous System Pharmacological Research. Oct, 2011 | Pubmed ID: 21767647 Decoding Functional Metabolomics with Docosahexaenoyl Ethanolamide (DHEA) Identifies Novel Bioactive Signals The Journal of Biological Chemistry. Sep, 2011 | Pubmed ID: 21757729 Endocannabinoid Signal in the Gut Controls Dietary Fat Intake Proceedings of the National Academy of Sciences of the United States of America. Aug, 2011 | Pubmed ID: 21730161 New Lipidomic Approaches in Cystic Fibrosis Methods in Molecular Biology (Clifton, N.J.). 2011 | Pubmed ID: 21547738 An Amyloid β(42)-dependent Deficit in Anandamide Mobilization is Associated with Cognitive Dysfunction in Alzheimer's Disease Neurobiology of Aging. May, 2011 | Pubmed ID: 21546126 Towards a Whole-body Systems [multi-organ] Lipidomics in Alzheimer's Disease Prostaglandins, Leukotrienes, and Essential Fatty Acids. Nov, 2011 | Pubmed ID: 21543199 Diacylglycerol Lipase-alpha and -beta Control Neurite Outgrowth in Neuro-2a Cells Through Distinct Molecular Mechanisms Molecular Pharmacology. Jul, 2011 | Pubmed ID: 21493725 Sympathetic Activity Controls Fat-induced Oleoylethanolamide Signaling in Small Intestine The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Apr, 2011 | Pubmed ID: 21490214 Plasma Lipidomics Reveals Potential Prognostic Signatures Within a Cohort of Cystic Fibrosis Patients Journal of Lipid Research. May, 2011 | Pubmed ID: 21335323 Understanding the Role of Carbamate Reactivity in Fatty Acid Amide Hydrolase Inhibition by QM/MM Mechanistic Modelling Chemical Communications (Cambridge, England). Mar, 2011 | Pubmed ID: 21240393 Proinflammatory Stimuli Control N-acylphosphatidylethanolamine-specific Phospholipase D Expression in Macrophages Molecular Pharmacology. Apr, 2011 | Pubmed ID: 21233218 Peripheral Antinociceptive Effects of Inhibitors of Monoacylglycerol Lipase in a Rat Model of Inflammatory Pain British Journal of Pharmacology. Aug, 2011 | Pubmed ID: 21198549 Deficiency of Lipoprotein Lipase in Neurons Modifies the Regulation of Energy Balance and Leads to Obesity Cell Metabolism. Jan, 2011 | Pubmed ID: 21195353 Central and Peripheral Endocannabinoids and Cognate Acylethanolamides in Humans: Association with Race, Adiposity, and Energy Expenditure The Journal of Clinical Endocrinology and Metabolism. Mar, 2011 | Pubmed ID: 21177788 Evaluation of the Emotional Phenotype and Serotonergic Neurotransmission of Fatty Acid Amide Hydrolase-deficient Mice Psychopharmacology. Mar, 2011 | Pubmed ID: 21042794 Blockade of Nicotine Reward and Reinstatement by Activation of Alpha-type Peroxisome Proliferator-activated Receptors Biological Psychiatry. Apr, 2011 | Pubmed ID: 20801430 PER2 Controls Lipid Metabolism by Direct Regulation of PPARγ Cell Metabolism. Nov, 2010 | Pubmed ID: 21035761 Ten Years of Nature Reviews Neuroscience: Insights from the Highly Cited Nature Reviews. Neuroscience. Oct, 2010 | Pubmed ID: 20852655 Anandamide Suppresses Pain Initiation Through a Peripheral Endocannabinoid Mechanism Nature Neuroscience. Oct, 2010 | Pubmed ID: 20852626 Changes in Cognition and Amyloid-β Processing with Long Term Cholesterol Reduction Using Atorvastatin in Aged Dogs Journal of Alzheimer's Disease : JAD. 2010 | Pubmed ID: 20847439 Deficient Liver Biosynthesis of Docosahexaenoic Acid Correlates with Cognitive Impairment in Alzheimer's Disease PloS One. 2010 | Pubmed ID: 20838618 Synthesis and Structure-activity Relationships of N-(2-oxo-3-oxetanyl)amides As N-acylethanolamine-hydrolyzing Acid Amidase Inhibitors Journal of Medicinal Chemistry. Aug, 2010 | Pubmed ID: 20604568 Genetic Deletion of Fatty Acid Amide Hydrolase Alters Emotional Behavior and Serotonergic Transmission in the Dorsal Raphe, Prefrontal Cortex, and Hippocampus Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Sep, 2010 | Pubmed ID: 20571484 The Fat-induced Satiety Factor Oleoylethanolamide Suppresses Feeding Through Central Release of Oxytocin The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. Jun, 2010 | Pubmed ID: 20554860 Evidence for a Role of Endocannabinoids, Astrocytes and P38 Phosphorylation in the Resolution of Postoperative Pain PloS One. 2010 | Pubmed ID: 20531936 Pitfalls and Solutions in Assaying Anandamide Transport in Cells Journal of Lipid Research. Aug, 2010 | Pubmed ID: 20447929 A Role for 2-arachidonoylglycerol and Endocannabinoid Signaling in the Locomotor Response to Novelty Induced by Olfactory Bulbectomy Pharmacological Research. May, 2010 | Pubmed ID: 20044005 CD36 Gene Deletion Decreases Oleoylethanolamide Levels in Small Intestine of Free-feeding Mice Pharmacological Research. Jan, 2010 | Pubmed ID: 19778614 Selective N-acylethanolamine-hydrolyzing Acid Amidase Inhibition Reveals a Key Role for Endogenous Palmitoylethanolamide in Inflammation Proceedings of the National Academy of Sciences of the United States of America. Dec, 2009 | Pubmed ID: 19926854 A Novel Lipidomic Strategy Reveals Plasma Phospholipid Signatures Associated with Respiratory Disease Severity in Cystic Fibrosis Patients PloS One. Nov, 2009 | Pubmed ID: 19893743 Discovery of Potent and Reversible Monoacylglycerol Lipase Inhibitors Chemistry & Biology. Oct, 2009 | Pubmed ID: 19875078 Lipidomic Analysis of Biological Samples by Liquid Chromatography Coupled to Mass Spectrometry Methods in Molecular Biology (Clifton, N.J.). 2009 | Pubmed ID: 19763477 A Second Generation of Carbamate-based Fatty Acid Amide Hydrolase Inhibitors with Improved Activity in Vivo ChemMedChem. Sep, 2009 | Pubmed ID: 19637155 The Endocannabinoid System As a Target for Novel Anxiolytic and Antidepressant Drugs International Review of Neurobiology. 2009 | Pubmed ID: 19607961 Targeted Lipidomics As a Tool to Investigate Endocannabinoid Function International Review of Neurobiology. 2009 | Pubmed ID: 19607960 Structure-property Relationships of a Class of Carbamate-based Fatty Acid Amide Hydrolase (FAAH) Inhibitors: Chemical and Biological Stability ChemMedChem. Sep, 2009 | Pubmed ID: 19554599 Fat-induced Satiety Factor Oleoylethanolamide Enhances Memory Consolidation Proceedings of the National Academy of Sciences of the United States of America. May, 2009 | Pubmed ID: 19416833 Central Administration of Palmitoylethanolamide Reduces Hyperalgesia in Mice Via Inhibition of NF-kappaB Nuclear Signalling in Dorsal Root Ganglia European Journal of Pharmacology. Jun, 2009 | Pubmed ID: 19386271 An Endocannabinoid Signal Associated with Desire for Alcohol is Suppressed in Recently Abstinent Alcoholics Psychopharmacology. Jul, 2009 | Pubmed ID: 19343330 Anandamide Elevation in Cerebrospinal Fluid in Initial Prodromal States of Psychosis The British Journal of Psychiatry : the Journal of Mental Science. Apr, 2009 | Pubmed ID: 19336792 Lipidomic Analysis of Endocannabinoid Metabolism in Biological Samples Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. Sep, 2009 | Pubmed ID: 19171504 Responses to Stress: from the Periphery to the Brain Current Opinion in Pharmacology. Feb, 2009 | Pubmed ID: 19162545 Rapid Pain Modulation with Nuclear Receptor Ligands Brain Research Reviews. Apr, 2009 | Pubmed ID: 19162071 Sleep Deprivation Increases Oleoylethanolamide in Human Cerebrospinal Fluid Journal of Neural Transmission (Vienna, Austria : 1996). Mar, 2009 | Pubmed ID: 19137236 Synthesis and Characterization of a Peripherally Restricted CB1 Cannabinoid Antagonist, URB447, That Reduces Feeding and Body-weight Gain in Mice Bioorganic & Medicinal Chemistry Letters. Feb, 2009 | Pubmed ID: 19128970 The Collisional Behavior of ESI-generated Protonated Molecules of Some Carbamate FAAH Inhibitors Isosteres and Its Relationships with Biological Activity Journal of Mass Spectrometry : JMS. Apr, 2009 | Pubmed ID: 19034887 The Endocannabinoid System As a Target for the Treatment of Cannabis Dependence Neuropharmacology. 2009 | Pubmed ID: 18691603 Distribution and Function of Monoacylglycerol Lipase in the Gastrointestinal Tract American Journal of Physiology. Gastrointestinal and Liver Physiology. Dec, 2008 | Pubmed ID: 18948437 The Lipid Messenger OEA Links Dietary Fat Intake to Satiety Cell Metabolism. Oct, 2008 | Pubmed ID: 18840358 Fatty Acid Amide Hydrolase Inhibition Heightens Anandamide Signaling Without Producing Reinforcing Effects in Primates Biological Psychiatry. Dec, 2008 | Pubmed ID: 18814866 Inhibition of Anandamide Hydrolysis by Cyclohexyl Carbamic Acid 3'-carbamoyl-3-yl Ester (URB597) Reverses Abuse-related Behavioral and Neurochemical Effects of Nicotine in Rats The Journal of Pharmacology and Experimental Therapeutics. Nov, 2008 | Pubmed ID: 18725543 The Element of Surprise Nature Medicine. Jul, 2008 | Pubmed ID: 18607371 An Endocannabinoid Signaling System Modulates Anxiety-like Behavior in Male Syrian Hamsters Psychopharmacology. Oct, 2008 | Pubmed ID: 18545985 Synthesis and Quantitative Structure-activity Relationship of Fatty Acid Amide Hydrolase Inhibitors: Modulation at the N-portion of Biphenyl-3-yl Alkylcarbamates Journal of Medicinal Chemistry. Jun, 2008 | Pubmed ID: 18507372 Increase of Brain Endocannabinoid Anandamide Levels by FAAH Inhibition and Alcohol Abuse Behaviours in the Rat Psychopharmacology. Jul, 2008 | Pubmed ID: 18446329 Targeted Enhancement of Oleoylethanolamide Production in Proximal Small Intestine Induces Across-meal Satiety in Rats American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. Jul, 2008 | Pubmed ID: 18434444 Effects of Palmitoylethanolamide on Signaling Pathways Implicated in the Development of Spinal Cord Injury The Journal of Pharmacology and Experimental Therapeutics. Jul, 2008 | Pubmed ID: 18367664 Endogenous Cannabinoids in Patients with Schizophrenia and Substance Use Disorder During Quetiapine Therapy Journal of Psychopharmacology (Oxford, England). May, 2008 | Pubmed ID: 18308802 Identification of Productive Inhibitor Binding Orientation in Fatty Acid Amide Hydrolase (FAAH) by QM/MM Mechanistic Modelling Chemical Communications (Cambridge, England). Jan, 2008 | Pubmed ID: 18092091 The Effect of Cannabidiol and URB597 on Conditioned Gaping (a Model of Nausea) Elicited by a Lithium-paired Context in the Rat Psychopharmacology. Feb, 2008 | Pubmed ID: 17992520 Identification of Biosynthetic Precursors for the Endocannabinoid Anandamide in the Rat Brain Journal of Lipid Research. Jan, 2008 | Pubmed ID: 17957091 The Endogenous Cannabinoid Anandamide Has Effects on Motivation and Anxiety That Are Revealed by Fatty Acid Amide Hydrolase (FAAH) Inhibition Neuropharmacology. Jan, 2008 | Pubmed ID: 17904589 URB602 Inhibits Monoacylglycerol Lipase and Selectively Blocks 2-arachidonoylglycerol Degradation in Intact Brain Slices Chemistry & Biology. Dec, 2007 | Pubmed ID: 18096504 Correlation Between Energetics of Collisionally Activated Decompositions, Interaction Energy and Biological Potency of Carbamate FAAH Inhibitors Journal of Mass Spectrometry : JMS. Dec, 2007 | Pubmed ID: 18085570 Identification of a Bioactive Impurity in a Commercial Sample of 6-methyl-2-p-tolylaminobenzo[d][1,3]oxazin-4-one (URB754) Annali Di Chimica. Sep, 2007 | Pubmed ID: 17970304 Enhancement of Endocannabinoid Signaling and the Pharmacotherapy of Depression Pharmacological Research : the Official Journal of the Italian Pharmacological Society. Nov, 2007 | Pubmed ID: 17945507 A Neuroscientist's Guide to Lipidomics Nature Reviews. Neuroscience. Oct, 2007 | Pubmed ID: 17882252 The Anandamide Transport Inhibitor AM404 Reduces Ethanol Self-administration The European Journal of Neuroscience. Jul, 2007 | Pubmed ID: 17650118 Hydrolysis of Prostaglandin Glycerol Esters by the Endocannabinoid-hydrolyzing Enzymes, Monoacylglycerol Lipase and Fatty Acid Amide Hydrolase Biochemistry. Aug, 2007 | Pubmed ID: 17649977 A Key Role for Diacylglycerol Lipase-alpha in Metabotropic Glutamate Receptor-dependent Endocannabinoid Mobilization Molecular Pharmacology. Sep, 2007 | Pubmed ID: 17584991 Anandamide Levels in Cerebrospinal Fluid of First-episode Schizophrenic Patients: Impact of Cannabis Use Schizophrenia Research. Aug, 2007 | Pubmed ID: 17566707 Acute Intracerebroventricular Administration of Palmitoylethanolamide, an Endogenous Peroxisome Proliferator-activated Receptor-alpha Agonist, Modulates Carrageenan-induced Paw Edema in Mice The Journal of Pharmacology and Experimental Therapeutics. Sep, 2007 | Pubmed ID: 17565008 The Antinociceptive Effects of Local Injections of Propofol in Rats Are Mediated in Part by Cannabinoid CB1 and CB2 Receptors Anesthesia and Analgesia. Jun, 2007 | Pubmed ID: 17513659 Antidepressant-like Activity of the Fatty Acid Amide Hydrolase Inhibitor URB597 in a Rat Model of Chronic Mild Stress Biological Psychiatry. Nov, 2007 | Pubmed ID: 17511970 Synergistic Antinociception by the Cannabinoid Receptor Agonist Anandamide and the PPAR-alpha Receptor Agonist GW7647 European Journal of Pharmacology. Jul, 2007 | Pubmed ID: 17434479 The Fatty Acid Amide Hydrolase Inhibitor URB597 (cyclohexylcarbamic Acid 3'-carbamoylbiphenyl-3-yl Ester) Reduces Neuropathic Pain After Oral Administration in Mice The Journal of Pharmacology and Experimental Therapeutics. Jul, 2007 | Pubmed ID: 17412883 Regulation of Brain Anandamide by Acute Administration of Ethanol The Biochemical Journal. May, 2007 | Pubmed ID: 17302558 The Endogenous Cannabinoid Anandamide Produces Delta-9-tetrahydrocannabinol-like Discriminative and Neurochemical Effects That Are Enhanced by Inhibition of Fatty Acid Amide Hydrolase but Not by Inhibition of Anandamide Transport The Journal of Pharmacology and Experimental Therapeutics. Apr, 2007 | Pubmed ID: 17210800 Determination of Anandamide and Other Fatty Acyl Ethanolamides in Human Serum by Electrospray Tandem Mass Spectrometry Analytical Biochemistry. Feb, 2007 | Pubmed ID: 17196922 Food Intake Regulates Oleoylethanolamide Formation and Degradation in the Proximal Small Intestine The Journal of Biological Chemistry. Jan, 2007 | Pubmed ID: 17121838 Effects of the FAAH Inhibitor, URB597, and Anandamide on Lithium-induced Taste Reactivity Responses: a Measure of Nausea in the Rat Psychopharmacology. Feb, 2007 | Pubmed ID: 17111174 Conformational Effects in Enzyme Catalysis: Reaction Via a High Energy Conformation in Fatty Acid Amide Hydrolase Biophysical Journal. Jan, 2007 | Pubmed ID: 17098788 Synergistic Antinociceptive Effects of Anandamide, an Endocannabinoid, and Nonsteroidal Anti-inflammatory Drugs in Peripheral Tissue: a Role for Endogenous Fatty-acid Ethanolamides? European Journal of Pharmacology. Nov, 2006 | Pubmed ID: 17027744 Rapid Broad-spectrum Analgesia Through Activation of Peroxisome Proliferator-activated Receptor-alpha The Journal of Pharmacology and Experimental Therapeutics. Dec, 2006 | Pubmed ID: 16997973 The Fatty-acid Amide Hydrolase Inhibitor URB597 Does Not Affect Triacylglycerol Hydrolysis in Rat Tissues Pharmacological Research. Nov, 2006 | Pubmed ID: 16935521 Synthesis and Structure-activity Relationships of FAAH Inhibitors: Cyclohexylcarbamic Acid Biphenyl Esters with Chemical Modulation at the Proximal Phenyl Ring ChemMedChem. Jan, 2006 | Pubmed ID: 16892344 Pharmacological Profile of the Selective FAAH Inhibitor KDS-4103 (URB597) CNS Drug Reviews. 2006 | Pubmed ID: 16834756 Cold Exposure Stimulates Synthesis of the Bioactive Lipid Oleoylethanolamide in Rat Adipose Tissue The Journal of Biological Chemistry. Aug, 2006 | Pubmed ID: 16785227 Molecular Composition of the Endocannabinoid System at Glutamatergic Synapses The Journal of Neuroscience : the Official Journal of the Society for Neuroscience. May, 2006 | Pubmed ID: 16723519 Pharmacological Characterization of Hydrolysis-resistant Analogs of Oleoylethanolamide with Potent Anorexiant Properties The Journal of Pharmacology and Experimental Therapeutics. Aug, 2006 | Pubmed ID: 16702440 Anxiolytic-like Properties of the Anandamide Transport Inhibitor AM404 Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. Dec, 2006 | Pubmed ID: 16541083 Role of the Basolateral Nucleus of the Amygdala in Endocannabinoid-mediated Stress-induced Analgesia Neuroscience Letters. Apr, 2006 | Pubmed ID: 16378681 Postprandial Increase of Oleoylethanolamide Mobilization in Small Intestine of the Burmese Python (Python Molurus) American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. May, 2006 | Pubmed ID: 16373434 Actions of the FAAH Inhibitor URB597 in Neuropathic and Inflammatory Chronic Pain Models British Journal of Pharmacology. Feb, 2006 | Pubmed ID: 16331291 Endocannabinoids at the Spinal Level Regulate, but Do Not Mediate, Nonopioid Stress-induced Analgesia Neuropharmacology. Mar, 2006 | Pubmed ID: 16316669 Oleylethanolamide Activates Ras-Erk Pathway and Improves Myocardial Function in Doxorubicin-induced Heart Failure Endocrinology. Feb, 2006 | Pubmed ID: 16269455 Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors Science (New York, N.Y.). Oct, 2005 | Pubmed ID: 16224028 QM/MM Modelling of Oleamide Hydrolysis in Fatty Acid Amide Hydrolase (FAAH) Reveals a New Mechanism of Nucleophile Activation Chemical Communications (Cambridge, England). Sep, 2005 | Pubmed ID: 16136230 Selective Inhibition of 2-AG Hydrolysis Enhances Endocannabinoid Signaling in Hippocampus Nature Neuroscience. Sep, 2005 | Pubmed ID: 16116451 Targeted Lipidomics: Signaling Lipids and Drugs of Abuse Prostaglandins & Other Lipid Mediators. Sep, 2005 | Pubmed ID: 16099407 The Challenge of Brain Lipidomics Prostaglandins & Other Lipid Mediators. Sep, 2005 | Pubmed ID: 16099388 Stimulation of Endocannabinoid Formation in Brain Slice Cultures Through Activation of Group I Metabotropic Glutamate Receptors Molecular Pharmacology. Nov, 2005 | Pubmed ID: 16051747 Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase Elisa Romeo1, Silvia Pontis1, Stefano Ponzano1, Fabiola Bonezzi1, Marco Migliore1, Simona Di Martino1, Maria Summa1, Daniele Piomelli1,2 1Drug Discovery and Development, Istituto Italiano di Tecnologia, 2Departments of Anatomy and Neurobiology, Pharmacology, and Biological Chemistry, University of California, Irvine School of Medicine JoVE 54652 Biochemistry
Preparation and In Vivo Use of an Activity-based Probe for N-acylethanolamine Acid Amidase Elisa Romeo1, Silvia Pontis1, Stefano Ponzano1, Fabiola Bonezzi1, Marco Migliore1, Simona Di Martino1, Maria Summa1, Daniele Piomelli1,2 1Drug Discovery and Development, Istituto Italiano di Tecnologia, 2Departments of Anatomy and Neurobiology, Pharmacology, and Biological Chemistry, University of California, Irvine School of Medicine JoVE 54652 Biochemistry