In JoVE (1)
Articles by Darcy R. Vandervort in JoVE
Screening for Endocrine Activity in Water Using Commercially-available In Vitro Transactivation Bioassays Alvine C. Mehinto1, B. Sumith Jayasinghe2, Darcy R. Vandervort1, Nancy D. Denslow2, Keith A. Maruya1 1Southern California Coastal Water Research Project Authority, 2Department of Physiological Sciences, University of Florida A protocol to screen for endocrine activity in organic extracts of water samples, including treated wastewater effluent and surface (receiving) water, was adapted using commercially available division-arrested ("freeze and thaw") in vitro transactivation bioassays.
Other articles by Darcy R. Vandervort on PubMed
Spatial Distribution of Unspecified Chronic Kidney Disease in El Salvador by Crop Area Cultivated and Ambient Temperature MEDICC Review. Apr, 2014 | Pubmed ID: 24878647 Chronic kidney disease of unknown etiology is occurring in various geographic areas worldwide. Cases lack typical risk factors associated with chronic kidney disease, such as diabetes and hypertension. It is epidemic in El Salvador, Central America, where it is diagnosed with increasing frequency in young, otherwise-healthy male farmworkers. Suspected causes include agrochemical use (especially in sugarcane fields), physical heat stress, and heavy metal exposure.
Transformation of Polyfluorinated Compounds in Natural Waters by Advanced Oxidation Processes Chemosphere. Feb, 2016 | Pubmed ID: 26524147 The presence of perfluorocarboxylic acids (PFCAs) in source and finished drinking waters is a concern with studies showing bioaccumulation and adverse toxicological effects in wildlife and potentially humans. Per/Polyfluoroalkyl substances (PFAS) such as fluorotelomer alcohols have been identified as precursors for PFCAs in biological pathways. In this study, we investigated the fate of 6:2 and 8:2 homologues of the fluorotelomer unsaturated carboxylic acids (FTUCAs) during advanced oxidation process (AOPs). Results showed 6:2 FTUCA and 8:2 FTUCA transformed into 6-C PFCA (PFHxA) and 8-C PFCA (PFOA) respectively with very little other PFCA formation for all AOPs. The degradation of 6:2 FTUCA and 8:2 FTUCA was greater in the GW compared to SW for the ozone processes but similar for UV/H2O2. The formation of n-C PFCA followed O3>O3/H2O2 at same dose and UV/H2O2 had much lower formation at the doses tested. Non-targeted analysis with the LC-MS-qTOF indicated the production of other PFCAs which contribute to the total mass balance, although no intermediate product was discovered indicating a rapid and direct transformation from the FTUCAs to the PFCAs and/or significant volatilization of intermediates. With the use of AOPs essential to water reuse treatment schemes, this work raises concerns over the risk of potential formation of PFCAs in the treatment and their adverse health effects in finished drinking water.